PT96143A - Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos - Google Patents

Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos

Info

Publication number
PT96143A
PT96143A PT96143A PT9614390A PT96143A PT 96143 A PT96143 A PT 96143A PT 96143 A PT96143 A PT 96143A PT 9614390 A PT9614390 A PT 9614390A PT 96143 A PT96143 A PT 96143A
Authority
PT
Portugal
Prior art keywords
pct
compounds
date jun
sec
derived
Prior art date
Application number
PT96143A
Other languages
English (en)
Other versions
PT96143B (pt
Inventor
Peter Edward Cross
Alexander Roderick Mackenzie
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT96143A publication Critical patent/PT96143A/pt
Publication of PT96143B publication Critical patent/PT96143B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
PT96143A 1989-12-12 1990-12-10 Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos PT96143B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898928041A GB8928041D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
PT96143A true PT96143A (pt) 1991-09-30
PT96143B PT96143B (pt) 1997-05-28

Family

ID=10667812

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96143A PT96143B (pt) 1989-12-12 1990-12-10 Processo para a preparacao de derivados de pirrolidina 3-substituida antagonistas de receptores muscarinicos

Country Status (14)

Country Link
US (1) US5281601A (pt)
EP (1) EP0505377B1 (pt)
JP (1) JPH0684370B2 (pt)
AT (1) ATE132488T1 (pt)
CA (1) CA2067816C (pt)
DE (1) DE69024663T2 (pt)
DK (1) DK0505377T3 (pt)
ES (1) ES2082013T3 (pt)
FI (1) FI104719B (pt)
GB (1) GB8928041D0 (pt)
GR (1) GR3019036T3 (pt)
IE (1) IE70733B1 (pt)
PT (1) PT96143B (pt)
WO (1) WO1991009015A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
CA2398409A1 (en) * 2000-01-20 2001-07-26 Eisai Co., Ltd. Nitrogen-containing cyclic compound and pharmaceutical composition containing the compound
CN1668585A (zh) 2002-07-08 2005-09-14 兰贝克赛实验室有限公司 用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物
US7265147B2 (en) * 2002-07-31 2007-09-04 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
US7410993B2 (en) * 2002-08-09 2008-08-12 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists
US7288562B2 (en) * 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
JP2006518707A (ja) * 2002-12-10 2006-08-17 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしての３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体
ATE386738T1 (de) * 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
WO2004056767A1 (en) * 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214520A1 (en) * 2003-04-09 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615887A1 (en) 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214535B2 (en) * 2003-04-10 2009-09-03 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089900A1 (en) * 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
WO2005007645A1 (en) * 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
US7234991B2 (en) * 2004-05-10 2007-06-26 Firecode Ltd. Moving toy
US20080319002A1 (en) * 2004-06-16 2008-12-25 Ranbaxy Laboratories Limited Xanthine Derivatives a Useful as Muscarinic Receptor Antagonists
EP1781607A2 (en) * 2004-08-19 2007-05-09 Ranbaxy Laboratories Limited Pyrrolidine derivatives as muscarinic receptor antagonists
WO2006032994A2 (en) * 2004-09-24 2006-03-30 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
EP1797040A1 (en) * 2004-09-29 2007-06-20 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2006054162A1 (en) * 2004-11-19 2006-05-26 Ranbaxy Laboratories Limited Azabicyclic muscarinic receptor antagonists
US20100035954A1 (en) * 2004-12-15 2010-02-11 Mohammad Salman Acid addition salts of muscarinic receptor antagonists
WO2006117754A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists
JP2009512676A (ja) 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
US20090010923A1 (en) * 2007-04-24 2009-01-08 University Of Maryland, Baltimore Treatment of cancer with anti-muscarinic receptor agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632403A (pt) * 1962-05-17 1900-01-01
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine

Also Published As

Publication number Publication date
EP0505377A1 (en) 1992-09-30
FI922344A (fi) 1992-05-22
ES2082013T3 (es) 1996-03-16
FI922344A0 (fi) 1992-05-22
GR3019036T3 (en) 1996-05-31
IE70733B1 (en) 1996-12-11
ATE132488T1 (de) 1996-01-15
JPH05501555A (ja) 1993-03-25
PT96143B (pt) 1997-05-28
DE69024663T2 (de) 1996-05-15
EP0505377B1 (en) 1996-01-03
DE69024663D1 (de) 1996-02-15
JPH0684370B2 (ja) 1994-10-26
CA2067816A1 (en) 1991-06-13
US5281601A (en) 1994-01-25
GB8928041D0 (en) 1990-02-14
DK0505377T3 (da) 1996-02-05
FI104719B (fi) 2000-03-31
WO1991009015A1 (en) 1991-06-27
IE904462A1 (en) 1991-06-19
CA2067816C (en) 1997-03-25

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910509

FG3A Patent granted, date of granting

Effective date: 19970307

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040907