PT97692A - Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico) - Google Patents
Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico)Info
- Publication number
- PT97692A PT97692A PT97692A PT9769291A PT97692A PT 97692 A PT97692 A PT 97692A PT 97692 A PT97692 A PT 97692A PT 9769291 A PT9769291 A PT 9769291A PT 97692 A PT97692 A PT 97692A
- Authority
- PT
- Portugal
- Prior art keywords
- methyl
- preparation
- aspartic acid
- heterocyclic derivatives
- nmda antagonist
- Prior art date
Links
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
- HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 title 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 abstract 1
- MNQZHTRAKIMKJF-UHFFFAOYSA-N piperidin-3-ylphosphonic acid Chemical class OP(O)(=O)C1CCCNC1 MNQZHTRAKIMKJF-UHFFFAOYSA-N 0.000 abstract 1
- 150000003235 pyrrolidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52529090A | 1990-05-17 | 1990-05-17 | |
| US07/675,156 US5194430A (en) | 1990-05-17 | 1991-03-28 | Heterocyclic-nmda antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT97692A true PT97692A (pt) | 1992-02-28 |
| PT97692B PT97692B (pt) | 1998-09-30 |
Family
ID=27061745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97692A PT97692B (pt) | 1990-05-17 | 1991-05-16 | Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico) |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5194430A (pt) |
| EP (1) | EP0457324B1 (pt) |
| JP (1) | JP2977950B2 (pt) |
| KR (1) | KR100196239B1 (pt) |
| CN (1) | CN1027695C (pt) |
| AT (1) | ATE131172T1 (pt) |
| AU (1) | AU641657B2 (pt) |
| CA (1) | CA2042473C (pt) |
| DE (1) | DE69115116T2 (pt) |
| DK (1) | DK0457324T3 (pt) |
| ES (1) | ES2083478T3 (pt) |
| FI (1) | FI97388C (pt) |
| GR (1) | GR3019047T3 (pt) |
| HU (1) | HU208831B (pt) |
| IE (1) | IE70437B1 (pt) |
| IL (1) | IL98148A (pt) |
| NO (1) | NO300502B1 (pt) |
| NZ (1) | NZ238124A (pt) |
| PT (1) | PT97692B (pt) |
| TW (1) | TW308596B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260286A (en) * | 1992-10-16 | 1993-11-09 | Japan Tobacco, Inc. | 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists |
| EP1436258A4 (en) * | 2001-03-08 | 2005-03-23 | Univ Emory | ANTAGONISTS OF THE NMDA RECEPTOR DEPENDENT OF PH |
| EP2170334B1 (en) * | 2007-06-29 | 2021-03-17 | Emory University | Nmda receptor antagonists for neuroprotection |
| CN102952130B (zh) * | 2011-08-24 | 2016-03-23 | 重庆华邦胜凯制药有限公司 | 手性合成(s,s)-2,8-二氮杂双环壬烷的方法 |
| CN102952065A (zh) * | 2011-08-24 | 2013-03-06 | 重庆华邦胜凯制药有限公司 | 一种拆分顺式2,3-吡啶二甲酸酯的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2706194A (en) * | 1951-05-14 | 1955-04-12 | Shell Dev | Esters of phosphonic acids |
| NL299936A (pt) * | 1963-10-30 | 1965-08-25 | ||
| JPS5251028A (en) * | 1975-10-22 | 1977-04-23 | Nippon Tokushu Noyaku Seizo Kk | Herbicide |
| US4094974A (en) * | 1977-02-24 | 1978-06-13 | Stauffer Chemical Company | Isoxazole phosphates and phosphonates |
| US4139708A (en) * | 1977-05-24 | 1979-02-13 | Sk&F Lab Co. | Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts |
| CA1248531A (en) * | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| US4906621A (en) * | 1985-05-24 | 1990-03-06 | Ciba-Geigy Corporation | Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade |
| PH23848A (en) * | 1985-05-24 | 1989-11-23 | Ciba Geigy Ag | Certain phosphonic acids and derivatives |
| US4746653A (en) * | 1986-02-28 | 1988-05-24 | Ciba-Geigy Corporation | Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals |
| US4657899A (en) * | 1986-04-09 | 1987-04-14 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors |
| ATE60776T1 (de) * | 1986-11-21 | 1991-02-15 | Ciba Geigy Ag | Ungesaettigte phosphonsaeure und derivate. |
| SE9003652D0 (sv) * | 1990-11-15 | 1990-11-15 | Astra Ab | New heterocyclic compounds |
-
1991
- 1991-03-28 US US07/675,156 patent/US5194430A/en not_active Expired - Fee Related
- 1991-05-13 NZ NZ238124A patent/NZ238124A/xx unknown
- 1991-05-13 CA CA002042473A patent/CA2042473C/en not_active Expired - Fee Related
- 1991-05-14 TW TW080103761A patent/TW308596B/zh active
- 1991-05-14 AU AU76498/91A patent/AU641657B2/en not_active Ceased
- 1991-05-15 IL IL9814891A patent/IL98148A/en active IP Right Grant
- 1991-05-16 NO NO911916A patent/NO300502B1/no not_active IP Right Cessation
- 1991-05-16 AT AT91107955T patent/ATE131172T1/de not_active IP Right Cessation
- 1991-05-16 PT PT97692A patent/PT97692B/pt not_active IP Right Cessation
- 1991-05-16 IE IE167691A patent/IE70437B1/en unknown
- 1991-05-16 FI FI912382A patent/FI97388C/fi not_active IP Right Cessation
- 1991-05-16 DK DK91107955.6T patent/DK0457324T3/da active
- 1991-05-16 HU HU911649A patent/HU208831B/hu not_active IP Right Cessation
- 1991-05-16 EP EP91107955A patent/EP0457324B1/en not_active Expired - Lifetime
- 1991-05-16 DE DE69115116T patent/DE69115116T2/de not_active Expired - Fee Related
- 1991-05-16 CN CN91103185A patent/CN1027695C/zh not_active Expired - Fee Related
- 1991-05-16 ES ES91107955T patent/ES2083478T3/es not_active Expired - Lifetime
- 1991-05-17 KR KR1019910008036A patent/KR100196239B1/ko not_active IP Right Cessation
- 1991-05-17 JP JP3140636A patent/JP2977950B2/ja not_active Expired - Fee Related
-
1993
- 1993-11-30 US US08/159,913 patent/US5470844A/en not_active Expired - Lifetime
-
1996
- 1996-02-21 GR GR960400451T patent/GR3019047T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19911028 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980602 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20011231 |
|
| NF3A | Restitutio in integrum |
Free format text: 20020604 RESTITUTIO IN INTEGRUM |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20041202 |