RO84246A - Procedeu de izolare si purificare a unor derivati de aminozaharuri cainhibitori de glicozihidrolaze - Google Patents

Procedeu de izolare si purificare a unor derivati de aminozaharuri cainhibitori de glicozihidrolaze

Info

Publication number
RO84246A
RO84246A RO7480038A RO8003874A RO84246A RO 84246 A RO84246 A RO 84246A RO 7480038 A RO7480038 A RO 7480038A RO 8003874 A RO8003874 A RO 8003874A RO 84246 A RO84246 A RO 84246A
Authority
RO
Romania
Prior art keywords
glinozihydrolase
cainhibers
purification
derivatives
insulation
Prior art date
Application number
RO7480038A
Other languages
English (en)
French (fr)
Other versions
RO84246B (ro
Inventor
Werner Frommer
Bodo Junge
Uwe Keup
Lutz Muller
Walter Puls
Delf Schmidt
Original Assignee
Bayer Ag,De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag,De filed Critical Bayer Ag,De
Publication of RO84246A publication Critical patent/RO84246A/ro
Publication of RO84246B publication Critical patent/RO84246B/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
RO80038A 1973-09-22 1974-09-21 Procedeu de izolare si purificare a unor derivati de aminozaharuri ca inhibitori de glicozihidrolaze RO84246B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2347782A DE2347782C3 (de) 1973-09-22 1973-09-22 Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
RO84246A true RO84246A (ro) 1984-05-23
RO84246B RO84246B (ro) 1984-07-30

Family

ID=5893358

Family Applications (1)

Application Number Title Priority Date Filing Date
RO80038A RO84246B (ro) 1973-09-22 1974-09-21 Procedeu de izolare si purificare a unor derivati de aminozaharuri ca inhibitori de glicozihidrolaze

Country Status (28)

Country Link
JP (2) JPS5439474B2 (ro)
AR (1) AR210988A1 (ro)
AT (1) AT338199B (ro)
BE (1) BE820147A (ro)
BG (1) BG24959A3 (ro)
CA (1) CA1044164A (ro)
CH (1) CH596312A5 (ro)
CS (1) CS200173B2 (ro)
DD (1) DD117249A5 (ro)
DE (1) DE2347782C3 (ro)
DK (1) DK139979C (ro)
EG (1) EG12207A (ro)
ES (1) ES430283A1 (ro)
FI (1) FI56698C (ro)
FR (1) FR2244536B1 (ro)
GB (1) GB1482543A (ro)
HK (1) HK29780A (ro)
IE (1) IE39856B1 (ro)
IL (1) IL45685A (ro)
LU (2) LU70953A1 (ro)
NL (2) NL180941C (ro)
NO (1) NO142755C (ro)
PH (1) PH12530A (ro)
RO (1) RO84246B (ro)
SE (1) SE432111B (ro)
SU (1) SU562202A3 (ro)
YU (1) YU254574A (ro)
ZA (1) ZA745972B (ro)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614393C3 (de) * 1976-04-02 1980-04-03 Bayer Ag, 5090 Leverkusen Aminozucker-Derivate und diese Verbindungen enthaltende Arzneimittel
US4175123A (en) * 1976-12-23 1979-11-20 Bayer Aktiengesellschaft Amino-sugar derivatives, process for their preparation and pharmaceutical composition thereof
DE2719912C3 (de) * 1977-05-04 1979-12-06 Bayer Ag, 5090 Leverkusen Verfahren zur Isolierung von 0- |4,6-Dideoxy-4- [JJl S-O,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2cyclohexen-1-yl] -amino] - a -D-glucopyranosyl} -(I Pfeil nach rechts 4)-0- a D-glucopyranosyl-(l Pfeil nach rechts 4)-D-glucopyranose aus Kulturbrühen
JPS5953920B2 (ja) * 1977-12-28 1984-12-27 東洋醸造株式会社 新規なアミノ糖化合物およびその製法
GB2016497A (en) * 1978-02-10 1979-09-26 Taisho Pharmaceutical Co Ltd Microbiological production of amylase inhibitor
CA1121290A (en) * 1978-02-14 1982-04-06 Yasuji Suhara Amino sugar derivatives
DE3134591A1 (de) * 1981-09-01 1983-03-10 Bayer Ag, 5090 Leverkusen Neue arzneimittelpraeparationen fuer glykosidhydrolasen-inhibitoren
DE3543999A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Hochreine acarbose
DE19507214A1 (de) * 1995-03-02 1996-10-31 Bayer Ag Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung
EP0796915A3 (de) * 1996-03-22 1999-04-14 Bayer Ag Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen
DE19637591A1 (de) * 1996-09-13 1998-03-19 Bayer Ag Osmokontrolliertes Fermentationsverfahren zur Herstellung von Acarbose
IT1293819B1 (it) * 1997-08-05 1999-03-10 Univ Massachusetts Lowell Procedimento per la preparazione di acarbosio
DE19844924A1 (de) * 1998-09-30 2000-04-06 Bayer Ag Immobilisierte Zellen von Actinoplanes acarbosefaciens SE 50/110, Immobilisierungsverfahren und Verwendung des Immobilisats zur Herstellung von Acarbose
US7022684B2 (en) 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
HRP20010792A2 (en) 2001-10-26 2003-04-30 Pliva D D Acarbose purification process
EP2145538A1 (de) 2008-07-15 2010-01-20 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Pflanzen- und Materialschutzmittel
TR201100148A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Stabil akarboz förmülasyonları.
TR201100150A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Suda çözünür dozaj formları
KR20140109922A (ko) 2011-12-08 2014-09-16 바이엘 인텔렉쳐 프로퍼티 게엠베하 연관된 방선균의 유전적 형질전환을 위한 플라스미드인 액티노플라네스 sp. SE50/110으로부터 유래한 신규한 방선균류 통합 및 접합 인자
WO2013115738A1 (en) 2012-01-31 2013-08-08 Mahmut Bilgic Micronized acarbose
EP2774619B1 (de) 2013-03-04 2016-05-18 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen

Also Published As

Publication number Publication date
FR2244536B1 (ro) 1978-07-28
IL45685A0 (en) 1974-11-29
DK139979B (da) 1979-05-28
BG24959A3 (en) 1978-06-15
JPS5439474B2 (ro) 1979-11-28
DK139979C (da) 1979-10-29
NL180941B (nl) 1986-12-16
FI56698C (fi) 1980-03-10
SE7411748L (ro) 1975-03-24
ATA757974A (de) 1976-12-15
YU254574A (en) 1982-02-28
GB1482543A (en) 1977-08-10
NO743210L (ro) 1975-04-21
NL180941C (nl) 1987-05-18
NL930036I1 (nl) 1993-08-02
CS200173B2 (en) 1980-08-29
DE2347782A1 (de) 1975-04-10
IL45685A (en) 1979-05-31
HK29780A (en) 1980-06-06
ES430283A1 (es) 1976-12-16
NO142755B (no) 1980-06-30
SE432111B (sv) 1984-03-19
FR2244536A1 (ro) 1975-04-18
FI274074A (ro) 1975-03-23
LU88274I2 (ro) 1994-02-03
NL7412478A (nl) 1975-03-25
JPS5053593A (ro) 1975-05-12
ZA745972B (en) 1975-10-29
JPS5536479A (en) 1980-03-14
AR210988A1 (es) 1977-10-14
BE820147A (fr) 1975-03-20
NL930036I2 (nl) 1993-10-01
DD117249A5 (ro) 1976-01-05
NO142755C (no) 1980-10-08
JPS5648518B2 (ro) 1981-11-16
LU70953A1 (ro) 1975-05-28
AT338199B (de) 1977-08-10
SU562202A3 (ru) 1977-06-15
PH12530A (en) 1979-05-17
EG12207A (en) 1979-03-31
FI56698B (fi) 1979-11-30
DE2347782C3 (de) 1979-10-11
CH596312A5 (ro) 1978-03-15
IE39856L (en) 1975-03-22
CA1044164A (en) 1978-12-12
AU7350374A (en) 1976-03-25
DK497374A (ro) 1975-06-02
RO84246B (ro) 1984-07-30
DE2347782B2 (de) 1979-02-15
IE39856B1 (en) 1979-01-17

Similar Documents

Publication Publication Date Title
RO84246A (ro) Procedeu de izolare si purificare a unor derivati de aminozaharuri cainhibitori de glicozihidrolaze
RO84020A (ro) Procedeu pentru prepararea unor derivati de anilina substituita
RO69182A (ro) Procedeu pentru prepararea unor aciloxi-aldehide
RO69411A (ro) Procedeu pentru prepararea unor derivati de chinazolona
RO74877A (ro) Procedeu pentru prepararea unor derivati de prolina
RO66907A (ro) Procedeu pentru prepararea unor derivati de 2-acil-4-oxopirazinoizochinolina
RO68460A (ro) Procedeu pentru prepararea unor derivati de azetidinona
RO73008A (ro) Procedeu pentru prepararea unor derivati de difenileter-4-trifluormetil-4-nitro halogenati
RO77533A (ro) Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina
RO69607A (ro) Procedeu pentru prepararea unor 3-carbamoiloximetilcefalosporine
RO73511A (ro) Procedeu pentru prepararea unor derivati de pirimidona
RO71963A (ro) Procedeu pentru prepararea unor derivati ai 2-fenilindolului
RO70568A (ro) Procedeu pentru prepararea unor derivati de 2-aril-amino-2-imidazoline
RO70677A (ro) Procedeu pentru prepararea unor derivati de difenilamina
RO68141A (ro) Procedeu pentru prepararea unor 3a-fenildecahidroizochinoline
RO79705A (ro) Procedeu pentru prepararea unor derivati ai pitimidinei
RO71575A (ro) Procedeu pentru prepararea unor derivati de pirido-benzodiazepinone
RO72980A (ro) Procedeu pentru prepararea unor derivati de 3-triaziniltiometilcefalosporina
RO70707A (ro) Procedeu pentru obtinerea unor derivati ai fosfonometilglicinei
RO72812A (ro) Procedeu pentru prepararea de biclorura fenilfosfonoasa
RO65456A (ro) Procedeu pentru prepararea unor 6-metil-8-metilergoline substituite
RO70078A (ro) Procedeu pentru prepararea unor derivati de difenilamina
RO72564A (ro) Procedeu pentru prepararea unor derivati ai triaminoandrostanului
RO87769A (ro) Procedeu pentru prepararea unor derivati de tiazolidina
RO74137A (ro) Procedeu pentru prepararea unor derivati spirooxazolidin dionici