RO87466B - Procedeu pentru prepararea unor chinazolinone substituite - Google Patents
Procedeu pentru prepararea unor chinazolinone substituiteInfo
- Publication number
- RO87466B RO87466B RO112200A RO11220083A RO87466B RO 87466 B RO87466 B RO 87466B RO 112200 A RO112200 A RO 112200A RO 11220083 A RO11220083 A RO 11220083A RO 87466 B RO87466 B RO 87466B
- Authority
- RO
- Romania
- Prior art keywords
- alkyl
- salts
- lower alkyl
- substd
- quat
- Prior art date
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 2
- -1 amine salt Chemical class 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
- 229940124550 renal vasodilator Drugs 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Tobacco Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor chinazolinone substituite cu formula generala I: (vezi formula) în care R reprezinta hidrogen sau o grupa amino sau nitro, R2 reprezinta hidrogen, alchil cu 1...10 atomi de carbon, cicloalchil cu 3...6 atomi de carbon, cicloalchilmetil cu 3...6 atomi de carbon în grupa alchil, trifluormetil sau norbornilmetil, R3 si R4 sunt identici sau diferiti si reprezinta hidrogen, alchil cu 1...4 atomi de carbon, fenil sau fenil substituit cu halogen sau alcoxi cu 1...4 atomi de carbon, x reprezinta carboxi, carbalcoxi cu 1...4 atomi de carbon în grupa alcoxi, cian, metansulfonil, formil, benzoil sau piridil, constînd din aceea ca un compus cu formula generala II: (vezi formula) în care R1 si R2 au semnificatiile de mai sus si R este hidrogen sau metil, reactioneaza cu o olefina cu formula generala III: (vezi formula) în care R3, R4 si X au semnificatiile de mai sus, în prezenta hidroxizilor de amoniu cuaternari de preferinta a hidroxidului de benziltrimetilamoniu ca agent bazic, la temperatura cuprinsa între temperatura camerei si cea de reflux, produsul de condensare obtinut în care R este metil si/sau X este carbalcoxi fiind transformat în compusul dorit cu formula I prin tratare cu acid halogenhidric, de preferinta acid bromhidric sau iodhidric.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO87466A RO87466A (ro) | 1985-08-31 |
| RO87466B true RO87466B (ro) | 1985-08-31 |
Family
ID=23708017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO112200A RO87466B (ro) | 1982-09-30 | 1983-09-29 | Procedeu pentru prepararea unor chinazolinone substituite |
| RO83116473A RO89787A (ro) | 1982-09-30 | 1983-09-29 | Procedeu pentru prepararea unor chinazolinone substituite |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO83116473A RO89787A (ro) | 1982-09-30 | 1983-09-29 | Procedeu pentru prepararea unor chinazolinone substituite |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (ro) |
| AT (2) | ATE58531T1 (ro) |
| DE (2) | DE3382013D1 (ro) |
| ES (4) | ES8503671A1 (ro) |
| HU (1) | HU192242B (ro) |
| IL (1) | IL69849A (ro) |
| NO (1) | NO833541L (ro) |
| NZ (1) | NZ205685A (ro) |
| PH (2) | PH19508A (ro) |
| RO (2) | RO87466B (ro) |
| SG (1) | SG31887G (ro) |
| YU (2) | YU196983A (ro) |
| ZW (1) | ZW20883A1 (ro) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/xx unknown
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/de not_active Expired - Lifetime
- 1983-09-29 AT AT86201912T patent/ATE58531T1/de not_active IP Right Cessation
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/xx unknown
- 1983-09-29 RO RO112200A patent/RO87466B/ro unknown
- 1983-09-29 NO NO833541A patent/NO833541L/no unknown
- 1983-09-29 RO RO83116473A patent/RO89787A/ro unknown
- 1983-09-29 ES ES526133A patent/ES8503671A1/es not_active Expired
- 1983-09-29 AT AT83305895T patent/ATE34979T1/de active
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/de not_active Expired
- 1983-09-29 HU HU833392A patent/HU192242B/hu unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/ko not_active Ceased
- 1983-09-30 YU YU01969/83A patent/YU196983A/xx unknown
-
1984
- 1984-05-29 ES ES532920A patent/ES532920A0/es active Granted
- 1984-05-29 ES ES532918A patent/ES8507510A1/es not_active Expired
- 1984-05-29 ES ES532919A patent/ES8507511A1/es not_active Expired
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/xx unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR840006218A (ko) | 1984-11-22 |
| DE3376978D1 (en) | 1988-07-14 |
| PH19508A (en) | 1986-05-14 |
| RO87466A (ro) | 1985-08-31 |
| ZW20883A1 (en) | 1985-05-01 |
| ATE58531T1 (de) | 1990-12-15 |
| IL69849A0 (en) | 1983-12-30 |
| PH21757A (en) | 1988-02-18 |
| SG31887G (en) | 1987-07-17 |
| IL69849A (en) | 1987-11-30 |
| ES526133A0 (es) | 1985-03-16 |
| ES532919A0 (es) | 1985-09-01 |
| YU192285A (en) | 1987-12-31 |
| ES532918A0 (es) | 1985-09-01 |
| ES8507512A1 (es) | 1985-09-01 |
| ES8507510A1 (es) | 1985-09-01 |
| ES8507511A1 (es) | 1985-09-01 |
| ES8503671A1 (es) | 1985-03-16 |
| HU192242B (en) | 1988-10-28 |
| NO833541L (no) | 1984-04-02 |
| YU196983A (en) | 1987-02-28 |
| ES532920A0 (es) | 1985-09-01 |
| DE3382013D1 (de) | 1991-01-03 |
| ATE34979T1 (de) | 1988-06-15 |
| NZ205685A (en) | 1987-03-31 |
| RO89787A (ro) | 1986-07-30 |
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