RO71209A - Procedeu pentru prepararea unor derivati pirolidinici sau piperidinici ai guanidinei - Google Patents

Procedeu pentru prepararea unor derivati pirolidinici sau piperidinici ai guanidinei

Info

Publication number
RO71209A
RO71209A RO7789709A RO8970977A RO71209A RO 71209 A RO71209 A RO 71209A RO 7789709 A RO7789709 A RO 7789709A RO 8970977 A RO8970977 A RO 8970977A RO 71209 A RO71209 A RO 71209A
Authority
RO
Romania
Prior art keywords
pyrolidine
guanidine
preparation
piperidine derivatives
piperidine
Prior art date
Application number
RO7789709A
Other languages
English (en)
French (fr)
Romanian (ro)
Inventor
Chris R Rasmussen
Original Assignee
Mcneil Laboratories Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Laboratories Inc,Us filed Critical Mcneil Laboratories Inc,Us
Publication of RO71209A publication Critical patent/RO71209A/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
RO7789709A 1976-03-19 1977-03-18 Procedeu pentru prepararea unor derivati pirolidinici sau piperidinici ai guanidinei RO71209A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66838676A 1976-03-19 1976-03-19
US75258876A 1976-12-20 1976-12-20

Publications (1)

Publication Number Publication Date
RO71209A true RO71209A (ro) 1981-11-04

Family

ID=27099888

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7789709A RO71209A (ro) 1976-03-19 1977-03-18 Procedeu pentru prepararea unor derivati pirolidinici sau piperidinici ai guanidinei

Country Status (21)

Country Link
JP (1) JPS52136168A (de)
AT (1) AT356669B (de)
AU (1) AU517804B2 (de)
CA (1) CA1100494A (de)
CH (4) CH635073A5 (de)
DD (1) DD130242A5 (de)
DE (1) DE2711757A1 (de)
DK (1) DK119477A (de)
ES (1) ES457010A1 (de)
FI (1) FI65243C (de)
FR (1) FR2361366A1 (de)
GB (1) GB1573532A (de)
GR (1) GR60780B (de)
IE (1) IE44792B1 (de)
IL (1) IL51694A (de)
NL (1) NL7703011A (de)
NO (1) NO148524C (de)
NZ (1) NZ183570A (de)
PH (1) PH16561A (de)
RO (1) RO71209A (de)
SE (1) SE423628B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Noシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
US4101659A (en) * 1977-08-29 1978-07-18 Mcneil Laboratories, Incorporated Benzhydryl guanidines
ZA793186B (en) * 1978-07-06 1981-02-25 Duphar Int Res New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds
DE3061396D1 (en) * 1979-04-20 1983-01-27 Beecham Group Plc Oxazoline and thiazoline derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS55160764A (en) * 1979-05-29 1980-12-13 Ciba Geigy Ag Guanidine* its manufacture and pharmaceutic medicine containing same
EP0028883A3 (de) * 1979-11-10 1981-06-03 Beecham Group Plc Benzimidazolin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPH06198992A (ja) * 1992-11-30 1994-07-19 Shinko Seisakusho Co Ltd 紙葉類搬送装置
EP0690851B1 (de) * 1993-03-23 1999-05-19 Astra Aktiebolag Guanidinderivate mit therapeutischer wirkung
US6297276B1 (en) 1993-10-04 2001-10-02 Glaxosmithkline Substituted urea and isothiourea derivatives as no synthase inhibitors
US6090846A (en) * 1994-06-01 2000-07-18 Glaxo Wellcome Inc. Substituted urea and isothiourea derivatives as no synthase inhibitors
US6225305B1 (en) 1993-10-04 2001-05-01 Glaxo Wellcome Inc. Substituted urea and isothiorea derivatives as no synthase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2205744A1 (de) * 1972-02-08 1973-08-09 Thomae Gmbh Dr K Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung
CH578539A5 (de) * 1972-03-17 1976-08-13 Mcneilab Inc
US3803170A (en) * 1972-08-11 1974-04-09 Richardson Merrell Inc 2-((1-benzylcyclopentyl)imino)pyrrolidine

Also Published As

Publication number Publication date
IL51694A (en) 1982-01-31
CH634557A5 (en) 1983-02-15
AU2335177A (en) 1978-09-21
NO148524C (no) 1983-10-26
ES457010A1 (es) 1978-07-16
FI65243C (fi) 1984-04-10
DE2711757A1 (de) 1977-09-22
FI770864A (de) 1977-09-20
IE44792B1 (en) 1982-04-07
ATA190677A (de) 1979-10-15
NL7703011A (nl) 1977-09-21
CA1100494A (en) 1981-05-05
CH632994A5 (en) 1982-11-15
DD130242A5 (de) 1978-03-15
FR2361366A1 (fr) 1978-03-10
NO148524B (no) 1983-07-18
GB1573532A (en) 1980-08-28
IE44792L (en) 1977-09-19
SE423628B (sv) 1982-05-17
JPS6327342B2 (de) 1988-06-02
CH635073A5 (en) 1983-03-15
AT356669B (de) 1980-05-12
NO770959L (no) 1977-09-20
CH636084A5 (en) 1983-05-13
NZ183570A (en) 1979-06-08
JPS52136168A (en) 1977-11-14
SE7703114L (sv) 1977-09-20
PH16561A (en) 1983-11-18
AU517804B2 (en) 1981-08-27
IL51694A0 (en) 1977-05-31
FI65243B (fi) 1983-12-30
DK119477A (da) 1977-09-20
FR2361366B1 (de) 1984-03-02
GR60780B (en) 1978-08-28

Similar Documents

Publication Publication Date Title
RO75256A (ro) Procedeu pentru prepararea unor derivato ai acidului 1,2,3, tiadiazol-5-carboxilic
RO83052A (ro) Procedeu pentru prepararea unor derivati de fenetanolamina
RO75248A (ro) Procedeu pentru prepararea unor derivati de chinozolina
RO70897A (ro) Procedeu pentru prepararea unor derivati de fenoxibenziloxicarbonil substituiti
RO82375A (ro) Procedeu pentru prepararea de derivati ai 9-aminodibenzopiran
RO70854A (ro) Procedeu de preparare a meta-ariloxibenzaldehidelor
RO75110A (ro) Procedeu pentru prepararea unor derivati de difenilamina
RO76087A (ro) Procedeu de preparare a unor derivati ai guanidinei
RO79969A (ro) Procedeu pentru prepararea unor derivati ai kanamicinei
RO79164A (ro) Procedeu pentru prepararea unor derivati de 1-alil-triazol
RO71209A (ro) Procedeu pentru prepararea unor derivati pirolidinici sau piperidinici ai guanidinei
RO76081A (ro) Procede de preparare a unor derivati de aminoglicozida
RO79048A (ro) Procedeu pentru prepararea unor derivati de 5,11-dihidro-6h-pirido-(2,3b)-(1,4)-benzodiazepin-6-ona
PT66781B (fr) Procede pour la preparation des derives de la phenoxy-hydroxypropylamine
RO78658A (ro) Procedeu de preparare a unor derivati ai antrachinonsulfonamidelor
PT66154B (fr) Procede pour la preparation de nouveaux derives de piperazine
RO76588A (ro) Procedeu pentru prepararea unor derivati de 1,3,4,tiadiazol
RO78091A (ro) Procedeu pentru prepararea unor derivati de 1-azoletena
RO72562A (ro) Procedeu pentru prepararea unor derivati de benzodioxol
RO71066A (ro) Procedeu pentru prepararea unor 2-clorsulfinilazetidin-4-one
RO77935A (ro) Procedeu pentru prepararea unor cis-4a-ariloctahidro-1h-2-pirinidine
RO77330A (ro) Procedeu pentru prepararea derivatilor aminochinazolinei substituite
RO75387A (ro) Procedeu pentru prepararea unor derivatidde 4"-aminooleandomicina
FR2275480A1 (fr) Procede pour la preparation de derives d'azetidone-tiazolidine
RO73274A (ro) Procedeu pentru prepararea unor derivati de azetidin-4-ona