PT79818A - Process for the preparation of alpha-acetylamin-ergolines - Google Patents

Process for the preparation of alpha-acetylamin-ergolines

Info

Publication number
PT79818A
PT79818A PT79818A PT7981885A PT79818A PT 79818 A PT79818 A PT 79818A PT 79818 A PT79818 A PT 79818A PT 7981885 A PT7981885 A PT 7981885A PT 79818 A PT79818 A PT 79818A
Authority
PT
Portugal
Prior art keywords
acetylamin
ergolines
alpha
preparation
Prior art date
Application number
PT79818A
Other languages
English (en)
Other versions
PT79818B (en
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT79818A publication Critical patent/PT79818A/pt
Publication of PT79818B publication Critical patent/PT79818B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT79818A 1984-01-12 1985-01-10 Process for the preparation of alpha-acetylamin-ergolines PT79818B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12

Publications (2)

Publication Number Publication Date
PT79818A true PT79818A (en) 1985-02-01
PT79818B PT79818B (en) 1987-01-07

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
PT79818A PT79818B (en) 1984-01-12 1985-01-10 Process for the preparation of alpha-acetylamin-ergolines

Country Status (28)

Country Link
US (2) US4950672A (pt)
JP (1) JPH0655739B2 (pt)
AT (1) AT391317B (pt)
AU (3) AU583489B2 (pt)
BE (1) BE901456A (pt)
CA (1) CA1245640A (pt)
CH (1) CH664568A5 (pt)
CY (1) CY1542A (pt)
DE (1) DE3500251C2 (pt)
DK (1) DK169891B1 (pt)
ES (1) ES8605514A1 (pt)
FI (1) FI82466C (pt)
FR (1) FR2560196B1 (pt)
GB (1) GB2152507B (pt)
GR (1) GR850065B (pt)
HK (1) HK48590A (pt)
HU (1) HU197569B (pt)
IE (1) IE58228B1 (pt)
IL (1) IL74043A (pt)
IT (1) IT1214648B (pt)
LU (1) LU85725A1 (pt)
NL (1) NL193541C (pt)
NZ (1) NZ210818A (pt)
PH (1) PH23286A (pt)
PT (1) PT79818B (pt)
SE (1) SE460420B (pt)
SG (1) SG32390G (pt)
ZA (1) ZA85276B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
ATE107647T1 (de) * 1984-04-09 1994-07-15 Schering Ag 2-substituierte ergolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
NL8700046A (nl) * 1986-01-24 1987-08-17 Sandoz Ag 8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
CA2974113A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
HU195810B (en) * 1984-12-24 1988-07-28 Sandoz Ag Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
GB8500454D0 (en) 1985-02-13
GB2152507B (en) 1987-07-15
AU618290B2 (en) 1991-12-19
HUT37148A (en) 1985-11-28
AT391317B (de) 1990-09-25
CY1542A (en) 1991-03-22
SE460420B (sv) 1989-10-09
GR850065B (pt) 1985-05-03
AU609539B2 (en) 1991-05-02
ZA85276B (en) 1986-08-27
IL74043A0 (en) 1985-04-30
AU3760985A (en) 1985-07-18
ES8605514A1 (es) 1986-03-16
FI850130L (fi) 1985-07-13
HK48590A (en) 1990-06-29
IE850064L (en) 1985-07-12
HU197569B (en) 1989-04-28
SE8500107D0 (sv) 1985-01-10
DK12685D0 (da) 1985-01-10
FI850130A0 (fi) 1985-01-11
JPH0655739B2 (ja) 1994-07-27
DE3500251A1 (de) 1985-07-18
FI82466C (fi) 1991-03-11
SG32390G (en) 1990-08-03
PT79818B (en) 1987-01-07
IT1214648B (it) 1990-01-18
IE58228B1 (en) 1993-08-11
DK169891B1 (da) 1995-03-27
ATA5985A (de) 1990-03-15
FR2560196A1 (fr) 1985-08-30
NL8500008A (nl) 1985-08-01
DK12685A (da) 1985-07-13
IT8547538A0 (it) 1985-01-11
FI82466B (fi) 1990-11-30
GB2152507A (en) 1985-08-07
AU583489B2 (en) 1989-05-04
CA1245640A (en) 1988-11-29
NL193541B (nl) 1999-09-01
PH23286A (en) 1989-06-30
FR2560196B1 (fr) 1986-07-18
ES539511A0 (es) 1986-03-16
US5077298A (en) 1991-12-31
DE3500251C2 (de) 1995-01-26
AU2506788A (en) 1989-03-02
JPS60174783A (ja) 1985-09-09
SE8500107L (sv) 1985-07-13
AU2506688A (en) 1989-02-23
IL74043A (en) 1988-10-31
US4950672A (en) 1990-08-21
CH664568A5 (de) 1988-03-15
LU85725A1 (fr) 1985-10-22
NZ210818A (en) 1989-02-24
NL193541C (nl) 2000-01-04
BE901456A (fr) 1985-07-08

Similar Documents

Publication Publication Date Title
HU900750D0 (en) Process for preparation of phenyl-hydrazine-derivatives
EP0165537A3 (en) Process for the preparation of heteroaryloxyacetamides
PT80178A (en) Process for the preparation of substituted alpha-amino-acids
PT79818A (en) Process for the preparation of alpha-acetylamin-ergolines
HRP921043B1 (en) Process for the preparation of hydroxy-4-2h-1-benzothiopyrane-2-ones
PT80919A (en) Process for the preparation of 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1h-indoles
PT81526A (en) Process for the preparation of new homopropargylamines
EP0194144A3 (en) Process for the preparation of 2-alkyl-cyclopent-2-enones
DE3562761D1 (en) Process for the preparation of linear polychlorophosphazenes
GB2158824B (en) Process for the preparation of 2-amino-s-triazines
DE3570653D1 (en) Process for the preparation of beta-aminoethylketones
DE3566249D1 (en) Process for the preparation of fluoroformiates
DE3476069D1 (en) Improved process for the preparation of polyhydroxybutadienes
PT80634A (en) Process for the preparation of naftoxazines
DE3560035D1 (en) Process for the preparation of 2-methyl-2-alkenals
EP0173202A3 (en) Process for the preparation of chloro-o-nitroanilines
DE3660590D1 (en) Process for the preparation of 2-alkyl-cyclopentanones
DE3660623D1 (en) Process for the preparation of 2-methyl-2-alkenals
EP0175364A3 (en) Process for the preparation of alpha-beta-diaminoacrylnitriles
EP0190994A3 (en) Process for the preparation of 1-amino-2-bromo-4-hydroxyanthraquinone
EP0166214A3 (en) Process for the preparation of dialkylsuccinylsuccinat
ZA857285B (en) Process for the preparation of lime-nitrogen
EP0190101A3 (en) Process for the preparation of n-alkyl-anilines
EP0191385A3 (en) Process for the preparation of thiocyanatomethylthiobenzothiazoles
DE3563045D1 (en) Process for the preparation of pure 2-ethylamino-4-nitro-1-alkoxy-benzenes

Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 971017 NOVARTIS AG CH

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000731