PT69618A - Neue imidazolderivate verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praparate - Google Patents
Neue imidazolderivate verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praparateInfo
- Publication number
- PT69618A PT69618A PT69618A PT6961879A PT69618A PT 69618 A PT69618 A PT 69618A PT 69618 A PT69618 A PT 69618A PT 6961879 A PT6961879 A PT 6961879A PT 69618 A PT69618 A PT 69618A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- imidazole derivatives
- praparates
- pharmaceutical
- preparation
- Prior art date
Links
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Resins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782823197 DE2823197A1 (de) | 1978-05-24 | 1978-05-24 | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT69618A true PT69618A (de) | 1979-06-01 |
Family
ID=6040343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT69618A PT69618A (de) | 1978-05-24 | 1979-05-16 | Neue imidazolderivate verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praparate |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US4269847A (en, 2012) |
| EP (1) | EP0005545B1 (en, 2012) |
| JP (1) | JPS54154766A (en, 2012) |
| AT (1) | ATE15662T1 (en, 2012) |
| AU (1) | AU4737979A (en, 2012) |
| BG (1) | BG32268A3 (en, 2012) |
| CA (1) | CA1177836A (en, 2012) |
| DD (1) | DD143770A5 (en, 2012) |
| DE (2) | DE2823197A1 (en, 2012) |
| DK (1) | DK208979A (en, 2012) |
| EG (1) | EG14365A (en, 2012) |
| ES (1) | ES480809A1 (en, 2012) |
| FI (1) | FI791639A7 (en, 2012) |
| FR (1) | FR2426682A1 (en, 2012) |
| GB (1) | GB2023600B (en, 2012) |
| GR (1) | GR72243B (en, 2012) |
| IE (1) | IE48416B1 (en, 2012) |
| IL (1) | IL57384A0 (en, 2012) |
| NO (1) | NO791707L (en, 2012) |
| NZ (1) | NZ190529A (en, 2012) |
| PL (1) | PL215774A1 (en, 2012) |
| PT (1) | PT69618A (en, 2012) |
| RO (1) | RO77293A (en, 2012) |
| ZA (1) | ZA792522B (en, 2012) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CY1302A (en) * | 1978-04-11 | 1985-12-06 | Ciba Geigy Ag | Mercapto-imidazole derivatives,their preparation,their pharmaceutical compositions and applications |
| DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4503065A (en) * | 1982-08-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl 1-2-halo imidazoles |
| US4728656A (en) * | 1985-12-12 | 1988-03-01 | Smithkline Beckman Corporation | 2,2-alkyldiylbis(thio)bis(imidazoles) useful for inhibition of the 5-lipoxygenase pathway |
| US4847270A (en) * | 1985-12-12 | 1989-07-11 | Smithkline Beckman Corporation | Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-alkyldiyl bis(thio)bis-imidazoles and derivatives |
| JPS6440467A (en) * | 1987-08-04 | 1989-02-10 | Hisamitsu Pharmaceutical Co | Novel substituted diphenylimidazole derivative |
| US4900744A (en) * | 1988-09-14 | 1990-02-13 | E. I. Du Pont De Nemours And Company | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles |
| GB9005966D0 (en) * | 1990-03-16 | 1990-05-09 | May & Baker Ltd | New compositions of matter |
| US5179117A (en) * | 1991-12-20 | 1993-01-12 | Du Pont Merck Pharmaceutical Company | Antihypercholesterolemic 2-substituted imidazoles |
| ATE193290T1 (de) * | 1992-02-11 | 2000-06-15 | Smithkline Beecham Corp | Coa-it- und paf-inhibitoren |
| US5663053A (en) * | 1992-02-11 | 1997-09-02 | Smithkline Beecham Corporation | Inhibition of inflammatory lipid mediators |
| EP0994858A1 (en) * | 1997-06-30 | 2000-04-26 | Ortho-McNeil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| DE10107683A1 (de) | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10114775A1 (de) * | 2001-03-26 | 2002-10-10 | Gerhard Dannhardt | 2-Mercapto-4,5-diarylimidazolderivate und ihre Verwendung in der Pharmazie |
| DE10238045A1 (de) | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| EP1894925A1 (en) * | 2006-08-24 | 2008-03-05 | Merckle Gmbh | Imidazole compounds having an antiinflammatory effect |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2981739A (en) * | 1958-01-27 | 1961-04-25 | Diamond Alkali Co | Certain alpha-haloaldehyde addition products of ethylenethioureas and process |
| FR1509975A (fr) * | 1965-10-21 | 1968-01-19 | Geigy Ag J R | Dérivés de l'imidazole et leur préparation |
| US3651080A (en) * | 1969-11-07 | 1972-03-21 | Ciba Geigy Corp | Certain substituted 2-alkylmercaptoimidazole derivatives |
| US3636003A (en) * | 1969-11-17 | 1972-01-18 | Geigy Chem Corp | Substituted 2-mercaptoimidazole derivatives |
| US3714179A (en) * | 1970-09-08 | 1973-01-30 | Searle & Co | 1-alkyl-2-furfurylthioimidazoles and congeners |
| JPS5343958B2 (en, 2012) * | 1972-07-29 | 1978-11-24 | ||
| DE2259627A1 (de) * | 1972-12-06 | 1974-06-12 | Hoechst Ag | Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung |
| US3842097A (en) * | 1973-01-22 | 1974-10-15 | Searle & Co | 2-(phenoxyalkylthio)imidazoles and congeners |
| US4190666A (en) * | 1975-08-11 | 1980-02-26 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones |
| SE428686B (sv) * | 1975-08-11 | 1983-07-18 | Du Pont | Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler |
| US4159338A (en) * | 1977-02-09 | 1979-06-26 | E. I. Du Pont De Nemours And Company | Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones |
| US4182769A (en) * | 1977-02-09 | 1980-01-08 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones |
| LU77703A1 (de) * | 1977-07-07 | 1979-03-26 | Ciba Geigy Ag | Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen |
| CY1302A (en) * | 1978-04-11 | 1985-12-06 | Ciba Geigy Ag | Mercapto-imidazole derivatives,their preparation,their pharmaceutical compositions and applications |
-
1978
- 1978-05-24 DE DE19782823197 patent/DE2823197A1/de not_active Withdrawn
-
1979
- 1979-05-16 PT PT69618A patent/PT69618A/pt unknown
- 1979-05-17 DE DE7979101509T patent/DE2967513D1/de not_active Expired
- 1979-05-17 AT AT79101509T patent/ATE15662T1/de not_active IP Right Cessation
- 1979-05-17 EP EP79101509A patent/EP0005545B1/de not_active Expired
- 1979-05-21 BG BG043677A patent/BG32268A3/xx unknown
- 1979-05-21 FR FR7912876A patent/FR2426682A1/fr not_active Withdrawn
- 1979-05-22 DD DD79213065A patent/DD143770A5/de unknown
- 1979-05-22 US US06/041,367 patent/US4269847A/en not_active Expired - Lifetime
- 1979-05-22 GR GR59147A patent/GR72243B/el unknown
- 1979-05-22 PL PL21577479A patent/PL215774A1/xx unknown
- 1979-05-22 ES ES480809A patent/ES480809A1/es not_active Expired
- 1979-05-22 DK DK208979A patent/DK208979A/da not_active Application Discontinuation
- 1979-05-23 ZA ZA792522A patent/ZA792522B/xx unknown
- 1979-05-23 FI FI791639A patent/FI791639A7/fi not_active Application Discontinuation
- 1979-05-23 CA CA000328095A patent/CA1177836A/en not_active Expired
- 1979-05-23 EG EG311/79A patent/EG14365A/xx active
- 1979-05-23 IL IL57384A patent/IL57384A0/xx unknown
- 1979-05-23 NO NO791707A patent/NO791707L/no unknown
- 1979-05-23 GB GB7917874A patent/GB2023600B/en not_active Expired
- 1979-05-23 JP JP6277479A patent/JPS54154766A/ja active Granted
- 1979-05-23 NZ NZ190529A patent/NZ190529A/xx unknown
- 1979-05-24 RO RO7997627A patent/RO77293A/ro unknown
- 1979-05-24 AU AU47379/79A patent/AU4737979A/en not_active Abandoned
- 1979-08-08 IE IE1000/79A patent/IE48416B1/en unknown
-
1980
- 1980-09-24 US US06/190,309 patent/US4355039A/en not_active Expired - Lifetime
-
1982
- 1982-03-24 US US06/361,225 patent/US4440776A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DD143770A5 (de) | 1980-09-10 |
| RO77293A (ro) | 1981-08-17 |
| FR2426682A1 (fr) | 1979-12-21 |
| BG32268A3 (bg) | 1982-06-15 |
| DE2967513D1 (en) | 1985-10-24 |
| IE791000L (en) | 1979-11-24 |
| NO791707L (no) | 1979-11-27 |
| GR72243B (en, 2012) | 1983-10-04 |
| US4440776A (en) | 1984-04-03 |
| FI791639A7 (fi) | 1981-01-01 |
| US4355039A (en) | 1982-10-19 |
| JPH0336834B2 (en, 2012) | 1991-06-03 |
| IL57384A0 (en) | 1979-09-30 |
| EP0005545A3 (en) | 1980-01-09 |
| ZA792522B (en) | 1980-06-25 |
| ES480809A1 (es) | 1979-12-01 |
| DK208979A (da) | 1979-11-25 |
| EP0005545B1 (de) | 1985-09-18 |
| EP0005545A2 (de) | 1979-11-28 |
| CA1177836A (en) | 1984-11-13 |
| IE48416B1 (en) | 1985-01-09 |
| GB2023600A (en) | 1980-01-03 |
| AU4737979A (en) | 1979-11-29 |
| PL215774A1 (en, 2012) | 1980-02-25 |
| ATE15662T1 (de) | 1985-10-15 |
| EG14365A (en) | 1984-03-31 |
| GB2023600B (en) | 1982-11-03 |
| JPS54154766A (en) | 1979-12-06 |
| DE2823197A1 (de) | 1979-11-29 |
| US4269847A (en) | 1981-05-26 |
| NZ190529A (en) | 1982-02-23 |
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