LT3055308T - Diazakarbazolo dariniai kaip taupet ligandai - Google Patents

Diazakarbazolo dariniai kaip taupet ligandai

Info

Publication number
LT3055308T
LT3055308T LTEP14781169.9T LT14781169T LT3055308T LT 3055308 T LT3055308 T LT 3055308T LT 14781169 T LT14781169 T LT 14781169T LT 3055308 T LT3055308 T LT 3055308T
Authority
LT
Lithuania
Prior art keywords
tau
ligands
pet
diazacarbazole derivatives
diazacarbazole
Prior art date
Application number
LTEP14781169.9T
Other languages
English (en)
Inventor
Luca Gobbi
Henner Knust
Matthias Koerner
Dieter MURI
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of LT3055308T publication Critical patent/LT3055308T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP14781169.9T 2013-10-08 2014-10-06 Diazakarbazolo dariniai kaip taupet ligandai LT3055308T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13187764 2013-10-08
PCT/EP2014/071283 WO2015052105A1 (en) 2013-10-08 2014-10-06 Diazacarbazole derivatives as tau-pet-ligands

Publications (1)

Publication Number Publication Date
LT3055308T true LT3055308T (lt) 2018-02-12

Family

ID=49301396

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14781169.9T LT3055308T (lt) 2013-10-08 2014-10-06 Diazakarbazolo dariniai kaip taupet ligandai

Country Status (33)

Country Link
US (2) US10004817B2 (lt)
EP (1) EP3055308B1 (lt)
JP (1) JP6194416B2 (lt)
KR (1) KR101770531B1 (lt)
CN (1) CN105358558B (lt)
AR (1) AR097931A1 (lt)
AU (1) AU2014333996B2 (lt)
CA (1) CA2917191C (lt)
CL (1) CL2016000728A1 (lt)
CR (1) CR20150663A (lt)
DK (1) DK3055308T3 (lt)
EA (1) EA028483B1 (lt)
ES (1) ES2657121T3 (lt)
HK (1) HK1215574A1 (lt)
HR (1) HRP20180049T1 (lt)
HU (1) HUE035413T2 (lt)
IL (1) IL243249A0 (lt)
LT (1) LT3055308T (lt)
MA (1) MA38935B1 (lt)
MX (1) MX2016002234A (lt)
MY (1) MY190196A (lt)
NO (1) NO3055308T3 (lt)
PE (1) PE20160159A1 (lt)
PH (1) PH12016500249B1 (lt)
PL (1) PL3055308T3 (lt)
PT (1) PT3055308T (lt)
RS (1) RS56777B1 (lt)
SG (1) SG11201602786UA (lt)
SI (1) SI3055308T1 (lt)
TW (1) TWI513698B (lt)
UA (1) UA116164C2 (lt)
WO (1) WO2015052105A1 (lt)
ZA (1) ZA201509013B (lt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110046378A1 (en) 2008-02-14 2011-02-24 Siemens Medical Solutions Usa, Inc. Novel Imaging Agents for Detecting Neurological Dysfunction
AU2014333996B2 (en) 2013-10-08 2018-03-15 F. Hoffmann-La Roche Ag Diazacarbazole derivatives as tau-pet-ligands
SG11201609281UA (en) 2014-05-13 2016-12-29 Hoffmann La Roche Deuterated heterocyclic compounds and their use as imaging agents
MY191590A (en) * 2015-02-02 2022-06-30 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
EP3118202A1 (en) 2015-07-15 2017-01-18 AC Immune S.A. Dihydropyridopyrrole derivatives as tau-pet-ligands
WO2017009454A1 (en) 2015-07-15 2017-01-19 Ac Immune S.A. Novel imaging compounds
CN109475648B (zh) * 2016-07-22 2023-03-14 Ac免疫有限公司 用于成像tau蛋白聚集体的化合物
US10865207B2 (en) 2016-07-22 2020-12-15 Ac Immune S.A. Compounds for imaging Tau protein aggregates
WO2018024642A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
WO2018024643A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
SI3510031T1 (sl) * 2016-09-09 2021-03-31 F. Hoffmann-La Roche Ag Postopek za pripravo 2-(6-nitropiridin-3-il)-9H-dipirido(2,3-b;3',4'-d)pirola
AU2019212170B2 (en) * 2018-01-24 2022-12-22 Ac Immune Sa Novel method of preparing an imaging compound
US20210041447A1 (en) 2018-01-24 2021-02-11 Ac Immune Sa Azacarboline compounds for the detection of tau aggregates
EP3743423A1 (en) 2018-01-24 2020-12-02 AC Immune SA Gamma-carboline compounds for the detection of tau aggregates
MX2020007487A (es) * 2018-01-24 2020-09-14 Ac Immune Sa Composiciones de diagnostico para produccion de imagenes de tomografia por emision de positrones, metodo para fabricar la composicion de diagnostico y su uso en diagnostico.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932557B2 (en) * 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
US20110046378A1 (en) * 2008-02-14 2011-02-24 Siemens Medical Solutions Usa, Inc. Novel Imaging Agents for Detecting Neurological Dysfunction
BRPI0909957A2 (pt) 2008-06-11 2016-04-19 Genentech Inc "composto, composição farmacêutica, método de inibir o crescimento anormal de células ou de tratar um distúrbio hiperproliferativo em um mamífero, método de tratamento do câncer em um mamífero"
US8420052B2 (en) 2008-07-24 2013-04-16 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying AD pathology
CA2756137C (en) * 2009-03-23 2015-11-24 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological disorders
US8691187B2 (en) * 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
US20150368244A1 (en) * 2011-01-31 2015-12-24 Genentech, Inc. Diazacarbazoles and methods of use
AU2014333996B2 (en) 2013-10-08 2018-03-15 F. Hoffmann-La Roche Ag Diazacarbazole derivatives as tau-pet-ligands

Also Published As

Publication number Publication date
US20160220712A1 (en) 2016-08-04
HK1215574A1 (zh) 2016-09-02
CA2917191A1 (en) 2015-04-16
NZ714831A (en) 2021-09-24
US20180326099A1 (en) 2018-11-15
KR20160047552A (ko) 2016-05-02
MX2016002234A (es) 2016-06-06
TW201520212A (zh) 2015-06-01
RS56777B1 (sr) 2018-04-30
AU2014333996B2 (en) 2018-03-15
ZA201509013B (en) 2016-10-26
PH12016500249A1 (en) 2016-05-16
HUE035413T2 (en) 2018-05-02
KR101770531B1 (ko) 2017-08-22
WO2015052105A1 (en) 2015-04-16
US10004817B2 (en) 2018-06-26
CN105358558A (zh) 2016-02-24
HRP20180049T1 (hr) 2018-02-09
PH12016500249B1 (en) 2016-05-16
EP3055308B1 (en) 2017-11-22
EA201690515A1 (ru) 2016-07-29
CA2917191C (en) 2021-08-10
DK3055308T3 (en) 2018-01-22
AU2014333996A1 (en) 2015-12-24
IL243249A0 (en) 2016-02-29
CR20150663A (es) 2016-01-27
PE20160159A1 (es) 2016-03-18
CN105358558B (zh) 2017-09-26
CL2016000728A1 (es) 2016-11-11
SI3055308T1 (en) 2018-03-30
TWI513698B (zh) 2015-12-21
MY190196A (en) 2022-04-04
MA38935B1 (fr) 2016-12-30
ES2657121T3 (es) 2018-03-01
EA028483B1 (ru) 2017-11-30
JP2016534979A (ja) 2016-11-10
EP3055308A1 (en) 2016-08-17
AR097931A1 (es) 2016-04-20
UA116164C2 (uk) 2018-02-12
PL3055308T3 (pl) 2018-03-30
PT3055308T (pt) 2018-01-18
SG11201602786UA (en) 2016-05-30
JP6194416B2 (ja) 2017-09-06
NO3055308T3 (lt) 2018-04-21
MA38935A1 (fr) 2016-04-29
US11058781B2 (en) 2021-07-13

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