DE69115116D1 - Heterocyclische NMDA Antagonisten. - Google Patents

Heterocyclische NMDA Antagonisten.

Info

Publication number
DE69115116D1
DE69115116D1 DE69115116T DE69115116T DE69115116D1 DE 69115116 D1 DE69115116 D1 DE 69115116D1 DE 69115116 T DE69115116 T DE 69115116T DE 69115116 T DE69115116 T DE 69115116T DE 69115116 D1 DE69115116 D1 DE 69115116D1
Authority
DE
Germany
Prior art keywords
nmda antagonists
heterocyclic
heterocyclic nmda
antagonists
phosphono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69115116T
Other languages
English (en)
Other versions
DE69115116T2 (de
Inventor
Jeffrey P Whitten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69115116D1 publication Critical patent/DE69115116D1/de
Publication of DE69115116T2 publication Critical patent/DE69115116T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DE69115116T 1990-05-17 1991-05-16 Heterocyclische NMDA Antagonisten. Expired - Fee Related DE69115116T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52529090A 1990-05-17 1990-05-17
US07/675,156 US5194430A (en) 1990-05-17 1991-03-28 Heterocyclic-nmda antagonists

Publications (2)

Publication Number Publication Date
DE69115116D1 true DE69115116D1 (de) 1996-01-18
DE69115116T2 DE69115116T2 (de) 1996-06-13

Family

ID=27061745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115116T Expired - Fee Related DE69115116T2 (de) 1990-05-17 1991-05-16 Heterocyclische NMDA Antagonisten.

Country Status (20)

Country Link
US (2) US5194430A (de)
EP (1) EP0457324B1 (de)
JP (1) JP2977950B2 (de)
KR (1) KR100196239B1 (de)
CN (1) CN1027695C (de)
AT (1) ATE131172T1 (de)
AU (1) AU641657B2 (de)
CA (1) CA2042473C (de)
DE (1) DE69115116T2 (de)
DK (1) DK0457324T3 (de)
ES (1) ES2083478T3 (de)
FI (1) FI97388C (de)
GR (1) GR3019047T3 (de)
HU (1) HU208831B (de)
IE (1) IE70437B1 (de)
IL (1) IL98148A (de)
NO (1) NO300502B1 (de)
NZ (1) NZ238124A (de)
PT (1) PT97692B (de)
TW (1) TW308596B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260286A (en) * 1992-10-16 1993-11-09 Japan Tobacco, Inc. 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
AU2002250256B2 (en) * 2001-03-08 2008-04-03 Emory University pH-dependent NMDA receptor antagonists
CN103497114A (zh) * 2007-06-29 2014-01-08 埃莫里大学 用于神经保护的nmda受体拮抗剂
CN102952065A (zh) * 2011-08-24 2013-03-06 重庆华邦胜凯制药有限公司 一种拆分顺式2,3-吡啶二甲酸酯的方法
CN102952130B (zh) * 2011-08-24 2016-03-23 重庆华邦胜凯制药有限公司 手性合成(s,s)-2,8-二氮杂双环壬烷的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2706194A (en) * 1951-05-14 1955-04-12 Shell Dev Esters of phosphonic acids
NL299935A (de) * 1963-10-30 1965-08-25
JPS5251028A (en) * 1975-10-22 1977-04-23 Nippon Tokushu Noyaku Seizo Kk Herbicide
US4094974A (en) * 1977-02-24 1978-06-13 Stauffer Chemical Company Isoxazole phosphates and phosphonates
US4139708A (en) * 1977-05-24 1979-02-13 Sk&F Lab Co. Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US4657899A (en) * 1986-04-09 1987-04-14 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors
EP0275820B1 (de) * 1986-11-21 1991-02-06 Ciba-Geigy Ag Ungesättigte Phosphonsäure und Derivate
SE9003652D0 (sv) * 1990-11-15 1990-11-15 Astra Ab New heterocyclic compounds

Also Published As

Publication number Publication date
HU208831B (en) 1994-01-28
HUT59150A (en) 1992-04-28
DE69115116T2 (de) 1996-06-13
NO911916L (no) 1991-11-18
IL98148A (en) 1996-10-16
PT97692B (pt) 1998-09-30
GR3019047T3 (en) 1996-05-31
US5470844A (en) 1995-11-28
FI912382A0 (fi) 1991-05-16
HU911649D0 (en) 1991-11-28
IE911676A1 (en) 1991-11-20
CA2042473A1 (en) 1991-11-18
AU7649891A (en) 1991-11-21
FI912382A (fi) 1991-11-18
ES2083478T3 (es) 1996-04-16
CA2042473C (en) 2002-01-01
CN1056499A (zh) 1991-11-27
IE70437B1 (en) 1996-11-27
CN1027695C (zh) 1995-02-22
AU641657B2 (en) 1993-09-30
NZ238124A (en) 1993-09-27
DK0457324T3 (da) 1996-01-02
PT97692A (pt) 1992-02-28
TW308596B (de) 1997-06-21
NO300502B1 (no) 1997-06-09
KR100196239B1 (ko) 1999-06-15
FI97388B (fi) 1996-08-30
NO911916D0 (no) 1991-05-16
JPH0812691A (ja) 1996-01-16
FI97388C (fi) 1996-12-10
JP2977950B2 (ja) 1999-11-15
ATE131172T1 (de) 1995-12-15
US5194430A (en) 1993-03-16
EP0457324A1 (de) 1991-11-21
KR910020023A (ko) 1991-12-19
EP0457324B1 (de) 1995-12-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee