PT778844E - Complexos funcionais de metais de terpiridina processos para a sua preparacao e conjugados oligonucleotideos com complexos de metais de terpiridina - Google Patents

Complexos funcionais de metais de terpiridina processos para a sua preparacao e conjugados oligonucleotideos com complexos de metais de terpiridina

Info

Publication number
PT778844E
PT778844E PT95931224T PT95931224T PT778844E PT 778844 E PT778844 E PT 778844E PT 95931224 T PT95931224 T PT 95931224T PT 95931224 T PT95931224 T PT 95931224T PT 778844 E PT778844 E PT 778844E
Authority
PT
Portugal
Prior art keywords
terpyridine
complexes
preparation
pct
oligonucleotide conjugates
Prior art date
Application number
PT95931224T
Other languages
English (en)
Inventor
Robert Haner
Jonathan Hall
Dieter Husken
Uwe Pieles
Heinz Moser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT778844E publication Critical patent/PT778844E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
PT95931224T 1994-09-02 1995-08-30 Complexos funcionais de metais de terpiridina processos para a sua preparacao e conjugados oligonucleotideos com complexos de metais de terpiridina PT778844E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH269394 1994-09-02

Publications (1)

Publication Number Publication Date
PT778844E true PT778844E (pt) 2003-04-30

Family

ID=4239459

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95931224T PT778844E (pt) 1994-09-02 1995-08-30 Complexos funcionais de metais de terpiridina processos para a sua preparacao e conjugados oligonucleotideos com complexos de metais de terpiridina

Country Status (15)

Country Link
US (1) US5925744A (pt)
EP (1) EP0778844B1 (pt)
JP (1) JPH10505354A (pt)
AT (1) ATE229969T1 (pt)
AU (1) AU695749B2 (pt)
CA (1) CA2197788A1 (pt)
CY (1) CY2435B1 (pt)
DE (1) DE59510515D1 (pt)
DK (1) DK0778844T3 (pt)
ES (1) ES2191060T3 (pt)
FI (1) FI970740A0 (pt)
HU (1) HU217774B (pt)
NO (1) NO316866B1 (pt)
PT (1) PT778844E (pt)
WO (1) WO1996007668A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000435A2 (en) * 1996-07-03 1998-01-08 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US6376664B1 (en) * 1999-03-17 2002-04-23 The Ohio State University Cyclic bis-benzimidazole ligands and metal complexes thereof
EP1244665B1 (en) * 1999-12-23 2005-08-10 Trinapco, Inc Triazatrinaphthyrins and the use thereof
US6407089B1 (en) 1999-12-23 2002-06-18 Trinapco Inc. Triazatrinaphthyrins and the use thereof
GB0007764D0 (en) * 2000-03-30 2000-05-17 Bp Chem Int Ltd Polymerisation catalyst
FR2810406B1 (fr) * 2000-06-15 2002-09-20 Cis Bio Int Nouveaux cryptates de terre rare peu sensibles a l'extinction de fluorescence
WO2007125173A2 (en) 2006-05-03 2007-11-08 Baltic Technology Development, Ltd. Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
EP3733871A1 (en) * 2008-05-27 2020-11-04 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
WO2011087707A1 (en) 2009-12-22 2011-07-21 Elitech Holding B.V. Hypertheromostable endonuclease iv substrate probe
US10662465B2 (en) 2011-09-30 2020-05-26 Agilent Technologies, Inc. Hybridization compositions and methods using formamide
EP2768974B1 (en) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
CN114315702A (zh) * 2022-02-11 2022-04-12 南京邮电大学 一种基于低维镧系金属配合物X射线激发闪烁体Eu-TPC及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (en) * 1986-10-28 1990-09-19 The Johns Hopkins University Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
AU636573B2 (en) * 1988-02-26 1993-05-06 Worcester Foundation For Biomedical Research, Inc. Inhibition of htlv-iii by exogenous oligonucleotides
US5559207A (en) * 1989-03-06 1996-09-24 Board Of Regents, University Of Texas Texaphyrin metal complex mediated ester hydrolysis
US5760191A (en) * 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods

Also Published As

Publication number Publication date
CY2435B1 (en) 2004-11-12
EP0778844B1 (de) 2002-12-18
AU695749B2 (en) 1998-08-20
JPH10505354A (ja) 1998-05-26
DK0778844T3 (da) 2003-03-31
FI970740A (fi) 1997-02-21
ATE229969T1 (de) 2003-01-15
NO970886L (no) 1997-04-25
HU217774B (hu) 2000-04-28
NO316866B1 (no) 2004-06-07
EP0778844A1 (de) 1997-06-18
AU3474495A (en) 1996-03-27
HUT77933A (hu) 1998-11-30
WO1996007668A1 (de) 1996-03-14
US5925744A (en) 1999-07-20
FI970740A0 (fi) 1997-02-21
NO970886D0 (no) 1997-02-27
ES2191060T3 (es) 2003-09-01
DE59510515D1 (de) 2003-01-30
CA2197788A1 (en) 1996-03-14

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