PT87218A - Process for preparing substituted pyrroles - Google Patents

Process for preparing substituted pyrroles

Info

Publication number
PT87218A
PT87218A PT87218A PT8721888A PT87218A PT 87218 A PT87218 A PT 87218A PT 87218 A PT87218 A PT 87218A PT 8721888 A PT8721888 A PT 8721888A PT 87218 A PT87218 A PT 87218A
Authority
PT
Portugal
Prior art keywords
preparing substituted
substituted pyrroles
pyrroles
preparing
substituted
Prior art date
Application number
PT87218A
Other languages
English (en)
Other versions
PT87218B (pt
Inventor
Walter Huebsch
Rolf Angerbauer
Peter Fey
Hilmar Bischoff
Dieter Petzinna
Delf Schmidt
Gunter Thomas
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873726528 external-priority patent/DE3726528A1/de
Priority claimed from IT8722636A external-priority patent/IT8722636A0/it
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PT87218A publication Critical patent/PT87218A/pt
Publication of PT87218B publication Critical patent/PT87218B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PT87218A 1987-04-14 1988-04-12 Processo para a preparacao de pirroles substituidos PT87218B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3712720 1987-04-14
DE19873726528 DE3726528A1 (de) 1987-04-14 1987-08-10 Substituierte pyrrole
IT8722636A IT8722636A0 (it) 1987-11-13 1987-11-13 Pirroli sostituiti.

Publications (2)

Publication Number Publication Date
PT87218A true PT87218A (pt) 1988-05-01
PT87218B PT87218B (pt) 1992-07-31

Family

ID=27195778

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87218A PT87218B (pt) 1987-04-14 1988-04-12 Processo para a preparacao de pirroles substituidos

Country Status (13)

Country Link
US (1) US4992462A (pt)
EP (1) EP0287890A1 (pt)
JP (1) JPS63275561A (pt)
KR (1) KR880012547A (pt)
CN (1) CN1030075A (pt)
AU (1) AU1465688A (pt)
DK (1) DK202088A (pt)
FI (1) FI881688A (pt)
HU (1) HUT48581A (pt)
IL (1) IL86033A0 (pt)
NO (1) NO881411L (pt)
NZ (1) NZ224207A (pt)
PT (1) PT87218B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722806A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
GB8728314D0 (en) * 1987-12-03 1988-01-06 May & Baker Ltd New compositions of matter
AU621874B2 (en) * 1988-02-22 1992-03-26 Warner-Lambert Company Improved process for trans-6-(2-(substituted-pyrrol-1-yl) alkyl)pyran-2-one inhibitors of cholesterol synthesis
EP0352575A3 (de) * 1988-07-28 1991-08-21 Bayer Ag Substituierte anellierte Pyrrole
JPH04270285A (ja) * 1988-11-14 1992-09-25 Nissan Chem Ind Ltd ピラゾロピリミジン系メバロノラクトン類
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
CA2043525A1 (en) * 1990-06-24 1991-12-25 Donald S. Karanewsky Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
US5128366A (en) * 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4243279A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5908858A (en) 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
AU2008274941A1 (en) 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
CN107445880B (zh) * 2017-07-20 2019-07-16 华南理工大学 一种三氟甲基修饰Aβ-42抑制剂结构类似物的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE564126C (de) * 1931-04-19 1932-11-14 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Pyrrolderivaten
DE1301313B (de) * 1966-12-03 1969-08-21 Ruetgerswerke Ag Verfahren zur Herstellung von Pyrryl-(2)-essigsaeureestern
CH522637A (de) * 1967-07-26 1972-06-30 Mcneilab Inc Verfahren zur Herstellung von 5-Aroyl-pyrrolyl-(2)-alkansäurederivaten
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0009326A3 (en) * 1978-08-30 1980-04-16 Pfizer Limited Pyrrolyl keto and amino acids and derivatives thereof, processes for their preparation and pharmaceutical compositions containing them
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4851427A (en) * 1985-10-25 1989-07-25 Sandoz Pharm. Corp. Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use
WO1987002662A2 (en) * 1985-10-25 1987-05-07 Sandoz Ag Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals
US4694018A (en) * 1985-11-29 1987-09-15 G. D. Serale & Co. Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives
US4792568A (en) * 1986-04-14 1988-12-20 Rorer Pharmaceutical Corporation Aryl pyrroles as useful antiallergy compounds
US4661483A (en) * 1986-05-05 1987-04-28 Merck & Co., Inc. Antihypercholesterolemic lactone compounds, compositions and use
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4735958A (en) * 1986-12-22 1988-04-05 Warner-Lambert Company Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US4789682A (en) * 1987-03-17 1988-12-06 Merck & Co., Inc. Antihypercholesterolemic compounds
US4902709A (en) * 1987-03-17 1990-02-20 Merck & Co., Inc. Novel antihypercholesterolemic compounds
US4795811A (en) * 1987-06-22 1989-01-03 Merck & Co., Inc. Intermediates for preparing HMG-CoA reductase inhibitors
DE3817808A1 (de) * 1987-07-21 1989-02-02 Bayer Ag Verfahren zur herstellung von 2-substituierten pyrrolen

Also Published As

Publication number Publication date
US4992462A (en) 1991-02-12
CN1030075A (zh) 1989-01-04
NO881411L (no) 1988-10-17
DK202088A (da) 1988-10-15
DK202088D0 (da) 1988-04-13
EP0287890A1 (de) 1988-10-26
IL86033A0 (en) 1988-09-30
PT87218B (pt) 1992-07-31
KR880012547A (ko) 1988-11-28
NZ224207A (en) 1991-02-26
FI881688A (fi) 1988-10-15
AU1465688A (en) 1988-10-20
HUT48581A (en) 1989-06-28
NO881411D0 (no) 1988-03-29
JPS63275561A (ja) 1988-11-14
FI881688A0 (fi) 1988-04-12

Similar Documents

Publication Publication Date Title
PT86866A (pt) Process for preparing piperazinyl-heterocyclic compounds
PT88596A (pt) Process for preparing 2-anilinopyrimidine derivatives useful aspesticidas
PT87273A (pt) Process for preparing substituted quinolones
YU130288A (en) Process for obtaining benzopirane derivatives
PT86660A (pt) Process for preparing adenosine 5:-carboxamide derivatives
IT1224737B (it) Perfezionato procedimento di stampa
HK99795A (en) Process for preparing 4-acyloxy-3-hydroxyethyl-azetidinones
PT87218A (pt) Process for preparing substituted pyrroles
NO172447C (no) Fremgangsmaate for fremstilling av b-avermectiner
NO885607L (no) Fremgangsmaate for fremstilling av piperidinylforbindelser.
YU55088A (en) Process for obtaining propylolephine derivatives
PT87564A (pt) Process for preparing substituted vinylcephalosporins useful as medicaments
EP0283905A3 (en) Process for preparing chloropolysilanes
FI902772A0 (fi) Menetelmä puutuotteiden valmistamiseksi
YU199089A (en) Process for obtaining quinolynic derivatives
PT87359A (pt) Process for the preparation of pyrrolidine derivatives
YU159688A (en) Process for preparing anilynphenyl-thiourins, -izothiourins and -carbonimides
NO883339D0 (no) Fremgangsmaate for fremstilling av benzimidazol-2-yl-pyridiniumforbindelser.
YU200888A (en) Process for preparing substituted azacyclohexylic derivatives
FI885045A0 (fi) Menetelmä polynukleotidien valmistamiseksi
PT87489A (pt) Process for preparing oximinio ether compounds
PT87779A (pt) Process for preparing substituted penem compounds
YU110888A (en) Process for obtaining timine derivatives
YU159788A (en) Process for preparing phenyl-thiourins, -izothiourins and -carbonimides
PT86829A (pt) Process for preparing thienothiopyran derivatives

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920124

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19930731