PE20110433A1 - Antagonistas de la via hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la via hedgehog de ftalazina disustituida

Info

Publication number
PE20110433A1
PE20110433A1 PE2011000937A PE2011000937A PE20110433A1 PE 20110433 A1 PE20110433 A1 PE 20110433A1 PE 2011000937 A PE2011000937 A PE 2011000937A PE 2011000937 A PE2011000937 A PE 2011000937A PE 20110433 A1 PE20110433 A1 PE 20110433A1
Authority
PE
Peru
Prior art keywords
fluorophenyl
antagonists
disustituted
carboxamide hydrochloride
hedgehog pathway
Prior art date
Application number
PE2011000937A
Other languages
English (en)
Spanish (es)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Daniel Jon Sall
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20110433A1 publication Critical patent/PE20110433A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PE2011000937A 2008-11-03 2009-10-22 Antagonistas de la via hedgehog de ftalazina disustituida PE20110433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03

Publications (1)

Publication Number Publication Date
PE20110433A1 true PE20110433A1 (es) 2011-07-09

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000937A PE20110433A1 (es) 2008-11-03 2009-10-22 Antagonistas de la via hedgehog de ftalazina disustituida

Country Status (29)

Country Link
US (1) US8404687B2 (en:Method)
EP (1) EP2364185B1 (en:Method)
JP (1) JP2012507535A (en:Method)
KR (1) KR101335746B1 (en:Method)
CN (1) CN102202737B (en:Method)
AU (1) AU2009320251C1 (en:Method)
BR (1) BRPI0921437A2 (en:Method)
CA (1) CA2742539C (en:Method)
CL (1) CL2011000979A1 (en:Method)
CO (1) CO6382123A2 (en:Method)
CR (1) CR20110202A (en:Method)
CY (1) CY1114023T1 (en:Method)
DK (1) DK2364185T3 (en:Method)
EA (1) EA018931B1 (en:Method)
EC (1) ECSP11011021A (en:Method)
ES (1) ES2418479T3 (en:Method)
HR (1) HRP20130527T1 (en:Method)
IL (1) IL211841A0 (en:Method)
MA (1) MA32726B1 (en:Method)
MX (1) MX2011004683A (en:Method)
NZ (1) NZ591945A (en:Method)
PE (1) PE20110433A1 (en:Method)
PL (1) PL2364185T3 (en:Method)
PT (1) PT2364185E (en:Method)
SI (1) SI2364185T1 (en:Method)
TN (1) TN2011000166A1 (en:Method)
UA (1) UA102115C2 (en:Method)
WO (1) WO2010062507A1 (en:Method)
ZA (1) ZA201102448B (en:Method)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ579402A (en) * 2007-03-15 2012-03-30 Novartis Ag Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway
MX2010011948A (es) 2008-04-29 2010-12-14 Lilly Co Eli Antagonistas de la trayectoria hedgehog de ftalazina disustituida.
US20100041663A1 (en) * 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
AU2009314288B2 (en) 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
CA2743483C (en) 2008-11-17 2014-03-11 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
EP4229828A4 (en) 2020-10-13 2024-08-28 Endeavor Biomedicines, Inc. METHODS OF TREATMENT OF FIBROSIS
US20240124451A1 (en) * 2022-09-23 2024-04-18 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
SI0876366T1 (en) * 1996-01-15 2001-12-31 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
ATE480521T1 (de) * 1996-10-01 2010-09-15 Kyowa Hakko Kirin Co Ltd Stickstoff enthaltende heterocyclische verbindungen
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
EP1067939B1 (en) 1998-04-09 2015-09-16 The Johns Hopkins University Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways
ATE283700T1 (de) 1999-06-08 2004-12-15 Lorantis Ltd Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
JP2005529876A (ja) 2002-04-22 2005-10-06 ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン Ｈｅｄｇｅｈｏｇシグナル伝達経路の調節因子、それに関連する組成物および使用
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
US8338591B2 (en) 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
KR20210090744A (ko) * 2004-09-02 2021-07-20 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
NZ579402A (en) * 2007-03-15 2012-03-30 Novartis Ag Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway
CA2690378A1 (en) * 2007-06-25 2008-12-31 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
MX2010011948A (es) 2008-04-29 2010-12-14 Lilly Co Eli Antagonistas de la trayectoria hedgehog de ftalazina disustituida.
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CA2743483C (en) 2008-11-17 2014-03-11 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
AU2009314288B2 (en) 2008-11-17 2013-05-02 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
AU2009320251A1 (en) 2010-06-03
HRP20130527T1 (en) 2013-07-31
EP2364185A1 (en) 2011-09-14
CA2742539A1 (en) 2010-06-03
ZA201102448B (en) 2012-09-26
CL2011000979A1 (es) 2011-10-07
TN2011000166A1 (en) 2012-12-17
EA201170640A1 (ru) 2011-12-30
CO6382123A2 (es) 2012-02-15
BRPI0921437A2 (pt) 2018-10-30
CN102202737B (zh) 2014-03-26
SI2364185T1 (sl) 2013-07-31
ECSP11011021A (es) 2011-06-30
AU2009320251B2 (en) 2013-01-24
KR101335746B1 (ko) 2013-12-12
JP2012507535A (ja) 2012-03-29
MA32726B1 (fr) 2011-10-02
ES2418479T3 (es) 2013-08-14
CY1114023T1 (el) 2016-07-27
PL2364185T3 (pl) 2013-10-31
EP2364185B1 (en) 2013-05-22
US20110190304A1 (en) 2011-08-04
US8404687B2 (en) 2013-03-26
HK1159010A1 (en) 2012-07-27
CN102202737A (zh) 2011-09-28
CA2742539C (en) 2014-05-06
KR20110066212A (ko) 2011-06-16
IL211841A0 (en) 2011-06-30
WO2010062507A1 (en) 2010-06-03
MX2011004683A (es) 2011-06-20
PT2364185E (pt) 2013-07-24
UA102115C2 (ru) 2013-06-10
EA018931B1 (ru) 2013-11-29
AU2009320251C1 (en) 2013-08-15
NZ591945A (en) 2012-10-26
DK2364185T3 (da) 2013-06-03
CR20110202A (es) 2011-06-09

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