PT3148540T - PROCESSO PARA A PREPARAÇAÞO DE DEPSIPÉPTIDOS CIìCLICOS - Google Patents
PROCESSO PARA A PREPARAÇAÞO DE DEPSIPÉPTIDOS CIìCLICOSInfo
- Publication number
- PT3148540T PT3148540T PT158000067T PT15800006T PT3148540T PT 3148540 T PT3148540 T PT 3148540T PT 158000067 T PT158000067 T PT 158000067T PT 15800006 T PT15800006 T PT 15800006T PT 3148540 T PT3148540 T PT 3148540T
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- cyclic depsipeptides
- depsipeptides
- cyclic
- Prior art date
Links
- 108010002156 Depsipeptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003369P | 2014-05-27 | 2014-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3148540T true PT3148540T (pt) | 2020-03-31 |
Family
ID=54699686
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT191855790T PT3578179T (pt) | 2014-05-27 | 2015-05-27 | Processo para a preparação de depsipéptidos cíclicos |
| PT158000067T PT3148540T (pt) | 2014-05-27 | 2015-05-27 | PROCESSO PARA A PREPARAÇAÞO DE DEPSIPÉPTIDOS CIìCLICOS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT191855790T PT3578179T (pt) | 2014-05-27 | 2015-05-27 | Processo para a preparação de depsipéptidos cíclicos |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US10100089B2 (pt) |
| EP (2) | EP3578179B1 (pt) |
| JP (4) | JP6522120B2 (pt) |
| KR (3) | KR102368235B1 (pt) |
| CN (2) | CN106456613B (pt) |
| CA (1) | CA2950315C (pt) |
| DK (1) | DK3578179T3 (pt) |
| ES (1) | ES2866104T3 (pt) |
| HU (1) | HUE053677T2 (pt) |
| PL (1) | PL3578179T3 (pt) |
| PT (2) | PT3578179T (pt) |
| TW (3) | TWI775203B (pt) |
| WO (1) | WO2015183897A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456613B (zh) | 2014-05-27 | 2019-07-09 | 恩库勒公司 | 制备环缩肽的方法 |
| US11203602B2 (en) | 2016-05-20 | 2021-12-21 | Onkure, Inc. | Thioester prodrugs of macrocycles as inhibitors of histone deacetylases |
| CN109134511B (zh) * | 2017-06-16 | 2021-07-02 | 复旦大学 | C19位氟代的Largazole类似物、其制备方法和用途 |
| CN109134512B (zh) * | 2017-06-16 | 2021-07-02 | 复旦大学 | C-18位氟代的Laragzole类似物、其制备方法和制备抗肿瘤剂的用途 |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
| AU2021410630A1 (en) * | 2020-12-21 | 2023-08-03 | Cetya Therapeutics, Inc. | Synthesis of structural analogs of largazole and associated compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080003334A (ko) | 2005-03-11 | 2008-01-07 | 더 리젠트스 오브 더 유니버시티 오브 콜로라도 | 암 세포를 표피 성장 인자 억제제에 대해 감작화시키는히스톤 데아세틸라제 억제제 |
| US8759512B2 (en) | 2008-02-24 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Methods of preparation of macrocyclic compounds |
| WO2010009334A1 (en) | 2008-07-17 | 2010-01-21 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
| CN101781321B (zh) * | 2010-02-08 | 2012-12-26 | 中国科学院广州生物医药与健康研究院 | 拉格唑拉（Largazole）及其类似物的合成方法 |
| MX2012013507A (es) * | 2010-05-27 | 2013-03-12 | Univ Colorado Regents | Compuestos macrociclicos utiles como inhibidores de histonas desacetilasas. |
| CN102391359B (zh) | 2011-11-17 | 2014-07-16 | 南京优科生物医药研究有限公司 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
| WO2013148324A1 (en) * | 2012-03-26 | 2013-10-03 | The Regents Of The University Of California | Anti-cancer polyketide compounds |
| CN103232474A (zh) * | 2013-04-16 | 2013-08-07 | 中国药科大学 | 组蛋白去乙酰化酶抑制剂 |
| CN106456613B (zh) * | 2014-05-27 | 2019-07-09 | 恩库勒公司 | 制备环缩肽的方法 |
-
2015
- 2015-05-27 CN CN201580027121.8A patent/CN106456613B/zh active Active
- 2015-05-27 PT PT191855790T patent/PT3578179T/pt unknown
- 2015-05-27 EP EP19185579.0A patent/EP3578179B1/en active Active
- 2015-05-27 KR KR1020207014187A patent/KR102368235B1/ko active IP Right Grant
- 2015-05-27 PL PL19185579T patent/PL3578179T3/pl unknown
- 2015-05-27 JP JP2017514999A patent/JP6522120B2/ja active Active
- 2015-05-27 US US15/313,800 patent/US10100089B2/en active Active
- 2015-05-27 HU HUE19185579A patent/HUE053677T2/hu unknown
- 2015-05-27 EP EP15800006.7A patent/EP3148540B1/en active Active
- 2015-05-27 WO PCT/US2015/032590 patent/WO2015183897A1/en active Application Filing
- 2015-05-27 TW TW109138257A patent/TWI775203B/zh active
- 2015-05-27 CA CA2950315A patent/CA2950315C/en active Active
- 2015-05-27 ES ES19185579T patent/ES2866104T3/es active Active
- 2015-05-27 CN CN201910227308.2A patent/CN110156874B/zh active Active
- 2015-05-27 TW TW108116572A patent/TWI711627B/zh active
- 2015-05-27 KR KR1020167036444A patent/KR102366527B1/ko active IP Right Grant
- 2015-05-27 KR KR1020227005999A patent/KR102432263B1/ko active IP Right Grant
- 2015-05-27 PT PT158000067T patent/PT3148540T/pt unknown
- 2015-05-27 DK DK19185579.0T patent/DK3578179T3/da active
- 2015-05-27 TW TW104117108A patent/TWI683823B/zh active
-
2018
- 2018-09-11 US US16/127,399 patent/US10689419B2/en active Active
-
2019
- 2019-03-12 JP JP2019044425A patent/JP6892471B2/ja active Active
-
2020
- 2020-02-04 US US16/781,233 patent/US11053284B2/en active Active
-
2021
- 2021-01-15 JP JP2021004695A patent/JP7033677B2/ja active Active
- 2021-06-07 US US17/340,731 patent/US11739123B2/en active Active
-
2022
- 2022-02-28 JP JP2022029025A patent/JP7269398B2/ja active Active
-
2023
- 2023-07-14 US US18/222,170 patent/US20240116989A1/en active Pending
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