PT2803659T - Processo de síntese do 3,4-dimetoxibiciclo[4.2.0]octatrieno- 7-carbonitrilo, sua aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico - Google Patents

Processo de síntese do 3,4-dimetoxibiciclo[4.2.0]octatrieno- 7-carbonitrilo, sua aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico

Info

Publication number
PT2803659T
PT2803659T PT141685594T PT14168559T PT2803659T PT 2803659 T PT2803659 T PT 2803659T PT 141685594 T PT141685594 T PT 141685594T PT 14168559 T PT14168559 T PT 14168559T PT 2803659 T PT2803659 T PT 2803659T
Authority
PT
Portugal
Prior art keywords
synthesising
dimethoxybicyclo
triene
octa
carbonitrile
Prior art date
Application number
PT141685594T
Other languages
English (en)
Inventor
Vaysse-Ludot Lucile
Vaultier Michel
Le Flohic Alexandre
Pucheault Mathieu
Kaminski Thomas
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT2803659T publication Critical patent/PT2803659T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
PT141685594T 2013-05-17 2014-05-16 Processo de síntese do 3,4-dimetoxibiciclo[4.2.0]octatrieno- 7-carbonitrilo, sua aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico PT2803659T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1354504A FR3005658B1 (fr) 2013-05-17 2013-05-17 "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable"

Publications (1)

Publication Number Publication Date
PT2803659T true PT2803659T (pt) 2017-02-14

Family

ID=48874340

Family Applications (1)

Application Number Title Priority Date Filing Date
PT141685594T PT2803659T (pt) 2013-05-17 2014-05-16 Processo de síntese do 3,4-dimetoxibiciclo[4.2.0]octatrieno- 7-carbonitrilo, sua aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitável do ponto de vista farmacêutico

Country Status (36)

Country Link
US (1) US8859763B1 (pt)
EP (1) EP2803659B1 (pt)
JP (1) JP5916793B2 (pt)
KR (1) KR101625128B1 (pt)
CN (1) CN104163777B (pt)
AR (1) AR096324A1 (pt)
AU (1) AU2014202434B2 (pt)
BR (1) BR102014011633A2 (pt)
CA (1) CA2851960C (pt)
CY (1) CY1120482T1 (pt)
DK (1) DK2803659T3 (pt)
EA (1) EA026224B1 (pt)
ES (1) ES2621804T3 (pt)
FR (1) FR3005658B1 (pt)
GE (1) GEP20156416B (pt)
HK (2) HK1200028A1 (pt)
HR (1) HRP20170394T1 (pt)
HU (1) HUE031370T2 (pt)
IN (1) IN2014DE01203A (pt)
JO (1) JO3276B1 (pt)
LT (1) LT2803659T (pt)
MD (1) MD4443C1 (pt)
ME (1) ME02636B (pt)
MX (1) MX345278B (pt)
NZ (1) NZ624774A (pt)
PL (1) PL2803659T3 (pt)
PT (1) PT2803659T (pt)
RS (1) RS55917B1 (pt)
SA (1) SA114350532B1 (pt)
SG (1) SG10201402034PA (pt)
SI (1) SI2803659T1 (pt)
TW (1) TWI500596B (pt)
UA (1) UA116337C2 (pt)
UY (1) UY35561A (pt)
WO (1) WO2014184501A1 (pt)
ZA (1) ZA201403543B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3005658B1 (fr) * 2013-05-17 2015-04-24 Servier Lab "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable"
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
JP5435127B2 (ja) 2010-05-06 2014-03-05 株式会社島津製作所 材料試験機
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
FR3005658B1 (fr) * 2013-05-17 2015-04-24 Servier Lab "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable"

Also Published As

Publication number Publication date
CA2851960A1 (fr) 2014-11-17
MX2014005822A (es) 2014-11-20
JP5916793B2 (ja) 2016-05-11
CN104163777A (zh) 2014-11-26
CA2851960C (fr) 2016-04-19
MD20140048A2 (en) 2014-11-30
IN2014DE01203A (pt) 2015-06-05
CN104163777B (zh) 2016-06-29
JO3276B1 (ar) 2018-09-16
AR096324A1 (es) 2015-12-23
JP2014237636A (ja) 2014-12-18
UA116337C2 (uk) 2018-03-12
MD4443B1 (ro) 2016-11-30
ZA201403543B (en) 2015-07-29
EA026224B1 (ru) 2017-03-31
MD4443C1 (ro) 2017-06-30
AU2014202434A1 (en) 2014-12-04
GEP20156416B (en) 2015-12-10
FR3005658B1 (fr) 2015-04-24
TWI500596B (zh) 2015-09-21
PL2803659T3 (pl) 2017-06-30
BR102014011633A2 (pt) 2015-06-02
EA201400473A1 (ru) 2014-12-30
HK1200028A1 (zh) 2015-07-31
UY35561A (es) 2014-11-28
RS55917B1 (sr) 2017-09-29
HUE031370T2 (hu) 2017-07-28
US8859763B1 (en) 2014-10-14
TW201446712A (zh) 2014-12-16
KR101625128B1 (ko) 2016-05-27
SI2803659T1 (sl) 2017-04-26
EP2803659A1 (fr) 2014-11-19
EP2803659B1 (fr) 2017-01-04
WO2014184501A1 (fr) 2014-11-20
MX345278B (es) 2017-01-24
SA114350532B1 (ar) 2015-07-09
NZ624774A (en) 2015-03-27
HRP20170394T1 (hr) 2017-05-05
ME02636B (me) 2017-06-20
CY1120482T1 (el) 2019-07-10
KR20140135658A (ko) 2014-11-26
HK1199872A1 (en) 2015-07-24
LT2803659T (lt) 2017-02-27
ES2621804T3 (es) 2017-07-05
AU2014202434B2 (en) 2017-11-02
DK2803659T3 (da) 2017-04-10
FR3005658A1 (fr) 2014-11-21
SG10201402034PA (en) 2014-12-30

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