PT2229433T - Diferenciação osteogénica de células estaminais da medula óssea e de células estaminais do mesênquima utilizando uma combinação de fatores de crescimento - Google Patents

Diferenciação osteogénica de células estaminais da medula óssea e de células estaminais do mesênquima utilizando uma combinação de fatores de crescimento

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Publication number
PT2229433T
PT2229433T PT97003537T PT09700353T PT2229433T PT 2229433 T PT2229433 T PT 2229433T PT 97003537 T PT97003537 T PT 97003537T PT 09700353 T PT09700353 T PT 09700353T PT 2229433 T PT2229433 T PT 2229433T
Authority
PT
Portugal
Prior art keywords
stem cells
combination
bone marrow
growth factors
osteogenic differentiation
Prior art date
Application number
PT97003537T
Other languages
English (en)
Portuguese (pt)
Inventor
Bastianelli Enrico
Badoer Cindy
Pesesse Xavier
Original Assignee
Bone Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Therapeutics Sa filed Critical Bone Therapeutics Sa
Publication of PT2229433T publication Critical patent/PT2229433T/pt

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C12N5/0689—Stem cells; Progenitors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells

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  • Health & Medical Sciences (AREA)
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  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
PT97003537T 2008-01-11 2009-01-09 Diferenciação osteogénica de células estaminais da medula óssea e de células estaminais do mesênquima utilizando uma combinação de fatores de crescimento PT2229433T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08000458 2008-01-11

Publications (1)

Publication Number Publication Date
PT2229433T true PT2229433T (pt) 2017-12-12

Family

ID=39415339

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97003537T PT2229433T (pt) 2008-01-11 2009-01-09 Diferenciação osteogénica de células estaminais da medula óssea e de células estaminais do mesênquima utilizando uma combinação de fatores de crescimento

Country Status (13)

Country Link
US (3) US20100278788A1 (cg-RX-API-DMAC7.html)
EP (1) EP2229433B1 (cg-RX-API-DMAC7.html)
JP (1) JP5524079B2 (cg-RX-API-DMAC7.html)
KR (3) KR20100126680A (cg-RX-API-DMAC7.html)
CN (2) CN101945993A (cg-RX-API-DMAC7.html)
AU (2) AU2009203682B2 (cg-RX-API-DMAC7.html)
CA (1) CA2710571C (cg-RX-API-DMAC7.html)
DK (1) DK2229433T3 (cg-RX-API-DMAC7.html)
ES (1) ES2650235T3 (cg-RX-API-DMAC7.html)
NO (1) NO2229433T3 (cg-RX-API-DMAC7.html)
PL (1) PL2229433T3 (cg-RX-API-DMAC7.html)
PT (1) PT2229433T (cg-RX-API-DMAC7.html)
WO (1) WO2009087213A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104357381A (zh) * 2008-10-31 2015-02-18 辛西斯有限责任公司 用于活化干细胞的方法和装置
EP2686418A4 (en) 2011-03-17 2015-04-22 Minerva Biotechnologies Corp METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS
BE1020528A3 (fr) 2011-10-11 2013-12-03 Bone Therapeutics Sa Utilisations du facteur de croissance et differenciation 8 (gdf 8).
CN109456932A (zh) 2011-10-17 2019-03-12 米纳瓦生物技术公司 用于干细胞增殖和诱导的培养基
CN107592789A (zh) * 2015-04-23 2018-01-16 骨治疗公司 治疗性细胞的体外保存
JP6890138B2 (ja) * 2016-07-21 2021-06-18 サンバイオ，インコーポレイティド Ｍｓｃ成長予測因子アッセイ
RU2020113411A (ru) * 2017-10-20 2021-11-22 Боун Терапьютикс Са Способы дифференцировки мезенхимальных стволовых клеток
BE1026600B1 (fr) 2018-09-25 2020-12-07 Bone Therapeutics Sa Procedes et utilisations pour determiner le potentiel osteogenique de cellules differenciees in vitro
BE1026595B9 (fr) * 2018-09-25 2020-11-03 Bone Therapeutics Sa Procedes de differenciation de cellules souches mesenchymateuses
CN111357990A (zh) * 2019-12-26 2020-07-03 浙江欧谱生物科技有限公司 增加骨量的保健食品组合物及其应用

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US5837539A (en) * 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5972703A (en) * 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
AU6144698A (en) * 1997-02-05 1998-08-25 Case Western Reserve University Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells
EP1684624A2 (en) * 2003-10-02 2006-08-02 The Regents Of The University Of Michigan Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤
WO2007002210A2 (en) * 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
CA2640794C (en) * 2006-02-16 2015-04-14 Universite Libre De Bruxelles A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof

Also Published As

Publication number Publication date
KR20100126680A (ko) 2010-12-02
NO2229433T3 (cg-RX-API-DMAC7.html) 2018-02-17
CN104250633A (zh) 2014-12-31
DK2229433T3 (da) 2017-11-13
US20200407688A1 (en) 2020-12-31
AU2014204491A1 (en) 2014-08-07
EP2229433A1 (en) 2010-09-22
US20130266544A1 (en) 2013-10-10
AU2009203682A1 (en) 2009-07-16
AU2014204491B2 (en) 2016-03-24
PL2229433T3 (pl) 2018-01-31
CA2710571A1 (en) 2009-07-16
CN101945993A (zh) 2011-01-12
JP5524079B2 (ja) 2014-06-18
CA2710571C (en) 2017-11-07
AU2009203682B2 (en) 2014-07-03
WO2009087213A1 (en) 2009-07-16
KR20180086305A (ko) 2018-07-30
KR20160039699A (ko) 2016-04-11
ES2650235T3 (es) 2018-01-17
KR101920128B1 (ko) 2018-11-19
JP2011509656A (ja) 2011-03-31
EP2229433B1 (en) 2017-09-20
US20100278788A1 (en) 2010-11-04

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