US5648254A
(en)
*
|
1988-01-15 |
1997-07-15 |
Zymogenetics, Inc. |
Co-expression in eukaryotic cells
|
JPH04503154A
(ja)
*
|
1988-11-07 |
1992-06-11 |
ルニベルシー・ド・ルタ・ア・リージュ |
変型ヒト成長ホルモン
|
US5126249A
(en)
*
|
1989-05-09 |
1992-06-30 |
Eli Lilly And Company |
Enzymatic removal of a protein amino-terminal sequence
|
US5756458A
(en)
*
|
1989-06-16 |
1998-05-26 |
Pharmacia & Upjohn Company |
Stabilized potent GRF analogs
|
CA2040649A1
(en)
|
1990-04-24 |
1991-10-25 |
Gerald S. Brooke |
Growth hormone releasing factor analogs
|
FR2669931B1
(fr)
*
|
1990-11-29 |
1995-03-31 |
Transgene |
Nouveaux variants derives des interferons-alpha et leur procede de production.
|
AU656353B2
(en)
*
|
1990-11-29 |
1995-02-02 |
Institut National De La Recherche Agronomique (Inra) |
New variants derived from interferons of type I, production process thereof and their applications
|
US6428771B1
(en)
|
1995-05-15 |
2002-08-06 |
Pharmaceutical Discovery Corporation |
Method for drug delivery to the pulmonary system
|
WO2001000654A2
(en)
|
1999-06-29 |
2001-01-04 |
Pharmaceutical Discovery Corporation |
Purification and stabilization of peptide and proteins in pharmaceutical agents
|
US9006175B2
(en)
|
1999-06-29 |
2015-04-14 |
Mannkind Corporation |
Potentiation of glucose elimination
|
EP1311269B1
(en)
|
2000-08-04 |
2012-02-29 |
DMI Biosciences, Inc. |
Method of using diketopiperazines and composition containing them
|
DE60318938T2
(de)
|
2002-03-20 |
2009-01-22 |
Mannkind Corp., Valencia |
Inhalationsgerät
|
ES2572975T3
(es)
|
2003-05-15 |
2016-06-03 |
Ampio Pharmaceuticals, Inc. |
Tratamiento de enfermedades mediadas por los linfocitos T
|
US20080090753A1
(en)
|
2004-03-12 |
2008-04-17 |
Biodel, Inc. |
Rapid Acting Injectable Insulin Compositions
|
DK1786784T3
(da)
|
2004-08-20 |
2011-02-14 |
Mannkind Corp |
Katalyse af diketopiperazinsyntese
|
JP4990142B2
(ja)
|
2004-08-23 |
2012-08-01 |
マンカインド コーポレイション |
薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
|
HUE028691T2
(en)
|
2005-09-14 |
2016-12-28 |
Mannkind Corp |
A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
|
US7713929B2
(en)
|
2006-04-12 |
2010-05-11 |
Biodel Inc. |
Rapid acting and long acting insulin combination formulations
|
US8084420B2
(en)
|
2005-09-29 |
2011-12-27 |
Biodel Inc. |
Rapid acting and long acting insulin combination formulations
|
ES2572952T3
(es)
|
2005-11-07 |
2016-06-03 |
Indiana University Research And Technology Corporation |
Análogos de glucagón que muestran solubilidad y estabilidad fisiológicas
|
AU2007216966C1
(en)
|
2006-02-22 |
2014-03-20 |
Mannkind Corporation |
A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
|
AU2007238114B2
(en)
|
2006-04-12 |
2010-10-14 |
Biodel, Inc. |
Rapid acting and long acting insulin combination formulations
|
ES2628063T3
(es)
|
2007-01-05 |
2017-08-01 |
Indiana University Research And Technology Corporation |
Análogos de glucagón que muestran una mayor solubilidad en tampones de pH fisiológicos
|
KR20090119876A
(ko)
|
2007-02-15 |
2009-11-20 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
글루카곤/glp-1 수용체 공동-항진물질
|
EP2167535A2
(en)
*
|
2007-07-09 |
2010-03-31 |
Imperial Innovations Limited |
Human pancreatic polypeptide (hpp) analogues and their effects on feeding behaviour
|
ES2558155T3
(es)
|
2007-10-30 |
2016-02-02 |
Indiana University Research And Technology Corporation |
Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1
|
WO2009058662A2
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
JP2011511778A
(ja)
|
2008-01-30 |
2011-04-14 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション |
エステルに基づいたペプチドプロドラッグ
|
EP2300011A4
(en)
|
2008-05-27 |
2012-06-20 |
Dmi Life Sciences Inc |
METHODS AND THERAPEUTIC COMPOUNDS
|
US8485180B2
(en)
|
2008-06-13 |
2013-07-16 |
Mannkind Corporation |
Dry powder drug delivery system
|
ES2655921T3
(es)
|
2008-06-13 |
2018-02-22 |
Mannkind Corporation |
Un inhalador de polvo seco y sistema para administración de fármacos
|
CN103641907A
(zh)
|
2008-06-17 |
2014-03-19 |
印第安纳大学研究及科技有限公司 |
胰高血糖素/glp-1受体共激动剂
|
KR20110040760A
(ko)
|
2008-06-17 |
2011-04-20 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
대사 질환 및 비만 치료용 gip-기초된 혼합형 항진제
|
CN104447980A
(zh)
|
2008-06-17 |
2015-03-25 |
印第安纳大学研究及科技有限公司 |
在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物
|
ES2904623T3
(es)
|
2008-06-20 |
2022-04-05 |
Mannkind Corp |
Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
|
TWI532497B
(zh)
|
2008-08-11 |
2016-05-11 |
曼凱公司 |
超快起作用胰島素之用途
|
EP2376521B1
(en)
|
2008-12-19 |
2016-04-13 |
Indiana University Research and Technology Corporation |
Amide-based insulin prodrugs
|
EP2376097A4
(en)
|
2008-12-19 |
2012-10-03 |
Univ Indiana Res & Tech Corp |
AMID-BASED PEPTIDE PRODRUGS OF THE GLUCAGON SUPERFAMILY
|
EP2376520B1
(en)
|
2008-12-19 |
2014-02-12 |
Indiana University Research&Technology Corporation |
Insulin analogs
|
US8314106B2
(en)
|
2008-12-29 |
2012-11-20 |
Mannkind Corporation |
Substituted diketopiperazine analogs for use as drug delivery agents
|
US9060927B2
(en)
|
2009-03-03 |
2015-06-23 |
Biodel Inc. |
Insulin formulations for rapid uptake
|
EP2405963B1
(en)
|
2009-03-11 |
2013-11-06 |
MannKind Corporation |
Apparatus, system and method for measuring resistance of an inhaler
|
WO2010144789A2
(en)
|
2009-06-12 |
2010-12-16 |
Mannkind Corporation |
Diketopiperazine microparticles with defined specific surface areas
|
CN102458371B
(zh)
|
2009-06-12 |
2015-08-05 |
曼金德公司 |
具有确定异构体含量的二酮哌嗪微粒
|
MX2011013625A
(es)
|
2009-06-16 |
2012-01-20 |
Univ Indiana Res & Tech Corp |
Compuestos glucagon activo de receptor de gip.
|
WO2011056889A1
(en)
|
2009-11-03 |
2011-05-12 |
Mannkind Corporation |
An apparatus and method for simulating inhalation efforts
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
BR112012018585A2
(pt)
|
2010-01-27 |
2017-01-10 |
Univ Indiana Res & Tech Corp |
conjungados e composições de glucagon antagonista-gip agonista para o tratamento de distúrbios metabólicos e de obesidade
|
CA2797095A1
(en)
|
2010-05-13 |
2011-11-17 |
Indiana University Research And Technology Corporation |
Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
|
BR112012028707A2
(pt)
|
2010-05-13 |
2019-09-24 |
Univ Indiana Res & Tech Corp |
composto de glucagon da superfamília de peptídeos exibindo atividade do receptor g com proteína acoplada, pró farmaco, dímero ou multímro, composição farmacêutica que o compreendem e método de administração do mesmo.
|
WO2011159895A2
(en)
|
2010-06-16 |
2011-12-22 |
Indiana University Research And Technology Corporation |
Single chain insulin agonists exhibiting high activity at the insulin receptor
|
KR20130117755A
(ko)
|
2010-06-21 |
2013-10-28 |
맨카인드 코포레이션 |
건조 분말 약물 운반 시스템 및 방법
|
JP2013540102A
(ja)
|
2010-06-24 |
2013-10-31 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション |
アミド結合を介して修飾されたグルカゴンスーパーファミリーのペプチドプロドラッグ
|
CA2803164C
(en)
|
2010-06-24 |
2018-08-21 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|
US8507496B2
(en)
|
2010-09-07 |
2013-08-13 |
Dmi Acquisition Corp. |
Treatment of diseases
|
JP6086067B2
(ja)
|
2010-12-22 |
2017-03-01 |
インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション |
Gipレセプター活性を示すグルカゴンアナローグ
|
CN105667994B
(zh)
|
2011-04-01 |
2018-04-06 |
曼金德公司 |
用于药物药盒的泡罩包装
|
WO2012174472A1
(en)
|
2011-06-17 |
2012-12-20 |
Mannkind Corporation |
High capacity diketopiperazine microparticles
|
AU2012273365A1
(en)
|
2011-06-22 |
2014-01-16 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
PT2723367T
(pt)
|
2011-06-22 |
2017-08-11 |
Univ Indiana Res & Tech Corp |
Co-agonistas do recetor da glucagina/glp-1
|
US9925300B2
(en)
|
2011-10-10 |
2018-03-27 |
Ampio Pharmaceuticals, Inc. |
Implantable medical devices with increased immune tolerance, and methods for making and implanting
|
EP3721884A1
(en)
|
2011-10-10 |
2020-10-14 |
Ampio Pharmaceuticals, Inc. |
Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine)
|
WO2013063160A1
(en)
|
2011-10-24 |
2013-05-02 |
Mannkind Corporation |
Methods and compositions for treating pain
|
WO2013063413A1
(en)
|
2011-10-28 |
2013-05-02 |
Ampio Pharmaceuticals, Inc. |
Treatment of rhinitis
|
RU2014117678A
(ru)
|
2011-11-17 |
2015-12-27 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептиды глюкагонового суперсемейства, обладающие глюкокортикоидной рецепторной активностью
|
CN104114183A
(zh)
|
2011-12-20 |
2014-10-22 |
印第安纳大学研究及科技有限公司 |
用于治疗糖尿病的基于ctp的胰岛素类似物
|
CN104583232B
(zh)
|
2012-06-21 |
2018-04-13 |
印第安纳大学研究及科技有限公司 |
展现gip受体活性的胰高血糖素类似物
|
CN108057154B
(zh)
|
2012-07-12 |
2021-04-16 |
曼金德公司 |
干粉药物输送系统和方法
|
JP6387008B2
(ja)
|
2012-09-26 |
2018-09-05 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリンアナローグダイマー
|
US10159644B2
(en)
|
2012-10-26 |
2018-12-25 |
Mannkind Corporation |
Inhalable vaccine compositions and methods
|
RU2678134C2
(ru)
|
2013-03-14 |
2019-01-23 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Конъюгаты инсулин-инкретин
|
CA2906864A1
(en)
|
2013-03-15 |
2014-09-18 |
Ampio Pharmaceuticals, Inc. |
Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
|
JP6523247B2
(ja)
|
2013-03-15 |
2019-05-29 |
マンカインド コーポレイション |
微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
|
EP3021834A1
(en)
|
2013-07-18 |
2016-05-25 |
MannKind Corporation |
Heat-stable dry powder pharmaceutical compositions and methods
|
EP3030294B1
(en)
|
2013-08-05 |
2020-10-07 |
MannKind Corporation |
Insufflation apparatus
|
US10307464B2
(en)
|
2014-03-28 |
2019-06-04 |
Mannkind Corporation |
Use of ultrarapid acting insulin
|
JP6723222B2
(ja)
|
2014-08-18 |
2020-07-15 |
アンピオ ファーマシューティカルズ,インコーポレイテッド |
関節病態の治療
|
ES2822994T3
(es)
|
2014-09-24 |
2021-05-05 |
Univ Indiana Res & Tech Corp |
Conjugados de incretina-insulina
|
WO2016049174A1
(en)
|
2014-09-24 |
2016-03-31 |
Indiana University Research And Technology Corporation |
Lipidated amide-based insulin prodrugs
|
US10561806B2
(en)
|
2014-10-02 |
2020-02-18 |
Mannkind Corporation |
Mouthpiece cover for an inhaler
|
WO2016209969A1
(en)
|
2015-06-22 |
2016-12-29 |
Ampio Pharmaceuticals, Inc. |
Use of low molecular weight fractions of human serum albumin in treating diseases
|
CN106855477A
(zh)
*
|
2015-12-09 |
2017-06-16 |
中国科学院大连化学物理研究所 |
基于埃德曼降解的蛋白质c-末端肽富集方法
|