PT91538A - Processo para a preparacao de novos derivados peptidicos com accao agonista do neuropeptido y - Google Patents

Processo para a preparacao de novos derivados peptidicos com accao agonista do neuropeptido y

Info

Publication number
PT91538A
PT91538A PT91538A PT9153889A PT91538A PT 91538 A PT91538 A PT 91538A PT 91538 A PT91538 A PT 91538A PT 9153889 A PT9153889 A PT 9153889A PT 91538 A PT91538 A PT 91538A
Authority
PT
Portugal
Prior art keywords
neuropeptido
preparation
agonist action
derivatives
peptidic derivatives
Prior art date
Application number
PT91538A
Other languages
English (en)
Other versions
PT91538B (pt
Inventor
John Leonard Krstenansky
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT91538A publication Critical patent/PT91538A/pt
Publication of PT91538B publication Critical patent/PT91538B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT91538A 1988-08-26 1989-08-24 Processo para a preparacao de novos derivados peptidicos com accao agonista do neuropeptido y PT91538B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23759188A 1988-08-26 1988-08-26

Publications (2)

Publication Number Publication Date
PT91538A true PT91538A (pt) 1990-03-08
PT91538B PT91538B (pt) 1995-05-04

Family

ID=22894367

Family Applications (1)

Application Number Title Priority Date Filing Date
PT91538A PT91538B (pt) 1988-08-26 1989-08-24 Processo para a preparacao de novos derivados peptidicos com accao agonista do neuropeptido y

Country Status (17)

Country Link
EP (1) EP0355793B1 (pt)
JP (1) JP2791955B2 (pt)
KR (1) KR0149160B1 (pt)
CN (1) CN1042155A (pt)
AT (1) ATE140235T1 (pt)
AU (1) AU618118B2 (pt)
CA (1) CA1341336C (pt)
DE (1) DE68926804T2 (pt)
DK (1) DK420789A (pt)
ES (1) ES2091757T3 (pt)
FI (1) FI894006A (pt)
HU (1) HU204852B (pt)
IL (1) IL91395A0 (pt)
NO (1) NO893430L (pt)
NZ (1) NZ230384A (pt)
PT (1) PT91538B (pt)
ZA (1) ZA896376B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0668910B1 (en) * 1991-11-06 1999-05-26 Garvan Institute Of Medical Research Human neuropeptide y-y1 receptor
AU662032B2 (en) * 1991-12-19 1995-08-17 Garvan Institute Of Medical Research A novel molecule which inhibits neuropeptide tyrosine biological function
CA2126212A1 (en) * 1991-12-19 1993-07-08 Albert Tseng A novel molecule which inhibits neuropeptide tyrosine biological function
GB9213215D0 (en) * 1992-06-20 1992-08-05 Wellcome Found Peptides
CA2165200A1 (en) * 1993-06-18 1995-01-05 Ambikaipakan Balasubramaniam Neuropeptide y antagonists and agonists
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) 1994-02-03 1996-08-13 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5989920A (en) 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
AUPN646795A0 (en) 1995-11-09 1995-11-30 Garvan Institute Of Medical Research Neuropeptide Y-Y5 receptor
DE19652033A1 (de) * 1996-12-13 1998-06-18 Irmgard Dr Med Guertner Neuropeptid (CGRP) als Modulator zur Zelldifferenzierung und Proliferation
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
CA2544573A1 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
AU2005210004B2 (en) 2004-02-05 2010-10-28 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
WO2008104580A1 (en) 2007-03-01 2008-09-04 Probiodrug Ag New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
EP2542549B1 (en) 2010-03-03 2016-05-11 Probiodrug AG Inhibitors of glutaminyl cyclase
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN111494606B (zh) * 2020-04-24 2021-12-14 广州医科大学 神经肽y的新应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811193A1 (de) * 1988-04-01 1989-10-19 Boehringer Ingelheim Kg Neue peptide, verfahren zu ihrer herstellung und diese peptide enthaltende pharmazeutische zusammensetzungen

Also Published As

Publication number Publication date
EP0355793A2 (en) 1990-02-28
ES2091757T3 (es) 1996-11-16
JPH02111794A (ja) 1990-04-24
AU4082889A (en) 1990-03-01
KR0149160B1 (ko) 1998-10-15
DK420789D0 (da) 1989-08-25
NZ230384A (en) 1996-03-26
CA1341336C (en) 2002-01-29
NO893430D0 (no) 1989-08-25
KR900002799A (ko) 1990-03-23
ZA896376B (en) 1990-05-30
IL91395A0 (en) 1990-04-29
DE68926804T2 (de) 1996-12-12
EP0355793A3 (en) 1992-04-22
DK420789A (da) 1990-02-27
CN1042155A (zh) 1990-05-16
ATE140235T1 (de) 1996-07-15
JP2791955B2 (ja) 1998-08-27
HU204852B (en) 1992-02-28
FI894006A (fi) 1990-02-27
HUT50849A (en) 1990-03-28
DE68926804D1 (de) 1996-08-14
NO893430L (no) 1990-02-27
AU618118B2 (en) 1991-12-12
FI894006A0 (fi) 1989-08-25
PT91538B (pt) 1995-05-04
EP0355793B1 (en) 1996-07-10

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19941013

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960430