RO128086B1 - Whitening and tartar removing toothpaste - Google Patents

Abstract

The invention relates to a whitening and tartar removing toothpaste composition employed in preventing teeth cavities and dental infections and in strengthening teeth enamel. According to the invention, the composition comprises 20...30 parts of sodium bicarbonate, 10...15 parts of oat (Avena sativa), 4...10 parts of lime tree oil (Tilia tomentosa), 3...8 parts of chamomile (Matricaria chamomilla), 6...11 parts of magnesium carbonate, 4...10 parts of sodium chloride, 4...8 parts of red currants oil (Ribes rubrum), 3...7 parts of gentian (Gentiana lutea) oil, 2...5 parts of vitamin C (ascorbic acid), 1...3 parts of zinc, 3...7 parts of glycerol, 15...20 parts of xanthan gum, 3...10 parts of propylene glycol, 1...3 parts of hydroxyethyl cellulose, 0.8...1.3 parts of orange flavour, 0.3...1 part of sodium benzoate, up to 100% deionized water, the parts being expressed by weight for solids and by volume for liquids.

Description

Everyone has the right to file in writing and motivated, at OSIM, a request for revocation of the patent, within 6 months from the publication of the mention of the decision granting it

RO 128086 Β1

The present invention relates to a toothpaste for whitening and descaling, having the effect of strengthening the mineral structure of dental tissue, for use in dentistry.

Dental deposits play an important role in the appearance of dental caries. These deposits contain microorganisms that cause the decomposition of food waste and promote the appearance of caries.

Several oral-dental compositions are known for the care of the oral cavity, which has the disadvantage that it does not ensure removal of tartar and does not have prophylactic effect in the process of dental caries.

RO 110773 B1 has a toothpaste, consisting of 40 ... 45% calcium carbonate, 1 ... 1.3% hydroxyethyl cellulose, 22 ... 25% propylene glycol, 1.8 ... 2% lauryl sulphate sodium, 0.09 ... 0.10% nipgin, 0.025 ... 0.30% nipasol, 0.25 ... 0.50% alkaline protease, 0.15 ... 0.25% acetate sodium, 0.10 ... 0.15% saccharin, 0.75 ... 1% flavoring composition, up to 100% by weight deionized water.

R0 104760 refers to a toothpaste composition used in oral and dental hygiene for prophylactic and therapeutic purposes, based on abrasives, disinfectants, humectants, preservatives, foaming and sweetening agents, flavoring, consisting of, providing a strong astringent effect and of increasing the resistance of the oral cavity to infections, consisting of:

42 .. .50% bicalcium phosphate, 16 ... 20% propylene glycol, 1.5 ... 2% sodium lauryl sulphate, 1.2 ... 1.5% hydroxyethyl cellulose, 0.1..0.3% acid saccharin, 0.1 ... 0.2% methyl p-hydroxynenzoate, 0.02 ... 0.3% sodium fluoride, 1 ... 1.5% flavorings, 0.05 ... 0 , 1 citric acid, 1 ... 1.2% ascorbic acid, and rest in% deionized water, the percentages being expressed by weight.

R0102610 describes a composition for medicinal toothpaste, used against gingival lesions or in periodontics, based on curative substances and volatile oils, consisting in the fact that 0.1% allantoin is added to 5% Rathaniae tincture, 21, 84% propylene glycol, 2.184% hydroxyethyl cellulose, 2.184% sodium lauryl sulfate, 2.184% sodium benzoate, 17.85% basic magnesium carbonate, 0.74% talc, 5.25% magnesium peroxide, 1.78% zinc chloride , 1.05% sodium fluoride, 1.05% sodium citrate, 0.525% salol, 0.1% soluble saccharin, 0.78% oleum Menthae, 0.078% oleum Spearmint, and the rest deionized water.

RO 79519 presents a medicinal toothpaste containing rathania tincture, sodium chloride and sodium fluoride, according to the main invention with the description of RO 78097, consisting of: rathania tincture 8.00%, zinc chloride concentration 45 %, 1.75% sodium fluoride, 0.10% in a toothpaste consisting of: magnesium carbonate 14.00 ... 17.00%, carboxyethylcellulose 2.00%, glycerol 20.00% , sodium lauryl sulfate 2.00% sodium benzoate 2.00%, saccharin 0.10%, menthae oil 0.70%, aniseed oil or 0.70% phenolic oil, possibly 5.00 ... 10.00% magnesium peroxide.

The objective technical problem that the invention aims to solve is to prevent tooth decay.

The toothpaste according to the invention consists of: 20. ..30 parts sodium bicarbonate,

10 .. .15 parts Avena sativa, 4 ... 10 parts Tilia tomentosa, 3 ... 8 parts Matricaria charmomilla, 6 ... 11 parts magnesium carbonate, 4 ... 10 parts sodium chloride, 4. ... .8 parts Ribes rubrum, 3 ... 7 parts Gentian Iutea, 2 ... 5 parts ascorbic acid, 1 ... .3 parts zinc, 3 ... 7 parts glycerin, 15 ... 20 parts Xanthan gum, 3 ... 10 parts propylene glycol, 1 ... 3 parts hydroxylethylcellulose, 0.8 ... 1.3 parts orange flavor, 0.3 ... 1 parts sodium benzoate and up to 100% deionized water, parts being expressed by weight, and liquids by volume.

The toothpaste according to the invention has the following advantages:

- contains powdery substances with antitartur, antimicrobial, anti-inflammatory action;

- it is made on the basis of cleansing and aromatic substances;

RO 128086 Β1

- presents natural active principles, rich in essential amino acids with antimicrobial role 1 and gums strengthening;

- Strengthens the mineral structure of the dental tissue, the root of the teeth and the health of the upper 3 gingival face.

The following is a concrete example of embodiment of the invention. 5

Example of realization. The following ingredients are weighed: 20 ml Sodium bicarbonate, 15 ml Oat extract, 10 ml Tei oil, 10 ml Sodium chloride, 8 ml Red currant tincture, 7 ml Gentian oil, 3 ml Muscovite tincture, 10 ml Xanthan gum, 5 ml MgCO ₃ , 4 ml Vitamin

C, 3 ml Glycerin, 2 ml Zinc, 3 ml Propylene glycol, 1 ml Orange flavor, 0.3 ml 9 sodium benzoate and up to 100% deionized water.

Melt in the water bath: Xanthan gum and glycerin, then add the following 11 extracts: Tei oil, Gentian oil, followed by zinc oxide, and under continuous stirring of the bath, add continuously, until cooling, the others elements: tincture of red currant, 13 tincture of chamomile, vitamin C, oat extract, sodium chloride, sodium bicarbonate, sodium benzoate, MgCO ₃ , propylene glycol, orange flavor, then water, until corn-15 filling the formula. After a perfect homogenization, a paste with a soft, yellowish-white color is obtained, with the typical smell of the plants in the composition. 17

The toothpaste is obtained by introducing the abrasive substance into the gel formed by water binder and propylene glycol, after dissolving the ingredients in water. To maintain the activity of the alkaline prosthesis in the toothpaste, sodium chloride and sodium bicarbonate were used as abrasive substances, as a hydroxylethyl cellulose binder, as a sodium benzoate stabilizer, as 21 anti-infectious substances, lime and musk. glycerin. The control of the raw materials was carried out regarding the standardized organoleptic qualities: odor, taste and 23 colors.

The small boxes are packaged in other large cardboard boxes, parallelepiped, inscribed 25 with the product name, method of administration, manufacturing batch and shelf life.

The invention is further described in detail. 27

It is known that MgCO ₃ (Magnesium carbonate) is used in cosmetics, toothpaste, is used as a laxative and to maintain color in food. In addition, magnesium carbonate of purity is used as an antacid and as an additive in table salt. Hydrated magnesium carbonate is used to soften the skin. As a food additive, magnesium carbonate is known as E504, for which, the only known adverse effect is that it can function as a laxative at high concentrations. 33

Zinc is known to be a microelement with antioxidant qualities. It is an active element in the constitution of 60 enzymes; plays an important role in: maintaining visual acuity, 35 metabolism of proteins, activity of the pancreas and sexual organs, speeding up the healing of burns and wounds including the buccal ones, stimulating the process of assimilating some vitamins, 37 forming leukocytes, activating the immune system, promoting the synthesis of nucleic acids and regeneration processes, etc. Zinc also stimulates mental activity and helps 39 the brain to function properly.

Zinc deficiency affects sexual growth and development, lowers appetite, 41 accelerates aging, leads to anemia, hair loss and nail deformation, liver disease, repeated infections, decreased taste and olfactory sensitivity, 43 difficulties in scarring, different neuralgia, prostatitis installation, impaired immune system, sexual impotence, decreased sperm production and reproductive system disorders, etc.

RO 128086 Β1

Disruption of zinc metabolism is the main cause of diabetes. Excess zinc can cause hypercholesterolemia and the subsequent installation of atherosclerosis. Zinc deficiency can occur in children malnourished with animal products (eggs, milk and dairy products, etc.).

It is known that ascorbic acid (Vitamin C) is: anti-infectious, invigorating, detoxifying, activates the thyroid and maintains capillary resistance.

The association in the predetermined reports of the indigenous plants presents an increased efficiency resulting from the mutual potentiation, increased, of the components, between which there is a synergistic effect, resulting in a cumulative action on the activity and presents soothing, anti-ulcer, energizing, toning, stomachic, antiparasitic effects. , anti-infectious, anti-inflammatory, but also an effect that consists of the obvious improvement of the state of health of the oral areas treated, lasting and without side effects.

Thus, the mutually reinforcing constituents are the following: volatile oils from: Oats, Teas, Red currants, Gentian, Orange, Muscat; mineral substances from: Oats, Red currants, Gentian, Orange, Muscat; sugars from: Tei, Orange, Redcurrant; Vitamin C from: Tei, Redcurrant, Mussel, Orange + additional recipe; B vitamins from: Oats; Redcurrants, Orange; carbohydrates from: Oats, Orange; proteins from: Oats, Oranges, Redcurrants; tannins from: Tei, Red currant, Gentian; vitamin A from: Oats; Red currant; flavonoids from: Red currant, Muşețel; carbohydrates from: Oats, Tei; pectinedin: Red currant, Orange; hill from: Tei, Muşețel; but also other substances that are contained in the above mentioned plants such as: avenin, carotene, vitamins PP and D, starch, saponins, lecithin, enzymes, follicular hormone principle, sterols, oxidase, acetylcholine, tyyroside, emulsine, rutoside, fatty acids, cellulose, vitamin PP, anthocyanin, gentiopicrin, amarogentin, gentisima, gentianin, genitotonic acid, gentiamarine, gentiaculin, isogentizine, sterols, lipids, gentianosis, gentiobiosis, bitter heterozygous, azulene, matricine, chlorogenic acid, resin, bluish sescviterpenic, coumarinic substances, mucilages, salicylic acid, phytosterines, glycosidic substances, camilin, hesperidin, ascorbic and citric acid and alkaloids such as betadine. Sodium chloride, Xantan gum, MgCO ₃ , Hydroxylethylcellulose, Zinc and Propylene glycol, complement the above qualities by reducing the capillary permeability and fragility, which demonstrates the complementation and potentiation of the qualities of the toothpaste plants claimed in the invention.

CLINICAL PRECLINICAL TESTS

Essential in achieving the composition of the toothpaste is the enhancement capacity of the component elements. To this end, several comparative tests have been performed with the biospectrum or bioresonance and with the help of the Kirlian effect. In all cases, the toothpaste claimed in the invention is significantly superior to other products of the same kind with which it has been compared. It also has the biological field about twice as much as the other similarly tested products.

Other advantages of the new formula are based on the natural active substances existing in the plants of the formula, such as: potassium, calcium, chlorine, magnesium, phosphorus, sodium, iron, carbohydrates, carotene, vitamins C, PP, D and Bl, gums, isoqercitrine, tyrosine, acetylcholine, sugar, rutoside, choline, malic acid, protides, carbohydrates, pectin, genciopicrin, amarogentina, holozides, gentianine, gentisima, bitter heterozygous, isoqercitrin, tannin, azulene, volatile oil, , umbeliferone, resin.

a. Comparison of the claimed paste, according to the invention, with respect to the products B1, B2, B3, by radiesthetic measurements.

The radiesthetic measurements showed the following values: the claimed product has 24,000 u.e., the product B1 has 13,600 u.e., the product B2 has 13,000 u.e., and the product B3 has 14,100 u.e. (u.e = energy units).

RO 128086 Β1

This test was corroborated with the test regarding the Kirlian effect, in which the three products were also tested, obtaining the following results: the length of the measured ends for the claimed paste was 3.7 ... 3.9 mm , forBI of 2.7 ... 2.9mm, for 3

B2, 2.5 ... 2.6 mm, and B3 2.9 ... 3.2 mm.

The conclusion is that, the claimed paste has an energy capacity approximately double 5 compared to products B1 and B2, and compared to B3 has a 45 ... 71% stronger effect, and in conjunction with the previous test it can be observed that, the therapeutic effect of the paste according to the invention, 7 is synergistic and complex with respect to products B1 and B2.

The Kirlian and radiesthetic tests demonstrate the energetic qualities of the claimed toothpaste 9, thus the energy radiated by it is sometimes approximately double, compared to the other products, showing that the toothpaste according to the invention can penetrate deeper into the subcutaneous layers than the others. products, thus managing to restore all subcutaneous states, including subcutaneous nerve endings, or pulp. 13

CLINICAL TESTS In the first phase, 12 volunteer patients were tested by two tests (mentioned below), 15 being used all the substances mentioned in the test packages. Only the substances contained in the claimed toothpaste recipe were tested, as follows: various 17 oils, various dyes, Sodium Bicarbonate, Xanthan gum, MgCO ₃ , Vitamin C, Glycerin, Hydroxylethylcellulose, Zinc, Propylene glycol, Sodium benzoate and water . 19

At the first consultation, a full history of possible dental causes was performed and applied for skin testing. 21

Small quantities of one of the tested substances were applied to the gums of the patient and kept for 3 to 5 min, to observe their reaction. 2. 3

At the second consultation, after a few days, another substance was tested.

Interpretation of tests: The allergist completed a form with the test results at the first 25 readings and at the following ones. The system used was the following: Negative reaction (-); Irritant reaction (IR); Equivalent result (+/-); Poorly positive reaction (+); Intense positive reaction 27 (++); Extremely positive reaction (+++).

Irritant reactions included discrete redness, follicular pustules, or reactions that mimic a burn.

The equivocal or irrelevant reactions consist in the pink coloring of the areas corresponding to the 31 test areas, the weak positive ones appear as slightly raised areas in the plane of the pink or red skin, and the intensely positive ones are papulovesqueous until flictene and even 33 ulcerations in those positive extremes.

The relevance of the tests depended on the type and location of the dermal reaction, as well as the specificity of the allergens.

The test is an allergic investigation useful in establishing a correct diagnosis of 37 dermatitis, thus being able to detect if the skin condition is caused or aggravated by a contact allergy. 39 In contact allergy skin testing, many substances can be used.

Sometimes the results may be inconclusive or the allergist may have difficulty reading them when the entire area tested is red and itchy, and is most often encountered in patients who are in a very active phase of the reaction 43 (results). false positive). At other times, a very weak, difficult to interpret reaction may occur in a substance that usually produces dermatitis or in which the patient's history is highly suggestive of incriminating it as a trigger factor (false negative results). in such situations it is necessary to repeat the test at a certain time interval. 47

RO 128086 Β1

Testing is a medical procedure used to establish or deny the involvement of contact with a particular substance as the cause of a contact eczema. Using this method we can see if a certain substance that comes in direct contact with the skin causes inflammation at this level, through an allergic mechanism. It reproduces in miniature the eczematous reaction after the application of allergens, under occlusion, on the intact skin of people allergic to these substances.

A) An evaluation of the therapeutic efficiency of the product, according to the invention, was performed as an adjuvant in the treatment of various types of teeth.

METHOD: Between January 2010 - January 2011, a number of 20 patients aged 10 to 60 years with various types of average dentition disorders were clinically monitored and monitored at the phytotherapeutic consultancy.

All have requested and accepted their completion with a phytotherapeutic treatment appropriate to their condition. Following the presentation of the patients to the practice and following the corroboration of the anamnestic, clinical and paraclinical data, the adjuvant treatment with this product was instituted.

Patients were presented to the clinic with complete medical documentation (paraclinical investigations), as well as the allopathic therapeutic schemes up to that date.

Following the administration of the individual treatment schemes (the conditions presented by each patient were taken into account), which involved the accompanying product with other dietary supplements recommended for the respective associated acute diseases, most of the patients have updated their clinical and paraclinical investigations, so that the clinical observations and the laboratory data found before and after the adjuvant treatment could be compared with the claimed paste.

The monitoring period was 90 days, patients presenting to the control every 30 days.

TREATMENT: The paste composition was applied to all patients twice a day for a period of 1 month. At the end of the administration period, there was an improvement until the effects on the dentition disappeared. The product was well tolerated. The results, after 1 month of treatment, were favorable. No adverse reactions were reported.

CONCLUSIONS: The results obtained in this group of patients prove that the use of the product for treating various dental problems, has many benefits. The properties of the product are due to the active principles of the composition, having antiseptic, decongestant, soothing and nutritional effects. These observations can be considered relevant for the inclusion of the product as an adjuvant treatment for a wide range of dental disorders.

B) An evaluation of the therapeutic efficacy of the claimed paste, according to the invention, was performed as an adjuvant in the treatment of various disorders associated with periodontal diseases.

METHOD: Between January 2010 and March 2011, a number of 22 patients between the ages of 22 and 58 were clinically monitored and followed at the phytotherapeutic consultancy.

Patients showed up at the clinic with various dental disorders: sensitive skin, cold or hot sensitive teeth, white or reddish spots, burns, etc.

Patients were presented with full medical documentation (paraclinical investigations), as well as allopathic therapeutic schemes, up to that date. All patients followed the proposed allopathic therapies, supplementing them with the claimed paste. All have requested and accepted their completion with a cosmetic treatment, appropriate to their condition.

following the administration of the individual treatment schemes (because the conditions presented by each patient were taken into account), which involved the accompanying with the claimed pasta,

Most patients have updated their clinical and paraclinical investigations, so that 1 could compare the clinical observations and laboratory data found before and after the adjuvant treatment with the claimed paste. 3

The monitoring period was 90 days, the patients presenting to the control at each

10-15 days. 5

RESULTS:

Decongestant treatment of gingival tissue. The paste was applied twice a day for 7 days. The results after 1 week of treatment in 4 persons were favorable. The gingival tissue has decongested, returning to normal color, the stain being removed. 9 The body's response to treatment was favorable. No adverse reactions were reported. The product was well tolerated and no adverse reactions were observed. 11

Oral calming treatment, with cold or hot reactions, which can look like a pulp.

The product was applied, for 2 weeks, to 4 persons, on sensitive places, these 13 becoming more resistant to temperature differences.

Anti-inflammatory treatment of the oral cavity, has been observed in 5 other people, with 15 skin irritated to various food products. After only 2 weeks of treatment, the coloration changed to pink, which demonstrates the beneficial action on the 17 subcutaneous nerve endings and on the peripheral circulatory system.

TREATMENT of teeth whitening that has obtained coloring from various food products, usually yellow-beige-brown. The product was applied, for 2 weeks, to 5 persons, and after 7 days the coloration began to return to normal, towards white. 21

TREATMENT anti-caries of teeth. Regarding the appearance of small caries, the treatment was applied to 4 persons who could bear the application of the product, and of course with respect to 23 conditions of oral hygiene, for 4 weeks; it was observed that the teeth were restored in the caries area previously. 25

Clinical tests performed indicate a good tolerance of toothpaste on mucous membranes and skin and a very good antimicrobial and antifungal activity. In the toxochemical tests 27, no side effects were recorded.

CONCLUSIONS: The results obtained in this group of patients prove that the use of the toothpaste 29 claimed for the treatment of various diseases of the tooth and the oral cavity has many benefits. The properties of the product are due to the active principles of the composition 31, which act synergistically, having antiseptic, decongestant, calming and nutritional effects of the tissue, as well as being anti-ulcerous, energizing, invigorating, stomachic, antiparasitic, 33 anti-infective, anti-inflammatory.

Claims (7)

3 Toothpaste for whitening and descaling, characterized in that it consists of: 20 ... 30 parts sodium bicarbonate, 10 ... 15 parts Avena sativa, 4 ... 10 parts Tilia tomentosa, 5 3 ... 8 parts Matricaria charmomilla, 6 ... 11 parts magnesium carbonate, 4 ... 10 parts sodium chloride, 4 ... 8 parts Ribes rubrum, 3 ... 7 parts Gentiania Iuțea, 2 ... 5 parts ascorbic acid, 1. .3 parts 7 zinc, 3 ... 7 parts glycerin, 15 ... 20 parts Xanthan gum, 3 ... 10 parts propylene glycol, 1 ... 3 parts hydroxylethylcellulose, 0, 8 ... 1.3 parts orange flavor, 0.3 ... 1 parts sodium benzoate and up 9 to 100% deionized water, parts being expressed by weight, and liquids by volume.