PT88390A - Pyrrolo <1,2-a> imidazole and pyrrolo <1,2-a> pyridine derivatives and the use as 5-lipoxygenase pathway inhibitors - Google Patents

Pyrrolo <1,2-a> imidazole and pyrrolo <1,2-a> pyridine derivatives and the use as 5-lipoxygenase pathway inhibitors

Info

Publication number
PT88390A
PT88390A PT88390A PT8839088A PT88390A PT 88390 A PT88390 A PT 88390A PT 88390 A PT88390 A PT 88390A PT 8839088 A PT8839088 A PT 8839088A PT 88390 A PT88390 A PT 88390A
Authority
PT
Portugal
Prior art keywords
pyrrolo
imidazole
pathway inhibitors
pyridine derivatives
lipoxygenase pathway
Prior art date
Application number
PT88390A
Other languages
English (en)
Other versions
PT88390B (pt
Inventor
Jerry Leroy Adams
Paul Elliot Bender
John Gerald Gleason
Nabil Hanna
John Frederik Newton Jr
Carl David Perchonok
Kazye Razgaitis
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PT88390A publication Critical patent/PT88390A/pt
Publication of PT88390B publication Critical patent/PT88390B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
PT88390A 1987-09-02 1988-08-31 Processo de preparacao de derivados do pirrolo{1,2-a}imidazolo e de imidazo{1,2-a}piridina e de composicoes farmaceuticas que os contem PT88390B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9225887A 1987-09-02 1987-09-02

Publications (2)

Publication Number Publication Date
PT88390A true PT88390A (pt) 1989-07-31
PT88390B PT88390B (pt) 1992-10-30

Family

ID=22232414

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88390A PT88390B (pt) 1987-09-02 1988-08-31 Processo de preparacao de derivados do pirrolo{1,2-a}imidazolo e de imidazo{1,2-a}piridina e de composicoes farmaceuticas que os contem

Country Status (15)

Country Link
EP (1) EP0306300B1 (pt)
JP (1) JPS6471876A (pt)
KR (1) KR900003167A (pt)
CN (1) CN1032011A (pt)
AT (1) ATE122044T1 (pt)
AU (1) AU1815092A (pt)
DE (1) DE3853704D1 (pt)
DK (1) DK483288A (pt)
FI (1) FI884017A (pt)
HU (1) HUT50475A (pt)
IL (1) IL87604A0 (pt)
MY (1) MY103766A (pt)
NO (1) NO883882L (pt)
NZ (1) NZ225967A (pt)
PT (1) PT88390B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
AU6355190A (en) * 1989-06-13 1991-01-17 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
CN102093366B (zh) * 2011-03-04 2012-11-28 中国医学科学院医药生物技术研究所 双环氨基吡唑类化合物及其在抗柯萨奇病毒中的应用
US10526345B2 (en) 2016-04-08 2020-01-07 Mankind Pharma Ltd. Compounds as GPR119 agonists
US10954229B2 (en) 2016-04-08 2021-03-23 Mankind Pharma Ltd. GPR119 agonist compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175127A (en) * 1978-09-27 1979-11-20 Smithkline Corporation Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
US4186205A (en) * 1979-01-08 1980-01-29 Smithkline Corporation 2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles
ZW24186A1 (en) * 1985-12-12 1987-07-08 Smithkline Beckman Corp Inhibition of the 5-lipoxygenase pathway

Also Published As

Publication number Publication date
NO883882L (no) 1989-03-03
KR900003167A (ko) 1990-03-23
EP0306300A3 (en) 1990-08-16
FI884017A (fi) 1989-03-03
NO883882D0 (no) 1988-08-31
HUT50475A (en) 1990-02-28
AU2174488A (en) 1989-05-25
MY103766A (en) 1993-09-30
JPS6471876A (en) 1989-03-16
ATE122044T1 (de) 1995-05-15
EP0306300A2 (en) 1989-03-08
CN1032011A (zh) 1989-03-29
DK483288A (da) 1989-03-03
AU621308B2 (en) 1992-03-12
DE3853704D1 (de) 1995-06-08
AU1815092A (en) 1992-08-27
FI884017A0 (fi) 1988-08-31
NZ225967A (en) 1992-03-26
DK483288D0 (da) 1988-08-30
EP0306300B1 (en) 1995-05-03
IL87604A0 (en) 1989-01-31
PT88390B (pt) 1992-10-30

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920413

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19941031