ATE56715T1 - Antihypercholesterinoemische verbindungen. - Google Patents

Antihypercholesterinoemische verbindungen.

Info

Publication number
ATE56715T1
ATE56715T1 AT87300544T AT87300544T ATE56715T1 AT E56715 T1 ATE56715 T1 AT E56715T1 AT 87300544 T AT87300544 T AT 87300544T AT 87300544 T AT87300544 T AT 87300544T AT E56715 T1 ATE56715 T1 AT E56715T1
Authority
AT
Austria
Prior art keywords
compounds
antihypercholesterinoemic
methylglutaryl
hmg
coenzyme
Prior art date
Application number
AT87300544T
Other languages
English (en)
Inventor
Robert L Smith
Gerald E Stokker
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE56715T1 publication Critical patent/ATE56715T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT87300544T 1986-01-31 1987-01-22 Antihypercholesterinoemische verbindungen. ATE56715T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/824,900 US4772626A (en) 1986-01-31 1986-01-31 Antihypercholesterolemic compounds
EP87300544A EP0232997B1 (de) 1986-01-31 1987-01-22 Antihypercholesterinömische Verbindungen

Publications (1)

Publication Number Publication Date
ATE56715T1 true ATE56715T1 (de) 1990-10-15

Family

ID=25242603

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87300544T ATE56715T1 (de) 1986-01-31 1987-01-22 Antihypercholesterinoemische verbindungen.

Country Status (7)

Country Link
US (1) US4772626A (de)
EP (1) EP0232997B1 (de)
JP (1) JPS62190144A (de)
AT (1) ATE56715T1 (de)
DE (1) DE3764967D1 (de)
DK (1) DK51087A (de)
ES (1) ES2029829T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855321A (en) * 1986-01-31 1989-08-08 Merck & Co., Inc. Antihypercholesterolemic compounds
US5169976A (en) * 1987-11-25 1992-12-08 Pfizer Inc. N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents
US4900754A (en) * 1987-12-21 1990-02-13 Rorer Pharmaceutical Corp. HMG-COA reductase inhibitors
US4939143A (en) * 1987-12-21 1990-07-03 Rorer Pharmaceutical Corporation Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US4904691A (en) * 1987-12-21 1990-02-27 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US5001128A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. HMG-COA reductase inhibitors
US4863957A (en) * 1987-12-21 1989-09-05 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US4876280A (en) * 1988-03-10 1989-10-24 Sandoz Pharm. Corp. Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use
DE3818570A1 (de) * 1988-06-01 1989-12-21 Boehringer Mannheim Gmbh Neue 6-substituierte-4-hydroxy-tetrahydro-pyran -2-on-derivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
DE3909378A1 (de) * 1989-03-22 1990-09-27 Bayer Ag Substituierte biphenyle
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
EP0445827B1 (de) * 1990-03-07 1996-09-25 Fujirebio Inc. 4-Hydroxytetrahydropyran-2-on Derivate nützlich als cholesterin- und lipidsenkende Agenzien
WO1991013616A1 (en) * 1990-03-08 1991-09-19 Rorer International (Overseas) Inc. NOVEL HMG-CoA REDUCTASE INHIBITORS
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
BRPI0721761A2 (pt) * 2007-05-29 2013-02-13 Evonik Degussa Gmbh hidrogenaÇço de compostos nitro hidrogenaÇço de aromÁticos nitrados hidrogenaÇço contÍnua de aromÁticos nitrados catalisadores de in ativado
US20210008084A1 (en) 2017-10-16 2021-01-14 Tsinghua University Mevalonate pathway inhibitor and pharmaceutical composition thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375475A (en) * 1979-08-17 1983-03-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4459422A (en) * 1979-08-17 1984-07-10 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
EP0232997A1 (de) 1987-08-19
US4772626A (en) 1988-09-20
DK51087A (da) 1987-08-01
EP0232997B1 (de) 1990-09-19
JPS62190144A (ja) 1987-08-20
DE3764967D1 (de) 1990-10-25
DK51087D0 (da) 1987-01-30
ES2029829T3 (es) 1992-10-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee