PT2364185E - Ftalazina dissubstituída antagonista da via hedgehog - Google Patents
Ftalazina dissubstituída antagonista da via hedgehog Download PDFInfo
- Publication number
- PT2364185E PT2364185E PT97406136T PT09740613T PT2364185E PT 2364185 E PT2364185 E PT 2364185E PT 97406136 T PT97406136 T PT 97406136T PT 09740613 T PT09740613 T PT 09740613T PT 2364185 E PT2364185 E PT 2364185E
- Authority
- PT
- Portugal
- Prior art keywords
- cancer
- fluorophenyl
- pharmaceutically acceptable
- fluoro
- phthalazin
- Prior art date
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- HGTOWYBEWJKRJB-KRWDZBQOSA-N tert-butyl (2s)-2-methyl-4-(4-phenylphthalazin-1-yl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(C1=CC=CC=C11)=NN=C1C1=CC=CC=C1 HGTOWYBEWJKRJB-KRWDZBQOSA-N 0.000 description 1
- OCJUKXWFPOGFHV-LBPRGKRZSA-N tert-butyl (2s)-4-(4-chlorophthalazin-1-yl)-2-methylpiperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C1=NN=C(Cl)C2=CC=CC=C12 OCJUKXWFPOGFHV-LBPRGKRZSA-N 0.000 description 1
- QIRCODZWGXNALP-KRWDZBQOSA-N tert-butyl (2s)-4-[4-(4-cyanophenyl)phthalazin-1-yl]-2-methylpiperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(C1=CC=CC=C11)=NN=C1C1=CC=C(C#N)C=C1 QIRCODZWGXNALP-KRWDZBQOSA-N 0.000 description 1
- DYACKSBXVUWLHA-KRWDZBQOSA-N tert-butyl (2s)-4-[4-(4-methoxyphenyl)phthalazin-1-yl]-2-methylpiperazine-1-carboxylate Chemical compound C1=CC(OC)=CC=C1C(C1=CC=CC=C11)=NN=C1N1C[C@H](C)N(C(=O)OC(C)(C)C)CC1 DYACKSBXVUWLHA-KRWDZBQOSA-N 0.000 description 1
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- CHHQTRKZJWJXAP-INIZCTEOSA-N tert-butyl (3s)-4-[4-(4-fluorophenyl)phthalazin-1-yl]-3-methylpiperazine-1-carboxylate Chemical compound C[C@H]1CN(C(=O)OC(C)(C)C)CCN1C(C1=CC=CC=C11)=NN=C1C1=CC=C(F)C=C1 CHHQTRKZJWJXAP-INIZCTEOSA-N 0.000 description 1
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- CPDJJMVQCMTCLO-UHFFFAOYSA-N tert-butyl-(4-methoxyphenyl)phosphane Chemical compound COC1=CC=C(PC(C)(C)C)C=C1 CPDJJMVQCMTCLO-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical group 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11070308P | 2008-11-03 | 2008-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2364185E true PT2364185E (pt) | 2013-07-24 |
Family
ID=41566219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97406136T PT2364185E (pt) | 2008-11-03 | 2009-10-22 | Ftalazina dissubstituída antagonista da via hedgehog |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8404687B2 (en:Method) |
| EP (1) | EP2364185B1 (en:Method) |
| JP (1) | JP2012507535A (en:Method) |
| KR (1) | KR101335746B1 (en:Method) |
| CN (1) | CN102202737B (en:Method) |
| AU (1) | AU2009320251C1 (en:Method) |
| BR (1) | BRPI0921437A2 (en:Method) |
| CA (1) | CA2742539C (en:Method) |
| CL (1) | CL2011000979A1 (en:Method) |
| CO (1) | CO6382123A2 (en:Method) |
| CR (1) | CR20110202A (en:Method) |
| CY (1) | CY1114023T1 (en:Method) |
| DK (1) | DK2364185T3 (en:Method) |
| EA (1) | EA018931B1 (en:Method) |
| EC (1) | ECSP11011021A (en:Method) |
| ES (1) | ES2418479T3 (en:Method) |
| HR (1) | HRP20130527T1 (en:Method) |
| IL (1) | IL211841A0 (en:Method) |
| MA (1) | MA32726B1 (en:Method) |
| MX (1) | MX2011004683A (en:Method) |
| NZ (1) | NZ591945A (en:Method) |
| PE (1) | PE20110433A1 (en:Method) |
| PL (1) | PL2364185T3 (en:Method) |
| PT (1) | PT2364185E (en:Method) |
| SI (1) | SI2364185T1 (en:Method) |
| TN (1) | TN2011000166A1 (en:Method) |
| UA (1) | UA102115C2 (en:Method) |
| WO (1) | WO2010062507A1 (en:Method) |
| ZA (1) | ZA201102448B (en:Method) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ579402A (en) * | 2007-03-15 | 2012-03-30 | Novartis Ag | Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway |
| MX2010011948A (es) | 2008-04-29 | 2010-12-14 | Lilly Co Eli | Antagonistas de la trayectoria hedgehog de ftalazina disustituida. |
| US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| AU2009314288B2 (en) | 2008-11-17 | 2013-05-02 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| CA2743483C (en) | 2008-11-17 | 2014-03-11 | Eli Lilly And Company | Tetrasubstituted pyridazine hedgehog pathway antagonists |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| US9814703B2 (en) | 2013-11-14 | 2017-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of BMP signaling |
| CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
| CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
| CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
| EP4229828A4 (en) | 2020-10-13 | 2024-08-28 | Endeavor Biomedicines, Inc. | METHODS OF TREATMENT OF FIBROSIS |
| US20240124451A1 (en) * | 2022-09-23 | 2024-04-18 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| SI0876366T1 (en) * | 1996-01-15 | 2001-12-31 | Janssen Pharmaceutica Nv | Angiogenesis inhibiting pyridazinamines |
| ATE480521T1 (de) * | 1996-10-01 | 2010-09-15 | Kyowa Hakko Kirin Co Ltd | Stickstoff enthaltende heterocyclische verbindungen |
| US6432970B2 (en) * | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| EP1067939B1 (en) | 1998-04-09 | 2015-09-16 | The Johns Hopkins University | Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways |
| ATE283700T1 (de) | 1999-06-08 | 2004-12-15 | Lorantis Ltd | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
| JP2005529876A (ja) | 2002-04-22 | 2005-10-06 | ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン | Ｈｅｄｇｅｈｏｇシグナル伝達経路の調節因子、それに関連する組成物および使用 |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| TW200533356A (en) | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| US8338591B2 (en) | 2004-05-08 | 2012-12-25 | Novartis International Pharmaceutical Ltd. | 3-aryl-5,6-disubstituted pyridazines |
| KR20210090744A (ko) * | 2004-09-02 | 2021-07-20 | 제넨테크, 인크. | 헤지호그 신호전달에 대한 피리딜 억제제 |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| NZ579402A (en) * | 2007-03-15 | 2012-03-30 | Novartis Ag | Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway |
| CA2690378A1 (en) * | 2007-06-25 | 2008-12-31 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| WO2009035568A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
| MX2010011948A (es) | 2008-04-29 | 2010-12-14 | Lilly Co Eli | Antagonistas de la trayectoria hedgehog de ftalazina disustituida. |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| CA2743483C (en) | 2008-11-17 | 2014-03-11 | Eli Lilly And Company | Tetrasubstituted pyridazine hedgehog pathway antagonists |
| AU2009314288B2 (en) | 2008-11-17 | 2013-05-02 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-10-22 EP EP09740613.6A patent/EP2364185B1/en active Active
- 2009-10-22 EA EA201170640A patent/EA018931B1/ru not_active IP Right Cessation
- 2009-10-22 US US13/122,212 patent/US8404687B2/en not_active Expired - Fee Related
- 2009-10-22 PE PE2011000937A patent/PE20110433A1/es not_active Application Discontinuation
- 2009-10-22 PL PL09740613T patent/PL2364185T3/pl unknown
- 2009-10-22 AU AU2009320251A patent/AU2009320251C1/en not_active Ceased
- 2009-10-22 CN CN200980143394.3A patent/CN102202737B/zh not_active Expired - Fee Related
- 2009-10-22 KR KR1020117010063A patent/KR101335746B1/ko not_active Expired - Fee Related
- 2009-10-22 HR HRP20130527AT patent/HRP20130527T1/hr unknown
- 2009-10-22 SI SI200930625T patent/SI2364185T1/sl unknown
- 2009-10-22 ES ES09740613T patent/ES2418479T3/es active Active
- 2009-10-22 PT PT97406136T patent/PT2364185E/pt unknown
- 2009-10-22 DK DK09740613.6T patent/DK2364185T3/da active
- 2009-10-22 JP JP2011534624A patent/JP2012507535A/ja active Pending
- 2009-10-22 CA CA2742539A patent/CA2742539C/en not_active Expired - Fee Related
- 2009-10-22 MX MX2011004683A patent/MX2011004683A/es active IP Right Grant
- 2009-10-22 BR BRPI0921437A patent/BRPI0921437A2/pt not_active IP Right Cessation
- 2009-10-22 UA UAA201105364A patent/UA102115C2/ru unknown
- 2009-10-22 NZ NZ591945A patent/NZ591945A/xx not_active IP Right Cessation
- 2009-10-22 WO PCT/US2009/061573 patent/WO2010062507A1/en not_active Ceased
-
2011
- 2011-03-21 IL IL211841A patent/IL211841A0/en unknown
- 2011-04-01 ZA ZA2011/02448A patent/ZA201102448B/en unknown
- 2011-04-07 TN TN2011000166A patent/TN2011000166A1/fr unknown
- 2011-04-15 CR CR20110202A patent/CR20110202A/es not_active Application Discontinuation
- 2011-04-22 MA MA33790A patent/MA32726B1/fr unknown
- 2011-05-02 EC EC2011011021A patent/ECSP11011021A/es unknown
- 2011-05-02 CL CL2011000979A patent/CL2011000979A1/es unknown
- 2011-05-11 CO CO11058054A patent/CO6382123A2/es active IP Right Grant
-
2013
- 2013-06-05 CY CY20131100447T patent/CY1114023T1/el unknown
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