PT2114951E - Inibidores inovadores da fosfodiesterase - Google Patents
Inibidores inovadores da fosfodiesterase Download PDFInfo
- Publication number
- PT2114951E PT2114951E PT87069225T PT08706922T PT2114951E PT 2114951 E PT2114951 E PT 2114951E PT 87069225 T PT87069225 T PT 87069225T PT 08706922 T PT08706922 T PT 08706922T PT 2114951 E PT2114951 E PT 2114951E
- Authority
- PT
- Portugal
- Prior art keywords
- phosphodiesterase inhibitors
- novel phosphodiesterase
- novel
- inhibitors
- phosphodiesterase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90384907P | 2007-02-28 | 2007-02-28 | |
| US94684907P | 2007-06-28 | 2007-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2114951E true PT2114951E (pt) | 2014-07-17 |
Family
ID=39415336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87069225T PT2114951E (pt) | 2007-02-28 | 2008-02-26 | Inibidores inovadores da fosfodiesterase |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8338431B2 (pt) |
| EP (1) | EP2114951B9 (pt) |
| JP (1) | JP5501770B2 (pt) |
| KR (1) | KR101571654B1 (pt) |
| AU (1) | AU2008221121B2 (pt) |
| BR (1) | BRPI0807749B8 (pt) |
| CA (1) | CA2676933C (pt) |
| CY (1) | CY1115227T1 (pt) |
| DK (1) | DK2114951T3 (pt) |
| ES (1) | ES2478670T3 (pt) |
| HK (1) | HK1138262A1 (pt) |
| HR (1) | HRP20140585T1 (pt) |
| IL (1) | IL200153A (pt) |
| MX (1) | MX2009009238A (pt) |
| MY (1) | MY150075A (pt) |
| NZ (1) | NZ578804A (pt) |
| PL (1) | PL2114951T3 (pt) |
| PT (1) | PT2114951E (pt) |
| RS (1) | RS53407B (pt) |
| RU (1) | RU2495043C2 (pt) |
| SI (1) | SI2114951T1 (pt) |
| WO (1) | WO2008104175A2 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2515865B1 (en) | 2009-12-22 | 2016-12-14 | Leo Pharma A/S | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
| US20130023501A1 (en) | 2009-12-22 | 2013-01-24 | Leo Pharma A/S | Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue |
| JP5816194B2 (ja) | 2009-12-22 | 2015-11-18 | レオ ファーマ アクティーゼルスカブ | カルシポトリオール一水和物ナノクリスタル |
| TWI507410B (zh) | 2010-06-24 | 2015-11-11 | Leo Pharma As | 新穎磷酸二酯酶抑制劑 |
| US20160022681A1 (en) * | 2012-02-14 | 2016-01-28 | University Of Rochester | Methods of increasing lymphatic transport |
| RU2637945C2 (ru) * | 2012-06-04 | 2017-12-08 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы |
| WO2014083099A1 (en) * | 2012-11-30 | 2014-06-05 | Leo Pharma A/S | A method of inhibiting the expression of il-22 in activated t-cells |
| PT3157930T (pt) * | 2014-06-23 | 2018-12-24 | Leo Pharma As | Métodos para a preparação de compostos heterocíclicos de 1,3-benzodioxole |
| WO2016205482A1 (en) | 2015-06-19 | 2016-12-22 | Bristol-Myers Squibb Company | Diamide macrocycles as factor xia inhibitors |
| RU2761337C2 (ru) * | 2015-12-18 | 2021-12-07 | Юнион Терапьютикс А/С | Способы получения гетероциклических соединений 1, 3-бензодиоксола |
| WO2018108230A1 (en) * | 2016-12-12 | 2018-06-21 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| US11065257B2 (en) * | 2016-12-12 | 2021-07-20 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| CN110099905A (zh) * | 2016-12-12 | 2019-08-06 | 利奥制药有限公司 | 取代的吡唑并氮杂*-8-酮类及其作为磷酸二酯酶抑制剂的用途 |
| MX2019013979A (es) | 2017-06-20 | 2020-07-13 | Union Therapeutics As | Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. |
| TW201919682A (zh) | 2017-08-08 | 2019-06-01 | 西班牙商阿爾米雷爾有限公司 | 活化Ｎｒｆ２路徑的新穎化合物 |
| ES2935615T3 (es) | 2017-12-15 | 2023-03-08 | Union Therapeutics As | Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
| US6514996B2 (en) * | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| DE69636086T2 (de) * | 1995-05-19 | 2006-11-30 | Kyowa Hakko Kogyo Co., Ltd. | Sauerstoff enthaltende heterocyclische verbindungen |
| CZ371998A3 (cs) | 1996-05-20 | 1999-03-17 | Darwin Discovery Limited | Benzofuranové karboxamidy a jejich terapeutické použití |
| SK284041B6 (sk) * | 1996-08-28 | 2004-08-03 | The Procter And Gamble Company | Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie |
| CA2272327A1 (en) | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
| ATE237612T1 (de) * | 1997-10-01 | 2003-05-15 | Kyowa Hakko Kogyo Kk | Benzofuranderivate |
| DE19907038C2 (de) | 1999-02-19 | 2003-04-10 | Schott Glas | Transluzente oder opake Glaskeramik mit Hochquarz-Mischkristallen als vorherrschender Kristallphase und deren Verwendung |
-
2008
- 2008-02-26 CA CA2676933A patent/CA2676933C/en active Active
- 2008-02-26 RU RU2009135810/04A patent/RU2495043C2/ru active
- 2008-02-26 WO PCT/DK2008/000080 patent/WO2008104175A2/en active Application Filing
- 2008-02-26 PT PT87069225T patent/PT2114951E/pt unknown
- 2008-02-26 KR KR1020097018073A patent/KR101571654B1/ko active IP Right Grant
- 2008-02-26 MX MX2009009238A patent/MX2009009238A/es active IP Right Grant
- 2008-02-26 US US12/528,649 patent/US8338431B2/en active Active
- 2008-02-26 EP EP08706922.5A patent/EP2114951B9/en active Active
- 2008-02-26 NZ NZ578804A patent/NZ578804A/en unknown
- 2008-02-26 MY MYPI20093168A patent/MY150075A/en unknown
- 2008-02-26 AU AU2008221121A patent/AU2008221121B2/en active Active
- 2008-02-26 RS RS20140365A patent/RS53407B/en unknown
- 2008-02-26 ES ES08706922.5T patent/ES2478670T3/es active Active
- 2008-02-26 JP JP2009551915A patent/JP5501770B2/ja active Active
- 2008-02-26 BR BRPI0807749A patent/BRPI0807749B8/pt active IP Right Grant
- 2008-02-26 DK DK08706922.5T patent/DK2114951T3/da active
- 2008-02-26 PL PL08706922T patent/PL2114951T3/pl unknown
- 2008-02-26 SI SI200831224T patent/SI2114951T1/sl unknown
-
2009
- 2009-07-30 IL IL200153A patent/IL200153A/en active IP Right Grant
-
2010
- 2010-04-07 HK HK10103418.6A patent/HK1138262A1/xx unknown
-
2014
- 2014-06-17 CY CY20141100437T patent/CY1115227T1/el unknown
- 2014-06-23 HR HRP20140585AT patent/HRP20140585T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0807749B1 (pt) | 2021-01-05 |
| JP2010519332A (ja) | 2010-06-03 |
| EP2114951B1 (en) | 2014-04-09 |
| MY150075A (en) | 2013-11-29 |
| IL200153A0 (en) | 2010-04-15 |
| JP5501770B2 (ja) | 2014-05-28 |
| US20100099688A1 (en) | 2010-04-22 |
| RU2495043C2 (ru) | 2013-10-10 |
| ES2478670T3 (es) | 2014-07-22 |
| MX2009009238A (es) | 2009-09-08 |
| AU2008221121A1 (en) | 2008-09-04 |
| HK1138262A1 (en) | 2010-08-20 |
| IL200153A (en) | 2016-11-30 |
| EP2114951A2 (en) | 2009-11-11 |
| WO2008104175A3 (en) | 2009-01-29 |
| NZ578804A (en) | 2012-04-27 |
| KR101571654B1 (ko) | 2015-11-25 |
| CY1115227T1 (el) | 2017-01-04 |
| RS53407B (en) | 2014-10-31 |
| BRPI0807749A2 (pt) | 2014-06-17 |
| DK2114951T3 (da) | 2014-06-23 |
| SI2114951T1 (sl) | 2014-08-29 |
| KR20090126252A (ko) | 2009-12-08 |
| US8338431B2 (en) | 2012-12-25 |
| WO2008104175A2 (en) | 2008-09-04 |
| BRPI0807749B8 (pt) | 2022-09-06 |
| CA2676933A1 (en) | 2008-09-04 |
| EP2114951B9 (en) | 2015-09-02 |
| CA2676933C (en) | 2015-09-29 |
| RU2009135810A (ru) | 2011-04-10 |
| PL2114951T3 (pl) | 2014-10-31 |
| AU2008221121B2 (en) | 2013-10-03 |
| HRP20140585T1 (hr) | 2014-09-12 |
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