PT96143A - Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos - Google Patents

Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos

Info

Publication number
PT96143A
PT96143A PT96143A PT9614390A PT96143A PT 96143 A PT96143 A PT 96143A PT 96143 A PT96143 A PT 96143A PT 9614390 A PT9614390 A PT 9614390A PT 96143 A PT96143 A PT 96143A
Authority
PT
Portugal
Prior art keywords
pct
compounds
date jun
sec
derived
Prior art date
Application number
PT96143A
Other languages
English (en)
Other versions
PT96143B (pt
Inventor
Peter Edward Cross
Alexander Roderick Mackenzie
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT96143A publication Critical patent/PT96143A/pt
Publication of PT96143B publication Critical patent/PT96143B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
PT96143A 1989-12-12 1990-12-10 Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos PT96143B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898928041A GB8928041D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
PT96143A true PT96143A (pt) 1991-09-30
PT96143B PT96143B (pt) 1997-05-28

Family

ID=10667812

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96143A PT96143B (pt) 1989-12-12 1990-12-10 Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos

Country Status (14)

Country Link
US (1) US5281601A (pt)
EP (1) EP0505377B1 (pt)
JP (1) JPH0684370B2 (pt)
AT (1) ATE132488T1 (pt)
CA (1) CA2067816C (pt)
DE (1) DE69024663T2 (pt)
DK (1) DK0505377T3 (pt)
ES (1) ES2082013T3 (pt)
FI (1) FI104719B (pt)
GB (1) GB8928041D0 (pt)
GR (1) GR3019036T3 (pt)
IE (1) IE70733B1 (pt)
PT (1) PT96143B (pt)
WO (1) WO1991009015A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
BR0107733A (pt) * 2000-01-20 2003-03-11 Eisai Co Ltd Composto, seu uso, composição farmacêutica, método para prevenir, tratar ou melhorar uma doença contra a qual um antogonista de cálcio é eficaz, método para suprimir uma morte cerebral neural ou proteger uma célula neural cerebral e método para prevenir, tratar ou melhorar doença neural ou dor
MXPA05000434A (es) 2002-07-08 2005-04-19 Ranbaxy Lab Ltd Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico.
WO2004014853A1 (en) * 2002-07-31 2004-02-19 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
EP1545508A4 (en) * 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS
EP1534675B1 (en) * 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
EP1572648B1 (en) * 2002-12-10 2008-07-09 Ranbaxy Laboratories, Ltd. 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists
AU2002347552A1 (en) * 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) * 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089898A1 (en) * 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089899A1 (en) 2003-04-10 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ATE362364T1 (de) * 2003-04-10 2007-06-15 Ranbaxy Lab Ltd Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
CN100436414C (zh) * 2003-04-11 2008-11-26 兰贝克赛实验室有限公司 作为毒蕈碱受体拮抗剂的氮杂双环衍生物
WO2005007645A1 (en) * 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
US7234991B2 (en) * 2004-05-10 2007-06-26 Firecode Ltd. Moving toy
ATE419246T1 (de) * 2004-06-16 2009-01-15 Ranbaxy Lab Ltd Als antagonisten des muscarinrezeptors geeignete xanthinderivate
EP1781607A2 (en) * 2004-08-19 2007-05-09 Ranbaxy Laboratories Limited Pyrrolidine derivatives as muscarinic receptor antagonists
US20080280883A1 (en) * 2004-09-24 2008-11-13 Mohammad Salman Muscarinic Receptor Antagonists
US20090105221A1 (en) * 2004-09-29 2009-04-23 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
EP1828174A1 (en) * 2004-11-19 2007-09-05 Ranbaxy Laboratories Limited Azabicyclic muscarinic receptor antagonists
WO2006064304A1 (en) * 2004-12-15 2006-06-22 Ranbaxy Laboratories Limited Acid addition salts of muscarinic receptor antagonists
WO2006117754A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists
CA2626612A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
US20090010923A1 (en) * 2007-04-24 2009-01-08 University Of Maryland, Baltimore Treatment of cancer with anti-muscarinic receptor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632403A (pt) * 1962-05-17 1900-01-01
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine

Also Published As

Publication number Publication date
JPH0684370B2 (ja) 1994-10-26
JPH05501555A (ja) 1993-03-25
FI104719B (fi) 2000-03-31
US5281601A (en) 1994-01-25
CA2067816C (en) 1997-03-25
IE904462A1 (en) 1991-06-19
EP0505377A1 (en) 1992-09-30
GB8928041D0 (en) 1990-02-14
EP0505377B1 (en) 1996-01-03
DE69024663T2 (de) 1996-05-15
ATE132488T1 (de) 1996-01-15
IE70733B1 (en) 1996-12-11
FI922344A0 (fi) 1992-05-22
WO1991009015A1 (en) 1991-06-27
FI922344A (fi) 1992-05-22
ES2082013T3 (es) 1996-03-16
DE69024663D1 (de) 1996-02-15
DK0505377T3 (da) 1996-02-05
GR3019036T3 (en) 1996-05-31
PT96143B (pt) 1997-05-28
CA2067816A1 (en) 1991-06-13

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Effective date: 19910509

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Effective date: 19970307

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Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040907