HK1215574A1 - 作為 -配體的二氮雜哢唑衍生物 - Google Patents
作為 -配體的二氮雜哢唑衍生物Info
- Publication number
- HK1215574A1 HK1215574A1 HK16103514.3A HK16103514A HK1215574A1 HK 1215574 A1 HK1215574 A1 HK 1215574A1 HK 16103514 A HK16103514 A HK 16103514A HK 1215574 A1 HK1215574 A1 HK 1215574A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tau
- pet
- ligands
- diazacarbazole derivatives
- diazacarbazole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13187764 | 2013-10-08 | ||
| PCT/EP2014/071283 WO2015052105A1 (en) | 2013-10-08 | 2014-10-06 | Diazacarbazole derivatives as tau-pet-ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1215574A1 true HK1215574A1 (zh) | 2016-09-02 |
Family
ID=49301396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16103514.3A HK1215574A1 (zh) | 2013-10-08 | 2016-03-24 | 作為 -配體的二氮雜哢唑衍生物 |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US10004817B2 (zh) |
| EP (1) | EP3055308B1 (zh) |
| JP (1) | JP6194416B2 (zh) |
| KR (1) | KR101770531B1 (zh) |
| CN (1) | CN105358558B (zh) |
| AR (1) | AR097931A1 (zh) |
| AU (1) | AU2014333996B2 (zh) |
| CA (1) | CA2917191C (zh) |
| CL (1) | CL2016000728A1 (zh) |
| CR (1) | CR20150663A (zh) |
| DK (1) | DK3055308T3 (zh) |
| EA (1) | EA028483B1 (zh) |
| ES (1) | ES2657121T3 (zh) |
| HK (1) | HK1215574A1 (zh) |
| HR (1) | HRP20180049T1 (zh) |
| HU (1) | HUE035413T2 (zh) |
| IL (1) | IL243249A0 (zh) |
| LT (1) | LT3055308T (zh) |
| MA (1) | MA38935B1 (zh) |
| MX (1) | MX2016002234A (zh) |
| MY (1) | MY190196A (zh) |
| NO (1) | NO3055308T3 (zh) |
| PE (1) | PE20160159A1 (zh) |
| PH (1) | PH12016500249A1 (zh) |
| PL (1) | PL3055308T3 (zh) |
| PT (1) | PT3055308T (zh) |
| RS (1) | RS56777B1 (zh) |
| SG (1) | SG11201602786UA (zh) |
| SI (1) | SI3055308T1 (zh) |
| TW (1) | TWI513698B (zh) |
| UA (1) | UA116164C2 (zh) |
| WO (1) | WO2015052105A1 (zh) |
| ZA (1) | ZA201509013B (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2247558T3 (pl) | 2008-02-14 | 2022-05-02 | Eli Lilly And Company | Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych |
| SI3055308T1 (en) | 2013-10-08 | 2018-03-30 | F. Hoffmann-La Roche Ag | Diazacarbazole derivatives in the form of tau-pet ligands |
| SI3143011T1 (sl) | 2014-05-13 | 2021-08-31 | F. Hoffmann-La Roche Ag | Devterirane heterociklične spojine in njihova uporaba kot kontrastna sredstva |
| MY191590A (en) * | 2015-02-02 | 2022-06-30 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
| EP3322707A1 (en) | 2015-07-15 | 2018-05-23 | AC Immune SA | Novel imaging compounds |
| EP3118202A1 (en) | 2015-07-15 | 2017-01-18 | AC Immune S.A. | Dihydropyridopyrrole derivatives as tau-pet-ligands |
| MY196981A (en) * | 2016-07-22 | 2023-05-16 | Ac Immune Sa | Compounds for imaging tau protein aggregates |
| US10865207B2 (en) | 2016-07-22 | 2020-12-15 | Ac Immune S.A. | Compounds for imaging Tau protein aggregates |
| WO2018024643A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
| WO2018024642A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
| JP6997769B2 (ja) * | 2016-09-09 | 2022-02-10 | エフ．ホフマン－ラ ロシュ アーゲー | ２－（６－ニトロピリジン－３－イル）－９Ｈ－ジピリド［２，３－ｂ；３’，４’－ｄ］ピロールの製造方法 |
| MX2020007487A (es) * | 2018-01-24 | 2020-09-14 | Ac Immune Sa | Composiciones de diagnostico para produccion de imagenes de tomografia por emision de positrones, metodo para fabricar la composicion de diagnostico y su uso en diagnostico. |
| US11306089B2 (en) | 2018-01-24 | 2022-04-19 | Life Molecular Imaging Limited | Gamma-carboline compounds for the detection of Tau aggregates |
| JP2021512064A (ja) * | 2018-01-24 | 2021-05-13 | エーシー・イミューン・エス・アー | 画像化化合物を調製する新規方法 |
| EP3743426A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Azacarboline compounds for the detection of tau aggregates |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932557B2 (en) * | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| PL2247558T3 (pl) * | 2008-02-14 | 2022-05-02 | Eli Lilly And Company | Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych |
| KR101764556B1 (ko) | 2008-06-11 | 2017-08-02 | 제넨테크, 인크. | 디아자카르바졸 및 사용 방법 |
| KR20110046503A (ko) * | 2008-07-24 | 2011-05-04 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | Ａｄ 병인을 확인하기에 유용한 영상화제 |
| CN103739605B (zh) | 2009-03-23 | 2016-08-17 | 伊莱利利公司 | 用于检测神经障碍的显像剂 |
| US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| US20110183938A1 (en) | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
| US20150368244A1 (en) * | 2011-01-31 | 2015-12-24 | Genentech, Inc. | Diazacarbazoles and methods of use |
| SI3055308T1 (en) | 2013-10-08 | 2018-03-30 | F. Hoffmann-La Roche Ag | Diazacarbazole derivatives in the form of tau-pet ligands |
-
2014
- 2014-10-06 SI SI201430549T patent/SI3055308T1/en unknown
- 2014-10-06 EA EA201690515A patent/EA028483B1/ru not_active IP Right Cessation
- 2014-10-06 AR ARP140103712A patent/AR097931A1/es active IP Right Grant
- 2014-10-06 RS RS20180058A patent/RS56777B1/sr unknown
- 2014-10-06 PT PT147811699T patent/PT3055308T/pt unknown
- 2014-10-06 JP JP2016515518A patent/JP6194416B2/ja active Active
- 2014-10-06 ES ES14781169.9T patent/ES2657121T3/es active Active
- 2014-10-06 WO PCT/EP2014/071283 patent/WO2015052105A1/en active Application Filing
- 2014-10-06 EP EP14781169.9A patent/EP3055308B1/en active Active
- 2014-10-06 KR KR1020167008013A patent/KR101770531B1/ko active IP Right Grant
- 2014-10-06 MY MYPI2016000604A patent/MY190196A/en unknown
- 2014-10-06 CN CN201480037389.5A patent/CN105358558B/zh active Active
- 2014-10-06 HU HUE14781169A patent/HUE035413T2/en unknown
- 2014-10-06 PE PE2015002706A patent/PE20160159A1/es active IP Right Grant
- 2014-10-06 CA CA2917191A patent/CA2917191C/en active Active
- 2014-10-06 AU AU2014333996A patent/AU2014333996B2/en active Active
- 2014-10-06 DK DK14781169.9T patent/DK3055308T3/en active
- 2014-10-06 LT LTEP14781169.9T patent/LT3055308T/lt unknown
- 2014-10-06 NO NO14781169A patent/NO3055308T3/no unknown
- 2014-10-06 MX MX2016002234A patent/MX2016002234A/es active IP Right Grant
- 2014-10-06 UA UAA201604290A patent/UA116164C2/uk unknown
- 2014-10-06 TW TW103134795A patent/TWI513698B/zh active
- 2014-10-06 PL PL14781169T patent/PL3055308T3/pl unknown
- 2014-10-06 SG SG11201602786UA patent/SG11201602786UA/en unknown
-
2015
- 2015-12-10 ZA ZA2015/09013A patent/ZA201509013B/en unknown
- 2015-12-15 CR CR20150663A patent/CR20150663A/es unknown
- 2015-12-21 IL IL243249A patent/IL243249A0/en active IP Right Grant
-
2016
- 2016-02-04 PH PH12016500249A patent/PH12016500249A1/en unknown
- 2016-03-24 HK HK16103514.3A patent/HK1215574A1/zh unknown
- 2016-03-25 MA MA38935A patent/MA38935B1/fr unknown
- 2016-03-30 CL CL2016000728A patent/CL2016000728A1/es unknown
- 2016-04-07 US US15/093,366 patent/US10004817B2/en active Active
-
2018
- 2018-01-10 HR HRP20180049TT patent/HRP20180049T1/hr unknown
- 2018-05-15 US US15/980,080 patent/US11058781B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1215795A1 (zh) | 鵝膏毒素衍生物 | |
| HK1215574A1 (zh) | 作為 -配體的二氮雜哢唑衍生物 | |
| HRP20170919T1 (hr) | Novi derivati pirazola | |
| SG11201506100XA (en) | Pyridazinone-amides derivatives | |
| ZA201601333B (en) | Oxoquinazolinyl-butanamide derivatives | |
| HUE038261T2 (hu) | Új azabenzimidazol-származékok | |
| HK1213484A1 (zh) | 刺激神經發生的異喹啉衍生物 | |
| SG11201605189YA (en) | Imidazopyrazinone derivatives | |
| EP2966074A4 (en) | morphinan | |
| HK1213566A1 (zh) | 新的四唑酮衍生物 | |
| EP3009444A4 (en) | ALPHA-oxoacyl-Amino-caprolactam derivative |