RO120171B1 - Cosmetic and hygiene products, process for preparing and for applying the same - Google Patents

Abstract

The invention relates to cosmetic and hygiene products for maintaining and improving the health condition by balancing and meliorating the cosmetologic status, to be employed in cosmetology, to a process for preparing and a process for applying said products. According to the invention, the cosmetic and hygiene products contain 5...96% by weight deuterium depleted water (ASD) where the deuterium content ranges between 2 and 80 ppm, in association with up to 95% pharmacologically acceptable excipients, with or without other active components embedded, and can be formulated as lotions, sprays, gels, creams, emulsions, mouth wash, tooth pastes, soaps, masks and shampoos.

Description

The present invention relates to cosmetic products and to hygiene with application in cosmetology for maintaining and improving the health status by balancing and improving the cosmetological status, a process for obtaining them and a process for their application.

It is known, from US patent 5788953, cosmetic and hygiene preparations used for the prevention and treatment of skin diseases, including maintenance and beauty products, which contain water with a deuterium content between 111 and 135 ppm. The cosmetic preparations described in the aforementioned patent show, due to their low deuterium content, an action to prevent cancerous skin diseases by lowering the concentration of deuterium in the skin. As a result of this low concentration of deuterium, the products thus obtained can be used to prevent and treat tumor diseases, to slow down aging processes and to treat other skin diseases, such as psoriasis, warts, excess skin pigmentation, skin tuberculosis. and including anti-theft action.

Since in many of the cases presented in the aforementioned patent it is found that only a limited improvement in time of the initial condition has been obtained, ie the symptoms of the disease have not been manifested for a while, there is still a need to develop new products that improve the health status by balancing and improving the cosmetological status.

The problem solved by the present invention is to produce products which, by their action, improve skin metabolism, energetically and constitutionally, improve the water balance at the cellular level and which have an immunomodulatory and control action of cell proliferation, with anti-wrinkle and skin aging control effect.

Surprisingly, it has been found that by reconsidering the deuterium content of water used as a basic component and the amount of deuterium-depleted water (ASD) used in the preparation of cosmetics and hygiene products, including maintenance and beauty products, effects are obtained. to improve and maintain the intense state of health, quickly installed, with a relatively long duration, sometimes without returning to the initial state that required the use of the product according to the invention.

The invention solves the technical problem in that cosmetic and hygiene products contain 5 ... 96% by weight deuterium-depleted water with a deuterium content of between 2 and 80 ppm, in combination with up to 95% pharmacologically acceptable excipients with or without other built-in active components.

The cosmetic and hygiene products according to the invention preferably contain 40 ... 90% and more preferably between 40 and 80% deuterium-depleted water, preferably 20 to 30 ppm in deuterium.

The cosmetic and hygiene products according to the invention are preferably formulated as lotions, sprays, creams, emulsions, gels, masks, mouthwash, toothpaste, mascara, soaps, shampoos, shampoos, conditioners, hair conditioners, etc. .

The cosmetic and hygiene products according to the invention possibly contain another active component, besides the water depleted in deuterium and which can be chosen from: vitamins, components of plant origin, sex hormones, phytohormones, bee products, seaweed extracts and sapropel sludge. , components of animal origin, inorganic compounds and drugs, such as antibiotics and antifungal agents.

The process of obtaining a cosmetic and hygiene product according to the invention consists in the fact that, in a first phase, the basic composition is obtained by hot mixing, preferably at 80 ° C, in the presence of the emulsifier. of the fatty components, for a minimum of 10 minutes, until the complete melting and homogenization of the mixture

RO 120171 Β1 result, upon which, under intense stirring, is gradually poured, a homogeneous mixture obtained, in a second, hot phase, preferably at 80 ° C, from deuterium-depleted water with a content of deuterium in the range 2 ... 80 ppm, propylene glycol, glycerine and preservative with 3 forming an emulsion which cools, under stirring, to 40 ° C and to which is added an emulsion obtained by mixing, in the presence of the emulsifier, of a 5 oily mixture, resulting, in a third phase, from: triglycerides, vegetable oils, vitamins, with a result aqueous solution, in a fourth phase, by mixing, at 40 ° C, the following 7 components : Deuterium-depleted water with deuterium content in the range

2 ... 80 ppm, allantoin, hyaluronate dimethylsilanol, plant extracts, moisturizing agent, 9 hydrolyzed and preservative collagen, finally obtaining the desired product having a pH in the range 4.5 .. .8,5, which, after homogenization , is packaged. 11

The process of applying cosmetic and hygiene products, in order to maintain the cosmetological status, consists in preparing the area of interest of the 13 human body by buffering, for 5 ... 12 days, daily 2 ... 3 times a day , preferably in the form of compresses or by spraying, with ASD with a deuterium content of 40. ..60 ppm, after which 15 apply any of the products, and between two successive applications with the product, with 10 ... 15 min Before application, the surface of interest is brought into contact with ASD with a content of 17 deuterium ranging from 40 to 60 ppm at body temperature.

The cosmetic and hygiene products according to the invention have the following 19 advantages:

- it revitalizes the skin's cellular and energetic and constitutional metabolism by improving the use of glucose and fats;

- they rapidly improve the water balance by much faster absorption and in greater quantity 23 of water in the cell, the water depleted in deuterium being hypotonic, thus exerting an excellent moisturizing effect;

- they have immunomodulatory action and as a result increase the local defense power;

- it controls the cell proliferation that has consequences on the epidermis, where it influences the 27 cell regeneration and the synthesis of collagen and elastic fibers;

- allow very good breathing of the skin and mucous membranes; 29

- the improvement of the cosmetological status occurs in a relatively short time and the level reached is maintained for a relatively long time.31

- as water depleted in deuterium, the water obtained according to the patent is used

RO 112422, which has the following characteristics: deuterium content 2 .... 80 ppm; pH -33

6.5 - 7.5; CI '<0.1 mg / l; SO ² ₄ - <0.1 mg / l; Ca2 +; <0.1 mg / l; Fe ²⁺ <0.1 mg / l; KMnO consumption <1.5mg / l; conductivity <1.5 pS / cm; PO ³ ' ₄ <0.1 mg / l; Mg ²⁺ <0.1 mg / l; With ²⁺ <0.1 mg / l.35 as another active component, in addition to deuterium-depleted water, cosmetics and hygiene products according to the invention can be used: 37

Vitamins, selected from the group of vitamins A, B, C, D, E, F, H, Biotin, D - Panthenol Components of plant origin such as: 39

- plant extracts, preferably from chamomile, yellows, friend, sage, nettle, aloe, tarragon, ponytail, gingo, ginseng, rose, Romanian, orange blossom, melissa, licorice 41, mackerel, chestnut, mint, corner flower, etc .;

- tree extracts and / or parts of trees, such as preferably chlorophyll; extracts 43 chestnut, ivy, linden, dwarf palm, willow, pineapple, henna, birch, hazelnut, coffee, thyme etc.

- extracts or juices of fruits or vegetables, such as preferably apricots, strawberries, 45 grape-fruit, grapes, lemon, cucumber, rice, barley, oats, carrots, tomatoes, garlic, guarana, garlic, rosemary, gut, lemon , caffeine etc; 47

RO 120171 Β1

- vegetable oils, such as grape seeds, olives, sunflower, almonds, lavender, avocado, castor, peanuts, cocoa, tea tree, apricot kernels, coconut, sesame seeds, argan seeds, peanuts, nuts, ceratonia, evening primrose etc;

- phytohormones contained in extracts from corn germs, wheat germs, soybeans, ceratonia etc;

- ceramides, sabosols, allantoin, urea etc;

Sex hormones.

- estrogens, androgens, etc.

Bee products, such as quince, pollen, propolis, wax, honey etc;

Extracts from seaweed and sapropel sludge, such as laminaria, brewer's yeast, fucus, etc.

Components of animal origin, such as:

- oils and fats, preferably cetaceum, mink oil, polar fox fat, etc .;

- milk protein extracts, milk lipids

amino acids, preferably alanine, creatine, glycine, cystic acid, aspartic acid, glycol, carnitine, polimanuroic acid, etc .;

- matrix components, for example collagen, glycosaminoglycans, glycoproteins, mucopolysaccharides, saccharides, hyaluronic acid and derivatives thereof, hydrolysed by gluten, elastin, etc .;

- extracts of placenta, thyme, etc .;

- phospholipids, preferably sericin, lecithin, etc .;

Inorganic compounds, such as:

- ions of metals and non-metals, preferably ions of S, CI, K, Ca, Zn, Hg;

-Oxides, bases, acids, salts, preferably perhydrol, titanium oxide, zinc oxide, sodium perborate, sodium hydroxide, boric acid, phosphinic acid derivatives, etc.

- kaolin, bentonite, etc .;

Medications such as antibiotics and antimycotics, for example, ketoconazole, cyclopyroxolamine, zinc pyrition, chloromethyl / methylisothiazolone, trichlorocarbanilide, etc. and others, such as silanols, hyaluronic acid and its derivatives, caviar extract, diamond powder, dimethicone copoliol, polycarbinol, trichlorocarbanilide, etc .;

In cosmetics and hygiene products, excipients and additives are commonly used in the field of cosmetology, for example propylene glycol, glycerin, cetyl alcohol, stearyl cetyl alcohol, glycerine monostearate, stearic acid, linoleic acid, caprylic / capric triglycerides, sodium isopropyl myristate, lauryl sulfate , sodium lauryl ether sulfate, coconut oil, liquid paraffin, sodium polyacrylate, low density polyethylene, polycarbinol, trichlorocarbanilide, dimethicone copoliol; stabilizers such as, preferably, disodium cocoampodiacetate, etc .; emulsifiers, such as, preferably, 12 cetyl stearyl alcohol, 20 cetyl stearyl alcohol, sodium polyacrylate, vinylpyrrolidone / styrene copolymer, etc .; thickening agents, such as preferably carboxivinyl polymer, etc .; pearl agents; surfactants, such as cocamidopropyl betaine, sulfosuccinated monoesters, etc .; substances with a protective action against solar radiation, such as preferably methyl methynynamate, benzophenone -3, etc .; preservatives, such as salicylic acid, boric acid, benzoic acid, p-hydroxybenzoic acid and / or its esters, phenonipetc .; antioxidants such as superoxide dismutase, hydroquinone, tocopherols, gallic acid esters, citric acid, tartaric acid, ascorbic acid, etc .; coloring, perfuming and flavoring agents.

RO 120171 Β1

It has been found, from the works carried out, that an increased efficiency of cosmetic products 1 and for hygiene, according to the invention, is obtained if, in advance, for 5 ... 12 days, daily of

2 ... 3 times a day, preferably in the form of compresses or by spraying, ASD with 3 with a deuterium content of 40 ... 60 ppm. Maintaining this high efficiency of the products, according to the invention, is ensured by application on the skin, with 10 ... 15 min before each application 5 of the cosmetic product, with ASD with a deuterium content between 40 ... 60 ppm at body temperature. . At the same time, it is recommended, in order to maintain the cosmetological status 7 achieved by applying the products according to the invention, that at least twice a year, preferably in spring and autumn, a maintenance cure of 1 ..2 months, consisting of 9 in local administration of ASD with deuterium content of 2 ... 20 ppm.

At the industrial application of cosmetic and hygiene products, according to the invention, 11 presented good stretching properties, provided that the transcutaneous penetration is fast and very good, from this point of view they can be included in class 13 vanishing, and at the same time they are very stable over time. It has been found that the cosmetic and hygiene products according to the invention have a surprising effect in terms of tolerance 15 and the response to the application is also suitable for sensitive skin, in which case no undesirable side effects were immediately manifested in this case. or after a long-term administration.

The medical and hygienic cosmetic products according to the invention are illustrated in more detail by the following examples, which are intended to exemplify and not to limit the present invention. 21

Example 1. Skin cream with flakes in a vessel, provided with shaking and heating jacket, clean, washed previously with 23 water and detergent, rinsed with distilled water and sterilized before use by exposure to UV rays for 30 min, introduce the components in the order and quantities mentioned in table 25 below and shake, at a temperature of 40'C, for about 15 min.

COMPONENTS QUANTITY, g ASD with deuterium content 25 ± 5ppm 95.0 allantoin 0.5 Hydrolyzed collagen 1.0 Aloe vera extract 1.0 Salicylic acid 0.5 emulsifier 1.4 preservative 0.4 Perfume 0.1

The cream-gel obtained is applied 2 times a day, with light massage, on the areas of interest and after application for 3 ... 7 days the skin has become smooth, supple, with marked reduction, up to 39 at the disappearance of the scales.

RO 120171 Β1

Example 2. Day cream for normal and dry skin

COMPONENTS QUANTITY, g Phase I Glycerol Monostearate Isopropyl myristate Paraffin oil Natural emulsifier, type Emulgin Cetyl alcohol 10.0 6.0 5.0 4.0 1.5 Phase II 25 + 5ppm ASD 23.0 Propylene Glycol 5.0 Glycerin 5.0 preservative 23.0 5.0 5.0 1.0 Phase III Capric acid / caprylic triglycerides Sun protection factors Jojoba oil Olive oil Grape seed oil Vitamin E 4.0 2.9 2.0 2.0 0.5 0.5 Phase IV ASD with deuterium content 25 ± 5ppm Aloe vera extract Moisturizing agents Hydrolyzed collagen Alantoin 0.5% Emulsifier Fragrance agent 22.2 1.0 3.0 0.5 0.1 0.7 0.1

In order to obtain the day cream for dry and normal skin, the following process steps are carried out:

Phase 1. In a vessel, provided with shaking and heating jacket, clean, previously washed with water and detergent, rinsed with distilled water and sterilized, before use by exposure to UV rays for 30 minutes, be introduced, in the quantities mentioned in the table, the components in the following order: gllicerol monostearate, isopropyl myristate, paraffin oil, natural emulator type Emulgin, cetyl alcohol and the vessel is heated on the water bath so that the temperature inside is 80 ° C and stir for a minimum of 10 minutes, until completely melted and homogenized.

Phase 2. In another vessel, similar to the one above, clean, washed, dried and sterilized, the following components are introduced under stirring: ASD in the quantity in the table above, propylene glycol, glycerine, preservatives and the vessel is heated, with stirring, at 80 ° C inside and stirring is continued until homogenized. Add 10% NaOH solution to pH 5.5. The resulting mixture is poured into a thin wire over the mixture obtained in phase I, at 80 ° C, under intense agitation and stirring is continued for at least 10 min until complete emulsification. The emulsion thus obtained is allowed to cool, under stirring, to 40 ° C.

Phase 3. In a vessel, provided with shaking and heating jacket, clean, dry and sterilized, the oil components are introduced in the quantities in the table and in the following order: capylic / caprylic acid triglycerides, sun protection factor, jojoba oil, olive oil, oil

EN 120171 Β1 of grape seed, vitamin E. during the addition the temperature in the vessel is raised and kept at 40 ° C and homogenized at this temperature. The resulting mixture is maintained at 40 ° C.3

Phase 4. In another vessel, provided with shaking and heating jacket, clean, dry and sterilized, the following components are added in order: ASD, allantoin, dimethylsilanolhialuronate, 5 aloe vera extract, hydrating agent and hydrolyzed collagen. . The mixture is heated to 40 ° C and stirred. Then add 10% NaOH solution to a pH of the mixture of 5.5.7 further, add the emulsifier to obtain an emulsion where the mixture obtained in Phase 3. is added, with shaking, in a thin wire. add to that resulting 9 from the mixing of phases I and II, homogenize, and then dosed in the desired packaging.

Day cream for normal and dry skin has the following characteristics: 11

a) - organoleptic properties'.

- Appearance: creamy, creamy, homogeneous mass13

- Color: white with slightly yellowish hue

- Smell: pleasant, depending on the fragrance agent used15

d) - physico-chemical properties:

- Emulsion type U / A17

- Water and volatile substances%: ................................. 63.3%

- Total fatty substances: .................................... 35.8% 19

- Mechiv peroxide index / kg 0.38

- pH 5,521 produced

c) - microbiological properties:

1-NTG / ml <10023

-E. Coli / ml Absent

- Staphylococcus coagulase + / ml Absent25

- Ps. Aeruginosa / ml Absent

5-D + M / ml <10027

The day cream thus obtained can be applied twice daily, in the morning and in the evening, or whenever it is needed, on the areas of interest. The effect on the skin is spectacular, on 29 which softens and energizes it, giving it a healthy glow, while having excellent moisturizing, emollient and antioxidant properties, preventing the appearance of wrinkles and rendering 31 the supple and silky appearance of the skin. It blocks the destructive action of free radicals, protecting the skin against oxidative stress and premature aging, increasing the skin's resistance to aggression through smog, ultraviolet rays and pollutants. It exerts a beneficial effect on stretch marks, protects against the aggressive action of ultraviolet A and B radiation and ensures the functional recovery of the physiological, healthy, skin conditions.

The cream has very good stretching properties; it has a very fast and very good transcutaneous penetration 37, which can be included in the "VANISHING" class; allows very good breathing of the skin and mucous membranes; increases the local defense power by the immunomodulatory effect. It is recommended, with high efficiency, for use on sensitive skin due to the excellent skin tolerance, amplified by the absolute lack of toxicity of deuterium-depleted water and by the combination with other specific active ingredients necessary for sensitive skin; does not produce unwanted side effects for long-term use because ASD is completely non-toxic and 43 non-irritating.

RO 120171 Β1

Example 3. Mouth water

COMPONENTS QUANTITY, g ASD with deuterium content 25 ± 5 ppm 77.4 Glycerin 4.0 Alcohol 96 16.0 Neutral soap (powder) 2.0 eucalyptol 0.5 Perfume 0.1

Example 4. Cream rhyme

COMPONENTS QUANTITY, g ASD with deuterium content 25 ± 5 ppm 35.0 Cetyl alcohol 10.0 Glycol stearate 30.0 Paraffin oil 15.0 Carbon black 10.0

Example 5. Toothpaste

COMPONENTS QUANTITY, g ASD with deuterium content 25 ± 5 ppm 15.0 Calcium carbonate 12.0 Calcium phosphate 26.0 Calcium n-lauryl saccharinate 2.0 Glycerin 30.0 Sodium alginate 1.0 Sodium benzoate 6.0 saccharine 0.6 Peppermint oil 7.4

Claims (9)

claims 1. Cosmetic and hygiene products, characterized in that they consist of 5 ... 96% by weight deuterium-depleted water, ASD, where the deuterium content is 2 ... 80ppm, in combination with up to 95% pharmacologically acceptable excipients with or without other embedded active components. RO 120171 Β1 2. Products according to claim 1, characterized in that they preferably contain 1 40 .. .90% by weight water depleted in deuterium, with the concentration of 2 ... 30 ppm deuterium. 3. The products according to claim 1, characterized in that they contain, even more preferably, 3 ... 3% by weight deuterium-depleted water, with a concentration of 20-30 ppm deuterium. 4.5 .. .8.5, which, after homogenization, is self-packaged in a known manner.27 4. Products according to claims 1 ... 3, characterized in that, possibly, they contain, besides the water depleted in deuterium and another active component that can be chosen from vitamins, components of plant origin, sex hormones, phytohormones. , bee products, 7 extracts of seaweed and sapropel sludge, animal components, inorganic compounds and medicines. 9 5. Products according to claims 1 ... 3, characterized in that they are formulated as lotions, sprays, creams, emulsions, gels, masks, mouthwash, toothpaste, mascara, shampoos, shampoos, conditioners. and hair fasteners. 6. Process for obtaining cosmetics and hygiene products defined in claims 13, 1 ... 4, characterized in that, in a first phase, a composition is obtained by hot mixing, preferably at a temperature of 80 'C, in the presence of emulsifier 15 greasy components, for a minimum of 10 minutes, until the complete melting and homogenization of the resulting mixture, over which is gradually poured under intense agitation, a homogeneous mixture obtained 17 in a second phase, at Warm, preferably at 80 ° C, from deuterium-depleted water with a deuterium content in the range 2 ... 80 ppm with propylene glycol, glycerine and preservative 19 to form an emulsion which cools, under stirring, to temperature of 40'C and to which is added an emulsion obtained by mixing, in the presence of the emulsifier, of an oil mixture 21, resulting in a third phase, of triglycerides, vegetable oils, vitamins, with aqueous solution resulting , in a fourth phase, by mixing, at 40'C, the components of 23 deuterium-depleted water with a deuterium content in the range of 2 ... 80 ppm with allantoin, hyaluronate dimethylsilanol, plant extracts, known hydrating agent In the art, collagen 25 is hydrolyzed and usually preservative with finally obtaining the desired product having a pH in the range Process according to claim 6, characterized in that the plant extracts are in the form of powders or fluids from medicinal plants, vegetables and fruits.29 8. Process according to claim 6, characterized in that the fatty components are of animal, mineral and / or vegetable origin. 9. Method of applying cosmetic and hygiene products, defined in claims 1 ... 5, in order to maintain the cosmetological status, characterized in that 33 the surface of interest of the human body is prepared by buffering, for 5 ... 12 days, daily 2 ... 3 times a day, preferably in the form of compresses or by spraying, with deuterium-depleted water 35 with a deuterium content of 40 ... 60 ppm, after which any of the products is applied, and between two successive applications with product, 10 ... 15 minutes before application, 37 the surface of interest is brought into contact with deuterium-depleted water with a deuterium content of between 40 and 60 ppm at body temperature. 39