PT3917538T - Derivados de desoxicitidina ou uridina para usar em terapias de cancro - Google Patents
Derivados de desoxicitidina ou uridina para usar em terapias de cancroInfo
- Publication number
- PT3917538T PT3917538T PT207034471T PT20703447T PT3917538T PT 3917538 T PT3917538 T PT 3917538T PT 207034471 T PT207034471 T PT 207034471T PT 20703447 T PT20703447 T PT 20703447T PT 3917538 T PT3917538 T PT 3917538T
- Authority
- PT
- Portugal
- Prior art keywords
- cytidine
- deoxy
- cancer therapies
- uridine derivatives
- uridine
- Prior art date
Links
- CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 title 1
- CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 title 1
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title 1
- 238000011275 oncology therapy Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1901427.3A GB2580963B (en) | 2019-02-01 | 2019-02-01 | Cancer therapies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3917538T true PT3917538T (pt) | 2023-08-17 |
Family
ID=65998012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT207034471T PT3917538T (pt) | 2019-02-01 | 2020-02-03 | Derivados de desoxicitidina ou uridina para usar em terapias de cancro |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11963973B2 (pt) |
| EP (2) | EP3917538B1 (pt) |
| JP (2) | JP7314289B2 (pt) |
| KR (2) | KR102653041B1 (pt) |
| CN (2) | CN113543789B (pt) |
| AU (2) | AU2020215801B2 (pt) |
| BR (1) | BR112021014898A2 (pt) |
| CA (1) | CA3126512A1 (pt) |
| DK (1) | DK3917538T3 (pt) |
| ES (1) | ES2956508T3 (pt) |
| FI (1) | FI3917538T3 (pt) |
| GB (1) | GB2580963B (pt) |
| HR (1) | HRP20230823T1 (pt) |
| HU (1) | HUE062708T2 (pt) |
| IL (2) | IL313546A (pt) |
| LT (1) | LT3917538T (pt) |
| MX (2) | MX2021009206A (pt) |
| NZ (1) | NZ777925A (pt) |
| PL (1) | PL3917538T3 (pt) |
| PT (1) | PT3917538T (pt) |
| RS (1) | RS64515B1 (pt) |
| SG (1) | SG11202107281XA (pt) |
| SI (1) | SI3917538T1 (pt) |
| WO (1) | WO2020157335A1 (pt) |
| ZA (1) | ZA202106190B (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023068404A1 (ko) * | 2021-10-21 | 2023-04-27 | 한국생명공학연구원 | Eml4-alk 양성 비소세포폐암 환자의 치료 약물 선택을 위한 정보 제공 방법 및 alk 저해제 내성 비소세포폐암 치료용 조성물 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE114949C (pt) | ||||
| DD114949A1 (pt) | 1974-09-23 | 1975-09-05 | ||
| US4148889A (en) | 1976-12-08 | 1979-04-10 | Canadian Patents And Development Limited | Treatment of viral infections |
| US5545629A (en) * | 1994-04-12 | 1996-08-13 | Montefiore Medical Center | 5-ethoxy-2'-deoxyuridines |
| WO1996026743A1 (en) | 1995-03-01 | 1996-09-06 | Human Gene Therapy Research Institute | Radiation enhanced gene therapy for treatment of tumors |
| CN1205640A (zh) * | 1995-12-22 | 1999-01-20 | 东卡罗来纳大学 | 治疗以胞苷脱氨酶或脱氧胞苷脱氨酶过量表达为特征的失调的方法 |
| JPH11513992A (ja) | 1995-12-22 | 1999-11-30 | イースト・カロライナ・ユニバーシティ | シチジンデアミナーゼまたはデオキシシチジンデアミナーゼの過剰発現を伴う疾患を治療するための薬剤および方法 |
| ATE339960T1 (de) | 1999-03-01 | 2006-10-15 | Halogenetics Inc | Verwendung von zusammensetzungen enthaltend cldc als strahlungssensibilisatoren in der behandlung von neoplastischen erkrankungen |
| WO2001014345A1 (en) | 1999-08-20 | 2001-03-01 | The Research Foundation Of State University Of New York | 5-propynylpyrimidine derivatives as cytotoxic enzyme inhibitors |
| WO2008085611A2 (en) | 2006-11-27 | 2008-07-17 | University Of Miami | Designer theraphy of pancreatic tumors |
| LT5708B (en) | 2009-04-02 | 2011-01-25 | Biotechnologijos Inst | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
| US8617540B2 (en) * | 2009-04-15 | 2013-12-31 | Fox Chase Cancer Center | Combinational chemotherapy treatment |
| CN102191233B (zh) | 2010-03-04 | 2014-06-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 新颖的10-23脱氧核酶类似物及其用途 |
| US20110230433A1 (en) * | 2010-03-16 | 2011-09-22 | University Of Washington | Compositions and methods for treatment of cancer |
| KR101715981B1 (ko) | 2010-03-31 | 2017-03-13 | 길리애드 파마셋 엘엘씨 | 뉴클레오사이드 포스포르아미데이트 |
| JP2013230985A (ja) | 2010-08-20 | 2013-11-14 | Osaka Univ | ５−ホルミル核酸の生成方法 |
| US20130237697A1 (en) | 2010-11-12 | 2013-09-12 | Ludwig-Maximilians-Universitat Munchen | Building blocks and methods for the synthesis of 5-hydroxymethylcytosine-containing nucleic acids |
| CN102125579B (zh) * | 2010-12-22 | 2013-12-11 | 中国科学院广州生物医药与健康研究院 | 5位修饰的2’脱氧胞苷衍生物或其磷酸盐在制药中的新应用 |
| EP3492109B1 (en) | 2011-10-03 | 2020-03-04 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| US8949307B2 (en) | 2011-11-15 | 2015-02-03 | Google Inc. | Cloud-to-device messaging for application activation and reporting |
| WO2014194250A2 (en) | 2013-05-31 | 2014-12-04 | University Of Cincinnati | Novel nanocarrier delivered cancer chemotherapeutic agents |
| WO2015142867A1 (en) | 2014-03-18 | 2015-09-24 | Stc.Unm | Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells |
| CN104592333B (zh) | 2014-07-23 | 2017-06-27 | 江西科技师范大学 | 一种合成5‑羧基‑2’‑脱氧胞苷的方法 |
| CZ309218B6 (cs) | 2014-08-26 | 2022-06-01 | Univerzita Palackého v Olomouci | Způsob stanovení aktivity enzymů přeměňujících cytosinové deriváty na uracilové deriváty v buňkách a tkáních |
| DE102014113936A1 (de) * | 2014-09-25 | 2016-03-31 | Christoph Pallua | Krebsmedikament |
| EP3429634A1 (en) * | 2016-04-15 | 2019-01-23 | Cellectis | A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression |
| WO2018085156A1 (en) | 2016-11-04 | 2018-05-11 | Intelligent Bio-Systems, Inc. | Thiol-containing cleave reagents and oxidative wash |
| GB201913030D0 (en) | 2019-09-10 | 2019-10-23 | Francis Crick Institute Ltd | Treatment of hr deficient cancer |
-
2019
- 2019-02-01 GB GB1901427.3A patent/GB2580963B/en active Active
-
2020
- 2020-02-03 NZ NZ777925A patent/NZ777925A/en unknown
- 2020-02-03 WO PCT/EP2020/052632 patent/WO2020157335A1/en unknown
- 2020-02-03 CN CN202080011688.7A patent/CN113543789B/zh active Active
- 2020-02-03 HU HUE20703447A patent/HUE062708T2/hu unknown
- 2020-02-03 CN CN202410273651.1A patent/CN118078850A/zh active Pending
- 2020-02-03 HR HRP20230823TT patent/HRP20230823T1/hr unknown
- 2020-02-03 PT PT207034471T patent/PT3917538T/pt unknown
- 2020-02-03 PL PL20703447.1T patent/PL3917538T3/pl unknown
- 2020-02-03 US US17/427,542 patent/US11963973B2/en active Active
- 2020-02-03 AU AU2020215801A patent/AU2020215801B2/en active Active
- 2020-02-03 DK DK20703447.1T patent/DK3917538T3/da active
- 2020-02-03 IL IL313546A patent/IL313546A/en unknown
- 2020-02-03 FI FIEP20703447.1T patent/FI3917538T3/fi active
- 2020-02-03 JP JP2021544852A patent/JP7314289B2/ja active Active
- 2020-02-03 ES ES20703447T patent/ES2956508T3/es active Active
- 2020-02-03 IL IL285207A patent/IL285207B1/en unknown
- 2020-02-03 LT LTEPPCT/EP2020/052632T patent/LT3917538T/lt unknown
- 2020-02-03 BR BR112021014898-1A patent/BR112021014898A2/pt unknown
- 2020-02-03 KR KR1020217027066A patent/KR102653041B1/ko active IP Right Grant
- 2020-02-03 SI SI202030240T patent/SI3917538T1/sl unknown
- 2020-02-03 MX MX2021009206A patent/MX2021009206A/es unknown
- 2020-02-03 CA CA3126512A patent/CA3126512A1/en active Pending
- 2020-02-03 KR KR1020247010119A patent/KR20240046612A/ko active Search and Examination
- 2020-02-03 EP EP20703447.1A patent/EP3917538B1/en active Active
- 2020-02-03 EP EP23174101.8A patent/EP4233879A1/en active Pending
- 2020-02-03 SG SG11202107281XA patent/SG11202107281XA/en unknown
- 2020-02-03 RS RS20230588A patent/RS64515B1/sr unknown
-
2021
- 2021-07-29 MX MX2024002409A patent/MX2024002409A/es unknown
- 2021-08-26 ZA ZA2021/06190A patent/ZA202106190B/en unknown
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2023
- 2023-07-11 JP JP2023113931A patent/JP2023153793A/ja active Pending
- 2023-08-02 AU AU2023210586A patent/AU2023210586A1/en active Pending
-
2024
- 2024-03-12 US US18/602,969 patent/US20240216415A1/en active Pending
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