SG11201804050QA - A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic - Google Patents

A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic

Info

Publication number
SG11201804050QA
SG11201804050QA SG11201804050QA SG11201804050QA SG11201804050QA SG 11201804050Q A SG11201804050Q A SG 11201804050QA SG 11201804050Q A SG11201804050Q A SG 11201804050QA SG 11201804050Q A SG11201804050Q A SG 11201804050QA SG 11201804050Q A SG11201804050Q A SG 11201804050QA
Authority
SG
Singapore
Prior art keywords
international
parma
corticosteroid
dry powder
pct
Prior art date
Application number
SG11201804050QA
Inventor
Claudio Cafiero
Leonardo Ortenzi
Francesca Schiaretti
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54548062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201804050Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of SG11201804050QA publication Critical patent/SG11201804050QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 1111111111111101110111111111110101111100111111H1111111111111111111111111111110111111 (43) International Publication Date 26 May 2017 (26.05.2017) (10) International Publication Number WO 2017/085004 Al WIPO I PCT (51) International Patent Classification: A61K 9/14 (2006.01) A61K 31/00 (2006.01) A61K 47/12 (2006.01) A61K 9/00 (2006.01) A61K 47/26 (2006.01) (21) International Application Number: PCT/EP2016/077558 (22) International Filing Date: 14 November 2016 (14.11.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15194660.5 16 November 2015 (16.11.2015) EP (71) Applicant: CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A, 43122 Parma (IT). (72) Inventors: CAFIERO, Claudio; c/o CHIESI FARMA- CEUTICI S.p.A., Via Palermo, 26/A, 43122 Parma (IT). ORTENZI, Leonardo; c/o CHIESI FARMACEUTICI S.p.A., Via Palermo, 26/A, 43122 Parma (IT). SCHIAR- ETTI, Francesca; c/o CHIESI FARMACEUTICI S.p.A., Via Palermo, 26/A, 43122 Parma (IT). (74) Agent: MINOJA, Fabrizio; Bianchetti Bracco Minoja S.r.1., Via Plinio, 63, 20129 Milano (IT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 17 /085 00 4 Al (54) Title: A PROCESS FOR PREPARING A DRY POWDER FORMULATION COMPRISING AN ANTICHOLINERGIC, A CORTICOSTEROID AND A BETA-ADRENERGIC (57) : The invention relates to a dry powder formulation for inhalation comprising a combination of an anti-cholinergic, a long-acting beta 2 -adrenoceptor agonist, and a corticosteroid, and to a process for preparation thereof.
SG11201804050QA 2015-11-16 2016-11-14 A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic SG11201804050QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15194660 2015-11-16
PCT/EP2016/077558 WO2017085004A1 (en) 2015-11-16 2016-11-14 A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic

Publications (1)

Publication Number Publication Date
SG11201804050QA true SG11201804050QA (en) 2018-06-28

Family

ID=54548062

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201804050QA SG11201804050QA (en) 2015-11-16 2016-11-14 A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
SG10201912093YA SG10201912093YA (en) 2015-11-16 2016-11-14 A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201912093YA SG10201912093YA (en) 2015-11-16 2016-11-14 A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic

Country Status (36)

Country Link
US (4) US10086004B2 (en)
EP (3) EP3628331B1 (en)
JP (1) JP6963548B2 (en)
KR (1) KR20180082443A (en)
CN (1) CN108289962B (en)
AR (1) AR106688A1 (en)
AU (1) AU2016356858B2 (en)
CA (1) CA3005290A1 (en)
CL (1) CL2018001298A1 (en)
CO (1) CO2018005141A2 (en)
CY (3) CY1123042T1 (en)
DK (3) DK3620176T3 (en)
EA (1) EA037716B1 (en)
ES (3) ES2895687T3 (en)
GE (1) GEP20207157B (en)
HR (3) HRP20211598T1 (en)
HU (3) HUE056441T2 (en)
IL (1) IL259329B (en)
LT (3) LT3620176T (en)
MA (3) MA50487B1 (en)
MD (3) MD3377108T2 (en)
ME (1) ME03778B (en)
MX (1) MX2018005977A (en)
MY (1) MY186229A (en)
PE (1) PE20181488A1 (en)
PH (1) PH12018501022A1 (en)
PL (3) PL3628331T3 (en)
PT (3) PT3620176T (en)
RS (3) RS62404B1 (en)
SA (1) SA518391570B1 (en)
SG (2) SG11201804050QA (en)
SI (3) SI3377108T1 (en)
TW (1) TWI731891B (en)
UA (1) UA125019C2 (en)
WO (1) WO2017085004A1 (en)
ZA (1) ZA201803168B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3060020A1 (en) * 2017-05-11 2018-11-15 Chiesi Farmaceutici S.P.A. A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
CN110612095A (en) * 2017-05-11 2019-12-24 奇斯药制品公司 Method for preparing dry powder formulations comprising anticholinergics, corticosteroids and beta-adrenergic agents
US11433063B1 (en) 2019-03-12 2022-09-06 Belhaven Biopharma, Inc. Intranasal composition of pharmaceutical countermeasures for chemical warfare nerve agents and accidental exposure to organophosphate pesticides
WO2020198716A1 (en) * 2019-03-27 2020-10-01 Kemin Industries, Inc. Methods for preparing metal carboxylates in one-pot reaction
CN112137957B (en) * 2019-06-26 2022-07-29 长风药业股份有限公司 Medicinal inhalation aerosol and preparation method thereof
WO2021143785A1 (en) * 2020-01-15 2021-07-22 四川海思科制药有限公司 Pharmaceutical composition of aerosol inhalant containing indacaterol and preparation method thereof
WO2022045995A1 (en) * 2020-08-28 2022-03-03 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi A process for the preparation of dry powder compositions for inhalation
US20220304894A1 (en) * 2021-03-24 2022-09-29 Cmpd Licensing, Llc Drug powderization within vials
WO2023117967A1 (en) 2021-12-21 2023-06-29 Chiesi Farmaceutici S.P.A. Dry powder formulations filled in an inhaler with improved resistance to humidity

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
PE20011227A1 (en) * 2000-04-17 2002-01-07 Chiesi Farma Spa PHARMACEUTICAL FORMULATIONS FOR DRY POWDER INHALERS IN THE FORM OF HARD AGGLOMERATES
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
DE60239639D1 (en) 2002-07-31 2011-05-12 Chiesi Farma Spa powder inhaler
EA021917B1 (en) * 2009-12-23 2015-09-30 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Combination therapy for asthma and copd
PL2928889T3 (en) * 2012-12-06 2018-09-28 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
RU2661877C2 (en) * 2012-12-06 2018-07-20 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Compounds having muscarinic receptor antagonist and beta-2-adrenergic receptor agonist activity
US9393202B2 (en) 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound
HUE053957T2 (en) * 2013-07-11 2021-08-30 Chiesi Farm Spa Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation

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LT3628331T (en) 2021-11-10
AR106688A1 (en) 2018-02-07
EP3628331B1 (en) 2021-08-11
MA43256A (en) 2018-09-26
EP3620176A1 (en) 2020-03-11
CL2018001298A1 (en) 2018-09-14
MA43256B1 (en) 2020-05-29
ES2895687T3 (en) 2022-02-22
RS62506B1 (en) 2021-11-30
PT3620176T (en) 2021-09-28
HUE049751T2 (en) 2020-10-28
DK3620176T3 (en) 2021-09-20
ES2783855T3 (en) 2020-09-18
DK3377108T3 (en) 2020-04-20
MA50488A (en) 2021-05-19
HUE056260T2 (en) 2022-02-28
DK3628331T3 (en) 2021-09-27
LT3620176T (en) 2021-11-10
MD3620176T2 (en) 2021-12-31
ES2891073T3 (en) 2022-01-26
ZA201803168B (en) 2019-07-31
SI3377108T1 (en) 2020-05-29
MA50487A (en) 2021-04-28
ME03778B (en) 2021-04-20
CA3005290A1 (en) 2017-05-26
MX2018005977A (en) 2018-08-29
EA037716B1 (en) 2021-05-13
MA50488B1 (en) 2021-09-30
US10086004B2 (en) 2018-10-02
US11628175B2 (en) 2023-04-18
PL3377108T3 (en) 2020-09-07
AU2016356858B2 (en) 2021-06-24
HUE056441T2 (en) 2022-02-28
PH12018501022B1 (en) 2018-12-17
KR20180082443A (en) 2018-07-18
BR112018009807A2 (en) 2018-11-06
UA125019C2 (en) 2021-12-29
PH12018501022A1 (en) 2018-12-17
MA50487B1 (en) 2021-09-30
RS60171B1 (en) 2020-05-29
HRP20211600T1 (en) 2022-01-21
CN108289962A (en) 2018-07-17
CY1123042T1 (en) 2021-10-29
JP6963548B2 (en) 2021-11-10
GEP20207157B (en) 2020-10-12
EA201890966A1 (en) 2018-11-30
EP3620176B1 (en) 2021-08-11
SA518391570B1 (en) 2022-03-27
US10772896B2 (en) 2020-09-15
TWI731891B (en) 2021-07-01
EP3377108B1 (en) 2020-02-19
JP2019501876A (en) 2019-01-24
US20210177866A1 (en) 2021-06-17
CY1124490T1 (en) 2022-07-22
PL3620176T3 (en) 2021-11-22
AU2016356858A1 (en) 2018-05-31
EP3628331A1 (en) 2020-04-01
HRP20211598T1 (en) 2022-01-07
PT3628331T (en) 2021-10-20
US20170136035A1 (en) 2017-05-18
SG10201912093YA (en) 2020-02-27
CO2018005141A2 (en) 2018-09-28
IL259329A (en) 2018-07-31
EP3377108A1 (en) 2018-09-26
SI3620176T1 (en) 2021-11-30
MD3628331T2 (en) 2021-12-31
HRP20200537T1 (en) 2020-06-26
US10966991B2 (en) 2021-04-06
RS62404B1 (en) 2021-10-29
LT3377108T (en) 2020-07-10
PE20181488A1 (en) 2018-09-18
PL3628331T3 (en) 2021-11-08
WO2017085004A1 (en) 2017-05-26
MY186229A (en) 2021-06-30
MD3377108T2 (en) 2020-07-31
IL259329B (en) 2020-10-29
CN108289962B (en) 2021-09-14
US20180360849A1 (en) 2018-12-20
BR112018009807A8 (en) 2019-02-26
US20200368252A1 (en) 2020-11-26
PT3377108T (en) 2020-04-08
TW201722404A (en) 2017-07-01
SI3628331T1 (en) 2021-11-30
CY1124475T1 (en) 2022-07-22

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