PT86648A - Method for the preparation of anti-retroviral compositions containing 3'-azido-2',3'-dideoxyuridine - Google Patents

Method for the preparation of anti-retroviral compositions containing 3'-azido-2',3'-dideoxyuridine

Info

Publication number
PT86648A
PT86648A PT86648A PT8664888A PT86648A PT 86648 A PT86648 A PT 86648A PT 86648 A PT86648 A PT 86648A PT 8664888 A PT8664888 A PT 8664888A PT 86648 A PT86648 A PT 86648A
Authority
PT
Portugal
Prior art keywords
dideoxyuridine
azido
preparation
compositions containing
retroviral
Prior art date
Application number
PT86648A
Other languages
English (en)
Other versions
PT86648B (pt
Original Assignee
Chung Kwang Chu
Schinazi Raymond Felix
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chung Kwang Chu, Schinazi Raymond Felix filed Critical Chung Kwang Chu
Publication of PT86648A publication Critical patent/PT86648A/pt
Publication of PT86648B publication Critical patent/PT86648B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT86648A 1987-01-28 1988-01-28 Metodo para a preparacao de composicoes anti-retrovirais contendo 3'-azido-2',3'-disesoxiuridina PT86648B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US747387A 1987-01-28 1987-01-28
US07/104,438 US4916122A (en) 1987-01-28 1987-10-02 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition

Publications (2)

Publication Number Publication Date
PT86648A true PT86648A (pt) 1988-02-01
PT86648B PT86648B (pt) 1991-02-08

Family

ID=26677039

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86648A PT86648B (pt) 1987-01-28 1988-01-28 Metodo para a preparacao de composicoes anti-retrovirais contendo 3'-azido-2',3'-disesoxiuridina

Country Status (14)

Country Link
US (1) US4916122A (pt)
EP (1) EP0301064B1 (pt)
JP (1) JPH0649652B2 (pt)
AR (1) AR240251A1 (pt)
AT (1) ATE110271T1 (pt)
AU (1) AU606391B2 (pt)
BR (1) BR8804823A (pt)
CA (1) CA1313498C (pt)
DE (1) DE3851187D1 (pt)
ES (1) ES2009168A6 (pt)
IL (1) IL85078A0 (pt)
MX (1) MX167702B (pt)
PT (1) PT86648B (pt)
WO (1) WO1988005657A1 (pt)

Families Citing this family (49)

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US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5122517A (en) * 1988-06-10 1992-06-16 Regents Of The University Of Minnesota Antiviral combination comprising nucleoside analogs
US6911470B1 (en) 1988-09-22 2005-06-28 Raymond F. Schinazi Polyoxometalate compounds as antiviral agents
FR2640508B1 (fr) * 1988-12-19 1994-07-01 Dietlin Francois Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire
US5118672A (en) * 1989-07-10 1992-06-02 University Of Georgia Research Foundation 5'-diphosphohexose nucleoside pharmaceutical compositions
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FR2653771B1 (fr) * 1989-10-27 1994-09-23 Univ Paris Curie Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6642245B1 (en) * 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5728575A (en) * 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
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US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US5583000A (en) * 1991-09-03 1996-12-10 The Regents Of The University Of California Protease-binding compounds and methods of use
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US6008045A (en) * 1991-11-15 1999-12-28 Board Of Trustees Of The Leland Stanford University Nucleic acid encoding human DNA polymerase α
US20050192299A1 (en) * 1992-04-16 2005-09-01 Yung-Chi Cheng Method of treating or preventing hepatitis B virus
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
WO1995007086A1 (en) 1993-09-10 1995-03-16 Emory University Nucleosides with anti-hepatitis b virus activity
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5824706A (en) * 1994-09-26 1998-10-20 Schinazi; Raymond F. Method, compositions, and apparatus for treating and preventing respiratory viral infections
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
EP0831852B1 (en) * 1995-06-07 2006-11-29 Emory University Nucleosides with anti-hepatitis b virus activity
AU6630996A (en) * 1995-08-04 1997-03-05 Kobayashi Perfumery Co., Ltd. Process for producing azido nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
AU4716299A (en) 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
CA2340156C (en) 1998-08-10 2007-10-23 Novirio Pharmaceuticals Limited .beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
CA2348470C (en) 1998-11-05 2007-06-05 Centre National De La Recherche Scientifique Nucleosides with anti-hepatitis b virus activity
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
KR100855907B1 (ko) * 2002-09-13 2008-09-02 노파르티스 아게 내성 ＨＢＶ 균주 치료용 β-Ｌ-2'-데옥시뉴클레오시드 및병용 요법
JP5504179B2 (ja) 2008-03-03 2014-05-28 トスク インコーポレーティッド 毒性を低減するためのメトトレキセートアジュバントおよびその使用法
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CN114276359B (zh) * 2022-01-05 2023-05-05 浙江大学 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

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GB8506868D0 (en) 1985-03-16 1985-04-17 Wellcome Found Antibacterial compound
GB8603450D0 (en) 1986-02-12 1986-03-19 Wellcome Found Antiviral compounds
GB8523881D0 (en) 1985-09-27 1985-10-30 Wellcome Found Antiviral compounds
GB8506869D0 (en) 1985-03-16 1985-04-17 Wellcome Found Antiviral compound
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GB8523878D0 (en) 1985-09-27 1985-10-30 Wellcome Found Therapeutic compounds
GB8603719D0 (en) 1986-02-14 1986-03-19 Wellcome Found Antiviral compounds
GB8603447D0 (en) 1986-02-12 1986-03-19 Wellcome Found Therapeutic compounds
GB8615322D0 (en) 1986-06-23 1986-07-30 Wellcome Found Antiviral combinations
GB8608272D0 (en) 1986-04-04 1986-05-08 Wellcome Found Antiviral combination
ZA867013B (en) * 1985-09-17 1988-04-27 Wellcome Found Therapeutic nucleosides
US4649161A (en) * 1986-06-16 1987-03-10 Massachusetts Institute Of Technology Method for treating depression with d-fenfluramine
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses

Also Published As

Publication number Publication date
EP0301064B1 (en) 1994-08-24
AU1242688A (en) 1988-08-24
DE3851187D1 (de) 1994-09-29
WO1988005657A1 (en) 1988-08-11
AU606391B2 (en) 1991-02-07
CA1313498C (en) 1993-02-09
AR240251A1 (es) 1990-03-30
IL85078A0 (en) 1988-06-30
ES2009168A6 (es) 1989-09-01
US4916122A (en) 1990-04-10
ATE110271T1 (de) 1994-09-15
JPH0649652B2 (ja) 1994-06-29
MX167702B (es) 1993-04-06
BR8804823A (pt) 1989-10-17
EP0301064A1 (en) 1989-02-01
JPH01502027A (ja) 1989-07-13
PT86648B (pt) 1991-02-08

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