PT2465935T - Proteínas recombinantes semelhantes a interferão humano - Google Patents

Proteínas recombinantes semelhantes a interferão humano

Info

Publication number
PT2465935T
PT2465935T PT121591283T PT12159128T PT2465935T PT 2465935 T PT2465935 T PT 2465935T PT 121591283 T PT121591283 T PT 121591283T PT 12159128 T PT12159128 T PT 12159128T PT 2465935 T PT2465935 T PT 2465935T
Authority
PT
Portugal
Prior art keywords
proteins
recombinant human
human interferon
interferon
recombinant
Prior art date
Application number
PT121591283T
Other languages
English (en)
Inventor
Wang Haitao
Mao Chunsheng
Li Jizhi
Wang Ling
Du Yong
Liu Longbin
Xu Jing
Zhang Rui
Original Assignee
Novagen Holding Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novagen Holding Corp filed Critical Novagen Holding Corp
Publication of PT2465935T publication Critical patent/PT2465935T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
PT121591283T 2007-06-18 2007-06-22 Proteínas recombinantes semelhantes a interferão humano PT2465935T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/764,786 US7625555B2 (en) 2007-06-18 2007-06-18 Recombinant human interferon-like proteins

Publications (1)

Publication Number Publication Date
PT2465935T true PT2465935T (pt) 2016-08-05

Family

ID=40132903

Family Applications (2)

Application Number Title Priority Date Filing Date
PT77200384T PT2078082E (pt) 2007-06-18 2007-06-22 Proteínas recombinantes semelhantes a interferão humano
PT121591283T PT2465935T (pt) 2007-06-18 2007-06-22 Proteínas recombinantes semelhantes a interferão humano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT77200384T PT2078082E (pt) 2007-06-18 2007-06-22 Proteínas recombinantes semelhantes a interferão humano

Country Status (21)

Country Link
US (8) US7625555B2 (pt)
EP (3) EP2078082B1 (pt)
JP (3) JP5439189B2 (pt)
KR (2) KR20130027043A (pt)
CN (3) CN102250918A (pt)
AU (1) AU2007355415B2 (pt)
BR (1) BRPI0716948B1 (pt)
CA (1) CA2692358C (pt)
DK (2) DK2465935T3 (pt)
ES (2) ES2524251T3 (pt)
HK (2) HK1129128A1 (pt)
IL (1) IL196673A (pt)
MX (1) MX2009001366A (pt)
MY (1) MY167485A (pt)
NZ (1) NZ574306A (pt)
PL (2) PL2078082T3 (pt)
PT (2) PT2078082E (pt)
RU (1) RU2469091C2 (pt)
TW (1) TWI375716B (pt)
WO (1) WO2008154719A1 (pt)
ZA (1) ZA200901680B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
KR101857825B1 (ko) * 2010-03-04 2018-05-14 피페넥스 인크. 변성 없이 가용성 재조합 인터페론 단백질을 제조하는 방법
KR102400963B1 (ko) * 2013-09-20 2022-05-24 고쿠리츠 켄큐 카이하츠 호진 이야쿠 키반 켄코 에이요 켄큐쇼 면역 부활 활성을 갖는 올리고뉴클레오티드 함유 복합체 및 그 용도
LT6164B (lt) 2013-10-15 2015-06-25 Uab Biotechnologinės Farmacijos Centras "Biotechpharma" Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas
EP3169697A4 (en) * 2014-07-14 2017-11-08 Gennova Biopharmaceuticals Ltd. A novel process for purification of rhu-gcsf
PL3507366T3 (pl) * 2016-09-01 2021-05-04 Proqr Therapeutics Ii B.V. Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna
WO2018101151A1 (ja) * 2016-12-02 2018-06-07 興人ライフサイエンス株式会社 リボース含有酵母調味料
US10780931B2 (en) * 2018-05-21 2020-09-22 Ronald Siwicki Kickstand assembly
CN109627343A (zh) * 2018-12-27 2019-04-16 北京美福源生物医药科技有限公司 长效细胞因子基因衍生物融合蛋白
CN113289006A (zh) * 2020-02-24 2021-08-24 杰华生物技术(青岛)有限公司 一种重组细胞因子基因衍生蛋白或其片段的用途

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US369922A (en) 1887-09-13 Jacket for steam-cylinders
US2004200A (en) * 1931-10-02 1935-06-11 Union Switch & Signal Co Lamp socket adapter
US3699222A (en) * 1958-03-11 1972-10-17 Nat Res Dev Production of viral interfering substances
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4640835A (en) * 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
GB8412564D0 (en) * 1984-05-17 1984-06-20 Searle & Co Structure and properties
DE3685996T2 (de) * 1985-06-11 1993-01-14 Ciba Geigy Ag Hybrid-interferone.
US4791192A (en) * 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
GB8803365D0 (en) * 1988-02-13 1988-03-16 Ciba Geigy Ag Antiviral combination
US5705363A (en) * 1989-03-02 1998-01-06 The Women's Research Institute Recombinant production of human interferon τ polypeptides and nucleic acids
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
PT730470E (pt) * 1993-11-10 2002-08-30 Enzon Inc Conjugados melhorados de interferao-polimero
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
FR2741892B1 (fr) * 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US6299869B1 (en) * 1997-12-08 2001-10-09 Genentech, Inc. Human interferon-epsilon: a type I interferon
US6685933B1 (en) * 1998-07-28 2004-02-03 The United States Of America As Represented By The Department Of Health And Human Services Interferon α hybrids
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
WO2001015736A2 (en) 1999-08-27 2001-03-08 Maxygen Aps Interferon-beta conjugates
US7431921B2 (en) * 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
US20040002474A1 (en) * 1999-10-07 2004-01-01 Maxygen Inc. IFN-alpha homologues
JP2003511031A (ja) 1999-10-07 2003-03-25 マキシジェン， インコーポレイテッド ＩＦＮ−αホモログ
WO2001036001A2 (en) 1999-11-12 2001-05-25 Maxygen Holdings Ltd Interferon gamma conjugates
IT1317835B1 (it) * 2000-02-15 2003-07-15 San Raffaele Centro Fond Citochine modificate per uso nella terapia del cancro.
CA2404511A1 (en) 2000-03-31 2001-10-04 Mochida Pharmaceutical Co., Ltd. Tlr/cd14 binding inhibitor
EP1334128A2 (en) 2000-11-02 2003-08-13 Maxygen Aps New multimeric interferon beta polypeptides
AU2002228886B2 (en) 2000-11-03 2007-08-30 Pestka Biomedical Laboratories, Inc. Interferons, uses and compositions related thereto
YU48703A (sh) 2001-02-27 2006-05-25 Maxygen Aps Novi interferonu beta-slični molekuli
WO2002081507A2 (en) 2001-04-06 2002-10-17 Maxygen Holdings Ltd. Interferon gamma polypeptide variants
US7038015B2 (en) * 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US6958388B2 (en) * 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
FR2825102B1 (fr) * 2001-05-23 2003-08-29 Genodyssee Nouveaux polynucleotides et polypeptides de l'interferon alpha 14
EP1414498A2 (en) 2001-06-29 2004-05-06 Maxygen Aps Stabilized formulations of interferons with sulfoalkyl ether cyclodextrins
CN1431018A (zh) 2002-01-10 2003-07-23 北京东康龙病毒生物技术工程研究中心 抗HSV感染和镇痛的人甲硫氨酸脑啡肽干扰素α－m融合蛋白制剂
IL163577A0 (en) 2002-03-12 2005-12-18 Maxygen Aps Interferon beta-like molecules for treatment of stroke
AU2003239774A1 (en) 2002-07-03 2004-01-23 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
WO2004020468A2 (en) 2002-08-28 2004-03-11 Maxygen Aps Interferon beta-like molecules for treatment of cancer
EP1539960B1 (en) * 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistant modified interferon alpha polypeptides
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
KR20050086498A (ko) 2002-11-18 2005-08-30 맥시겐, 인크. 인터페론-알파 폴리펩티드 및 접합체
AU2004270102B2 (en) * 2003-05-23 2009-10-01 Pestka Biomedical Laboratories, Inc. Uses of interferons for the treatment of severe acute respiratory syndrome and other viral infections
WO2005113592A2 (en) 2004-05-19 2005-12-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
KR20070085227A (ko) * 2004-08-09 2007-08-27 앨리오스 바이오파마 인크. 합성 초글리코실화, 프로테아제 저항성 폴리펩티드 변이체,경구 제제 및 이를 이용한 방법
US20060051859A1 (en) * 2004-09-09 2006-03-09 Yan Fu Long acting human interferon analogs
BRPI0609809A2 (pt) * 2005-05-18 2011-10-11 Maxygen Inc polipeptìdeo isolado ou recombinante, conjugado, composição, polinucleotìdeo isolado ou recombinante, célula hospedeira, vetor, métodos para preparar o polipeptìdeo, para preparar um conjugado, para inibir replicação de um vìrus em células infectadas com o vìrus para reduzir o numero de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna de hcv no soro de um paciente infectado com hcv, para reduzir o nìvel de dna de hbv em soro de um paciente infectado com hbv e para reduzir o nìvel de rna de hiv em soro de um paciente infectado com hiv, e, uso do polipeptìdeo ou do conjugado
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins

Also Published As

Publication number Publication date
US20100303759A1 (en) 2010-12-02
US20170015723A1 (en) 2017-01-19
KR20100033468A (ko) 2010-03-30
PL2465935T3 (pl) 2017-08-31
TW200900504A (en) 2009-01-01
HK1171048A1 (zh) 2013-03-15
US20080312148A1 (en) 2008-12-18
EP2078082A4 (en) 2009-12-16
EP2465935A2 (en) 2012-06-20
KR101384307B1 (ko) 2014-05-21
EP2465935A3 (en) 2012-08-15
RU2009104749A (ru) 2010-11-20
MX2009001366A (es) 2009-04-17
HK1129128A1 (en) 2009-11-20
ES2586398T3 (es) 2016-10-14
US7868151B2 (en) 2011-01-11
JP2010515466A (ja) 2010-05-13
US20100099612A1 (en) 2010-04-22
AU2007355415A1 (en) 2008-12-24
EP2078082B1 (en) 2014-08-20
RU2469091C2 (ru) 2012-12-10
KR20130027043A (ko) 2013-03-14
CN103483443A (zh) 2014-01-01
BRPI0716948B1 (pt) 2022-04-05
CN101432428A (zh) 2009-05-13
CN101432428B (zh) 2013-06-19
EP2078082A1 (en) 2009-07-15
BRPI0716948A2 (pt) 2013-02-19
PL2078082T3 (pl) 2015-02-27
DK2078082T3 (en) 2014-12-01
JP5439189B2 (ja) 2014-03-12
DK2465935T3 (en) 2016-08-22
US20100129904A1 (en) 2010-05-27
CA2692358A1 (en) 2008-12-24
AU2007355415B2 (en) 2012-07-26
IL196673A0 (en) 2011-08-01
US20200369741A1 (en) 2020-11-26
JP2014036657A (ja) 2014-02-27
JP2016117753A (ja) 2016-06-30
CA2692358C (en) 2012-11-20
EP3133161A1 (en) 2017-02-22
PT2078082E (pt) 2014-11-27
US9234022B2 (en) 2016-01-12
EP2465935B1 (en) 2016-05-18
US20190077843A1 (en) 2019-03-14
US9982028B2 (en) 2018-05-29
WO2008154719A1 (en) 2008-12-24
US8425895B2 (en) 2013-04-23
IL196673A (en) 2015-08-31
CN102250918A (zh) 2011-11-23
US7867482B2 (en) 2011-01-11
US20130189226A1 (en) 2013-07-25
US7625555B2 (en) 2009-12-01
NZ574306A (en) 2012-07-27
ES2524251T3 (es) 2014-12-04
ZA200901680B (en) 2010-03-31
MY167485A (en) 2018-08-30
US10538565B2 (en) 2020-01-21
TWI375716B (en) 2012-11-01
JP6099095B2 (ja) 2017-03-22

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