PT90958A - Processo para a preparacao de derivados de tetra-hidropiranona e seus analogos de anel aberto, uteis como inibidores da reductase hmg-coa - Google Patents
Processo para a preparacao de derivados de tetra-hidropiranona e seus analogos de anel aberto, uteis como inibidores da reductase hmg-coaInfo
- Publication number
- PT90958A PT90958A PT90958A PT9095889A PT90958A PT 90958 A PT90958 A PT 90958A PT 90958 A PT90958 A PT 90958A PT 9095889 A PT9095889 A PT 9095889A PT 90958 A PT90958 A PT 90958A
- Authority
- PT
- Portugal
- Prior art keywords
- hydropyranone
- tetra
- derivatives
- preparation
- open ring
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003528 tetrahydropyranones Chemical class 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21301088A | 1988-06-29 | 1988-06-29 | |
US07/250,646 US4921974A (en) | 1988-09-29 | 1988-09-29 | Intermediates and processes in the preparation of 5-oxygenated HMG-COA reductase inhibitors |
US07/322,398 US4963538A (en) | 1988-06-29 | 1989-03-13 | 5-oxygenated HMG-CoA reductase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
PT90958A true PT90958A (pt) | 1989-12-29 |
PT90958B PT90958B (pt) | 1994-11-30 |
Family
ID=27395805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT90958A PT90958B (pt) | 1988-06-29 | 1989-06-23 | Processo para a preparacao de derivados de tetra-hidropiranona e seus analogos de anel aberto, uteis como inibidores da reductase hmg-coa |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0349063B1 (pt) |
JP (1) | JPH0253752A (pt) |
KR (1) | KR910000694A (pt) |
AT (1) | ATE127798T1 (pt) |
AU (1) | AU619563B2 (pt) |
CA (1) | CA1328876C (pt) |
DE (1) | DE68924205T2 (pt) |
DK (1) | DK319989A (pt) |
FI (1) | FI893004A (pt) |
HU (1) | HUT50803A (pt) |
IL (1) | IL90781A0 (pt) |
NO (1) | NO892677L (pt) |
NZ (1) | NZ229671A (pt) |
PT (1) | PT90958B (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT88364A (pt) * | 1987-09-02 | 1989-07-31 | Merck & Co Inc | Process for preparing novel hmg-coa reductase inhibitors |
US5200549A (en) * | 1988-11-14 | 1993-04-06 | Hoffman-La Roche Inc. | Antipsoriatic agents |
US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
CA2036962C (en) * | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
US5059696A (en) * | 1990-03-15 | 1991-10-22 | Merck & Co., Inc. | Processes and intermediates for the preparation of 5-oxygenated hmg-coa reductase inhibitors |
MY106564A (en) * | 1990-07-06 | 1995-06-30 | Squibb & Sons Inc | Sulfur-substituted mevinic acid derivatives. |
US5286746A (en) * | 1991-12-20 | 1994-02-15 | E. R. Squibb & Sons, Inc. | Sulfur-substituted mevinic acid derivatives |
US5369123A (en) * | 1992-10-09 | 1994-11-29 | E. R. Squibb & Sons, Inc. | Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors |
SI20159A (sl) * | 1999-02-04 | 2000-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nov postopek za odstranitev sililoksi zaščitne skupine iz 4-sililoksi tetrahidro-piran-2-on-ov |
SI21187A (sl) * | 2002-03-26 | 2003-10-31 | Krka, Tovarna Zdravil D.D., Novo Mesto | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
EP3698797A1 (en) | 2017-10-16 | 2020-08-26 | Tsinghua University | Mevalonic acid pathway inhibitor and pharmaceutical composition thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
JPS58188872A (ja) * | 1982-04-26 | 1983-11-04 | Suntory Ltd | オクタヒドロナフタレン誘導体及びその製造法 |
JPS59186972A (ja) * | 1983-03-09 | 1984-10-23 | Suntory Ltd | オクタヒドロナフタレン誘導体並びにその製造法 |
US4668699A (en) * | 1985-08-05 | 1987-05-26 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
PT88364A (pt) * | 1987-09-02 | 1989-07-31 | Merck & Co Inc | Process for preparing novel hmg-coa reductase inhibitors |
-
1989
- 1989-06-19 FI FI893004A patent/FI893004A/fi not_active IP Right Cessation
- 1989-06-22 DE DE68924205T patent/DE68924205T2/de not_active Expired - Fee Related
- 1989-06-22 AT AT89201642T patent/ATE127798T1/de not_active IP Right Cessation
- 1989-06-22 NZ NZ229671A patent/NZ229671A/xx unknown
- 1989-06-22 EP EP89201642A patent/EP0349063B1/en not_active Expired - Lifetime
- 1989-06-23 PT PT90958A patent/PT90958B/pt not_active IP Right Cessation
- 1989-06-27 CA CA000604033A patent/CA1328876C/en not_active Expired - Fee Related
- 1989-06-27 NO NO89892677A patent/NO892677L/no unknown
- 1989-06-27 KR KR1019890008847A patent/KR910000694A/ko not_active Application Discontinuation
- 1989-06-28 DK DK319989A patent/DK319989A/da not_active Application Discontinuation
- 1989-06-28 AU AU37116/89A patent/AU619563B2/en not_active Ceased
- 1989-06-28 HU HU893252A patent/HUT50803A/hu unknown
- 1989-06-29 IL IL90781A patent/IL90781A0/xx unknown
- 1989-06-29 JP JP1165523A patent/JPH0253752A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0349063A3 (en) | 1990-05-09 |
CA1328876C (en) | 1994-04-26 |
EP0349063B1 (en) | 1995-09-13 |
NZ229671A (en) | 1991-11-26 |
HUT50803A (en) | 1990-03-28 |
IL90781A0 (en) | 1990-01-18 |
DE68924205T2 (de) | 1996-03-28 |
EP0349063A2 (en) | 1990-01-03 |
DK319989D0 (da) | 1989-06-28 |
AU619563B2 (en) | 1992-01-30 |
FI893004A (fi) | 1989-12-30 |
NO892677L (no) | 1990-01-02 |
FI893004A0 (fi) | 1989-06-19 |
DE68924205D1 (de) | 1995-10-19 |
JPH0253752A (ja) | 1990-02-22 |
AU3711689A (en) | 1990-01-04 |
ATE127798T1 (de) | 1995-09-15 |
PT90958B (pt) | 1994-11-30 |
KR910000694A (ko) | 1991-01-30 |
DK319989A (da) | 1990-01-02 |
NO892677D0 (no) | 1989-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO905306D0 (no) | Spirocykliske forbindelser som inneholder nitrogen. | |
ATE51402T1 (de) | Infrarot-absorber. | |
ATE114463T1 (de) | Azaspirane mit immunmodulierender wirkung. | |
PT90958A (pt) | Processo para a preparacao de derivados de tetra-hidropiranona e seus analogos de anel aberto, uteis como inibidores da reductase hmg-coa | |
FI932445A0 (fi) | Farmaceutiska foereningar | |
ATE56715T1 (de) | Antihypercholesterinoemische verbindungen. | |
ES2107998T3 (es) | Alcanolaminas derivatizadas como agentes cardiovasculares. | |
AU8062487A (en) | New substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents | |
ES2099206T3 (es) | Derivados de benceno que favorecen la produccion del factor de crecimiento de los nervios humanos. | |
IL94027A0 (en) | Diaminoethylene compounds | |
ITMI931012A1 (it) | Composti spiro-piranici dotati di caratteristiche fotocromatiche | |
DE69214827D1 (de) | Tetrazolamide als acat inhibitoren | |
DE69018531T2 (de) | Monocyclische Terpen-Derivate. | |
FI932691A (fi) | Nya benzyl- och benzhydrylalkoholer | |
DK243487A (da) | Heterocyclisk-aromatiske forbindelser, deres fremstilling og farmaceutiske anvendelse | |
ATE135352T1 (de) | 3-keto-hmg-coa reduktase-inhibitoren | |
ES2051722T3 (es) | Procedimiento para estabilizar derivados de procaterol. | |
ES2039270T3 (es) | Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos. | |
ES2194871T3 (es) | Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico. | |
YU127289A (sh) | INHIBITORI 5-OKSIGENISANE HMG-CoA REDUKTAZE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19940519 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19951130 |