PY1829804A - Derivados de imidazol pentacíclico fusionado como moduladores de la actividad de tnf - Google Patents

Derivados de imidazol pentacíclico fusionado como moduladores de la actividad de tnf

Info

Publication number
PY1829804A
PY1829804A PY201801829804A PY1829804A PY1829804A PY 1829804 A PY1829804 A PY 1829804A PY 201801829804 A PY201801829804 A PY 201801829804A PY 1829804 A PY1829804 A PY 1829804A PY 1829804 A PY1829804 A PY 1829804A
Authority
PY
Paraguay
Prior art keywords
disorders
modulators
tnf activity
imidazole derivatives
fused pentacyclic
Prior art date
Application number
PY201801829804A
Other languages
English (en)
Spanish (es)
Inventor
Christopher Brookings Daniel
Tracey Horsley Helen
Andrew Johnson James
Maccoss Malcolm
Clive Hutchings Martin
Xuan Mengyang
De Haro Garcia Teresa
Foricher Yann
Zhu Zhaoning
Original Assignee
Sanofi Sa
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58632834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PY1829804(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa, Ucb Biopharma Sprl filed Critical Sanofi Sa
Publication of PY1829804A publication Critical patent/PY1829804A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PY201801829804A 2017-04-25 2018-04-25 Derivados de imidazol pentacíclico fusionado como moduladores de la actividad de tnf PY1829804A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17168027 2017-04-25

Publications (1)

Publication Number Publication Date
PY1829804A true PY1829804A (es) 2019-03-01

Family

ID=58632834

Family Applications (1)

Application Number Title Priority Date Filing Date
PY201801829804A PY1829804A (es) 2017-04-25 2018-04-25 Derivados de imidazol pentacíclico fusionado como moduladores de la actividad de tnf

Country Status (33)

Country Link
US (4) US10980814B2 (https=)
EP (2) EP3615534B1 (https=)
JP (2) JP7083358B2 (https=)
KR (1) KR102565132B1 (https=)
CN (1) CN110582495B (https=)
AR (1) AR111426A1 (https=)
AU (1) AU2018259040B2 (https=)
CA (1) CA3058980A1 (https=)
CL (1) CL2019002875A1 (https=)
CO (1) CO2019012856A2 (https=)
CR (1) CR20190526A (https=)
DK (1) DK3615534T3 (https=)
EA (1) EA039049B1 (https=)
ES (2) ES2893807T3 (https=)
HR (1) HRP20211927T1 (https=)
HU (1) HUE056593T2 (https=)
IL (1) IL269890B (https=)
LT (1) LT3615534T (https=)
MA (2) MA49055B1 (https=)
MX (1) MX2019012443A (https=)
MY (1) MY197212A (https=)
PE (1) PE20200662A1 (https=)
PH (1) PH12019502182B1 (https=)
PL (2) PL3939980T3 (https=)
PT (2) PT3939980T (https=)
PY (1) PY1829804A (https=)
RS (1) RS62596B1 (https=)
SG (1) SG11201908871SA (https=)
SI (1) SI3615534T1 (https=)
TW (1) TWI801378B (https=)
UY (1) UY37700A (https=)
WO (1) WO2018197503A1 (https=)
ZA (1) ZA201906255B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10766906B2 (en) * 2016-04-01 2020-09-08 UCB Biopharma SRL Fused hexacyclic imidazole derivatives as modulators of TNF activity
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
CA3117344A1 (en) * 2018-10-24 2020-04-30 UCB Biopharma SRL Fused pentacyclic imidazole derivatives as modulators of tnf activity
CN120418259A (zh) 2022-11-23 2025-08-01 弗沃德医疗公司 TNFα活性的调节剂
TW202508596A (zh) 2023-04-26 2025-03-01 法商賽諾菲公司 使用腫瘤壞死因子α之小分子抑制劑治療乾癬
WO2024251282A1 (zh) * 2023-06-09 2024-12-12 上海翰森生物医药科技有限公司 五环类衍生物抑制剂、其制备方法和应用
TW202519231A (zh) 2023-07-04 2025-05-16 法商賽諾菲公司 結晶形式
TW202521544A (zh) 2023-08-16 2025-06-01 美商雷瑟拉股份有限公司 TNFα活性調節劑及其用途
WO2025068505A1 (en) 2023-09-29 2025-04-03 Sanofi Preparation of bridged pentacyclic imidazole derivatives as modulators of tnf activity, intermeditates and their preparation
TW202602881A (zh) * 2024-03-27 2026-01-16 大陸商海思科醫藥集團股份有限公司 雜環衍生物及其在醫藥上的應用
WO2025212627A1 (en) 2024-04-03 2025-10-09 Forward Therapeutics, Inc. Modulators of tnf-alpha activity
WO2025218735A1 (zh) * 2024-04-17 2025-10-23 上海翰森生物医药科技有限公司 五环类衍生物抑制剂、其制备方法和应用
WO2025247401A1 (zh) * 2024-05-31 2025-12-04 海思科医药集团股份有限公司 一种稠合杂环衍生物及其在医药上的应用
WO2025252251A1 (zh) * 2024-06-07 2025-12-11 上海翰森生物医药科技有限公司 含氧杂环类衍生物抑制剂、其制备方法和应用
WO2026012303A1 (en) * 2024-07-09 2026-01-15 Hangzhou Highlightll Pharmaceutical Co., Ltd NOVEL BENZO [4, 5] IMIDAZO COMPOUNDS AS TNFα MODULATORS
WO2026022134A1 (en) 2024-07-23 2026-01-29 Sanofi Novel aminocarbonylation processes
WO2026021586A1 (zh) * 2024-07-26 2026-01-29 上海瀚辰星泰医药科技有限公司 一种多环化合物及其制备方法和应用
WO2026027449A1 (en) 2024-07-29 2026-02-05 Sanofi Fused pentacyclic imidazole derivatives
WO2026051930A1 (zh) * 2024-09-04 2026-03-12 苏州湃玥生物科技有限公司 一种作为tnf活性调节剂的稠合五环苯并咪唑衍生物及其制备方法和应用
WO2026055519A1 (en) 2024-09-06 2026-03-12 Rapt Therapeutics, Inc. Fused ring imidazole compounds
WO2026064602A1 (en) * 2024-09-23 2026-03-26 Synnovation Therapeutics, Inc. HETEROCYCLIC COMPOUNDS AS MODULATORS OF TNFα ACTIVITY
WO2026068677A1 (en) 2024-09-27 2026-04-02 Sanofi Processes for the preparation of fused pentacyclic imidazoles and intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9550737B2 (en) * 2012-06-11 2017-01-24 Ucb Biopharma Sprl TNF -α modulating benzimidazoles
GB201212513D0 (en) * 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
CN104619709B (zh) * 2012-07-13 2016-11-09 Ucb生物制药私人有限公司 作为tnf活性调节剂的咪唑并吡啶衍生物
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
MX380578B (es) * 2014-10-03 2025-03-12 Ucb Biopharma Sprl Derivados de imidazol pentaciclicos fusionados.
EP3288939A1 (en) * 2015-04-17 2018-03-07 AbbVie Inc. Tricyclic modulators of tnf signaling

Also Published As

Publication number Publication date
HRP20211927T1 (hr) 2022-03-18
US20210252012A1 (en) 2021-08-19
AU2018259040A1 (en) 2019-10-31
DK3615534T3 (da) 2021-10-18
MA49055A (fr) 2021-05-05
MA57699B1 (fr) 2023-11-30
PH12019502182B1 (en) 2024-01-31
CR20190526A (es) 2020-01-07
UY37700A (es) 2018-11-30
JP7299382B2 (ja) 2023-06-27
CL2019002875A1 (es) 2020-03-06
EP3939980B1 (en) 2023-07-26
US20200046723A1 (en) 2020-02-13
KR102565132B1 (ko) 2023-08-08
SI3615534T1 (sl) 2022-01-31
AR111426A1 (es) 2019-07-10
AU2018259040B2 (en) 2022-04-28
EP3615534B1 (en) 2021-09-15
CN110582495A (zh) 2019-12-17
JP2022116233A (ja) 2022-08-09
PL3615534T3 (pl) 2022-01-31
LT3615534T (lt) 2021-11-25
TWI801378B (zh) 2023-05-11
SG11201908871SA (en) 2019-10-30
IL269890B (en) 2022-03-01
WO2018197503A1 (en) 2018-11-01
ZA201906255B (en) 2021-01-27
ES2956555T3 (es) 2023-12-22
HUE056593T2 (hu) 2022-02-28
MA49055B1 (fr) 2021-12-31
BR112019020314A2 (pt) 2020-04-28
EA201992407A1 (ru) 2020-04-06
MX2019012443A (es) 2020-01-13
EA039049B1 (ru) 2021-11-26
KR20190141200A (ko) 2019-12-23
US20230250105A1 (en) 2023-08-10
RS62596B1 (sr) 2021-12-31
JP7083358B2 (ja) 2022-06-10
PE20200662A1 (es) 2020-06-11
EP3615534A1 (en) 2020-03-04
ES2893807T3 (es) 2022-02-10
PT3615534T (pt) 2021-10-21
US10980814B2 (en) 2021-04-20
PH12019502182A1 (en) 2020-06-08
JP2020517637A (ja) 2020-06-18
CO2019012856A2 (es) 2020-01-17
EP3939980A1 (en) 2022-01-19
PL3939980T3 (pl) 2024-02-05
TW201841918A (zh) 2018-12-01
US20250127795A1 (en) 2025-04-24
NZ758198A (en) 2024-01-26
CN110582495B (zh) 2022-04-01
PT3939980T (pt) 2023-08-07
CA3058980A1 (en) 2018-11-01
MY197212A (en) 2023-06-01

Similar Documents

Publication Publication Date Title
PY1829804A (es) Derivados de imidazol pentacíclico fusionado como moduladores de la actividad de tnf
ECSP17027306A (es) Derivados de imidazol pentacíclicos fusionados
BR112018069937A2 (pt) derivados de imidazol hexacíclicos fundidos como moduladores de atividade do tnf
BR112018069936A2 (pt) derivados de imidazol pentacíclicos fundidos como moduladores de atividade do tnf
MX381313B (es) Derivados de benzimidazol como moduladores de ror-gamma
CA2931589C (en) Fused bicyclic heteroaromatic derivatives as modulators of tnf activity
BR112016012990A2 (pt) Derivados de imidazol tricíclicos fundidos como moduladores de atividade de tnf
MX2017015521A (es) Derivados de heterociclilos sustituidos como inhibidores de cdk.
MX2016011038A (es) Compuestos para el tratamiento de trastornos mediados por complemento.
BR112018069941A2 (pt) derivados de imidazol pentacíclicos fundidos como moduladores de atividade do tnf
BR112016012997A2 (pt) Derivados de benzimidazóis tricíclicos fundidos como moduladores de atividade de tnf
BR112016012258A2 (pt) Derivados de tetra-hidrobenzimidazol como moduladores de atividade de tnf
BR112016011483A2 (pt) Derivados de imidazotriazina como moduladores de atividade de tnf
BR112016012261A2 (pt) Derivados de tetra-hidroimidazopiridina como moduladores de atividade de tnf
CL2016001441A1 (es) Compuestos derivados de 1h-indol, 1h-indazol, 1hpirrolo-[2,3-b]-piridin, 1h-pirazolo-[3,4-b]-piridin, moduladores de ror; composición farmacéutica; útiles para el tratamiento de una enfermedad, trastornos o síndrome mediado por ror?t, tales como enfermedades inflamatorias o autoinmunes.
EA201792686A1 (ru) Производные индазола в качестве модуляторов активности tnf
TR201910983T4 (tr) Tnf aktivitesinin modülatörleri olarak imidazotiazol türevleri.
BR112016013007A2 (pt) Derivados de tetra-hidroimidazopiridina como moduladores de atividade de tnf
BR112017025601A2 (pt) imidazopirazinas tricíclicas fundidas como moduladoras da atividade de tnf
CO2017011020A2 (es) Derivados de 6-morfolinil-2-pirazolil-9h-purina y su uso como inhibidores de fosfoinositol-3-cinasa (pi3k)
EA201892149A1 (ru) Конденсированные пентациклические производные имидазола в качестве модуляторов активности tnf
CO2019007115A2 (es) Derivado de benzimidazol sustituido como modulador de la actividad del factor de necrosis tumoral