MX9709471A - Complejos metalicos multidentados y metodos para preparar y usar los mismos. - Google Patents

Complejos metalicos multidentados y metodos para preparar y usar los mismos.

Info

Publication number
MX9709471A
MX9709471A MX9709471A MX9709471A MX9709471A MX 9709471 A MX9709471 A MX 9709471A MX 9709471 A MX9709471 A MX 9709471A MX 9709471 A MX9709471 A MX 9709471A MX 9709471 A MX9709471 A MX 9709471A
Authority
MX
Mexico
Prior art keywords
optionally substituted
proviso
substituents
phenyl
independently
Prior art date
Application number
MX9709471A
Other languages
English (en)
Inventor
David R Piwnica-Worms
Vijay Sharma
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of MX9709471A publication Critical patent/MX9709471A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se relaciona con complejos metálicos multidentados que tienen la formula (I) en la cual M es Fe, In, Ga o Al; las líneas punteadas representan independientemente un enlace sencillo o doble; las líneas rayadas presentan la coordinacion con el cation metálico (M); A y B son oxçigeno, o en el caso en donde Ar es 2-piridilo o 2-pirrolilo, un par de electrones compartidos sobre el nitrogeno; Ar es fenilo opcionalmente sustituido, naftilo, opcionalmente sustituido, 2-piridilo opcionalmentesustituido o 2-pirrolilo opcionalmente sustituido, con la condicion de que al menos uno de los sustituyentes comprenda un átomo de boro; X es alternativamente (i) (CHR2)p[NR3(CHR4)q]r, en donde p y q sin independientemente 1, 2, 3, 4, 5, o 6; r es 0, 1 o 2; y R2, R3 y R4 son indpendientemente hidrogeno, alquilo inferior o fenilo, o dos grupos R2 o R4 adyacentes representan un enlace doble o un anillo de benceno fusionado en donde p o q, respectivamente, es mayor de 2; con la condicion de que en donde r es 1 o , entonces existen 1 o 2 sitios adicionales de coordinacion para el metal; o ii) fenilo opcionalmente sustituido, en donde el fenilo, cuando está sustituido, tiene sustituyentes alquilo inferior, opcionalmente con: condicion (A), en donde al menos uno de los sustituyentes de Ar comprende boro, o con la condicion (B), en donde al menos uno de los sustituyentes de Ar comprende un enlace con un sustituyente farmacéuticamente activo.
MX9709471A 1995-06-07 1996-06-07 Complejos metalicos multidentados y metodos para preparar y usar los mismos. MX9709471A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48799195A 1995-06-07 1995-06-07
PCT/US1996/010079 WO1996040108A1 (en) 1995-06-07 1996-06-07 Multidentate metal complexes and methods of making and using thereof

Publications (1)

Publication Number Publication Date
MX9709471A true MX9709471A (es) 1998-02-28

Family

ID=23937936

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709471A MX9709471A (es) 1995-06-07 1996-06-07 Complejos metalicos multidentados y metodos para preparar y usar los mismos.

Country Status (6)

Country Link
EP (1) EP0831806A1 (es)
JP (1) JPH11507641A (es)
AU (1) AU6477196A (es)
CA (1) CA2224115A1 (es)
MX (1) MX9709471A (es)
WO (1) WO1996040108A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6203822B1 (en) * 1996-09-03 2001-03-20 University Of Iowa Research Foundation Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection
WO2001085210A2 (en) 2000-05-10 2001-11-15 Sirbasku David A Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth
US20030072812A1 (en) 2001-05-10 2003-04-17 Sirbasku David A Breast cancer eradication program
AU2002343714A1 (en) * 2001-11-13 2003-05-26 David A. Sirbasku Breast cancer eradication program
CN1255106C (zh) 2003-09-26 2006-05-10 李国桥 复方青蒿素
EP2673257B1 (en) * 2011-02-11 2018-07-18 Washington University Pet/spect agents for applications in biomedical imaging
SI2809327T1 (sl) 2012-01-30 2018-12-31 Fresenius Kabi Deutschland Gmbh Hidroksialkil škrob v kombinaciji s citostatiki za zdravljenje rakov z zmanjševanjem stopenj rasti tumorja
DK3564246T3 (da) * 2018-05-03 2021-08-09 Univ Almeria Guld(iii)-kompleks, et konjugat af guld(iii)-kompleks, en farmakologisk sammensætning, der omfatter guld(iii)-komplekset, og anvendelser og en fremgangsmåde til forberedelse af guld(iii)-komplekset

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9111689D0 (en) * 1991-05-31 1991-07-24 Johnson Matthey Plc Gallium compounds

Also Published As

Publication number Publication date
CA2224115A1 (en) 1996-12-19
EP0831806A1 (en) 1998-04-01
JPH11507641A (ja) 1999-07-06
AU6477196A (en) 1996-12-30
WO1996040108A1 (en) 1996-12-19

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