ES8506009A1 - Un procedimiento para la preparacion de derivados de oxacefalosporina - Google Patents

Un procedimiento para la preparacion de derivados de oxacefalosporina

Info

Publication number
ES8506009A1
ES8506009A1 ES527804A ES527804A ES8506009A1 ES 8506009 A1 ES8506009 A1 ES 8506009A1 ES 527804 A ES527804 A ES 527804A ES 527804 A ES527804 A ES 527804A ES 8506009 A1 ES8506009 A1 ES 8506009A1
Authority
ES
Spain
Prior art keywords
hydrogen
protecting group
derivatives
preparation
combating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527804A
Other languages
English (en)
Other versions
ES527804A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES8506009A1 publication Critical patent/ES8506009A1/es
Publication of ES527804A0 publication Critical patent/ES527804A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE OXACEFALOSPORINA.CONSISTE EN NEUTRALIZAR UN DERIVADO DEL ACIDO 7BBB-UREIDOACETAMIDO-7 -METOXI3-1-(2-HIDROXIETIL)-1H-TETRAZOL-5-IL TIOMETIL-1-DESTIA-1-OXA-3-CEFEM-4-CARBOXILICO DE FORMULA (II), CON UNA BASE COMO BICARBONATO METALICO ALCALINO, A UNA TEMPERATURA H50JC Y DURANTE 1 A 10 MIN., PARA OBTENER UN COMPUESTO DE FORMULA (II). SIENDO, R, ARILO O HETEROALILO; R1 ES H O ALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO O PIRIDINILO; R2, H O UN GRUPO PROTECTOR DE HIDROXI Y R3 ES UN RESTO DE UNA BASE.SE UTILIZAN COMO ANTIBIOTICOS CONTRA LAS BACETERIAS GRAM (B) Y GRAM (C).
ES527804A 1982-12-06 1983-12-05 Un procedimiento para la preparacion de derivados de oxacefalosporina Granted ES527804A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57214112A JPS59104389A (ja) 1982-12-06 1982-12-06 オキサセファム誘導体

Publications (2)

Publication Number Publication Date
ES8506009A1 true ES8506009A1 (es) 1985-06-16
ES527804A0 ES527804A0 (es) 1985-06-16

Family

ID=16650427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527804A Granted ES527804A0 (es) 1982-12-06 1983-12-05 Un procedimiento para la preparacion de derivados de oxacefalosporina

Country Status (8)

Country Link
US (1) US4529722A (es)
EP (1) EP0111421B1 (es)
JP (1) JPS59104389A (es)
KR (1) KR840007005A (es)
CA (1) CA1209997A (es)
DE (1) DE3365480D1 (es)
ES (1) ES527804A0 (es)
GB (1) GB2131803B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE319447T1 (de) * 1999-08-16 2006-03-15 Revaax Pharmaceuticals Llc Pharmazeutische zubereitungen die clavulansäure oder derivate enthalten zur behandlund von neurologischen störungen
US6489319B2 (en) * 1999-08-16 2002-12-03 Revaax Pharmaceuticals, Llc Neurotherapeutic use of carboxypeptidase inhibitors
US6426342B2 (en) * 1999-08-16 2002-07-30 Revaax Pharmaceuticals, Llc Use of β-lactamase inhibitors as neuroprotectants
JP2004168775A (ja) * 2002-11-08 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd オキサセファロスポリンの改良合成法
KR100749163B1 (ko) 2005-11-10 2007-08-14 주식회사 엔지켐 7α-메톡시옥사세펨 유도체의 제조방법
CA2758029A1 (en) * 2009-04-29 2011-11-04 Rexahn Pharmaceuticals, Inc. Clavulanate formulation for neuroprotection and treatment of neurodegenerative disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178005C (nl) * 1972-11-06 1986-01-02 Merck & Co Inc Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
NL7314706A (es) * 1972-11-06 1974-05-08
GB1510794A (en) * 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor
US4096329A (en) * 1976-03-05 1978-06-20 E. R. Squibb & Sons, Inc. 7-Cyanoalkylureido 3 heterocylic thio methyl cephalosporins
JPS609515B2 (ja) * 1976-08-09 1985-03-11 塩野義製薬株式会社 ３′−ノルオキサセファロスポリン類
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JPS54117494A (en) * 1978-03-03 1979-09-12 Takeda Chem Ind Ltd Cephalosporin compound and its preparation
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound
DE3045331A1 (de) * 1980-12-02 1982-07-01 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3047082A1 (de) * 1980-12-13 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0111421A1 (en) 1984-06-20
DE3365480D1 (en) 1986-09-25
GB2131803A (en) 1984-06-27
EP0111421B1 (en) 1986-08-20
CA1209997A (en) 1986-08-19
JPH0354673B2 (es) 1991-08-20
ES527804A0 (es) 1985-06-16
JPS59104389A (ja) 1984-06-16
US4529722A (en) 1985-07-16
GB2131803B (en) 1986-06-04
GB8332551D0 (en) 1984-01-11
KR840007005A (ko) 1984-12-04

Similar Documents

Publication Publication Date Title
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
PT76336B (de) Cephalosporinderivate und verfahren zu ihrer herstellung
ATE37882T1 (de) Cephalosporinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
NZ218642A (en) Pyrazoline derivatives and insecticidal and acaricidal compositions
ES8506639A1 (es) Procedimiento para preparar nuevos azoles
SE8204237L (sv) Karbostyrilforeningar, kompositioner innehallande dessa samt forfaranden for framstellning derav
DE3869907D1 (de) Chinolincarbonsaeure-derivate.
PT83104B (en) Novel guanidinomethylbenzoic acid derivatives
ATE22078T1 (de) 1-ethyl-6,8-difluor-1,4-dihydro-7-(1-imidazolyl - 4-oxochinolincarbonsaeurederivate, verfahren zu ihrer herstellung und antibakterielle zusammensetzungen.
NZ236293A (en) 1-(alkyl or alkoxyalkyl)-4-phenyl piperidine-4-carboxylic acid amide derivatives; preparatory processes and pharmaceutical compositions
ES8506009A1 (es) Un procedimiento para la preparacion de derivados de oxacefalosporina
DE69330601D1 (de) Serotoninergische ergolin derivate
ES2001852A6 (es) Procedimiento para preparar un derivado de acido quinolocarboxilico
DE69132578D1 (de) Cephemderivate
ES8300096A1 (es) "un procedimiento para preparar derivados de halofenil-piridil-alilamina".
ATE10844T1 (de) Chinolincarbonsaeurederivat, verfahren zu seiner herstellung und es enthaltende bakterizide mittel.
ES8201979A1 (es) Procedimiento para la obtencion de derivados de bifeni- lil-azoliletano
ES8307778A1 (es) Procedimiento para preparar difenilbutil-1-piperazinocarboxilatos.
ES2001031A6 (es) Un procedimiento para la preparacion de penicilinas que contienen un grupo oximino
EP0252875A3 (en) Microbicidal agent
JPS5770889A (en) 1-ethyl-1,8-naphthyridine derivative and salt thereof
ATE21908T1 (de) Derivate von 1,4-diaminocyclitol, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES2019579B3 (es) Eteres de triazolilglicol, fungicidas y biorreguladores.
ES8504816A1 (es) Un procedimiento de preparacion de un derivado de cefalosporina
DE3460079D1 (en) Substituted thioamides of hydroxy-malonic acids, process for their preparation and their use as pesticides