PT3455213T - Método para purificar compostos canabinoides através de cromatografia em leito móvel simulado - Google Patents
Método para purificar compostos canabinoides através de cromatografia em leito móvel simuladoInfo
- Publication number
- PT3455213T PT3455213T PT167288414T PT16728841T PT3455213T PT 3455213 T PT3455213 T PT 3455213T PT 167288414 T PT167288414 T PT 167288414T PT 16728841 T PT16728841 T PT 16728841T PT 3455213 T PT3455213 T PT 3455213T
- Authority
- PT
- Portugal
- Prior art keywords
- cannabinoid compounds
- purifying
- purifying cannabinoid
- compounds
- cannabinoid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/185—Simulated moving beds characterized by the components to be separated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
- B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
- B01D2215/023—Simulated moving beds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2016/060905 WO2017194173A1 (en) | 2016-05-13 | 2016-05-13 | Method for purifying cannabinoid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3455213T true PT3455213T (pt) | 2022-03-01 |
Family
ID=56121022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT167288414T PT3455213T (pt) | 2016-05-13 | 2016-05-13 | Método para purificar compostos canabinoides através de cromatografia em leito móvel simulado |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10647691B2 (pt) |
| EP (1) | EP3455213B1 (pt) |
| CN (1) | CN109153661B (pt) |
| CA (1) | CA3023760C (pt) |
| DK (1) | DK3455213T3 (pt) |
| ES (1) | ES2907623T3 (pt) |
| PL (1) | PL3455213T3 (pt) |
| PT (1) | PT3455213T (pt) |
| WO (1) | WO2017194173A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| US11213558B2 (en) | 2017-05-17 | 2022-01-04 | Orochem Technologies, Inc. | CBX extraction-isolation process |
| US10189762B1 (en) | 2017-07-07 | 2019-01-29 | Orochem Technologies, Inc. | Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves |
| WO2019152736A1 (en) | 2018-01-31 | 2019-08-08 | Canopy Holdings, LLC | Hemp powder |
| US11851415B2 (en) * | 2018-03-07 | 2023-12-26 | Cleen Technology Inc. | Continuous isolation of cannabidiol and cannabinoids and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol |
| US11192870B2 (en) | 2018-03-07 | 2021-12-07 | Socati Technologies—Oregon, Llc | Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol |
| GB2587918B (en) * | 2018-03-07 | 2023-10-11 | Cleen Tech Inc | Continuous isolation of cannabidiol |
| US11485700B2 (en) * | 2018-06-28 | 2022-11-01 | Symrise Ag | Synthesis of (+)-cannabinoids and their therapeutic effects |
| CA3073093A1 (en) | 2018-08-03 | 2020-02-06 | Biomass Oil Separation Solutions, Llc | Processes and apparatus for extraction of substances and enriched extracts from plant material |
| AU2019324126A1 (en) * | 2018-08-20 | 2021-04-08 | Bessor Pharma, Llc | Process for the production of cannabinoids |
| US11324718B2 (en) * | 2018-10-09 | 2022-05-10 | Sartorius Chromatography Equipment | Method for purifying cannabinoids |
| WO2020077153A1 (en) | 2018-10-10 | 2020-04-16 | Canopy Holdings, LLC | Synthesis of cannabigerol |
| US20200172503A1 (en) * | 2018-12-04 | 2020-06-04 | Orochem Technologies Inc. | Process for purifying tetrahydrocannabinol using a chromatographic stationary phase |
| US10413845B1 (en) | 2018-12-14 | 2019-09-17 | Socati Technologies | Processes for solvent extraction of cannabinoids, terpenes and flavonoids from biomass |
| CN109734591A (zh) * | 2018-12-26 | 2019-05-10 | 江苏暨明医药科技有限公司 | 一种大麻二酚中间体及其制备方法与及应用 |
| JP2022531807A (ja) * | 2019-05-10 | 2022-07-11 | ベヌビア・マニュファクチャリング・エル・エル・シー | カンナビジオール又はカンナビジバリンの製造方法及びカンナビジオール又はカンナビジバリンの製造中間体 |
| CN111943813B (zh) * | 2019-05-17 | 2023-04-14 | 上海特化医药科技有限公司 | 大麻二酚类化合物的制备方法 |
| KR20220012298A (ko) * | 2019-05-23 | 2022-02-03 | 카레 케미컬 테크놀로지스 인코포레이티드 | 촉매 칸나비노이드 공정 및 전구체 |
| CN110270134A (zh) * | 2019-05-31 | 2019-09-24 | 江苏哈工药机科技股份有限公司 | 一种高纯度cbd分离纯化装置及其分离纯化方法 |
| US10799546B1 (en) | 2019-07-26 | 2020-10-13 | Biomass Oil Separation Solutions, Llc | Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material |
| CN110724589B (zh) * | 2019-08-27 | 2023-01-10 | 桂林莱茵生物科技股份有限公司 | 一种制备大麻二酚联产大麻全谱油的方法 |
| US11542243B1 (en) | 2019-09-26 | 2023-01-03 | FusionFarms, LLC | Method of converting delta9-THC to delta10-THC and the purification of the delta10-THC by crystallization |
| CN110746275A (zh) * | 2019-11-08 | 2020-02-04 | 河南汉麻生物科技有限公司 | 一种利用连续色谱系统分离大麻二酚的方法 |
| CN113896616A (zh) * | 2020-07-06 | 2022-01-07 | 复旦大学 | 一种大麻二酚的制备方法 |
| CN114432187A (zh) * | 2020-11-03 | 2022-05-06 | 北京东方淼森生物科技有限公司 | 一种桃花油的制备方法及在化妆品中的应用 |
| WO2022125966A1 (en) * | 2020-12-10 | 2022-06-16 | Orochem Technologies Inc. | Process for removing thc from cannabinoids |
| CN112843788B (zh) * | 2021-01-19 | 2022-10-28 | 温州大学新材料与产业技术研究院 | 一种采用流动相独立环外置换的温度梯度模拟移动床装置及其分离方法 |
| CN113135885A (zh) * | 2021-04-07 | 2021-07-20 | 上海同田生物技术有限公司 | 一种高速逆流色谱分离纯化四氢次大麻酚的方法 |
| LU500093B1 (de) * | 2021-04-27 | 2022-10-31 | K D Pharma Bexbach Gmbh | Verfahren zum Trennen einer Stoffmischung |
| JP2024518338A (ja) * | 2021-04-27 | 2024-05-01 | カーデー・ファルマ・ベクスバッハ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 物質混合物を分離するための方法 |
| CN113683490B (zh) * | 2021-08-02 | 2022-03-25 | 云南翰谷生物科技有限公司 | 一种次大麻二酚晶体的制备方法 |
| CN115010690B (zh) * | 2022-06-06 | 2023-03-21 | 云南翰谷生物科技有限公司 | 一种高纯大麻酚晶体制备方法 |
| CN115385780B (zh) * | 2022-08-26 | 2024-02-27 | 晨光生物科技集团股份有限公司 | 一种次大麻二酚结晶多晶型物及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342971A (en) | 1992-12-29 | 1994-08-30 | The Australian National University | Process for the preparation of dibenzo[b,d]pyrans |
| WO2002045115A1 (en) | 2000-11-28 | 2002-06-06 | Orion Electric Co., Ltd. | Color plasma display panel with an improvement of color temperature and brightness |
| DE10106024B4 (de) | 2001-02-09 | 2004-10-14 | Thc Pharm Gmbh | Verfahren zur Herstellung von Dronabinol |
| GB0112752D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Synthesis of cannabinoids |
| GB0329635D0 (en) * | 2003-12-23 | 2004-01-28 | Johnson Matthey Plc | Process for purifying trans-tetrahydrocannabinol |
| EP1773801A1 (de) | 2004-07-19 | 2007-04-18 | Cilag Ltd. | Verfahren zur gewinnung von reinem tetrahydrocannabinol |
| TWI369203B (en) * | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol |
| DE102005028937B4 (de) | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| JP2009510078A (ja) | 2005-09-29 | 2009-03-12 | エーエムアール テクノロジー インコーポレイテッド | Δ−９−テトラヒドロカンナビノールの生成法 |
| GB0807915D0 (en) | 2008-05-01 | 2008-06-04 | Resolution Chemicals Ltd | Production of delta 9 tetrahydrocannabinol |
| DE102009019322A1 (de) | 2009-04-30 | 2010-11-11 | The Health Concept Gmbh | Verfahren zur Herstellung von Synthetischen Cannabinoiden |
| EP2760444B1 (de) | 2011-09-29 | 2020-04-22 | THC Pharm GmbH The Health Concept | Cannabinoidcarbonsäuren, salze von cannabinoidcarbonsäuren, deren herstellung und anwendungen |
| EP2842933B1 (de) | 2013-09-03 | 2015-07-29 | Symrise AG | Mischungen cannabinoider Verbindungen, deren Herstellung und Verwendung |
-
2016
- 2016-05-13 CA CA3023760A patent/CA3023760C/en active Active
- 2016-05-13 PT PT167288414T patent/PT3455213T/pt unknown
- 2016-05-13 WO PCT/EP2016/060905 patent/WO2017194173A1/en unknown
- 2016-05-13 ES ES16728841T patent/ES2907623T3/es active Active
- 2016-05-13 PL PL16728841T patent/PL3455213T3/pl unknown
- 2016-05-13 CN CN201680085631.5A patent/CN109153661B/zh active Active
- 2016-05-13 US US16/300,205 patent/US10647691B2/en active Active
- 2016-05-13 DK DK16728841.4T patent/DK3455213T3/da active
- 2016-05-13 EP EP16728841.4A patent/EP3455213B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017194173A1 (en) | 2017-11-16 |
| ES2907623T3 (es) | 2022-04-25 |
| CN109153661A (zh) | 2019-01-04 |
| EP3455213B1 (en) | 2021-11-24 |
| US10647691B2 (en) | 2020-05-12 |
| PL3455213T3 (pl) | 2022-04-04 |
| CN109153661B (zh) | 2023-01-17 |
| CA3023760C (en) | 2023-10-03 |
| EP3455213A1 (en) | 2019-03-20 |
| CA3023760A1 (en) | 2017-11-16 |
| DK3455213T3 (da) | 2022-03-07 |
| US20190144414A1 (en) | 2019-05-16 |
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