PT2714710T - Processo para a produção de intermediários de estetrol - Google Patents
Processo para a produção de intermediários de estetrolInfo
- Publication number
- PT2714710T PT2714710T PT127290542T PT12729054T PT2714710T PT 2714710 T PT2714710 T PT 2714710T PT 127290542 T PT127290542 T PT 127290542T PT 12729054 T PT12729054 T PT 12729054T PT 2714710 T PT2714710 T PT 2714710T
- Authority
- PT
- Portugal
- Prior art keywords
- production
- estetrol
- intermediates
- estetrol intermediates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492300P | 2011-06-01 | 2011-06-01 | |
| EP11168561 | 2011-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2714710T true PT2714710T (pt) | 2016-07-12 |
Family
ID=45003353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127290542T PT2714710T (pt) | 2011-06-01 | 2012-06-01 | Processo para a produção de intermediários de estetrol |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11053274B2 (enExample) |
| EP (1) | EP2714710B1 (enExample) |
| JP (2) | JP6425540B2 (enExample) |
| KR (1) | KR101994805B1 (enExample) |
| CN (2) | CN107266514A (enExample) |
| AU (1) | AU2012264602B2 (enExample) |
| BR (1) | BR112013030830B1 (enExample) |
| CA (1) | CA2835981C (enExample) |
| CY (1) | CY1118150T1 (enExample) |
| DK (1) | DK2714710T3 (enExample) |
| EA (1) | EA023991B1 (enExample) |
| ES (1) | ES2579175T3 (enExample) |
| HR (1) | HRP20160692T2 (enExample) |
| HU (1) | HUE029252T2 (enExample) |
| ME (1) | ME02454B (enExample) |
| MX (1) | MX341561B (enExample) |
| PL (1) | PL2714710T3 (enExample) |
| PT (1) | PT2714710T (enExample) |
| RS (1) | RS54880B1 (enExample) |
| SG (1) | SG195118A1 (enExample) |
| SI (1) | SI2714710T1 (enExample) |
| SM (1) | SMT201600206B (enExample) |
| WO (1) | WO2012164096A1 (enExample) |
| ZA (1) | ZA201308446B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2714710T1 (sl) | 2011-06-01 | 2016-08-31 | Estetra S.P.R.L. | Postopek za proizvodnjo intermediatov estetrola |
| DK2714712T3 (en) | 2011-06-01 | 2016-12-05 | Estetra Sprl | A process for the preparation of intermediates estetrol |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| MX348917B (es) | 2011-10-07 | 2017-07-04 | Estetra Sprl | Proceso para la producción de estetrol. |
| SI3310346T1 (sl) | 2015-06-18 | 2021-07-30 | Estetra Sprl | Orodisperzibilna tableta, ki vsebuje estetrol |
| PT3310345T (pt) | 2015-06-18 | 2021-05-28 | Estetra Sprl | Comprimido orodispersível contendo estetrol |
| SMT201800232T1 (it) | 2015-06-18 | 2018-07-17 | Mithra Pharmaceuticals S A | Unita' di dosaggio orodispersibile contenente un componente di estetrolo |
| LT3310333T (lt) | 2015-06-18 | 2020-06-25 | Estetra Sprl | Burnoje dirperguojama vaisto formą, turinti estetrolio komponentą |
| CN105837424A (zh) * | 2016-03-31 | 2016-08-10 | 常州大学 | 一种1-氯-3-甲基-3-丁烯-2-酮的合成方法 |
| CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
| JP6935766B2 (ja) | 2018-02-15 | 2021-09-15 | 日本精工株式会社 | スピンドル装置 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| IT201900017414A1 (it) | 2019-09-27 | 2021-03-27 | Ind Chimica Srl | Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo |
| UY38895A (es) | 2019-09-27 | 2021-04-30 | Ind Chimica Srl | PROCESO PARA PREPARAR (15a,16a,17ß)-ESTRA-1,3,5(10)-TRIENO-3,15,16,17-TETROL (ESTETROL) E INTERMEDIOS DE DICHO PROCESO |
| IT201900021879A1 (it) | 2019-11-22 | 2021-05-22 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| WO2023021026A1 (en) | 2021-08-17 | 2023-02-23 | Aspen Oss B.V. | A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol |
| CN118251402A (zh) | 2021-10-01 | 2024-06-25 | 工业化学有限公司 | 制备(15α,16α,17β)-雌甾-1,3,5(10)-三烯-3,15,16,17-四醇（雌四醇）一水合物的方法 |
| HUP2500316A1 (en) | 2023-02-02 | 2025-11-28 | Ind Chimica Srl | Process for preparing (15alpha,16alpha,17beta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol (estetrol) monohydrate |
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| DE144266C (enExample) | ||||
| US3138588A (en) | 1962-08-24 | 1964-06-23 | American Home Prod | 17-ketals of estrone and derivatives thereof |
| US3177206A (en) | 1963-03-07 | 1965-04-06 | American Home Prod | Selective bromination of a-ring aromatic 17-ketalized steroids |
| US3433785A (en) | 1966-07-11 | 1969-03-18 | Sterling Drug Inc | 15,16-disubstituted aromatic steroids,intermediates and processes |
| US3673180A (en) | 1970-06-18 | 1972-06-27 | Merck & Co Inc | 19-nor-6,6-ethylene-20-spiroxenes |
| US4792620A (en) | 1983-10-14 | 1988-12-20 | Bp Chemicals Limited | Carbonylation catalysts |
| US4739078A (en) | 1984-02-17 | 1988-04-19 | The Upjohn Company | Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors |
| IE60780B1 (en) | 1987-01-23 | 1994-08-10 | Akzo Nv | New 11-aryl steroid derivatives |
| DE3710728A1 (de) | 1987-03-31 | 1988-10-13 | Schering Ag | Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren |
| US5073374A (en) | 1988-11-30 | 1991-12-17 | Schering Corporation | Fast dissolving buccal tablet |
| US5340586A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
| JPH07101977A (ja) | 1993-10-05 | 1995-04-18 | Kureha Chem Ind Co Ltd | ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤 |
| WO1997004752A1 (en) | 1995-07-26 | 1997-02-13 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions of conjugated estrogens and methods for their use |
| US6117446A (en) | 1999-01-26 | 2000-09-12 | Place; Virgil A. | Drug dosage unit for buccal administration of steroidal active agents |
| TW548277B (en) | 1999-07-16 | 2003-08-21 | Akzo Nobel Nv | Orally active androgens |
| US20020132801A1 (en) | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| EP1260225A1 (en) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | A pharmaceutical composition for use in hormone replacement therapy |
| ATE350041T1 (de) | 2001-05-18 | 2007-01-15 | Pantarhei Bioscience Bv | Pharmaceutishe zusammensetzung für die hormonersatztherapie |
| DE60223795T2 (de) | 2001-05-23 | 2008-11-27 | Pantarhei Bioscience B.V. | Tetrahydroxyliertes Östrogen enthaltendes Arzneistoffverabreichungssystem zur Verwendung in der hormonalen Kontrazeption |
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| WO2003018026A1 (en) | 2001-08-31 | 2003-03-06 | Pantarhei Bioscience B.V. | Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy |
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| HU227198B1 (en) | 2001-11-27 | 2010-10-28 | Richter Gedeon Nyrt | Pharmaceutical composition for emergency contraception containing levonorgestrel |
| DK1478373T3 (da) | 2002-02-21 | 2007-01-15 | Schering Ag | Farmaceutisk præparat omfattende ét eller flere steroider, én eller flere tetrahydrofolatbestanddele og vitamin B 12 |
| US20050147670A1 (en) | 2002-05-29 | 2005-07-07 | Impax Laboratories Inc. | Oral disintegrating dosage forms |
| WO2003103684A1 (en) | 2002-06-11 | 2003-12-18 | Pantarhei Bioscience B.V. | Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein |
| ES2399423T3 (es) | 2002-06-11 | 2013-04-01 | Pantarhei Bioscience B.V. | Método para tratar la piel humana y una composición para el cuidado de la piel para su uso en tal método |
| AU2003253506A1 (en) | 2002-07-12 | 2004-02-02 | Pantarhei Biosciences B.V. | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
| CA2503549C (en) | 2002-10-23 | 2012-07-10 | Pantarhei Bioscience B.V. | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
| CA2505190C (en) | 2002-11-08 | 2012-07-10 | Pantarhei Bioscience B.V. | Synthesis of estetrol via estrone derived steroids |
| ATE340580T1 (de) | 2003-05-22 | 2006-10-15 | Pantarhei Bioscience Bv | Verwendung von zusammensetzungen enthaltend ein oestrogen zur behandlung und verhinderung von muskelskelettschmerzen |
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| ATE478946T1 (de) | 2005-07-25 | 2010-09-15 | Riboxx Gmbh | Verfahren und kit zur amplifikation von heteropolymerer oder poly(c)- rna |
| US20070048369A1 (en) | 2005-08-26 | 2007-03-01 | National Starch And Chemical Investment Holding Corporation | Mucosal delivery tablet |
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| US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| DK2714712T3 (en) | 2011-06-01 | 2016-12-05 | Estetra Sprl | A process for the preparation of intermediates estetrol |
| SI2714710T1 (sl) | 2011-06-01 | 2016-08-31 | Estetra S.P.R.L. | Postopek za proizvodnjo intermediatov estetrola |
| EP2383279A1 (en) * | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| ES2545337T3 (es) | 2011-07-19 | 2015-09-10 | Pantarhei Bioscience B.V. | Comprimido que contiene dehidroepiandrosterona (DHEA) |
| ME02723B (me) | 2011-08-11 | 2017-10-20 | Estetra Sprl | Upotreba estetrola kao kontraceptivnog sredstva u hitnim slučajevima |
| RU2633640C2 (ru) | 2011-09-16 | 2017-10-16 | Ферринг Б.В. | Быстрорастворимая фармацевтическая композиция |
| MX348917B (es) | 2011-10-07 | 2017-07-04 | Estetra Sprl | Proceso para la producción de estetrol. |
| US9808470B2 (en) | 2012-04-19 | 2017-11-07 | Universite De Liege | Estrogenic components for use in the treatment of neurological disorders |
| EP2653163A1 (en) | 2012-04-19 | 2013-10-23 | Université de Liège | Estrogenic components for use in the treatment of neurological disorders |
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| CA2924255C (en) | 2013-09-18 | 2022-11-22 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol |
| ES2655076T3 (es) | 2013-12-12 | 2018-02-16 | Donesta Bioscience B.V. | Unidad de dosificación sólida de desintegración oral con un componente de estetrol |
| SMT201800232T1 (it) | 2015-06-18 | 2018-07-17 | Mithra Pharmaceuticals S A | Unita' di dosaggio orodispersibile contenente un componente di estetrolo |
| PT3310345T (pt) | 2015-06-18 | 2021-05-28 | Estetra Sprl | Comprimido orodispersível contendo estetrol |
| LT3310333T (lt) | 2015-06-18 | 2020-06-25 | Estetra Sprl | Burnoje dirperguojama vaisto formą, turinti estetrolio komponentą |
| SI3310346T1 (sl) | 2015-06-18 | 2021-07-30 | Estetra Sprl | Orodisperzibilna tableta, ki vsebuje estetrol |
-
2012
- 2012-06-01 SI SI201230598A patent/SI2714710T1/sl unknown
- 2012-06-01 KR KR1020137031483A patent/KR101994805B1/ko active Active
- 2012-06-01 DK DK12729054.2T patent/DK2714710T3/en active
- 2012-06-01 MX MX2013014045A patent/MX341561B/es active IP Right Grant
- 2012-06-01 PL PL12729054T patent/PL2714710T3/pl unknown
- 2012-06-01 SG SG2013086681A patent/SG195118A1/en unknown
- 2012-06-01 CN CN201710354709.5A patent/CN107266514A/zh active Pending
- 2012-06-01 PT PT127290542T patent/PT2714710T/pt unknown
- 2012-06-01 US US14/122,872 patent/US11053274B2/en active Active
- 2012-06-01 ES ES12729054.2T patent/ES2579175T3/es active Active
- 2012-06-01 WO PCT/EP2012/060447 patent/WO2012164096A1/en not_active Ceased
- 2012-06-01 ME MEP-2016-130A patent/ME02454B/me unknown
- 2012-06-01 RS RS20160478A patent/RS54880B1/sr unknown
- 2012-06-01 CN CN201280026162.1A patent/CN103703014A/zh active Pending
- 2012-06-01 AU AU2012264602A patent/AU2012264602B2/en active Active
- 2012-06-01 CA CA2835981A patent/CA2835981C/en active Active
- 2012-06-01 EP EP12729054.2A patent/EP2714710B1/en active Active
- 2012-06-01 HU HUE12729054A patent/HUE029252T2/en unknown
- 2012-06-01 EA EA201301316A patent/EA023991B1/ru unknown
- 2012-06-01 BR BR112013030830A patent/BR112013030830B1/pt active IP Right Grant
- 2012-06-01 JP JP2014513214A patent/JP6425540B2/ja active Active
- 2012-06-01 HR HRP20160692TT patent/HRP20160692T2/hr unknown
-
2013
- 2013-11-11 ZA ZA2013/08446A patent/ZA201308446B/en unknown
-
2016
- 2016-06-15 CY CY20161100525T patent/CY1118150T1/el unknown
- 2016-06-30 SM SM201600206T patent/SMT201600206B/it unknown
-
2017
- 2017-08-10 JP JP2017155801A patent/JP6479912B2/ja active Active
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