PT3055308T - Resumo - Google Patents

Resumo

Info

Publication number
PT3055308T
PT3055308T PT147811699T PT14781169T PT3055308T PT 3055308 T PT3055308 T PT 3055308T PT 147811699 T PT147811699 T PT 147811699T PT 14781169 T PT14781169 T PT 14781169T PT 3055308 T PT3055308 T PT 3055308T
Authority
PT
Portugal
Application number
PT147811699T
Other languages
English (en)
Portuguese (pt)
Inventor
Koerner Matthias
Knust Henner
Gobbi Luca
Muri Dieter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT3055308T publication Critical patent/PT3055308T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT147811699T 2013-10-08 2014-10-06 Resumo PT3055308T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13187764 2013-10-08

Publications (1)

Publication Number Publication Date
PT3055308T true PT3055308T (pt) 2018-01-18

Family

ID=49301396

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147811699T PT3055308T (pt) 2013-10-08 2014-10-06 Resumo

Country Status (32)

Country Link
US (2) US10004817B2 (OSRAM)
EP (1) EP3055308B1 (OSRAM)
JP (1) JP6194416B2 (OSRAM)
KR (1) KR101770531B1 (OSRAM)
CN (1) CN105358558B (OSRAM)
AR (1) AR097931A1 (OSRAM)
AU (1) AU2014333996B2 (OSRAM)
CA (1) CA2917191C (OSRAM)
CL (1) CL2016000728A1 (OSRAM)
CR (1) CR20150663A (OSRAM)
DK (1) DK3055308T3 (OSRAM)
EA (1) EA028483B1 (OSRAM)
ES (1) ES2657121T3 (OSRAM)
HR (1) HRP20180049T1 (OSRAM)
HU (1) HUE035413T2 (OSRAM)
IL (1) IL243249A0 (OSRAM)
LT (1) LT3055308T (OSRAM)
MA (1) MA38935B1 (OSRAM)
MX (1) MX373153B (OSRAM)
MY (1) MY190196A (OSRAM)
NO (1) NO3055308T3 (OSRAM)
PE (1) PE20160159A1 (OSRAM)
PH (1) PH12016500249A1 (OSRAM)
PL (1) PL3055308T3 (OSRAM)
PT (1) PT3055308T (OSRAM)
RS (1) RS56777B1 (OSRAM)
SG (1) SG11201602786UA (OSRAM)
SI (1) SI3055308T1 (OSRAM)
TW (1) TWI513698B (OSRAM)
UA (1) UA116164C2 (OSRAM)
WO (1) WO2015052105A1 (OSRAM)
ZA (1) ZA201509013B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2247558T (lt) 2008-02-14 2022-04-11 Eli Lilly And Company Nauji vizualizavimo agentai neurologinės disfunkcijos aptikimui
NO3055308T3 (OSRAM) 2013-10-08 2018-04-21
SI3143011T1 (sl) 2014-05-13 2021-08-31 F. Hoffmann-La Roche Ag Devterirane heterociklične spojine in njihova uporaba kot kontrastna sredstva
CA2973648C (en) 2015-02-02 2023-09-26 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
EP3118202A1 (en) 2015-07-15 2017-01-18 AC Immune S.A. Dihydropyridopyrrole derivatives as tau-pet-ligands
EP3322707A1 (en) 2015-07-15 2018-05-23 AC Immune SA Novel imaging compounds
JP7059270B2 (ja) * 2016-07-22 2022-04-25 エーシー・イミューン・エス・アー タウタンパク質凝集体を画像化するための化合物
IL264239B (en) * 2016-07-22 2022-08-01 Ac Immune Sa Compounds for imaging tau protein aggregates
WO2018024642A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
WO2018024643A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
CN109689653B (zh) * 2016-09-09 2022-04-12 豪夫迈·罗氏有限公司 用于制备2-(6-硝基吡啶-3-基)-9H-二吡啶并[2,3-b;3’,4’-d]吡咯的方法
JP7260552B2 (ja) * 2018-01-24 2023-04-18 エーシー・イミューン・エス・アー Pet画像化のための診断用組成物、診断用組成物を製造するための方法及び診断におけるその使用
US20210038747A1 (en) * 2018-01-24 2021-02-11 Ac Immune Sa Novel method of preparing an imaging compound
EP3743423A1 (en) 2018-01-24 2020-12-02 AC Immune SA Gamma-carboline compounds for the detection of tau aggregates
EP3743426A1 (en) 2018-01-24 2020-12-02 AC Immune SA Azacarboline compounds for the detection of tau aggregates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932557B2 (en) * 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
LT2247558T (lt) * 2008-02-14 2022-04-11 Eli Lilly And Company Nauji vizualizavimo agentai neurologinės disfunkcijos aptikimui
US20110124654A1 (en) 2008-06-11 2011-05-26 Huifen Chen Diazacarbazoles and methods of use
EP2323697A2 (en) * 2008-07-24 2011-05-25 Siemens Medical Solutions USA, Inc. Imaging agents useful for identifying ad pathology
US8691187B2 (en) * 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
EP2411057B1 (en) * 2009-03-23 2020-05-06 Eli Lilly and Company Imaging agents for detecting neurological disorders
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
US20150368244A1 (en) * 2011-01-31 2015-12-24 Genentech, Inc. Diazacarbazoles and methods of use
NO3055308T3 (OSRAM) * 2013-10-08 2018-04-21

Also Published As

Publication number Publication date
CR20150663A (es) 2016-01-27
CA2917191A1 (en) 2015-04-16
LT3055308T (lt) 2018-02-12
HUE035413T2 (en) 2018-05-02
MA38935A1 (fr) 2016-04-29
CA2917191C (en) 2021-08-10
AU2014333996B2 (en) 2018-03-15
CL2016000728A1 (es) 2016-11-11
PH12016500249B1 (en) 2016-05-16
MY190196A (en) 2022-04-04
EA201690515A1 (ru) 2016-07-29
EP3055308A1 (en) 2016-08-17
TW201520212A (zh) 2015-06-01
AR097931A1 (es) 2016-04-20
MA38935B1 (fr) 2016-12-30
UA116164C2 (uk) 2018-02-12
IL243249A0 (en) 2016-02-29
PH12016500249A1 (en) 2016-05-16
NO3055308T3 (OSRAM) 2018-04-21
NZ714831A (en) 2021-09-24
US11058781B2 (en) 2021-07-13
MX2016002234A (es) 2016-06-06
AU2014333996A1 (en) 2015-12-24
PL3055308T3 (pl) 2018-03-30
US20180326099A1 (en) 2018-11-15
ES2657121T3 (es) 2018-03-01
JP6194416B2 (ja) 2017-09-06
EP3055308B1 (en) 2017-11-22
SG11201602786UA (en) 2016-05-30
SI3055308T1 (en) 2018-03-30
US10004817B2 (en) 2018-06-26
MX373153B (es) 2020-04-21
JP2016534979A (ja) 2016-11-10
KR20160047552A (ko) 2016-05-02
WO2015052105A1 (en) 2015-04-16
RS56777B1 (sr) 2018-04-30
PE20160159A1 (es) 2016-03-18
EA028483B1 (ru) 2017-11-30
US20160220712A1 (en) 2016-08-04
CN105358558B (zh) 2017-09-26
CN105358558A (zh) 2016-02-24
DK3055308T3 (en) 2018-01-22
KR101770531B1 (ko) 2017-08-22
ZA201509013B (en) 2016-10-26
HK1215574A1 (zh) 2016-09-02
TWI513698B (zh) 2015-12-21
HRP20180049T1 (hr) 2018-02-09

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