PT92503A - Processo para a preparacao de novos derivados peptidicos com accao anti-coagulante - Google Patents

Processo para a preparacao de novos derivados peptidicos com accao anti-coagulante

Info

Publication number
PT92503A
PT92503A PT92503A PT9250389A PT92503A PT 92503 A PT92503 A PT 92503A PT 92503 A PT92503 A PT 92503A PT 9250389 A PT9250389 A PT 9250389A PT 92503 A PT92503 A PT 92503A
Authority
PT
Portugal
Prior art keywords
preparation
peptidic derivatives
coagulant action
new peptidic
new
Prior art date
Application number
PT92503A
Other languages
English (en)
Other versions
PT92503B (pt
Inventor
John Leonard Krstenansky
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT92503A publication Critical patent/PT92503A/pt
Publication of PT92503B publication Critical patent/PT92503B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT92503A 1988-12-07 1989-12-06 Processo para a preparacao de novos derivados peptidicos com accao anti-coagulante PT92503B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28112188A 1988-12-07 1988-12-07

Publications (2)

Publication Number Publication Date
PT92503A true PT92503A (pt) 1990-06-29
PT92503B PT92503B (pt) 1995-08-09

Family

ID=23076036

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92503A PT92503B (pt) 1988-12-07 1989-12-06 Processo para a preparacao de novos derivados peptidicos com accao anti-coagulante

Country Status (17)

Country Link
EP (1) EP0372503B1 (pt)
JP (1) JP2916182B2 (pt)
KR (1) KR0162893B1 (pt)
CN (1) CN1043134A (pt)
AT (1) ATE177432T1 (pt)
AU (1) AU630132B2 (pt)
CA (1) CA2004885C (pt)
DE (1) DE68928942T2 (pt)
DK (1) DK614489A (pt)
ES (1) ES2131041T3 (pt)
FI (1) FI895844A0 (pt)
HU (1) HU201965B (pt)
IL (1) IL92551A0 (pt)
NO (1) NO894880L (pt)
NZ (1) NZ231636A (pt)
PT (1) PT92503B (pt)
ZA (1) ZA899247B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2026376C (en) * 1989-10-03 2002-01-01 John L. Krstenansky Anticoagulant peptides
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
JP3532920B2 (ja) * 1993-06-11 2004-05-31 メレル ファーマスーティカルズ インコーポレイテッド 三機能性の抗血栓及び抗血小板ペプチド類
AU6099496A (en) * 1995-06-07 1996-12-30 G.D. Searle & Co. Pipecolic acid derivatives of proline threonine amides usefu l for the treatment of rheumatoid arthritis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides

Also Published As

Publication number Publication date
IL92551A0 (en) 1990-08-31
EP0372503A2 (en) 1990-06-13
HUT53125A (en) 1990-09-28
CA2004885C (en) 2000-03-28
FI895844A0 (fi) 1989-12-07
DK614489D0 (da) 1989-12-06
HU896448D0 (en) 1990-02-28
AU630132B2 (en) 1992-10-22
PT92503B (pt) 1995-08-09
ATE177432T1 (de) 1999-03-15
KR900009699A (ko) 1990-07-05
DE68928942T2 (de) 1999-08-12
EP0372503B1 (en) 1999-03-10
JP2916182B2 (ja) 1999-07-05
ES2131041T3 (es) 1999-07-16
ZA899247B (en) 1990-09-26
JPH02218692A (ja) 1990-08-31
NO894880D0 (no) 1989-12-06
EP0372503A3 (en) 1991-06-12
NZ231636A (en) 1993-03-26
HU201965B (en) 1991-01-28
DE68928942D1 (de) 1999-04-15
AU4588089A (en) 1990-06-14
CA2004885A1 (en) 1990-06-07
DK614489A (da) 1990-06-08
KR0162893B1 (ko) 1998-11-16
CN1043134A (zh) 1990-06-20
NO894880L (no) 1990-06-08

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PT92503A (pt) Processo para a preparacao de novos derivados peptidicos com accao anti-coagulante
FI904852A0 (fi) Antikoagulantpeptider.
PT90504A (pt) Processo para a preparacao de alcoois peptidicos com actividade anticoagulante
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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19950404

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19961031