NO911916D0 - Fremgangsmaate for fremstilling av heterocykliske nmda-antagonister. - Google Patents

Fremgangsmaate for fremstilling av heterocykliske nmda-antagonister.

Info

Publication number
NO911916D0
NO911916D0 NO1991911916A NO911916A NO911916D0 NO 911916 D0 NO911916 D0 NO 911916D0 NO 1991911916 A NO1991911916 A NO 1991911916A NO 911916 A NO911916 A NO 911916A NO 911916 D0 NO911916 D0 NO 911916D0
Authority
NO
Norway
Prior art keywords
procedure
nmda antagonists
manufacturing
heterocyclic nmda
manufacturing heterocyclic
Prior art date
Application number
NO1991911916A
Other languages
English (en)
Other versions
NO300502B1 (no
NO911916L (no
Inventor
Jeffrey Paul Whitten
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO911916D0 publication Critical patent/NO911916D0/no
Publication of NO911916L publication Critical patent/NO911916L/no
Publication of NO300502B1 publication Critical patent/NO300502B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
NO911916A 1990-05-17 1991-05-16 Analogifremgangsmåte for fremstilling av heterosykliske NMDA-antagonister NO300502B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52529090A 1990-05-17 1990-05-17
US07/675,156 US5194430A (en) 1990-05-17 1991-03-28 Heterocyclic-nmda antagonists

Publications (3)

Publication Number Publication Date
NO911916D0 true NO911916D0 (no) 1991-05-16
NO911916L NO911916L (no) 1991-11-18
NO300502B1 NO300502B1 (no) 1997-06-09

Family

ID=27061745

Family Applications (1)

Application Number Title Priority Date Filing Date
NO911916A NO300502B1 (no) 1990-05-17 1991-05-16 Analogifremgangsmåte for fremstilling av heterosykliske NMDA-antagonister

Country Status (20)

Country Link
US (2) US5194430A (no)
EP (1) EP0457324B1 (no)
JP (1) JP2977950B2 (no)
KR (1) KR100196239B1 (no)
CN (1) CN1027695C (no)
AT (1) ATE131172T1 (no)
AU (1) AU641657B2 (no)
CA (1) CA2042473C (no)
DE (1) DE69115116T2 (no)
DK (1) DK0457324T3 (no)
ES (1) ES2083478T3 (no)
FI (1) FI97388C (no)
GR (1) GR3019047T3 (no)
HU (1) HU208831B (no)
IE (1) IE70437B1 (no)
IL (1) IL98148A (no)
NO (1) NO300502B1 (no)
NZ (1) NZ238124A (no)
PT (1) PT97692B (no)
TW (1) TW308596B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260286A (en) * 1992-10-16 1993-11-09 Japan Tobacco, Inc. 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
EP1436258A4 (en) * 2001-03-08 2005-03-23 Univ Emory ANTAGONISTS OF THE NMDA RECEPTOR DEPENDENT OF PH
EP2170334B1 (en) * 2007-06-29 2021-03-17 Emory University Nmda receptor antagonists for neuroprotection
CN102952130B (zh) * 2011-08-24 2016-03-23 重庆华邦胜凯制药有限公司 手性合成(s,s)-2,8-二氮杂双环壬烷的方法
CN102952065A (zh) * 2011-08-24 2013-03-06 重庆华邦胜凯制药有限公司 一种拆分顺式2,3-吡啶二甲酸酯的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2706194A (en) * 1951-05-14 1955-04-12 Shell Dev Esters of phosphonic acids
NL299936A (no) * 1963-10-30 1965-08-25
JPS5251028A (en) * 1975-10-22 1977-04-23 Nippon Tokushu Noyaku Seizo Kk Herbicide
US4094974A (en) * 1977-02-24 1978-06-13 Stauffer Chemical Company Isoxazole phosphates and phosphonates
US4139708A (en) * 1977-05-24 1979-02-13 Sk&F Lab Co. Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US4657899A (en) * 1986-04-09 1987-04-14 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors
ATE60776T1 (de) * 1986-11-21 1991-02-15 Ciba Geigy Ag Ungesaettigte phosphonsaeure und derivate.
SE9003652D0 (sv) * 1990-11-15 1990-11-15 Astra Ab New heterocyclic compounds

Also Published As

Publication number Publication date
CN1027695C (zh) 1995-02-22
HUT59150A (en) 1992-04-28
US5470844A (en) 1995-11-28
DE69115116D1 (de) 1996-01-18
TW308596B (no) 1997-06-21
AU641657B2 (en) 1993-09-30
CN1056499A (zh) 1991-11-27
EP0457324B1 (en) 1995-12-06
FI912382A (fi) 1991-11-18
EP0457324A1 (en) 1991-11-21
US5194430A (en) 1993-03-16
ATE131172T1 (de) 1995-12-15
FI912382A0 (fi) 1991-05-16
DK0457324T3 (da) 1996-01-02
FI97388B (fi) 1996-08-30
ES2083478T3 (es) 1996-04-16
PT97692B (pt) 1998-09-30
CA2042473A1 (en) 1991-11-18
JP2977950B2 (ja) 1999-11-15
NZ238124A (en) 1993-09-27
KR910020023A (ko) 1991-12-19
NO300502B1 (no) 1997-06-09
AU7649891A (en) 1991-11-21
PT97692A (pt) 1992-02-28
DE69115116T2 (de) 1996-06-13
HU911649D0 (en) 1991-11-28
NO911916L (no) 1991-11-18
JPH0812691A (ja) 1996-01-16
IL98148A (en) 1996-10-16
FI97388C (fi) 1996-12-10
IE70437B1 (en) 1996-11-27
CA2042473C (en) 2002-01-01
IE911676A1 (en) 1991-11-20
KR100196239B1 (ko) 1999-06-15
GR3019047T3 (en) 1996-05-31
HU208831B (en) 1994-01-28

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Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN NOVEMBER 2000