PT719864E - Vacina viva recombinante aviaria usando como vector um herpesvirus aviario - Google Patents
Vacina viva recombinante aviaria usando como vector um herpesvirus aviarioInfo
- Publication number
- PT719864E PT719864E PT95402970T PT95402970T PT719864E PT 719864 E PT719864 E PT 719864E PT 95402970 T PT95402970 T PT 95402970T PT 95402970 T PT95402970 T PT 95402970T PT 719864 E PT719864 E PT 719864E
- Authority
- PT
- Portugal
- Prior art keywords
- aviary
- herpesvirus
- vector
- recombinant vaccine
- avian recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16141—Use of virus, viral particle or viral elements as a vector
- C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16341—Use of virus, viral particle or viral elements as a vector
- C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9416017A FR2728795B1 (fr) | 1994-12-30 | 1994-12-30 | Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire |
Publications (1)
Publication Number | Publication Date |
---|---|
PT719864E true PT719864E (pt) | 2004-03-31 |
Family
ID=9470530
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95402970T PT719864E (pt) | 1994-12-30 | 1995-12-28 | Vacina viva recombinante aviaria usando como vector um herpesvirus aviario |
PT03025194T PT1403375E (pt) | 1994-12-30 | 1995-12-28 | Vacina viva recombinante aviária, utilizando como vector um vírus de herpes aviário |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT03025194T PT1403375E (pt) | 1994-12-30 | 1995-12-28 | Vacina viva recombinante aviária, utilizando como vector um vírus de herpes aviário |
Country Status (10)
Country | Link |
---|---|
US (2) | US5980906A (pt) |
EP (2) | EP0719864B1 (pt) |
JP (2) | JPH0920682A (pt) |
AU (1) | AU708077B2 (pt) |
BR (1) | BR9506138A (pt) |
CA (1) | CA2166367C (pt) |
DE (2) | DE69532068T2 (pt) |
ES (2) | ES2212798T3 (pt) |
FR (1) | FR2728795B1 (pt) |
PT (2) | PT719864E (pt) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2757061B1 (fr) * | 1996-12-16 | 1999-03-26 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire |
FR2758986B1 (fr) | 1997-01-31 | 1999-04-30 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire |
US6632664B1 (en) * | 1997-10-03 | 2003-10-14 | Nippon Zeon Co., Ltd. | Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same |
WO2015013178A1 (en) * | 2013-07-23 | 2015-01-29 | University Of Maryland | Infectious laryngotracheitis virus (iltv) vaccine using recombinant newcastle disease virus vector |
WO2001005988A1 (en) * | 1999-07-16 | 2001-01-25 | Merial Select, Inc | Live recombinant vaccine against avian leukosis virus using a marek's disease virus (mdv) virus as vector |
EP1241177A1 (en) * | 2001-03-15 | 2002-09-18 | Akzo Nobel N.V. | Recombinant infectious laryngotracheitis virus vaccine |
FR2823222B1 (fr) | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
US6764684B2 (en) * | 2001-09-28 | 2004-07-20 | Zeon Corporation | Avian herpesvirus-based recombinant infectious bursal disease vaccine |
US20040241723A1 (en) * | 2002-03-18 | 2004-12-02 | Marquess Foley Leigh Shaw | Systems and methods for improving protein and milk production of dairy herds |
EP1606419A1 (en) | 2003-03-18 | 2005-12-21 | Quantum Genetics Ireland Limited | Systems and methods for improving protein and milk production of dairy herds |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
WO2005049794A2 (en) | 2003-11-13 | 2005-06-02 | University Of Georgia Research Foundation, Inc. | Methods of characterizing infectious bursal disease virus |
ATE510928T1 (de) | 2004-02-19 | 2011-06-15 | Univ Alberta | Leptinpromotor-polymorphismen und verwendungen davon |
JPWO2005093070A1 (ja) * | 2004-03-29 | 2008-02-14 | 日本ゼオン株式会社 | 組み換えヘルペスウイルス及びその利用 |
ES2343270T3 (es) | 2005-04-25 | 2010-07-27 | Merial Ltd. | Vacunas contra el virus nipah. |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
EP3147296A1 (en) | 2005-11-14 | 2017-03-29 | Merial, Inc. | Gene therapy for renal failure |
US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
CN102428099B (zh) | 2009-04-03 | 2016-03-16 | 梅里亚有限公司 | 运载新城疫病毒的禽疫苗 |
MX344103B (es) | 2010-08-31 | 2016-12-05 | Merial Ltd | Vacunas de virus herpes vectorizado con virus de enfermedad de newcastle. |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
EP2694678A2 (en) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
AU2012240240A1 (en) | 2011-04-04 | 2013-05-09 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
US9216213B2 (en) | 2011-04-20 | 2015-12-22 | Merial, Inc. | Adjuvanted rabies vaccine with improved viscosity profile |
CN103945864A (zh) | 2011-04-25 | 2014-07-23 | 先进生物学实验室股份有限公司 | 截短的hiv包膜蛋白(env)、其相关方法和组合物 |
US9669085B2 (en) | 2011-06-01 | 2017-06-06 | Merial Inc. | Needle-free administration of PRRSV vaccines |
CN103841963B (zh) | 2011-08-12 | 2018-04-24 | 梅里亚股份有限公司 | 用于生物产品特别是疫苗的真空辅助保存 |
CA3146727C (en) | 2011-10-21 | 2023-10-31 | Intervet International B.V. | Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens |
EP2768529A1 (en) | 2011-10-21 | 2014-08-27 | Intervet International B.V. | Recombinant nonpathogenic mdv vector providing multivalent immunity |
US9114108B2 (en) | 2011-11-30 | 2015-08-25 | Merial, Inc. | Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof |
US9101598B2 (en) | 2011-11-30 | 2015-08-11 | Merial, Inc. | Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof |
ES2719409T5 (es) | 2011-11-30 | 2022-12-07 | Boehringer Ingelheim Animal Health Usa Inc | Vectores recombinantes de Gallid herpesvirus 3 (mdv serotipo 2) que expresan antígenos de patógenos aviares y usos de los mismos |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
EP2644702A1 (en) | 2012-03-30 | 2013-10-02 | Ceva Sante Animale | Multivalent recombinant avian herpes virus and vaccine for immunizing avian species |
EP2968514A1 (en) | 2013-03-12 | 2016-01-20 | Merial, Inc. | Reverse genetics schmallenberg virus vaccine compositions, and methods of use thereof |
EP2845904A1 (en) * | 2013-09-06 | 2015-03-11 | Ceva Sante Animale | Recombinant Marek's disease viruses and uses thereof |
NZ731659A (en) | 2014-11-03 | 2018-10-26 | Merial Inc | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
AR103245A1 (es) | 2014-12-24 | 2017-04-26 | Intervet Int Bv | Vacuna vectorial basada en hvt (herpes virus de los pavos) frente a nd (enfermedad de newcastle) - ibd (enfermedad de gumboro) mejorada |
EP3050572A1 (en) | 2015-01-29 | 2016-08-03 | Ceva Sante Animale | Recombinant MDV1 and the uses thereof |
PL3313864T3 (pl) | 2015-06-23 | 2022-01-03 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory wirusowe zawierające drugorzędne białko prrsv oraz sposoby ich wytwarzania i zastosowania |
US10537628B2 (en) | 2015-08-10 | 2020-01-21 | The Texas A&M University System | Recombinant turkey herpesvirus vaccines and uses thereof |
WO2017216287A1 (en) | 2016-06-17 | 2017-12-21 | Intervet International B.V. | Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and infectious bursal disease virus antigens |
EP3263129A1 (en) | 2016-06-29 | 2018-01-03 | Ceva Sante Animale | Duck enteritis virus and the uses thereof |
JOP20190088A1 (ar) | 2016-10-21 | 2019-04-21 | Us Agriculture | نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها |
MA55772A (fr) | 2016-12-14 | 2022-03-02 | Boehringer Ingelheim Animal Health Usa Inc | Vecteurs hvt recombinants exprimant de multiples antigènes de pathogènes aviaires, et vaccins les contenant |
CN111542599A (zh) | 2017-10-12 | 2020-08-14 | 英特维特国际股份有限公司 | 编码多种异源抗原的重组非致病性马尔克氏病病毒构建体 |
BR112021012434A2 (pt) | 2018-12-27 | 2021-09-28 | Ceva Sante Animale | Vírus recombinantes e usos dos mesmos |
CN114616325A (zh) | 2019-09-11 | 2022-06-10 | 硕腾服务有限责任公司 | 表达禽病原体抗原的重组火鸡疱疹病毒载体和其用途 |
IL299033A (en) | 2020-06-17 | 2023-02-01 | Boehringer Ingelheim Vetmedica Gmbh | Recombinant HVT vectors expressing influenza hemagglutinin and immunogenic compounds, production and uses thereof |
JP2023549787A (ja) | 2020-11-12 | 2023-11-29 | インターベット インターナショナル ベー. フェー. | キメラコロナウイルススパイクタンパク質をコードする組換えベクターおよびその使用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4859587A (en) * | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
US5965138A (en) * | 1985-09-06 | 1999-10-12 | Syntro Corporation | Recombinant chimeric virus and uses thereof |
US5928648A (en) * | 1985-09-06 | 1999-07-27 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
EP0332677B1 (en) * | 1987-07-27 | 1995-07-19 | Syntro Corporation | Attenuated herpes viruses, herpes viruses which include foreign dna encoding an amino acid sequence and vaccines containing same |
JP2583115B2 (ja) * | 1988-09-10 | 1997-02-19 | 財団法人化学及血清療法研究所 | 組換えマレック病ウイルスおよびその製法 |
IL91627A (en) * | 1988-09-13 | 1995-08-31 | Rhone Merieux | Viral nucleotide segments |
FR2659349B1 (fr) * | 1990-03-12 | 1993-12-24 | Rhone Merieux | Virus herpes recombinants notamment pour la realisation de vaccins, leur procede de preparation, les plasmides realises au cours de ce procede et les vaccins obtenus. |
ES2056565T3 (es) * | 1990-07-30 | 1994-10-01 | Akzo Nobel Nv | Virus recombinante de la enfermedad de marek. |
WO1992003554A1 (en) * | 1990-08-24 | 1992-03-05 | Arthur Webster Pty. Ltd. | Infectious laryngotracheitis virus vaccine |
FR2666589B1 (fr) * | 1990-09-07 | 1994-08-05 | Rhone Merieux | Nouveaux virus herpes recombinants, vaccin a base de ces recombinants, leur procede de preparation, genes, vecteurs et plasmides utilises dans ce procede. |
BE1004877A3 (fr) * | 1991-05-27 | 1993-02-16 | Solvay | Virus de l'avipox recombinant, culture de cellules infectees par ce virus et vaccins pour la volaille derives de ce virus. |
JP3428666B2 (ja) * | 1991-07-09 | 2003-07-22 | 財団法人化学及血清療法研究所 | 組換えマレック病ウイルスおよびその製法 |
US5853733A (en) * | 1993-02-26 | 1998-12-29 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
FR2697534A1 (fr) * | 1992-11-02 | 1994-05-06 | Rhone Merieux | Virus herpès de la dinde recombinant pour la réalisation de vaccin de la maladie de Gumboro, son procédé de préparation et vaccin obtenu. |
AU4489896A (en) * | 1994-12-30 | 1996-07-24 | Rhone Merieux | Avian recombinant live vaccine |
-
1994
- 1994-12-30 FR FR9416017A patent/FR2728795B1/fr not_active Expired - Lifetime
-
1995
- 1995-12-26 US US08/578,096 patent/US5980906A/en not_active Expired - Lifetime
- 1995-12-28 AU AU40715/95A patent/AU708077B2/en not_active Expired
- 1995-12-28 DE DE69532068T patent/DE69532068T2/de not_active Expired - Lifetime
- 1995-12-28 PT PT95402970T patent/PT719864E/pt unknown
- 1995-12-28 EP EP95402970A patent/EP0719864B1/fr not_active Expired - Lifetime
- 1995-12-28 EP EP03025194A patent/EP1403375B1/fr not_active Expired - Lifetime
- 1995-12-28 ES ES95402970T patent/ES2212798T3/es not_active Expired - Lifetime
- 1995-12-28 PT PT03025194T patent/PT1403375E/pt unknown
- 1995-12-28 JP JP7355020A patent/JPH0920682A/ja not_active Withdrawn
- 1995-12-28 ES ES03025194T patent/ES2295497T3/es not_active Expired - Lifetime
- 1995-12-28 DE DE69535618T patent/DE69535618T2/de not_active Expired - Lifetime
- 1995-12-29 CA CA002166367A patent/CA2166367C/en not_active Expired - Lifetime
- 1995-12-29 BR BR9506138A patent/BR9506138A/pt active IP Right Grant
-
1999
- 1999-01-29 US US09/240,426 patent/US6045803A/en not_active Expired - Lifetime
-
2006
- 2006-12-06 JP JP2006329245A patent/JP4641024B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6045803A (en) | 2000-04-04 |
DE69532068D1 (de) | 2003-12-11 |
AU4071595A (en) | 1996-07-11 |
JP2007126465A (ja) | 2007-05-24 |
DE69535618D1 (de) | 2007-11-22 |
FR2728795A1 (fr) | 1996-07-05 |
EP1403375B1 (fr) | 2007-10-10 |
ES2295497T3 (es) | 2008-04-16 |
CA2166367A1 (en) | 1996-07-01 |
CA2166367C (en) | 2003-06-10 |
BR9506138A (pt) | 1998-03-31 |
EP1403375A2 (fr) | 2004-03-31 |
PT1403375E (pt) | 2008-01-17 |
EP0719864A2 (fr) | 1996-07-03 |
EP0719864B1 (fr) | 2003-11-05 |
EP1403375A3 (fr) | 2005-10-19 |
FR2728795B1 (fr) | 1997-03-21 |
AU708077B2 (en) | 1999-07-29 |
US5980906A (en) | 1999-11-09 |
ES2212798T3 (es) | 2004-08-01 |
DE69532068T2 (de) | 2004-08-26 |
DE69535618T2 (de) | 2008-08-14 |
JPH0920682A (ja) | 1997-01-21 |
JP4641024B2 (ja) | 2011-03-02 |
EP0719864A3 (fr) | 1996-12-04 |
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