PT81652B - Processo para a preparacao de derivados 1-substituidos do acido 6-fluoro-7-(pirrolil-1)-1,4-dihidro-4-oxoquinoleino-3-carboxilico e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados 1-substituidos do acido 6-fluoro-7-(pirrolil-1)-1,4-dihidro-4-oxoquinoleino-3-carboxilico e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT81652B PT81652B PT81652A PT8165285A PT81652B PT 81652 B PT81652 B PT 81652B PT 81652 A PT81652 A PT 81652A PT 8165285 A PT8165285 A PT 8165285A PT 81652 B PT81652 B PT 81652B
- Authority
- PT
- Portugal
- Prior art keywords
- radical
- dihydro
- fluoro
- carboxylic acid
- substituted derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 2-hydroxyethyl radical Chemical class 0.000 abstract 3
- ZISJTKAJAHGVNL-UHFFFAOYSA-N 6-fluoro-4-oxo-7-pyrrol-1-yl-1h-quinoline-3-carboxylic acid Chemical class FC=1C=C2C(=O)C(C(=O)O)=CNC2=CC=1N1C=CC=C1 ZISJTKAJAHGVNL-UHFFFAOYSA-N 0.000 abstract 2
- YKPQUSLRUFLVDA-UHFFFAOYSA-N $l^{2}-azanylmethane Chemical compound [NH]C YKPQUSLRUFLVDA-UHFFFAOYSA-N 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical compound [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- VHPYNVZYZFYVII-UHFFFAOYSA-N fluoroethane Chemical compound [CH2]CF VHPYNVZYZFYVII-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- RMCDUNHIVVEEDD-UHFFFAOYSA-N methylcyclopropane Chemical compound [CH2]C1CC1 RMCDUNHIVVEEDD-UHFFFAOYSA-N 0.000 abstract 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical compound C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8419001A FR2574404B1 (fr) | 1984-12-12 | 1984-12-12 | Derives 1-substitues de l'acide 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoleine-3-carboxylique, leur preparation et leur application en tant que medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT81652A PT81652A (fr) | 1986-01-01 |
| PT81652B true PT81652B (pt) | 1988-04-21 |
Family
ID=9310528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT81652A PT81652B (pt) | 1984-12-12 | 1985-12-11 | Processo para a preparacao de derivados 1-substituidos do acido 6-fluoro-7-(pirrolil-1)-1,4-dihidro-4-oxoquinoleino-3-carboxilico e de composicoes farmaceuticas que os contem |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4727080A (en, 2012) |
| EP (1) | EP0187085B1 (en, 2012) |
| JP (1) | JPS61197577A (en, 2012) |
| AT (1) | ATE56446T1 (en, 2012) |
| CS (1) | CS258136B2 (en, 2012) |
| DD (1) | DD242042A5 (en, 2012) |
| DE (1) | DE3579683D1 (en, 2012) |
| ES (1) | ES8704930A1 (en, 2012) |
| FR (1) | FR2574404B1 (en, 2012) |
| HU (1) | HU195802B (en, 2012) |
| PL (1) | PL146541B1 (en, 2012) |
| PT (1) | PT81652B (en, 2012) |
| RO (1) | RO93482B (en, 2012) |
| SU (1) | SU1426453A3 (en, 2012) |
| YU (1) | YU43691B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3519286A1 (de) * | 1985-05-30 | 1986-12-04 | Bayer Ag, 5090 Leverkusen | 7-azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3- chinolincarbonsaeuren und -1,8-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3606698A1 (de) * | 1986-03-01 | 1987-09-03 | Bayer Ag | 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate |
| US5153204A (en) * | 1986-03-01 | 1992-10-06 | Bayer Aktiengesellschaft | 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives |
| DE3639465A1 (de) * | 1986-11-18 | 1988-05-19 | Hoechst Ag | Optisch aktive gyrasehemmer, ihre herstellung und verwendung als antibiotika |
| FR2629456B1 (fr) * | 1988-03-31 | 1991-07-05 | Esteve Labor Dr | Derives des acides 7-(1-imidazolyl),1,4-dihydro-4-oxo-6,8-difluoro-1-cyclopropyl-3-quinoleincarboxylique, leur preparation et leur application en tant que medicaments |
| US5103040A (en) * | 1988-06-21 | 1992-04-07 | Pfizer Inc. | 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor |
| US5039682A (en) * | 1988-06-21 | 1991-08-13 | Pfizer Inc. | 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor |
| US5104868A (en) * | 1988-06-21 | 1992-04-14 | Pfizer Inc. | Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters |
| US5233091A (en) * | 1988-06-21 | 1993-08-03 | Pfizer Inc. | 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor |
| EP0486687A4 (en) * | 1989-07-21 | 1992-06-17 | Iolab Corporation | Quinolonecarboxylic acid derivatives |
| US20070275994A1 (en) * | 2003-06-06 | 2007-11-29 | Lohray Braj B | Novel Antinfective Compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1175836A (en) * | 1977-09-20 | 1984-10-09 | Marcel Pesson | Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives |
| DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| SE440354B (sv) * | 1981-02-19 | 1985-07-29 | Kyorin Seiyaku Kk | Kinolinkarboxylsyraderivat |
| US4499091A (en) * | 1982-03-31 | 1985-02-12 | Sterling Drug Inc. | 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents |
| DE3248507A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel auf chinoloncarbonsaeure basis |
| FR2559484B2 (fr) * | 1983-07-06 | 1986-09-26 | Provesan Sa | Nouveau derive 7-(pyrrol-1-yl) de l'acide 1-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridin)-3-carboxylique, sa preparation et son application en tant que medicament |
| IT1221492B (it) * | 1984-03-13 | 1990-07-06 | Biochem Design Srl | Acidi 7-(1-pirril)-e 7-(1-pirroli-dinil)-6-fluoro-1-etil-1,4-diidro-4-chetochinolin-3-carbossilici ad attivita' antimicrobiche,loro procedimento di preparazione e composti farmaceutici che li contengono |
| US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
| US4636506A (en) * | 1984-12-06 | 1987-01-13 | Pfizer, Inc. | 7-heterocyclic-1,4-dihydroquinolones |
-
1984
- 1984-12-12 FR FR8419001A patent/FR2574404B1/fr not_active Expired
-
1985
- 1985-12-09 US US06/806,695 patent/US4727080A/en not_active Expired - Fee Related
- 1985-12-10 RO RO121090A patent/RO93482B/ro unknown
- 1985-12-10 AT AT85402450T patent/ATE56446T1/de not_active IP Right Cessation
- 1985-12-10 EP EP85402450A patent/EP0187085B1/fr not_active Expired - Lifetime
- 1985-12-10 DE DE8585402450T patent/DE3579683D1/de not_active Expired - Fee Related
- 1985-12-11 SU SU853991041A patent/SU1426453A3/ru active
- 1985-12-11 JP JP60277054A patent/JPS61197577A/ja active Granted
- 1985-12-11 YU YU1923/85A patent/YU43691B/xx unknown
- 1985-12-11 PT PT81652A patent/PT81652B/pt unknown
- 1985-12-11 DD DD85284140A patent/DD242042A5/de not_active IP Right Cessation
- 1985-12-12 CS CS859213A patent/CS258136B2/cs unknown
- 1985-12-12 PL PL1985256757A patent/PL146541B1/pl unknown
- 1985-12-12 HU HU854757A patent/HU195802B/hu not_active IP Right Cessation
- 1985-12-12 ES ES550689A patent/ES8704930A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0187085A1 (fr) | 1986-07-09 |
| ES8704930A1 (es) | 1987-05-01 |
| SU1426453A3 (ru) | 1988-09-23 |
| HUT40640A (en) | 1987-01-28 |
| PL146541B1 (en) | 1989-02-28 |
| CS921385A2 (en) | 1987-12-17 |
| RO93482B (ro) | 1988-01-02 |
| RO93482A (ro) | 1987-12-31 |
| CS258136B2 (en) | 1988-07-15 |
| ES550689A0 (es) | 1987-05-01 |
| YU192385A (en) | 1988-04-30 |
| ATE56446T1 (de) | 1990-09-15 |
| HU195802B (en) | 1988-07-28 |
| PT81652A (fr) | 1986-01-01 |
| PL256757A1 (en) | 1986-10-07 |
| YU43691B (en) | 1989-10-31 |
| EP0187085B1 (fr) | 1990-09-12 |
| JPH0312064B2 (en, 2012) | 1991-02-19 |
| DE3579683D1 (de) | 1990-10-18 |
| FR2574404B1 (fr) | 1987-04-24 |
| JPS61197577A (ja) | 1986-09-01 |
| FR2574404A1 (fr) | 1986-06-13 |
| DD242042A5 (de) | 1987-01-14 |
| US4727080A (en) | 1988-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR8805182A (pt) | Azois e azinas substituidos heterociclicamente,processo para a sua preparacao,composicao herbicida,aplicacao e processo para a preparacao de composicoes | |
| ES2076935T3 (es) | Compuesto de pirazolopiridina y procedimientos para su preparacion. | |
| PT91766A (pt) | Processo para a preparacao de derivados do acido 3,5-dihidroxihept-6-ina-carboxilico substituidos na posicao, de seus compostos intermedios e de composicoes farmaceuticas que os contem | |
| BR9002200A (pt) | Utilizacao de derivados substituidos de amidas de aminoacidos,derivados substituidos,processo para sua preparacao,composicoes pesticidas,processo para o combate a parasitas e para a preparacao de composicoes | |
| MX9206541A (es) | Derivados de acido acetico, procedimiento para su preparacion y composicion farmaceutica que los contiene. | |
| PT99545A (pt) | Processo de preparacao de compostos inibidores da protease retroviral dos seus intermediarios e de composicoes farmaceuticas que os contem | |
| ATE61050T1 (de) | Pyridazinamine wirksam gegen viren. | |
| MX9205208A (es) | Compuestos derivados del acido 5-amino-4-hidroxihexanoico, procedimiento para su preparacion y compociciones farmaceuticas que los contienen | |
| IT8268024A0 (it) | Per la loro preparazione e composi carbapenem derivati procedimento zioni farmaceutiche contenenti tali derivati come agenti antibatterici | |
| PT81652B (pt) | Processo para a preparacao de derivados 1-substituidos do acido 6-fluoro-7-(pirrolil-1)-1,4-dihidro-4-oxoquinoleino-3-carboxilico e de composicoes farmaceuticas que os contem | |
| PE20030738A1 (es) | Sales de acido succinico de 5,7,14-triazatetraciclo[10.3.1.02,11.04,9] -hexadeca-2(11),3,5,7,9-pentaeno y composiciones farmaceuticas de las mismas | |
| MX9207383A (es) | Derivados de 2-imidazolin-5-onas y 2-imidazolin-5-tionas, procedimiento para su preparacion y composiciones fungicidas que los contienen. | |
| PT92146A (pt) | Processo para a preparacao do inibidor de glicosidade salbostatina e de composicoes farmaceuticas que a contem | |
| PT83909B (pt) | Processo para a preparacao de 5-amino e 5-hidroxi-6,8-difluoroquinolonas e de composicoes farmaceuticas antibacterianas que as contem | |
| IT1139974B (it) | Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo | |
| PT93160A (pt) | Processo para a preparacao de benzenossulfonamidas e de composicoes farmaceuticas que as contem | |
| AR240930A1 (es) | "derivados de p-clorofenil-2-furanil-metilen-triazol, intermediarios para su preparacion, procedimientos para la preparacion de dichos compuestos e intermediarios y composiciones fungicidas que contienen a dichos compuestos." | |
| PT82512B (pt) | Processo para a preparacao de derivados de quinolilglicinamidas com actividade psicotropica e de composicoes farmaceuticas que os contem | |
| ES2007759A6 (es) | Una composicion fungicida y procedimiento para su preparacion. | |
| MX9200121A (es) | Derivados substituidos de amidas de aminoacidos, procedimiento para su preparacion y composiciones fungicidas que los contienen | |
| ES2082882T3 (es) | Procedimiento para la fabricacion de derivados de acidos-3-amino-2-(het)aroil-acrilicos. | |
| PT91362A (pt) | Processo para a preparacao de novos acidos 6-fluor-3,5-di-hidroxi-carboxilicos e seus derivados, e de composicoes farmaceuticas que os contem e de produtos intermediarios | |
| PT87986A (pt) | Processo para a preparacao de derivados de tieno-imidazol substituido e de composicoes farmaceuticas que os contem, apropriadas como agentes inibidores da secrecao do acido do estomago, para a proteccao do estomago, assim como para o tratamento de inflamacoes intestinais | |
| PT87927A (pt) | Processo para a preparacao de acidos 3,5-dihidroxi-hepta-6-enoicos substituidos por 7-{1h-pirrol-3-ilo}, das suas correspondentes delta-lactonas e sais, e de composicoes farmaceuticas que os contem | |
| ES8506009A1 (es) | Un procedimiento para la preparacion de derivados de oxacefalosporina |