NO892677D0 - Fremgangsmaate for fremstilling av 5-oxygenerte hmg-coa-reduktaseinhibitorer. - Google Patents
Fremgangsmaate for fremstilling av 5-oxygenerte hmg-coa-reduktaseinhibitorer.Info
- Publication number
- NO892677D0 NO892677D0 NO892677A NO892677A NO892677D0 NO 892677 D0 NO892677 D0 NO 892677D0 NO 892677 A NO892677 A NO 892677A NO 892677 A NO892677 A NO 892677A NO 892677 D0 NO892677 D0 NO 892677D0
- Authority
- NO
- Norway
- Prior art keywords
- coa reductase
- hmg
- reductase inhibitors
- oxygenate
- procedure
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 2
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 2
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21301088A | 1988-06-29 | 1988-06-29 | |
US07/250,646 US4921974A (en) | 1988-09-29 | 1988-09-29 | Intermediates and processes in the preparation of 5-oxygenated HMG-COA reductase inhibitors |
US07/322,398 US4963538A (en) | 1988-06-29 | 1989-03-13 | 5-oxygenated HMG-CoA reductase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO892677D0 true NO892677D0 (no) | 1989-06-27 |
NO892677L NO892677L (no) | 1990-01-02 |
Family
ID=27395805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO89892677A NO892677L (no) | 1988-06-29 | 1989-06-27 | Fremgangsmaate for fremstilling av 5-oxygenerte hmg-coa-reduktaseinhibitorer. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0349063B1 (no) |
JP (1) | JPH0253752A (no) |
KR (1) | KR910000694A (no) |
AT (1) | ATE127798T1 (no) |
AU (1) | AU619563B2 (no) |
CA (1) | CA1328876C (no) |
DE (1) | DE68924205T2 (no) |
DK (1) | DK319989A (no) |
FI (1) | FI893004A (no) |
HU (1) | HUT50803A (no) |
IL (1) | IL90781A0 (no) |
NO (1) | NO892677L (no) |
NZ (1) | NZ229671A (no) |
PT (1) | PT90958B (no) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT88364A (pt) * | 1987-09-02 | 1989-07-31 | Merck & Co Inc | Process for preparing novel hmg-coa reductase inhibitors |
US5200549A (en) * | 1988-11-14 | 1993-04-06 | Hoffman-La Roche Inc. | Antipsoriatic agents |
US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
CA2036962C (en) * | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
US5059696A (en) * | 1990-03-15 | 1991-10-22 | Merck & Co., Inc. | Processes and intermediates for the preparation of 5-oxygenated hmg-coa reductase inhibitors |
MY106564A (en) * | 1990-07-06 | 1995-06-30 | Squibb & Sons Inc | Sulfur-substituted mevinic acid derivatives. |
US5286746A (en) * | 1991-12-20 | 1994-02-15 | E. R. Squibb & Sons, Inc. | Sulfur-substituted mevinic acid derivatives |
US5369123A (en) * | 1992-10-09 | 1994-11-29 | E. R. Squibb & Sons, Inc. | Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors |
SI20159A (sl) | 1999-02-04 | 2000-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nov postopek za odstranitev sililoksi zaščitne skupine iz 4-sililoksi tetrahidro-piran-2-on-ov |
SI21187A (sl) | 2002-03-26 | 2003-10-31 | Krka, Tovarna Zdravil D.D., Novo Mesto | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
EP3698797A1 (en) | 2017-10-16 | 2020-08-26 | Tsinghua University | Mevalonic acid pathway inhibitor and pharmaceutical composition thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
JPS58188872A (ja) * | 1982-04-26 | 1983-11-04 | Suntory Ltd | オクタヒドロナフタレン誘導体及びその製造法 |
JPS59186972A (ja) * | 1983-03-09 | 1984-10-23 | Suntory Ltd | オクタヒドロナフタレン誘導体並びにその製造法 |
US4668699A (en) * | 1985-08-05 | 1987-05-26 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
PT88364A (pt) * | 1987-09-02 | 1989-07-31 | Merck & Co Inc | Process for preparing novel hmg-coa reductase inhibitors |
-
1989
- 1989-06-19 FI FI893004A patent/FI893004A/fi not_active IP Right Cessation
- 1989-06-22 AT AT89201642T patent/ATE127798T1/de not_active IP Right Cessation
- 1989-06-22 NZ NZ229671A patent/NZ229671A/xx unknown
- 1989-06-22 EP EP89201642A patent/EP0349063B1/en not_active Expired - Lifetime
- 1989-06-22 DE DE68924205T patent/DE68924205T2/de not_active Expired - Fee Related
- 1989-06-23 PT PT90958A patent/PT90958B/pt not_active IP Right Cessation
- 1989-06-27 NO NO89892677A patent/NO892677L/no unknown
- 1989-06-27 KR KR1019890008847A patent/KR910000694A/ko not_active Application Discontinuation
- 1989-06-27 CA CA000604033A patent/CA1328876C/en not_active Expired - Fee Related
- 1989-06-28 HU HU893252A patent/HUT50803A/hu unknown
- 1989-06-28 AU AU37116/89A patent/AU619563B2/en not_active Ceased
- 1989-06-28 DK DK319989A patent/DK319989A/da not_active Application Discontinuation
- 1989-06-29 JP JP1165523A patent/JPH0253752A/ja active Pending
- 1989-06-29 IL IL90781A patent/IL90781A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU3711689A (en) | 1990-01-04 |
PT90958B (pt) | 1994-11-30 |
NZ229671A (en) | 1991-11-26 |
FI893004A0 (fi) | 1989-06-19 |
EP0349063A2 (en) | 1990-01-03 |
PT90958A (pt) | 1989-12-29 |
KR910000694A (ko) | 1991-01-30 |
DE68924205D1 (de) | 1995-10-19 |
HUT50803A (en) | 1990-03-28 |
EP0349063B1 (en) | 1995-09-13 |
JPH0253752A (ja) | 1990-02-22 |
AU619563B2 (en) | 1992-01-30 |
CA1328876C (en) | 1994-04-26 |
DK319989D0 (da) | 1989-06-28 |
IL90781A0 (en) | 1990-01-18 |
FI893004A (fi) | 1989-12-30 |
EP0349063A3 (en) | 1990-05-09 |
NO892677L (no) | 1990-01-02 |
DK319989A (da) | 1990-01-02 |
DE68924205T2 (de) | 1996-03-28 |
ATE127798T1 (de) | 1995-09-15 |
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