PT87194A - Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate verfahren zu ihrer herstellung sie enthaltende mittel sowie deren verwendung - Google Patents

Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate verfahren zu ihrer herstellung sie enthaltende mittel sowie deren verwendung

Info

Publication number
PT87194A
PT87194A PT87194A PT8719488A PT87194A PT 87194 A PT87194 A PT 87194A PT 87194 A PT87194 A PT 87194A PT 8719488 A PT8719488 A PT 8719488A PT 87194 A PT87194 A PT 87194A
Authority
PT
Portugal
Prior art keywords
neue
dicarbonyl
derivate
verfahren
sie
Prior art date
Application number
PT87194A
Other languages
English (en)
Other versions
PT87194B (pt
Inventor
Rainer Henning
Franz Hock
Hansjoerg Urbach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT87194A publication Critical patent/PT87194A/pt
Publication of PT87194B publication Critical patent/PT87194B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT87194A 1987-04-11 1988-04-08 Processo para a preparacao de novos derivados de pirrolidino-2-(1,3-dicarbonilo) e de composicoes farmaceuticas que os contem PT87194B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712364 DE3712364A1 (de) 1987-04-11 1987-04-11 Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung

Publications (2)

Publication Number Publication Date
PT87194A true PT87194A (pt) 1988-05-01
PT87194B PT87194B (pt) 1992-07-31

Family

ID=6325456

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87194A PT87194B (pt) 1987-04-11 1988-04-08 Processo para a preparacao de novos derivados de pirrolidino-2-(1,3-dicarbonilo) e de composicoes farmaceuticas que os contem

Country Status (15)

Country Link
US (1) US4912128A (pt)
EP (1) EP0286927A3 (pt)
JP (1) JPS63258852A (pt)
KR (1) KR880012542A (pt)
AU (1) AU607987B2 (pt)
DE (1) DE3712364A1 (pt)
DK (1) DK191988A (pt)
FI (1) FI87456C (pt)
HU (1) HU199785B (pt)
IL (1) IL86028A (pt)
NO (1) NO881545L (pt)
NZ (1) NZ224181A (pt)
PH (1) PH26048A (pt)
PT (1) PT87194B (pt)
ZA (1) ZA882460B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3742431A1 (de) * 1987-12-15 1989-07-13 Hoechst Ag Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
EP0536399B1 (en) * 1990-06-07 1996-01-24 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
JPH05186498A (ja) * 1991-12-27 1993-07-27 Japan Tobacco Inc プロリン誘導体
US5254696A (en) * 1990-09-13 1993-10-19 Bayer Aktiengesellschaft N-acylpyrrolidine derivatives
DE4029054A1 (de) * 1990-09-13 1992-03-19 Bayer Ag N-acylpyrrolidin-derivate
JP3810097B2 (ja) * 1993-01-15 2006-08-16 明治製菓株式会社 ピロリジン−２−イルカルボニル複素環式化合物誘導体
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492640A (en) * 1975-07-08 1977-11-23 Ucb Sa L-pyroglutamyl-l-prolinamide
US4560795A (en) * 1979-04-10 1985-12-24 Merrell Dow France et Cie. α-Halomethyl derivatives of α-amino acids
US4499102A (en) * 1979-12-13 1985-02-12 Santen Pharmaceutical Co., Ltd. Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
GB2083030B (en) * 1980-08-23 1984-03-07 Merrell Toraude & Co Fluorinated pentene diamine derivatives
US4456594A (en) * 1981-11-06 1984-06-26 Smithkline Beckman Corporation N-Carboxyalkylproline-containing tripeptides
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0655758B2 (ja) * 1984-08-24 1994-07-27 味の素株式会社 アミノ酸誘導体
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
CA1309805C (en) * 1985-04-16 1992-11-03 Naoki Higuchi Dipeptide derivative and synthesis and use thereof
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
JPH0653757B2 (ja) * 1985-12-06 1994-07-20 味の素株式会社 プロリン誘導体の芳香族スルホン酸塩
JPH08806B2 (ja) * 1986-11-18 1996-01-10 サントリー株式会社 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712363A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung

Also Published As

Publication number Publication date
EP0286927A2 (de) 1988-10-19
NO881545D0 (no) 1988-04-08
DK191988A (da) 1988-10-12
EP0286927A3 (de) 1991-05-08
FI881612A0 (fi) 1988-04-07
PH26048A (en) 1992-01-29
FI87456B (fi) 1992-09-30
ZA882460B (en) 1988-09-29
AU607987B2 (en) 1991-03-21
FI881612A (fi) 1988-10-12
KR880012542A (ko) 1988-11-28
IL86028A0 (en) 1988-09-30
US4912128A (en) 1990-03-27
JPS63258852A (ja) 1988-10-26
PT87194B (pt) 1992-07-31
DK191988D0 (da) 1988-04-08
AU1446588A (en) 1988-10-13
NZ224181A (en) 1990-07-26
HU199785B (en) 1990-03-28
FI87456C (fi) 1993-01-11
IL86028A (en) 1993-03-15
HUT46659A (en) 1988-11-28
NO881545L (no) 1988-10-12
DE3712364A1 (de) 1988-10-27

Similar Documents

Publication Publication Date Title
DE69211076T3 (de) Polyasparaginsäure-zusammensetzung, verfahren zu ihrer herstellung und ihre verwendung
DE58909834D1 (de) Phthalimidoperoxihexansäure, Verfahren zu deren Herstellung und deren Verwendung
DE3768530D1 (de) Methacrylatharz-zusammensetzung und verfahren zu deren herstellung.
DE3766878D1 (de) Prothesenteil sowie verfahren zu seiner herstellung.
DE3586597D1 (de) Polyetherverbindungen und verfahren zu ihrer herstellung.
DE3670483D1 (de) 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung.
DE3782994D1 (de) Erythromycin-a-derivate und verfahren zu ihrer herstellung.
DE59208394D1 (de) Diallylammonium-Verbindungen, Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE3580487D1 (de) Aromatische aminosulfonverbindungen und verfahren zu deren herstellung.
PT84460A (de) 1,1-disubstituierte cyclopropanderivate verfahren zu ihrer herstellung und ihre verwendung
DE3778148D1 (de) Zusammensetzungen mit discorhabdin, sowie verfahren zu deren verwendung.
PT87195A (pt) Neue 2-acylpyrrolidin-derivate verfahren zu ihrer herstellung sie enthaltende mittel sowie deren verwendung
DE3588039D1 (de) Azetidinonderivate und Verfahren zu ihrer Herstellung.
PT87194A (pt) Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate verfahren zu ihrer herstellung sie enthaltende mittel sowie deren verwendung
DE3767789D1 (de) Substituierte aminodihydrooxazole, -thiazole und -imidazole, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE58903212D1 (de) Eisenoxidpigmente, verfahren zu ihrer herstellung sowie deren verwendung.
PT84459A (de) 1,1-disubstituierte cyclopropanderivate verfahren zu ihrer herstellung sowie ihre verwendung als antimykotika oder als zwischenprodukte
DE59001359D1 (de) Rutilmischphasenpigment-mikrogranulate, verfahren zu ihrer herstellung sowie deren verwendung.
DE59010759D1 (de) 3-Aminopyrrole, Verfahren zu ihrer Herstellung und ihre Verwendung als Antikonvulsiva
DE3887628D1 (de) Polymere Hydridosilazane und Verfahren zu ihrer Herstellung sowie ihre Verwendung.
PT88516A (pt) Neue aminosaereester verfahren zu ihrer herstellung sie enthaltende arzneimittel und deren verwendung
PT87456A (pt) Diarylalkyl-substituierte alkylamine verfahren zu ihrer herstellung ihre verwendung sowie sie enthaltende arzneimittel
DE3765181D1 (de) Isocarbacycline und verfahren zu ihrer herstellung.
PT80906A (de) Substituierte guanidinobenzoesaeurephenylester verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PT87196A (pt) Neue pyrrol-idin-derivate verfahren zu ihrer herstellung sie enthaltende mittel sowie deren verwendung

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920116

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19930731