PT2861602T - 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]pirimidin-2-il]-1,7-diazaspiro[4.4]nonan-6-ona - Google Patents

7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]pirimidin-2-il]-1,7-diazaspiro[4.4]nonan-6-ona

Info

Publication number
PT2861602T
PT2861602T PT137254389T PT13725438T PT2861602T PT 2861602 T PT2861602 T PT 2861602T PT 137254389 T PT137254389 T PT 137254389T PT 13725438 T PT13725438 T PT 13725438T PT 2861602 T PT2861602 T PT 2861602T
Authority
PT
Portugal
Prior art keywords
methyl
diazaspiro
nonan
pyrimidin
trifluoromethyl
Prior art date
Application number
PT137254389T
Other languages
English (en)
Portuguese (pt)
Inventor
M P Giblin Gerard
T Macpherson David
R Witty David
J Stanway Steven
Original Assignee
Convergence Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convergence Pharmaceuticals filed Critical Convergence Pharmaceuticals
Publication of PT2861602T publication Critical patent/PT2861602T/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT137254389T 2012-05-22 2013-05-22 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]pirimidin-2-il]-1,7-diazaspiro[4.4]nonan-6-ona PT2861602T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US201361773710P 2013-03-06 2013-03-06

Publications (1)

Publication Number Publication Date
PT2861602T true PT2861602T (pt) 2016-11-14

Family

ID=46546493

Family Applications (2)

Application Number Title Priority Date Filing Date
PT161777008T PT3106464T (pt) 2012-05-22 2013-05-22 Compostos novos
PT137254389T PT2861602T (pt) 2012-05-22 2013-05-22 7-metil-2-[4-metil-6-[4-(trifluorometil)-fenil]pirimidin-2-il]-1,7-diazaspiro[4.4]nonan-6-ona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT161777008T PT3106464T (pt) 2012-05-22 2013-05-22 Compostos novos

Country Status (27)

Country Link
US (7) US9376445B2 (OSRAM)
EP (3) EP2861594B1 (OSRAM)
JP (3) JP2015517562A (OSRAM)
KR (2) KR102161101B1 (OSRAM)
CN (2) CN107344942B (OSRAM)
AU (3) AU2013265001B2 (OSRAM)
BR (1) BR112014029280B1 (OSRAM)
CA (1) CA2873956C (OSRAM)
CY (2) CY1118274T1 (OSRAM)
DK (2) DK2861602T3 (OSRAM)
EA (1) EA025579B1 (OSRAM)
ES (3) ES2602308T3 (OSRAM)
GB (1) GB201209015D0 (OSRAM)
HR (2) HRP20161349T1 (OSRAM)
HU (2) HUE049445T2 (OSRAM)
IL (4) IL235805A (OSRAM)
IN (1) IN2014MN02393A (OSRAM)
LT (2) LT3106464T (OSRAM)
MX (1) MX355303B (OSRAM)
PL (2) PL2861602T3 (OSRAM)
PT (2) PT3106464T (OSRAM)
RS (2) RS60368B1 (OSRAM)
SG (2) SG11201407755UA (OSRAM)
SI (2) SI2861602T1 (OSRAM)
SM (2) SMT202000210T1 (OSRAM)
WO (2) WO2013175206A1 (OSRAM)
ZA (1) ZA201408253B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
AU2018338884A1 (en) * 2017-09-28 2020-04-16 Biogen Inc. Novel salts
MA50371A (fr) 2017-10-10 2021-03-31 Biogen Inc Procédé de préparation de dérivés spiro
WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL374434A1 (en) * 2002-07-05 2005-10-17 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
JP5139307B2 (ja) 2005-10-10 2013-02-06 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
EP1934191B1 (en) * 2005-10-12 2012-03-28 Vertex Pharmaceuticals, Inc. Biphenyl derivatives as modulators of voltage gated ion channels
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
TW200825091A (en) 2006-10-12 2008-06-16 Xenon Pharmaceuticals Inc Spiro-oxindole compounds useful in treating sodium channel-mediated diseases or conditions
MX2009003874A (es) 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
MX2009007916A (es) * 2007-01-24 2009-07-31 Glaxo Group Ltd Composiciones farmaceuticas que comprenden 3,5-diamino-6-(2,3-dicl orofenil)-l,2,4,-triazina; o r(-)-2,4-diamino-5-(2,3-diclorofenil) -6-fluorometil pirimidina y un receptor neuroquinina 1.
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
AR077252A1 (es) * 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
SI2477964T1 (sl) 2009-09-14 2015-10-30 Convergence Pharmaceuticals Limited Postopek za pripravo derivatov alfa-karboksamida
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
US9426305B2 (en) * 2012-03-21 2016-08-23 Interdigital Patent Holdings, Inc. Sponsoring of a mobile station session by another mobile station in a wireless network
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

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IL280595A (en) 2021-03-25
CN104640867A (zh) 2015-05-20
IL252033A0 (en) 2017-06-29
IN2014MN02393A (OSRAM) 2015-08-21
HRP20200580T1 (hr) 2020-10-02
IL271330A (en) 2020-01-30
MX2014014274A (es) 2015-06-17
ZA201408253B (en) 2015-12-23
US20170304303A1 (en) 2017-10-26
US20200289508A1 (en) 2020-09-17
LT2861602T (lt) 2016-11-10
LT3106464T (lt) 2020-04-10
CY1123044T1 (el) 2021-10-29
EP2861602A1 (en) 2015-04-22
BR112014029280B1 (pt) 2022-10-04
SMT202000210T1 (it) 2020-05-08
PL3106464T3 (pl) 2020-11-16
IL235805A0 (en) 2015-02-01
SMT201600421B (it) 2017-01-10
EP3106464A1 (en) 2016-12-21
IL271330B (en) 2021-02-28
AU2017201421B2 (en) 2017-12-07
AU2017201421A1 (en) 2017-03-23
ES2602308T3 (es) 2017-02-20
SI2861602T1 (sl) 2017-03-31
RS60368B1 (sr) 2020-07-31
EA025579B1 (ru) 2017-01-30
EP2861594A1 (en) 2015-04-22
AU2013265001B2 (en) 2016-12-01
US9737536B2 (en) 2017-08-22
SI3106464T1 (sl) 2020-12-31
US9309254B2 (en) 2016-04-12
US20160184306A1 (en) 2016-06-30
US20150166551A1 (en) 2015-06-18
SG11201407755UA (en) 2014-12-30
CY1118274T1 (el) 2017-06-28
ES2602193T3 (es) 2017-02-20
PT3106464T (pt) 2020-04-03
JP2015517561A (ja) 2015-06-22
CA2873956A1 (en) 2013-11-28
EP2861602B1 (en) 2016-08-10
KR20200113027A (ko) 2020-10-05
KR20150023401A (ko) 2015-03-05
CN104640867B (zh) 2017-07-21
ES2782088T3 (es) 2020-09-10
US10010551B2 (en) 2018-07-03
HUE031664T2 (en) 2017-07-28
SG10201703527WA (en) 2017-06-29
CA2873956C (en) 2021-03-23
US20160263115A1 (en) 2016-09-15
EP2861594B1 (en) 2016-08-24
RS55415B1 (sr) 2017-04-28
US9376445B2 (en) 2016-06-28
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