PT2079732E - 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)- piridazina, os seus sais e solvatos e a sua utilização a título de antagonista do receptor h3 de histamina - Google Patents
3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)- piridazina, os seus sais e solvatos e a sua utilização a título de antagonista do receptor h3 de histamina Download PDFInfo
- Publication number
- PT2079732E PT2079732E PT07729379T PT07729379T PT2079732E PT 2079732 E PT2079732 E PT 2079732E PT 07729379 T PT07729379 T PT 07729379T PT 07729379 T PT07729379 T PT 07729379T PT 2079732 E PT2079732 E PT 2079732E
- Authority
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- Portugal
- Prior art keywords
- compound
- combination
- compounds
- histamine
- treatment
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06114615 | 2006-05-29 | ||
EP06120117 | 2006-09-05 |
Publications (1)
Publication Number | Publication Date |
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PT2079732E true PT2079732E (pt) | 2012-02-02 |
Family
ID=38458030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07729379T PT2079732E (pt) | 2006-05-29 | 2007-05-22 | 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)- piridazina, os seus sais e solvatos e a sua utilização a título de antagonista do receptor h3 de histamina |
Country Status (24)
Country | Link |
---|---|
US (1) | US8378097B2 (fr) |
EP (2) | EP2402324A1 (fr) |
JP (1) | JP5694661B2 (fr) |
KR (1) | KR20090040259A (fr) |
CN (2) | CN101460487A (fr) |
AT (1) | ATE538116T1 (fr) |
AU (1) | AU2007267197B2 (fr) |
BR (1) | BRPI0711370A2 (fr) |
CA (1) | CA2659570C (fr) |
CY (1) | CY1112455T1 (fr) |
DK (1) | DK2079732T3 (fr) |
EA (1) | EA016026B1 (fr) |
ES (1) | ES2375872T3 (fr) |
HR (1) | HRP20120227T1 (fr) |
IL (1) | IL194681A (fr) |
MX (1) | MX2008014766A (fr) |
NZ (1) | NZ571972A (fr) |
PL (1) | PL2079732T3 (fr) |
PT (1) | PT2079732E (fr) |
RS (1) | RS52234B (fr) |
SG (1) | SG163547A1 (fr) |
SI (1) | SI2079732T1 (fr) |
WO (1) | WO2007137968A1 (fr) |
ZA (1) | ZA200808730B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103110635A (zh) * | 2005-07-04 | 2013-05-22 | 海波因特制药有限责任公司 | 组胺h3受体拮抗剂 |
JP2009501733A (ja) * | 2005-07-20 | 2009-01-22 | メルク フロスト カナダ リミテツド | ステアロイルコエンザイムaデルタ−9デサチュラーゼの阻害剤としてのヘテロ芳香族化合物 |
WO2007071023A1 (fr) * | 2005-12-20 | 2007-06-28 | Merck Frosst Canada Ltd. | Composés hétéroaromatiques en tant qu'inhibiteurs de stéaroyl-coenzyme a delta-9 désaturase |
CA2653062A1 (fr) * | 2006-05-23 | 2007-11-29 | Transtech Pharma, Inc. | Nouveaux medicaments |
CA2659570C (fr) | 2006-05-29 | 2015-10-06 | High Point Pharmaceuticals, Llc | 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, ses sels et solvates et leur utilisation en tant qu'antagoniste du recepteur de l'histamine h3 |
JP5203360B2 (ja) | 2006-06-23 | 2013-06-05 | アボット・ラボラトリーズ | ヒスタミンh3受容体調節剤としてのシクロプロピルアミン誘導体 |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
EP2014656A3 (fr) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | Nouveaux antagonistes d'hétéocycliques h3 |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
EP3256126B1 (fr) | 2015-02-09 | 2024-03-27 | F. Hoffmann-La Roche AG | Composés pour le traitement du cancer |
WO2020086864A1 (fr) * | 2018-10-24 | 2020-04-30 | Vanderbilt University | Modulateurs allostériques positifs du récepteur d'acétylcholine muscarinique m1 |
WO2022053541A1 (fr) * | 2020-09-10 | 2022-03-17 | Eracal Therapeutics Ltd. | Composés à utiliser comme anorexigène |
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AU6325599A (en) | 1998-10-21 | 2000-05-08 | Dr. Reddy's Research Foundation | New compounds, their preparation and use |
WO2000023425A1 (fr) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | Nouveaux composes, preparation et utilisation correspondantes |
JP2002527502A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、それらの調製及び使用 |
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EP1140945B1 (fr) | 1998-12-18 | 2003-06-04 | Novo Nordisk A/S | Derives de 1,2,4-thiadiazine fusionnes, leur preparation et utilisation |
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WO2000063193A1 (fr) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Nouvelles formes polymorphes d'un agent antidiabetique: leur procede de preparation et composition pharmaceutique contenant lesdites formes |
AU2953699A (en) | 1999-04-16 | 2000-11-02 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
HUP0200758A3 (en) | 1999-04-16 | 2003-07-28 | Reddys Lab Ltd Dr | Novel polymorphic forms of an antidiabetic agent: process for their preparation and pharmaceutical compositions containing them |
CZ20013558A3 (cs) | 1999-04-20 | 2002-05-15 | Novo Nordisk A/S | Sloučenina, farmaceutický prostředek, způsob léčby, jejich příprava a vyuľití |
AU3958200A (en) | 1999-04-20 | 2000-11-02 | Novo Nordisk A/S | New compounds, their preparation and use |
EP1171438A1 (fr) | 1999-04-20 | 2002-01-16 | Novo Nordisk A/S | Composes, preparation et utilisation associees |
AU3957900A (en) | 1999-04-20 | 2000-11-02 | Novo Nordisk A/S | New compounds, their preparation and use |
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-
2007
- 2007-05-22 CA CA2659570A patent/CA2659570C/fr not_active Expired - Fee Related
- 2007-05-22 RS RS20120078A patent/RS52234B/en unknown
- 2007-05-22 SG SG201004699-3A patent/SG163547A1/en unknown
- 2007-05-22 NZ NZ571972A patent/NZ571972A/en not_active IP Right Cessation
- 2007-05-22 PL PL07729379T patent/PL2079732T3/pl unknown
- 2007-05-22 AT AT07729379T patent/ATE538116T1/de active
- 2007-05-22 WO PCT/EP2007/054940 patent/WO2007137968A1/fr active Application Filing
- 2007-05-22 SI SI200730845T patent/SI2079732T1/sl unknown
- 2007-05-22 CN CNA2007800197395A patent/CN101460487A/zh active Pending
- 2007-05-22 ES ES07729379T patent/ES2375872T3/es active Active
- 2007-05-22 KR KR1020087028536A patent/KR20090040259A/ko active Search and Examination
- 2007-05-22 PT PT07729379T patent/PT2079732E/pt unknown
- 2007-05-22 EP EP11182795A patent/EP2402324A1/fr not_active Withdrawn
- 2007-05-22 JP JP2009512547A patent/JP5694661B2/ja not_active Expired - Fee Related
- 2007-05-22 US US12/302,132 patent/US8378097B2/en not_active Expired - Fee Related
- 2007-05-22 AU AU2007267197A patent/AU2007267197B2/en not_active Ceased
- 2007-05-22 MX MX2008014766A patent/MX2008014766A/es active IP Right Grant
- 2007-05-22 BR BRPI0711370-6A patent/BRPI0711370A2/pt not_active IP Right Cessation
- 2007-05-22 CN CN2011101822989A patent/CN102295606A/zh active Pending
- 2007-05-22 DK DK07729379.3T patent/DK2079732T3/da active
- 2007-05-22 EA EA200870586A patent/EA016026B1/ru not_active IP Right Cessation
- 2007-05-22 EP EP07729379A patent/EP2079732B9/fr active Active
-
2008
- 2008-10-12 IL IL194681A patent/IL194681A/en not_active IP Right Cessation
- 2008-10-13 ZA ZA2008/08730A patent/ZA200808730B/en unknown
-
2012
- 2012-03-07 CY CY20121100230T patent/CY1112455T1/el unknown
- 2012-03-12 HR HR20120227T patent/HRP20120227T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EA200870586A1 (ru) | 2009-10-30 |
PL2079732T3 (pl) | 2012-05-31 |
JP5694661B2 (ja) | 2015-04-01 |
CA2659570C (fr) | 2015-10-06 |
NZ571972A (en) | 2011-09-30 |
EP2079732B9 (fr) | 2012-03-21 |
ES2375872T9 (es) | 2012-07-19 |
CY1112455T1 (el) | 2015-12-09 |
JP2009538861A (ja) | 2009-11-12 |
AU2007267197B2 (en) | 2011-12-01 |
ES2375872T3 (es) | 2012-03-07 |
KR20090040259A (ko) | 2009-04-23 |
CN101460487A (zh) | 2009-06-17 |
HRP20120227T1 (hr) | 2012-04-30 |
CN102295606A (zh) | 2011-12-28 |
SG163547A1 (en) | 2010-08-30 |
SI2079732T1 (sl) | 2012-03-30 |
DK2079732T3 (da) | 2012-01-23 |
CA2659570A1 (fr) | 2007-12-06 |
ATE538116T1 (de) | 2012-01-15 |
MX2008014766A (es) | 2009-03-06 |
BRPI0711370A2 (pt) | 2011-11-01 |
US8378097B2 (en) | 2013-02-19 |
US20090176793A1 (en) | 2009-07-09 |
ZA200808730B (en) | 2010-02-24 |
EA016026B1 (ru) | 2012-01-30 |
IL194681A (en) | 2013-09-30 |
EP2079732A1 (fr) | 2009-07-22 |
AU2007267197A1 (en) | 2007-12-06 |
EP2402324A1 (fr) | 2012-01-04 |
EP2079732B1 (fr) | 2011-12-21 |
RS52234B (en) | 2012-10-31 |
WO2007137968A1 (fr) | 2007-12-06 |
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