RO85833B - Procedeu pentru prepararea unor derivati de 20-aminotilozina - Google Patents
Procedeu pentru prepararea unor derivati de 20-aminotilozinaInfo
- Publication number
- RO85833B RO85833B RO110152A RO11015283A RO85833B RO 85833 B RO85833 B RO 85833B RO 110152 A RO110152 A RO 110152A RO 11015283 A RO11015283 A RO 11015283A RO 85833 B RO85833 B RO 85833B
- Authority
- RO
- Romania
- Prior art keywords
- amino
- preparing
- tylosin derivatives
- tylosin
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de 30-aminotilozina, cu formula generala I: (vezi formula) în care R reprezinta hidrogen, o grupa hidroxi sau micinosiloxi, Q reprezinta hidrogen sau micarosil, X reprezinta o gruaare cu formula: (vezi formula) în care (i) R1 si R2 reprezinta, independent, hidrogen, o grupa alchil C1-4, cicloalchil C3-10, sau o grupa de formula: -(CH2)npH în care n este 0, 1 sau 2 si pH este o grupa fenil, eventual, substituit cu o grupa alcoxicarbonil C1-4 sau un atom de halogen; (ii) numai unul din simbolurile R1 si R2 eprezinta o grupare de formula: (vezi formula) în care R3 este hidrogen sau o grupa alchil C1-4, celalalt simbol R1 sau R2 avînd semnificatiile de la punctul (i) de mai sus; sau (iii) R1 si R2, luati împreuna cu atomul de azot adiacent, formeaza inelul heterociclic, continînd 5 pîna la 7 atomi în inel si cuprinzînd înca un heteroatom oxigen sau azot; sau a unei sari sau a unui ester de acil al acestuia, procedeul caracterizat prin aceea ca o aldehida cu formula generala II: (vezi formula 9 în care R si q au definitia de mai sus reactioneatza cu un agent aminare cu formula generala III: (vezi formula) în care R1 si R2 au definitia de mai sus, sau o sare de aditie cu acid a cestuia; în mediu de solvent organic inert ales dintr alcanoli inferiori, la temperatura camerei.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57029480A JPS58146595A (ja) | 1982-02-25 | 1982-02-25 | マクロライド系抗生物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85833A RO85833A (ro) | 1984-11-25 |
| RO85833B true RO85833B (ro) | 1984-11-30 |
Family
ID=12277244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO110152A RO85833B (ro) | 1982-02-25 | 1983-02-24 | Procedeu pentru prepararea unor derivati de 20-aminotilozina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4440759A (ro) |
| EP (1) | EP0087921B1 (ro) |
| JP (1) | JPS58146595A (ro) |
| KR (1) | KR850000962B1 (ro) |
| AT (1) | ATE16008T1 (ro) |
| AU (1) | AU555979B2 (ro) |
| CA (1) | CA1202022A (ro) |
| CS (1) | CS235309B2 (ro) |
| DD (1) | DD210283A5 (ro) |
| DE (1) | DE3360951D1 (ro) |
| DK (1) | DK153795C (ro) |
| ES (2) | ES520037A0 (ro) |
| FI (1) | FI72322C (ro) |
| GB (1) | GB2115813B (ro) |
| GR (1) | GR78112B (ro) |
| HU (1) | HU194269B (ro) |
| IL (1) | IL67973A0 (ro) |
| NZ (1) | NZ203365A (ro) |
| PH (1) | PH18435A (ro) |
| PL (1) | PL138759B1 (ro) |
| PT (1) | PT76272B (ro) |
| RO (1) | RO85833B (ro) |
| SU (1) | SU1360588A3 (ro) |
| ZA (1) | ZA831206B (ro) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL69666A (en) * | 1982-09-13 | 1987-10-20 | Lilly Co Eli | 20-amino-20-deoxo-5-o-mycaminosyl-23-o-mycinosyltylonolide derivatives,their preparation and veterinary antibiotic use |
| US4820695A (en) * | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| US4443436A (en) * | 1982-09-13 | 1984-04-17 | Eli Lilly And Company | C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin |
| ZA841277B (en) * | 1983-02-28 | 1985-09-25 | Lilly Co Eli | C-20-and c-23-modified macrolide derivatives |
| IL71032A0 (en) * | 1983-02-28 | 1984-05-31 | Lilly Co Eli | C-20 and c-23-modified macrolide derivatives |
| US4629786A (en) * | 1983-02-28 | 1986-12-16 | Eli Lilly And Company | C-20- and C-23 modified macrolide derivatives |
| US4801721A (en) * | 1984-08-16 | 1989-01-31 | Ryan James W | Stereospecific synthesis of carboxyalkyl peptides |
| US4921947A (en) * | 1986-03-31 | 1990-05-01 | Eli Lilly And Company | Process for preparing macrolide derivatives |
| FR2638458A1 (fr) * | 1988-10-27 | 1990-05-04 | Adir | Nouveaux derives de la tylosine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5354708A (en) * | 1992-06-04 | 1994-10-11 | Taskar Nikhil R | Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine |
| TW309505B (ro) * | 1993-03-31 | 1997-07-01 | Toto Ltd | |
| WO1996009312A1 (en) * | 1994-09-22 | 1996-03-28 | Pfizer Inc. | Antibiotic macrolides |
| EP0778283A3 (en) * | 1995-12-05 | 1998-01-28 | Pfizer Inc. | Antibiotic macrolides |
| CN110590885A (zh) * | 2019-09-30 | 2019-12-20 | 郑州大学 | 20-取代-5-o-碳霉胺糖基-泰乐内酯衍生物 |
| CN117304241B (zh) * | 2023-11-30 | 2024-03-01 | 中国农业科学院饲料研究所 | 一种大环内酯类化合物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3178341A (en) * | 1960-06-27 | 1965-04-13 | Lilly Co Eli | Antibiotics tylosin and desmycosin and derivatives thereof |
| GB1587685A (en) * | 1977-03-09 | 1981-04-08 | Microbial Chem Res Found | Macrolactone derivatives and their production |
| JPS53132584A (en) * | 1977-04-26 | 1978-11-18 | Toyo Jozo Co Ltd | 18-cyano-18-substituted amino-18-deoxy-macrolide anibiotic substance derivative |
| NL8004922A (nl) * | 1979-09-19 | 1981-03-23 | Toyo Jozo Kk | Deformyltylosinederivaten. |
| US4279896A (en) * | 1980-06-23 | 1981-07-21 | Schering Corporation | Novel 20-imino macrolide antibacterial agents |
-
1982
- 1982-02-25 JP JP57029480A patent/JPS58146595A/ja active Granted
-
1983
- 1983-02-21 CS CS831163A patent/CS235309B2/cs unknown
- 1983-02-22 NZ NZ203365A patent/NZ203365A/en unknown
- 1983-02-22 PT PT76272A patent/PT76272B/pt unknown
- 1983-02-22 PH PH28552A patent/PH18435A/en unknown
- 1983-02-22 FI FI830585A patent/FI72322C/fi not_active IP Right Cessation
- 1983-02-22 IL IL67973A patent/IL67973A0/xx unknown
- 1983-02-23 AT AT83300953T patent/ATE16008T1/de not_active IP Right Cessation
- 1983-02-23 GB GB08305005A patent/GB2115813B/en not_active Expired
- 1983-02-23 EP EP83300953A patent/EP0087921B1/en not_active Expired
- 1983-02-23 CA CA000422205A patent/CA1202022A/en not_active Expired
- 1983-02-23 DE DE8383300953T patent/DE3360951D1/de not_active Expired
- 1983-02-23 SU SU833555405A patent/SU1360588A3/ru active
- 1983-02-23 KR KR1019830000732A patent/KR850000962B1/ko active IP Right Grant
- 1983-02-23 DD DD83248168A patent/DD210283A5/de not_active IP Right Cessation
- 1983-02-23 GR GR70585A patent/GR78112B/el unknown
- 1983-02-23 ZA ZA831206A patent/ZA831206B/xx unknown
- 1983-02-23 PL PL1983240735A patent/PL138759B1/pl unknown
- 1983-02-24 AU AU11801/83A patent/AU555979B2/en not_active Ceased
- 1983-02-24 HU HU83642A patent/HU194269B/hu not_active IP Right Cessation
- 1983-02-24 DK DK087783A patent/DK153795C/da not_active IP Right Cessation
- 1983-02-24 ES ES520037A patent/ES520037A0/es active Granted
- 1983-02-24 US US06/469,535 patent/US4440759A/en not_active Expired - Lifetime
- 1983-02-24 RO RO110152A patent/RO85833B/ro unknown
- 1983-10-17 ES ES526529A patent/ES8505207A1/es not_active Expired
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