BR8804823A - Composicao farmaceutica,processo para tratamento de hiv e prevencao de infeccao por hiv em um ser humano e processo para producao de composicao - Google Patents

Composicao farmaceutica,processo para tratamento de hiv e prevencao de infeccao por hiv em um ser humano e processo para producao de composicao

Info

Publication number
BR8804823A
BR8804823A BR8804823A BR8804823A BR8804823A BR 8804823 A BR8804823 A BR 8804823A BR 8804823 A BR8804823 A BR 8804823A BR 8804823 A BR8804823 A BR 8804823A BR 8804823 A BR8804823 A BR 8804823A
Authority
BR
Brazil
Prior art keywords
hiv
prevention
human
composition
pharmaceutical composition
Prior art date
Application number
BR8804823A
Other languages
English (en)
Inventor
Chung Kwang Chu
Raymond Felix Schinazi
Original Assignee
Chung Kwang Chu
Raymond Felix Schinazi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chung Kwang Chu, Raymond Felix Schinazi filed Critical Chung Kwang Chu
Publication of BR8804823A publication Critical patent/BR8804823A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BR8804823A 1987-01-28 1988-01-13 Composicao farmaceutica,processo para tratamento de hiv e prevencao de infeccao por hiv em um ser humano e processo para producao de composicao BR8804823A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US747387A 1987-01-28 1987-01-28
US07/104,438 US4916122A (en) 1987-01-28 1987-10-02 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
PCT/US1988/000073 WO1988005657A1 (en) 1987-01-28 1988-01-13 3'-azido-2',3'-dideoxyuridine anti-retroviral composition

Publications (1)

Publication Number Publication Date
BR8804823A true BR8804823A (pt) 1989-10-17

Family

ID=26677039

Family Applications (1)

Application Number Title Priority Date Filing Date
BR8804823A BR8804823A (pt) 1987-01-28 1988-01-13 Composicao farmaceutica,processo para tratamento de hiv e prevencao de infeccao por hiv em um ser humano e processo para producao de composicao

Country Status (14)

Country Link
US (1) US4916122A (pt)
EP (1) EP0301064B1 (pt)
JP (1) JPH0649652B2 (pt)
AR (1) AR240251A1 (pt)
AT (1) ATE110271T1 (pt)
AU (1) AU606391B2 (pt)
BR (1) BR8804823A (pt)
CA (1) CA1313498C (pt)
DE (1) DE3851187D1 (pt)
ES (1) ES2009168A6 (pt)
IL (1) IL85078A0 (pt)
MX (1) MX167702B (pt)
PT (1) PT86648B (pt)
WO (1) WO1988005657A1 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
AU2526188A (en) * 1987-09-22 1989-04-18 Regents Of The University Of California, The Liposomal nucleoside analogues for treating aids
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5122517A (en) * 1988-06-10 1992-06-16 Regents Of The University Of Minnesota Antiviral combination comprising nucleoside analogs
US6911470B1 (en) 1988-09-22 2005-06-28 Raymond F. Schinazi Polyoxometalate compounds as antiviral agents
FR2640508B1 (fr) * 1988-12-19 1994-07-01 Dietlin Francois Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire
US5118672A (en) * 1989-07-10 1992-06-02 University Of Georgia Research Foundation 5'-diphosphohexose nucleoside pharmaceutical compositions
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
FR2653771B1 (fr) * 1989-10-27 1994-09-23 Univ Paris Curie Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5728575A (en) * 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6642245B1 (en) 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US5583000A (en) * 1991-09-03 1996-12-10 The Regents Of The University Of California Protease-binding compounds and methods of use
FI90552C (fi) * 1991-10-09 1994-02-25 Leiras Oy Menetelmä nukleosidijohdannaisten valmistamiseksi
US6008045A (en) * 1991-11-15 1999-12-28 Board Of Trustees Of The Leland Stanford University Nucleic acid encoding human DNA polymerase α
US20050192299A1 (en) * 1992-04-16 2005-09-01 Yung-Chi Cheng Method of treating or preventing hepatitis B virus
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
CA2171550C (en) 1993-09-10 2008-08-26 Raymond F. Schinazi Nucleosides with anti-hepatitis b virus activity
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5824706A (en) * 1994-09-26 1998-10-20 Schinazi; Raymond F. Method, compositions, and apparatus for treating and preventing respiratory viral infections
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
ES2276404T3 (es) 1995-06-07 2007-06-16 Emory University Nucleosidos con actividad antivirus de la hepatitis-b.
AU6630996A (en) * 1995-08-04 1997-03-05 Kobayashi Perfumery Co., Ltd. Process for producing azido nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
AU4716299A (en) 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
ES2579903T3 (es) * 1998-08-10 2016-08-17 Centre National De La Recherche Scientifique (Cnrs) Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
ATE315574T1 (de) 1998-11-05 2006-02-15 Centre Nat Rech Scient Nukleoside mit anti-hepatitis b virus wirkung
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
ES2547002T3 (es) 2002-09-13 2015-09-30 Novartis Ag Beta-L-2' desoxinucleósidos para el tratamiento de cepas de VHB resistentes
CA2729613C (en) 2008-03-03 2017-02-07 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same
PA8852101A1 (es) * 2008-12-08 2010-07-27 Medivir Ab Nucleótidos uracil ciclopropílicos
CN114276359B (zh) * 2022-01-05 2023-05-05 浙江大学 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

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US3755295A (en) * 1969-10-24 1973-08-28 Syntex Corp 1-(2-amino-2-deoxy-{62 -d-ribofuranosyl) pyrimidines and derivatives thereof
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DE2627076A1 (de) * 1976-06-16 1977-12-29 Max Planck Gesellschaft Mittel zur inhibierung des zellwachstums
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
US4093715A (en) * 1977-04-28 1978-06-06 Research Corporation 5-Iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable salts thereof
US4128639A (en) * 1977-12-14 1978-12-05 Research Corporation Nitrosourea analogs of thymidine
US4210638A (en) * 1978-03-17 1980-07-01 Pcr, Inc. Antiviral composition and method of treating virus diseases
US4230698A (en) * 1978-05-12 1980-10-28 Research Corporation 2-Substituted arabinofuranosyl nucleosides and nucleotides
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4604382A (en) * 1983-01-17 1986-08-05 Research Corporation 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
US4540566A (en) * 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
DD224490A1 (de) * 1984-04-30 1985-07-10 Adw Ddr Verfahren zur herstellung eines virostatischen mittels
GB8603450D0 (en) 1986-02-12 1986-03-19 Wellcome Found Antiviral compounds
GB8506868D0 (en) 1985-03-16 1985-04-17 Wellcome Found Antibacterial compound
GB8523881D0 (en) 1985-09-27 1985-10-30 Wellcome Found Antiviral compounds
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
GB8511775D0 (en) 1985-05-09 1985-06-19 Wellcome Found Antibacterial compounds
EP0291633B1 (en) * 1985-03-16 1992-11-04 The Wellcome Foundation Limited Use of 3'-azido-3'-deoxythymidine in the treatment or prophylaxis of human retroviral infections
GB8511774D0 (en) 1985-05-09 1985-06-19 Wellcome Found Antiviral compounds
GB8506869D0 (en) 1985-03-16 1985-04-17 Wellcome Found Antiviral compound
IE73219B1 (en) * 1985-03-16 1997-05-07 Wellcome Found Therapeutic nucleosides
DD251984A5 (de) * 1985-09-17 1987-12-02 The Wellcome Foundation Limited,Gb Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon
GB8615322D0 (en) 1986-06-23 1986-07-30 Wellcome Found Antiviral combinations
GB8608272D0 (en) 1986-04-04 1986-05-08 Wellcome Found Antiviral combination
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
GB8603447D0 (en) 1986-02-12 1986-03-19 Wellcome Found Therapeutic compounds
GB8523878D0 (en) 1985-09-27 1985-10-30 Wellcome Found Therapeutic compounds
GB8603719D0 (en) 1986-02-14 1986-03-19 Wellcome Found Antiviral compounds
US4649161A (en) * 1986-06-16 1987-03-10 Massachusetts Institute Of Technology Method for treating depression with d-fenfluramine
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses

Also Published As

Publication number Publication date
WO1988005657A1 (en) 1988-08-11
MX167702B (es) 1993-04-06
EP0301064A1 (en) 1989-02-01
US4916122A (en) 1990-04-10
ATE110271T1 (de) 1994-09-15
IL85078A0 (en) 1988-06-30
EP0301064B1 (en) 1994-08-24
JPH0649652B2 (ja) 1994-06-29
AU606391B2 (en) 1991-02-07
JPH01502027A (ja) 1989-07-13
PT86648B (pt) 1991-02-08
AU1242688A (en) 1988-08-24
CA1313498C (en) 1993-02-09
AR240251A1 (es) 1990-03-30
PT86648A (pt) 1988-02-01
DE3851187D1 (de) 1994-09-29
ES2009168A6 (es) 1989-09-01

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