PT82077B - Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides - Google Patents

Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides

Info

Publication number
PT82077B
PT82077B PT82077A PT8207786A PT82077B PT 82077 B PT82077 B PT 82077B PT 82077 A PT82077 A PT 82077A PT 8207786 A PT8207786 A PT 8207786A PT 82077 B PT82077 B PT 82077B
Authority
PT
Portugal
Prior art keywords
renin
acidic proteases
aminoalcohol derivatives
obtaining peptide
derivatives inhibitors
Prior art date
Application number
PT82077A
Other languages
English (en)
French (fr)
Portuguese (pt)
Other versions
PT82077A (fr
Inventor
Jean Wagnon
Remy Guegan
Colette Lacour
Dino Nisato
Original Assignee
Sanofi Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8502763A external-priority patent/FR2577931B1/fr
Priority claimed from FR8511728A external-priority patent/FR2585708B1/fr
Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa
Publication of PT82077A publication Critical patent/PT82077A/pt
Publication of PT82077B publication Critical patent/PT82077B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT82077A 1985-02-26 1986-02-24 Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides PT82077B (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8502763A FR2577931B1 (fr) 1985-02-26 1985-02-26 Derives aminodiols peptidiques inhibiteurs de la renine et des proteases acides, leur procede de preparation et leur application en therapeutique
FR8511728A FR2585708B1 (fr) 1985-07-31 1985-07-31 Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
PT82077A PT82077A (fr) 1986-03-01
PT82077B true PT82077B (fr) 1987-09-25

Family

ID=26224394

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82077A PT82077B (fr) 1985-02-26 1986-02-24 Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides

Country Status (9)

Country Link
EP (1) EP0214209A1 (ko)
KR (1) KR860006487A (ko)
AU (1) AU587426B2 (ko)
DK (1) DK89286A (ko)
ES (1) ES8900018A1 (ko)
GR (1) GR860532B (ko)
NZ (1) NZ215282A (ko)
PT (1) PT82077B (ko)
WO (1) WO1986004901A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
IL83663A0 (en) * 1986-10-27 1988-01-31 Robins Co Inc A H Preparation of 3-pyrrolidinols
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions
DE3721855A1 (de) * 1987-03-12 1988-09-22 Merck Patent Gmbh Aminosaeurederivate
DE4136443A1 (de) * 1991-11-06 1993-05-13 Boehringer Ingelheim Int Expression der reifen proteinase 2a, ihre partielle reinigung und bereitstellung kompetitiv wirkender substrate
EP1346983A3 (en) * 1998-02-20 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Phthalimido arylpiperazines as alpha 1A receptor antagonists useful in the treatment of benign prostatic hyperplasia
TW536538B (en) 1998-02-20 2003-06-11 Ortho Mcneil Pharm Inc Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
ZA991319B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia.
US9624264B2 (en) 2012-07-24 2017-04-18 Merck Patent Gmbh Hydroxystatin derivatives for the treatment of arthrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate

Also Published As

Publication number Publication date
PT82077A (fr) 1986-03-01
KR860006487A (ko) 1986-09-11
GR860532B (en) 1986-06-24
EP0214209A1 (fr) 1987-03-18
AU587426B2 (en) 1989-08-17
ES552407A0 (es) 1988-11-16
DK89286A (da) 1986-08-27
DK89286D0 (da) 1986-02-26
ES8900018A1 (es) 1988-11-16
NZ215282A (en) 1989-08-29
WO1986004901A1 (fr) 1986-08-28
AU5410086A (en) 1986-09-04

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