PT1807434E - Tienopiridinas a título de potenciadores alostéricos do receptor muscarínicom4 - Google Patents
Tienopiridinas a título de potenciadores alostéricos do receptor muscarínicom4 Download PDFInfo
- Publication number
- PT1807434E PT1807434E PT05812144T PT05812144T PT1807434E PT 1807434 E PT1807434 E PT 1807434E PT 05812144 T PT05812144 T PT 05812144T PT 05812144 T PT05812144 T PT 05812144T PT 1807434 E PT1807434 E PT 1807434E
- Authority
- PT
- Portugal
- Prior art keywords
- compound
- mmol
- methyl
- chloro
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
- Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62178504P | 2004-10-25 | 2004-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1807434E true PT1807434E (pt) | 2010-09-22 |
Family
ID=36021809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05812144T PT1807434E (pt) | 2004-10-25 | 2005-10-18 | Tienopiridinas a título de potenciadores alostéricos do receptor muscarínicom4 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8071776B2 (https=) |
| EP (1) | EP1807434B1 (https=) |
| JP (1) | JP4945453B2 (https=) |
| CN (1) | CN100577666C (https=) |
| AT (1) | ATE478876T1 (https=) |
| AU (1) | AU2005299957B2 (https=) |
| BR (1) | BRPI0517438A (https=) |
| CA (1) | CA2583550C (https=) |
| CY (1) | CY1111477T1 (https=) |
| DE (1) | DE602005023197D1 (https=) |
| DK (1) | DK1807434T3 (https=) |
| ES (1) | ES2349416T3 (https=) |
| MX (1) | MX2007004794A (https=) |
| PL (1) | PL1807434T3 (https=) |
| PT (1) | PT1807434E (https=) |
| WO (1) | WO2006047124A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9493481B2 (en) | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2014035829A1 (en) * | 2012-08-31 | 2014-03-06 | Vanderbilt University | Substituted 3-aminothieno[2,3-c]pyridine-2-carboxamide analogs as positive allosteric modulators |
| US9908893B2 (en) | 2013-06-11 | 2018-03-06 | Latvian Institute Of Organic Synthesis | Thieno [2,3-b] pyridines as multidrug resistance modulators |
| US9637498B2 (en) | 2013-08-23 | 2017-05-02 | Vanderbilt University | Substituted thieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| US10329289B2 (en) | 2015-12-23 | 2019-06-25 | Merck Sharp & Dohme Corp. | 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| MX385384B (es) | 2016-06-22 | 2025-03-18 | Univ Vanderbilt | Moduladores alostericos positivos del receptor muscarinico de acetilcolina m4 |
| WO2018002760A1 (en) | 2016-07-01 | 2018-01-04 | Pfizer Inc. | 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases |
| GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
| WO2018085803A1 (en) | 2016-11-07 | 2018-05-11 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| US10961253B2 (en) | 2016-11-07 | 2021-03-30 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2018085813A1 (en) * | 2016-11-07 | 2018-05-11 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112840A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6, 5-fused heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| BR112019026955A2 (pt) | 2017-06-22 | 2020-06-30 | Pfizer Inc. | derivados de di-hidro-pirrolo-piridina |
| WO2019000236A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000237A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| JP2021505581A (ja) | 2017-12-05 | 2021-02-18 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子 |
| TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
| WO2025201078A1 (zh) * | 2024-03-25 | 2025-10-02 | 四川科伦药物研究院有限公司 | 化合物、包含其的药物组合物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3430284A1 (de) * | 1984-08-17 | 1986-02-27 | Troponwerke GmbH & Co KG, 5000 Köln | Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung |
| MX9700696A (es) * | 1994-07-27 | 1997-04-30 | Sankyo Co | Compuestos heterociclicos, utiles como productores de efecto aloesterico en receptores muscarinicos. |
| US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| GB9924962D0 (en) * | 1999-10-21 | 1999-12-22 | Mrc Collaborative Centre | Allosteric sites on muscarinic receptors |
| CN1249051C (zh) * | 2000-04-28 | 2006-04-05 | 阿卡蒂亚药品公司 | 毒蕈碱性激动剂 |
| CA2475773A1 (en) * | 2002-02-20 | 2003-09-04 | Pharmacia & Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
| US6974870B2 (en) * | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
-
2005
- 2005-10-18 BR BRPI0517438-4A patent/BRPI0517438A/pt not_active IP Right Cessation
- 2005-10-18 DK DK05812144.3T patent/DK1807434T3/da active
- 2005-10-18 WO PCT/US2005/037271 patent/WO2006047124A1/en not_active Ceased
- 2005-10-18 US US11/577,508 patent/US8071776B2/en not_active Expired - Fee Related
- 2005-10-18 CN CN200580036624A patent/CN100577666C/zh not_active Expired - Fee Related
- 2005-10-18 PL PL05812144T patent/PL1807434T3/pl unknown
- 2005-10-18 CA CA2583550A patent/CA2583550C/en not_active Expired - Fee Related
- 2005-10-18 EP EP05812144A patent/EP1807434B1/en not_active Expired - Lifetime
- 2005-10-18 DE DE602005023197T patent/DE602005023197D1/de not_active Expired - Lifetime
- 2005-10-18 JP JP2007537951A patent/JP4945453B2/ja not_active Expired - Fee Related
- 2005-10-18 MX MX2007004794A patent/MX2007004794A/es active IP Right Grant
- 2005-10-18 AU AU2005299957A patent/AU2005299957B2/en not_active Ceased
- 2005-10-18 PT PT05812144T patent/PT1807434E/pt unknown
- 2005-10-18 ES ES05812144T patent/ES2349416T3/es not_active Expired - Lifetime
- 2005-10-18 AT AT05812144T patent/ATE478876T1/de active
-
2010
- 2010-10-14 CY CY20101100921T patent/CY1111477T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8071776B2 (en) | 2011-12-06 |
| PL1807434T3 (pl) | 2011-02-28 |
| AU2005299957B2 (en) | 2011-04-21 |
| CN101048413A (zh) | 2007-10-03 |
| EP1807434B1 (en) | 2010-08-25 |
| CN100577666C (zh) | 2010-01-06 |
| ES2349416T3 (es) | 2011-01-03 |
| JP4945453B2 (ja) | 2012-06-06 |
| WO2006047124A1 (en) | 2006-05-04 |
| CY1111477T1 (el) | 2015-08-05 |
| EP1807434A1 (en) | 2007-07-18 |
| AU2005299957A1 (en) | 2006-05-04 |
| DK1807434T3 (da) | 2010-11-22 |
| JP2008517913A (ja) | 2008-05-29 |
| MX2007004794A (es) | 2007-07-09 |
| ATE478876T1 (de) | 2010-09-15 |
| CA2583550C (en) | 2013-05-14 |
| DE602005023197D1 (de) | 2010-10-07 |
| US20090105244A1 (en) | 2009-04-23 |
| CA2583550A1 (en) | 2006-05-04 |
| BRPI0517438A (pt) | 2008-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1807434E (pt) | Tienopiridinas a título de potenciadores alostéricos do receptor muscarínicom4 | |
| RU2725140C2 (ru) | Тетрациклические соединения | |
| CN116583502A (zh) | 二环-杂环衍生物及其作为食欲素-2受体激动剂的用途 | |
| EA017187B1 (ru) | Конденсированные производные тиазола в качестве ингибиторов киназ | |
| EP3594203A1 (en) | Substituted pyrrolidine compound and use thereof | |
| HU196792B (en) | Process for producing 3,3-disubstituted indolin derivatives and pharmaceutical compositions containing them | |
| TW202237597A (zh) | 新型egfr降解劑 | |
| AU2012248629A1 (en) | Novel 3-hydroxyisothiazole 1-oxide derivative | |
| BRPI0712771A2 (pt) | sais de n-hidróxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino] metil]fenil]-2e-2-propenamida | |
| ES2245731T3 (es) | Sal citrato de 5,8,14-triazatetraciclo(10.3.1.02,11.04,9)-hexadeca-2(11),3,5,7,9-pentaeno. | |
| ES2340772T3 (es) | Nuevas formas cristalinas (2-(1-(3,5-bis-trifluorometilbencil)-5-piridin-4-il-1h-(1,2,3)triazol-4-il)-piridin-3-il)-(2-clorofenil)-metadona. | |
| TWI870440B (zh) | 活化素受體樣激酶抑制劑之鹽及晶體形式 | |
| JP2021526156A (ja) | ジメチルホスフィンオキシド化合物 | |
| CN105555778B (zh) | 环状胺衍生物及其药物用途 | |
| CN117157295A (zh) | 含吲哚啉螺环类衍生物、其制备方法及其在医药上的应用 | |
| CA2623154A1 (en) | Novel fused pyrrole derivative | |
| WO2022174765A1 (zh) | 作为Wee-1抑制剂的稠环化合物 | |
| CN116057061A (zh) | Usp7抑制剂 | |
| UA114295C2 (uk) | Сполука бензотіазолону | |
| EP4588921A1 (en) | Free base crystal form of polycyclic compound of nitrogen-containing heterocycle, and preparation method therefor | |
| CN110709401B (zh) | 杂环化合物 | |
| KR20200120915A (ko) | mGlu5 수용체의 조절제로서 트리아졸, 이미다졸 및 피롤 축합된 피페라진 유도체 및 이의 용도 | |
| AU2020328534B2 (en) | Salt and crystal forms of an activin receptor-like kinase inhibitor | |
| JP2018083767A (ja) | ヘテロアリールアミド化合物 | |
| WO2025185706A1 (zh) | 一种kif18a抑制剂的可药用盐、晶型及其制备方法和应用 |