PT3620176T - Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico - Google Patents

Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico

Info

Publication number
PT3620176T
PT3620176T PT192059806T PT19205980T PT3620176T PT 3620176 T PT3620176 T PT 3620176T PT 192059806 T PT192059806 T PT 192059806T PT 19205980 T PT19205980 T PT 19205980T PT 3620176 T PT3620176 T PT 3620176T
Authority
PT
Portugal
Prior art keywords
anticholinergic
corticosteroid
adrenergic
beta
preparing
Prior art date
Application number
PT192059806T
Other languages
English (en)
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54548062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3620176(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of PT3620176T publication Critical patent/PT3620176T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PT192059806T 2015-11-16 2016-11-14 Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico PT3620176T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15194660 2015-11-16

Publications (1)

Publication Number Publication Date
PT3620176T true PT3620176T (pt) 2021-09-28

Family

ID=54548062

Family Applications (3)

Application Number Title Priority Date Filing Date
PT192059806T PT3620176T (pt) 2015-11-16 2016-11-14 Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico
PT192059368T PT3628331T (pt) 2015-11-16 2016-11-14 Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico
PT168019826T PT3377108T (pt) 2015-11-16 2016-11-14 Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT192059368T PT3628331T (pt) 2015-11-16 2016-11-14 Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico
PT168019826T PT3377108T (pt) 2015-11-16 2016-11-14 Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico

Country Status (36)

Country Link
US (4) US10086004B2 (pt)
EP (3) EP3628331B1 (pt)
JP (1) JP6963548B2 (pt)
KR (1) KR20180082443A (pt)
CN (1) CN108289962B (pt)
AR (1) AR106688A1 (pt)
AU (1) AU2016356858B2 (pt)
CA (1) CA3005290A1 (pt)
CL (1) CL2018001298A1 (pt)
CO (1) CO2018005141A2 (pt)
CY (3) CY1123042T1 (pt)
DK (3) DK3620176T3 (pt)
EA (1) EA037716B1 (pt)
ES (3) ES2895687T3 (pt)
GE (1) GEP20207157B (pt)
HR (3) HRP20211598T1 (pt)
HU (3) HUE056441T2 (pt)
IL (1) IL259329B (pt)
LT (3) LT3620176T (pt)
MA (3) MA50487B1 (pt)
MD (3) MD3377108T2 (pt)
ME (1) ME03778B (pt)
MX (1) MX2018005977A (pt)
MY (1) MY186229A (pt)
PE (1) PE20181488A1 (pt)
PH (1) PH12018501022A1 (pt)
PL (3) PL3628331T3 (pt)
PT (3) PT3620176T (pt)
RS (3) RS62404B1 (pt)
SA (1) SA518391570B1 (pt)
SG (2) SG11201804050QA (pt)
SI (3) SI3377108T1 (pt)
TW (1) TWI731891B (pt)
UA (1) UA125019C2 (pt)
WO (1) WO2017085004A1 (pt)
ZA (1) ZA201803168B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3060020A1 (en) * 2017-05-11 2018-11-15 Chiesi Farmaceutici S.P.A. A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
CN110612095A (zh) * 2017-05-11 2019-12-24 奇斯药制品公司 制备包含抗胆碱能药、皮质类固醇和β-肾上腺素能药的干粉制剂的方法
US11433063B1 (en) 2019-03-12 2022-09-06 Belhaven Biopharma, Inc. Intranasal composition of pharmaceutical countermeasures for chemical warfare nerve agents and accidental exposure to organophosphate pesticides
WO2020198716A1 (en) * 2019-03-27 2020-10-01 Kemin Industries, Inc. Methods for preparing metal carboxylates in one-pot reaction
CN112137957B (zh) * 2019-06-26 2022-07-29 长风药业股份有限公司 一种药用吸入气雾剂及其制备方法
WO2021143785A1 (zh) * 2020-01-15 2021-07-22 四川海思科制药有限公司 一种含茚达特罗的吸入气雾剂药物组合物及其制备方法
WO2022045995A1 (en) * 2020-08-28 2022-03-03 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi A process for the preparation of dry powder compositions for inhalation
US20220304894A1 (en) * 2021-03-24 2022-09-29 Cmpd Licensing, Llc Drug powderization within vials
WO2023117967A1 (en) 2021-12-21 2023-06-29 Chiesi Farmaceutici S.P.A. Dry powder formulations filled in an inhaler with improved resistance to humidity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011227A1 (es) * 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
DE60239639D1 (de) 2002-07-31 2011-05-12 Chiesi Farma Spa Pulverinhalator
EA021917B1 (ru) * 2009-12-23 2015-09-30 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Комбинированная терапия астмы и copd
PL2928889T3 (pl) * 2012-12-06 2018-09-28 Chiesi Farmaceutici S.P.A. Związki wykazujące aktywność antagonisty receptorów muskarynowych i aktywność agonisty receptorów beta-2 adrenergicznych
RU2661877C2 (ru) * 2012-12-06 2018-07-20 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Соединения, обладающие активностью антагонистов мускариновых рецепторов и агонистов бета-2-адренергических рецепторов
US9393202B2 (en) 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound
HUE053957T2 (hu) * 2013-07-11 2021-08-30 Chiesi Farm Spa Antikolinerg, kortikoszteroid és béta-adrenerg anyagot tartalmazó száraz porkészítmény inhalálással történõ beadásra

Also Published As

Publication number Publication date
LT3628331T (lt) 2021-11-10
AR106688A1 (es) 2018-02-07
EP3628331B1 (en) 2021-08-11
MA43256A (fr) 2018-09-26
EP3620176A1 (en) 2020-03-11
CL2018001298A1 (es) 2018-09-14
MA43256B1 (fr) 2020-05-29
ES2895687T3 (es) 2022-02-22
RS62506B1 (sr) 2021-11-30
HUE049751T2 (hu) 2020-10-28
DK3620176T3 (da) 2021-09-20
ES2783855T3 (es) 2020-09-18
DK3377108T3 (da) 2020-04-20
MA50488A (fr) 2021-05-19
HUE056260T2 (hu) 2022-02-28
DK3628331T3 (da) 2021-09-27
LT3620176T (lt) 2021-11-10
MD3620176T2 (ro) 2021-12-31
ES2891073T3 (es) 2022-01-26
ZA201803168B (en) 2019-07-31
SI3377108T1 (sl) 2020-05-29
MA50487A (fr) 2021-04-28
ME03778B (me) 2021-04-20
CA3005290A1 (en) 2017-05-26
MX2018005977A (es) 2018-08-29
EA037716B1 (ru) 2021-05-13
MA50488B1 (fr) 2021-09-30
US10086004B2 (en) 2018-10-02
SG11201804050QA (en) 2018-06-28
US11628175B2 (en) 2023-04-18
PL3377108T3 (pl) 2020-09-07
AU2016356858B2 (en) 2021-06-24
HUE056441T2 (hu) 2022-02-28
PH12018501022B1 (en) 2018-12-17
KR20180082443A (ko) 2018-07-18
BR112018009807A2 (pt) 2018-11-06
UA125019C2 (uk) 2021-12-29
PH12018501022A1 (en) 2018-12-17
MA50487B1 (fr) 2021-09-30
RS60171B1 (sr) 2020-05-29
HRP20211600T1 (hr) 2022-01-21
CN108289962A (zh) 2018-07-17
CY1123042T1 (el) 2021-10-29
JP6963548B2 (ja) 2021-11-10
GEP20207157B (en) 2020-10-12
EA201890966A1 (ru) 2018-11-30
EP3620176B1 (en) 2021-08-11
SA518391570B1 (ar) 2022-03-27
US10772896B2 (en) 2020-09-15
TWI731891B (zh) 2021-07-01
EP3377108B1 (en) 2020-02-19
JP2019501876A (ja) 2019-01-24
US20210177866A1 (en) 2021-06-17
CY1124490T1 (el) 2022-07-22
PL3620176T3 (pl) 2021-11-22
AU2016356858A1 (en) 2018-05-31
EP3628331A1 (en) 2020-04-01
HRP20211598T1 (hr) 2022-01-07
PT3628331T (pt) 2021-10-20
US20170136035A1 (en) 2017-05-18
SG10201912093YA (en) 2020-02-27
CO2018005141A2 (es) 2018-09-28
IL259329A (en) 2018-07-31
EP3377108A1 (en) 2018-09-26
SI3620176T1 (sl) 2021-11-30
MD3628331T2 (ro) 2021-12-31
HRP20200537T1 (hr) 2020-06-26
US10966991B2 (en) 2021-04-06
RS62404B1 (sr) 2021-10-29
LT3377108T (lt) 2020-07-10
PE20181488A1 (es) 2018-09-18
PL3628331T3 (pl) 2021-11-08
WO2017085004A1 (en) 2017-05-26
MY186229A (en) 2021-06-30
MD3377108T2 (ro) 2020-07-31
IL259329B (en) 2020-10-29
CN108289962B (zh) 2021-09-14
US20180360849A1 (en) 2018-12-20
BR112018009807A8 (pt) 2019-02-26
US20200368252A1 (en) 2020-11-26
PT3377108T (pt) 2020-04-08
TW201722404A (zh) 2017-07-01
SI3628331T1 (sl) 2021-11-30
CY1124475T1 (el) 2022-07-22

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