CY2435B1 - Functional terpyridine metal complexes, methods for their preparation and oligonucleotide conjugateswith terpyridine metal complexes. - Google Patents

Functional terpyridine metal complexes, methods for their preparation and oligonucleotide conjugateswith terpyridine metal complexes.

Info

Publication number
CY2435B1
CY2435B1 CY0400024A CY0400024A CY2435B1 CY 2435 B1 CY2435 B1 CY 2435B1 CY 0400024 A CY0400024 A CY 0400024A CY 0400024 A CY0400024 A CY 0400024A CY 2435 B1 CY2435 B1 CY 2435B1
Authority
CY
Cyprus
Prior art keywords
terpyridine
metal complexes
pct
preparation
terpyridine metal
Prior art date
Application number
CY0400024A
Other languages
English (en)
Inventor
Robert Haener
Jonathan Hall
Dieter Huesken
Uwe Pieles
Heinz Moser
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CY2435B1 publication Critical patent/CY2435B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CY0400024A 1994-09-02 2004-03-30 Functional terpyridine metal complexes, methods for their preparation and oligonucleotide conjugateswith terpyridine metal complexes. CY2435B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH269394 1994-09-02

Publications (1)

Publication Number Publication Date
CY2435B1 true CY2435B1 (en) 2004-11-12

Family

ID=4239459

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0400024A CY2435B1 (en) 1994-09-02 2004-03-30 Functional terpyridine metal complexes, methods for their preparation and oligonucleotide conjugateswith terpyridine metal complexes.

Country Status (15)

Country Link
US (1) US5925744A (xx)
EP (1) EP0778844B1 (xx)
JP (1) JPH10505354A (xx)
AT (1) ATE229969T1 (xx)
AU (1) AU695749B2 (xx)
CA (1) CA2197788A1 (xx)
CY (1) CY2435B1 (xx)
DE (1) DE59510515D1 (xx)
DK (1) DK0778844T3 (xx)
ES (1) ES2191060T3 (xx)
FI (1) FI970740A (xx)
HU (1) HU217774B (xx)
NO (1) NO316866B1 (xx)
PT (1) PT778844E (xx)
WO (1) WO1996007668A1 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739391B2 (en) * 1996-07-03 2001-10-11 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US6376664B1 (en) * 1999-03-17 2002-04-23 The Ohio State University Cyclic bis-benzimidazole ligands and metal complexes thereof
US6407089B1 (en) 1999-12-23 2002-06-18 Trinapco Inc. Triazatrinaphthyrins and the use thereof
EP1244665B1 (en) * 1999-12-23 2005-08-10 Trinapco, Inc Triazatrinaphthyrins and the use thereof
GB0007764D0 (en) * 2000-03-30 2000-05-17 Bp Chem Int Ltd Polymerisation catalyst
FR2810406B1 (fr) * 2000-06-15 2002-09-20 Cis Bio Int Nouveaux cryptates de terre rare peu sensibles a l'extinction de fluorescence
WO2007125173A2 (en) 2006-05-03 2007-11-08 Baltic Technology Development, Ltd. Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
ES2668555T3 (es) 2008-05-27 2018-05-18 Dako Denmark A/S Composiciones y métodos para la detección de aberraciones cromosómicas con tampones de hibridación novedosos
US9303287B2 (en) 2009-02-26 2016-04-05 Dako Denmark A/S Compositions and methods for RNA hybridization applications
US20110151457A1 (en) 2009-12-22 2011-06-23 Elitech Holding B.V. Hypertheromostable endonuclease iv substrate probe
EP2761028A1 (en) 2011-09-30 2014-08-06 Dako Denmark A/S Hybridization compositions and methods using formamide
EP2768974B1 (en) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
CN114315702A (zh) * 2022-02-11 2022-04-12 南京邮电大学 一种基于低维镧系金属配合物X射线激发闪烁体Eu-TPC及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (en) * 1986-10-28 1990-09-19 The Johns Hopkins University Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
DE68925278T2 (de) * 1988-02-26 1996-09-19 Worcester Found Ex Biology Hemmung von htlv-iii durch exogene oligonukleotide
US5559207A (en) * 1989-03-06 1996-09-24 Board Of Regents, University Of Texas Texaphyrin metal complex mediated ester hydrolysis
US5760191A (en) * 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods

Also Published As

Publication number Publication date
DE59510515D1 (de) 2003-01-30
EP0778844A1 (de) 1997-06-18
FI970740A0 (fi) 1997-02-21
AU3474495A (en) 1996-03-27
NO316866B1 (no) 2004-06-07
JPH10505354A (ja) 1998-05-26
ATE229969T1 (de) 2003-01-15
FI970740A (fi) 1997-02-21
DK0778844T3 (da) 2003-03-31
NO970886D0 (no) 1997-02-27
ES2191060T3 (es) 2003-09-01
CA2197788A1 (en) 1996-03-14
NO970886L (no) 1997-04-25
PT778844E (pt) 2003-04-30
AU695749B2 (en) 1998-08-20
WO1996007668A1 (de) 1996-03-14
US5925744A (en) 1999-07-20
HU217774B (hu) 2000-04-28
EP0778844B1 (de) 2002-12-18
HUT77933A (hu) 1998-11-30

Similar Documents

Publication Publication Date Title
CY2435B1 (en) Functional terpyridine metal complexes, methods for their preparation and oligonucleotide conjugateswith terpyridine metal complexes.
HK1152246A1 (en) Compositions for treating cancer
GR3032355T3 (en) Cyclodextrin cellular delivery system for oligonucleotides
WO1997026270A3 (en) Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
ZA200106737B (en) Process for producing nitrosonium ions.
MX9605716A (es) Metodos y composiciones para el tratamiento de restenosis y cancer usando ribozimas.
SI1075477T1 (en) Novel Benzonaphthyridine-N-oxides
GB9200607D0 (en) Pharmaceutical compositions containing nifedipine and process for the preparation thereof
EP0683781A4 (en) NEW ADENOSINE MONOPHOSPHATE DEAMINASE INHIBITORS.
IL151289A0 (en) Method for preparing functionalised polyalkylenimines, composition containing same and uses thereof
GB9221163D0 (en) Dna compounds
HK1014035A1 (en) A process for producing immunosuppressives and a novel microbial species to be employed therein
IL86223A (en) Amperometric method for the quantitative determination of 1,4-dihydronicotinamide adenine dinucleotide (nadh) in solution using resin- bonded noble metal containing activated carbon electrode
Ohnishi et al. Oxidative DNA Damage Induced by a Metabolite of 2–Naphthylamine, a Smoking‐related Bladder Carcinogen
HU9402040D0 (en) New adenosine derivatives and process for producing them
Suzuki et al. Nucleotide sequence cleavages of manganese-bleomycin induced by reductant, hydrogen peroxide and ultraviolet light. Comparison with iron-and cobalt-bleomycins
BG104034A (en) Method for the preparation of pharmaceutical compounds of antidepressive effect and against the parkinson syndrome effect
AP2001002312A0 (en) New aromatic amides sustituted by a ribose, their preparation process and their use as medicaments.
MX9709471A (es) Complejos metalicos multidentados y metodos para preparar y usar los mismos.
ZA200005110B (en) Process for preparing intermediates.
AP2000001835A0 (en) Agents.
MX9710501A (es) Metodo de purificacion por extraccion a partir de un medio liquido.
ATE273027T1 (de) Zusammensetzung zur behandlung von entzündungen
PL322847A1 (en) Condensed b-carbolins
SELVERSTON Chromosomal RNA: Its Properties