PT1691833E - Composições compreendendo polipéptidos - Google Patents

Composições compreendendo polipéptidos Download PDF

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Publication number
PT1691833E
PT1691833E PT04803302T PT04803302T PT1691833E PT 1691833 E PT1691833 E PT 1691833E PT 04803302 T PT04803302 T PT 04803302T PT 04803302 T PT04803302 T PT 04803302T PT 1691833 E PT1691833 E PT 1691833E
Authority
PT
Portugal
Prior art keywords
polypeptide
ser
gly
thr
antigen
Prior art date
Application number
PT04803302T
Other languages
English (en)
Portuguese (pt)
Inventor
Nadja Prang
Robert Hofmeister
Andreas Wolf
Frank Hanakam
Thomas Urbig
Christian Itin
Patrick Baeuerle
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Publication of PT1691833E publication Critical patent/PT1691833E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT04803302T 2003-11-28 2004-11-26 Composições compreendendo polipéptidos PT1691833E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03027511 2003-11-28

Publications (1)

Publication Number Publication Date
PT1691833E true PT1691833E (pt) 2010-06-08

Family

ID=34626385

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04803302T PT1691833E (pt) 2003-11-28 2004-11-26 Composições compreendendo polipéptidos

Country Status (18)

Country Link
US (1) US10000574B2 (enExample)
EP (2) EP1691833B1 (enExample)
AT (1) ATE459374T1 (enExample)
AU (1) AU2004293182B2 (enExample)
BE (1) BE2016C023I2 (enExample)
CA (1) CA2544532C (enExample)
CY (2) CY1110689T1 (enExample)
DE (1) DE602004025840D1 (enExample)
DK (1) DK1691833T3 (enExample)
ES (1) ES2341252T3 (enExample)
FR (1) FR16C1000I2 (enExample)
HU (1) HUS1600019I1 (enExample)
LU (1) LU93067I2 (enExample)
NL (1) NL300807I2 (enExample)
PL (1) PL1691833T3 (enExample)
PT (1) PT1691833E (enExample)
SI (1) SI1691833T1 (enExample)
WO (1) WO2005052004A2 (enExample)

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CA2986263A1 (en) 2015-06-17 2016-12-22 Genentech, Inc. Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes
UA126278C2 (uk) 2015-09-21 2022-09-14 Аптево Рісьорч Енд Девелопмент Ллс Поліпептиди, які зв'язують cd3
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
PL3377103T5 (pl) 2015-11-19 2025-07-07 Revitope Limited Komplementacja funkcjonalnego fragmentu przeciwciała dla dwuskładnikowego układu do przekierowanego zabijania niepożądanych komórek
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CA2997406C (en) 2015-12-09 2024-05-28 F. Hoffmann-La Roche Ag Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release
US10596257B2 (en) 2016-01-08 2020-03-24 Hoffmann-La Roche Inc. Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
EP3252078A1 (en) 2016-06-02 2017-12-06 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
CA3059010A1 (en) 2016-06-02 2018-12-06 F. Hoffmann-La Roche Ag Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
CN109963871A (zh) 2016-08-05 2019-07-02 豪夫迈·罗氏有限公司 具有激动活性的多价及多表位抗体以及使用方法
JP7250674B2 (ja) 2016-08-08 2023-04-03 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト がんの治療及び診断方法
CA3039430A1 (en) 2016-12-19 2018-06-28 F. Hoffmann-La Roche Ag Combination therapy with targeted 4-1bb (cd137) agonists
MX2019006954A (es) 2016-12-20 2019-08-01 Hoffmann La Roche Terapia de combinacion de anticuerpos biespecificos anti-cd20/anti-cd3 y agonistas de 4-1bb (cd137).
BR112020007630A2 (pt) 2017-11-01 2020-11-17 F. Hoffmann-La Roche Ag anticorpo biespecífico ox40, produto farmacêutico, composição farmacêutica e anticorpos biespecíficos anti-fap/ anti-ox40
TWI841551B (zh) 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 使用靶向4-1bb (cd137)之促效劑的組合療法
JP7159332B2 (ja) 2018-03-13 2022-10-24 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 4-1bbアゴニストと抗cd20抗体の治療的組み合わせ
US12404328B2 (en) * 2018-06-07 2025-09-02 Cullinan Management, Inc. Multi-specific binding proteins and methods of use thereof
CA3111809A1 (en) 2018-09-21 2020-03-26 Genentech, Inc. Diagnostic methods for triple-negative breast cancer
TWI872030B (zh) 2018-11-05 2025-02-11 美商建南德克公司 在原核宿主細胞中產生二鏈蛋白質之方法
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BR112021022682A2 (pt) 2019-05-14 2022-02-22 Provention Bio Inc Métodos e composições para prevenir diabetes do tipo 1
CU20210096A7 (es) 2019-05-21 2022-06-06 Novartis Ag Moléculas de unión a cd19
AU2020403273A1 (en) 2019-12-11 2022-06-30 Cullinan Oncology, Inc. Anti-CD19 antibodies and multi-specific binding proteins
CA3182445A1 (en) 2020-06-11 2021-12-16 Francisco Leon Methods and compositions for preventing type 1 diabetes
KR20230025691A (ko) 2020-06-16 2023-02-22 제넨테크, 인크. 삼중 음성 유방암을 치료하기 위한 방법과 조성물
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KR20230152032A (ko) 2021-02-03 2023-11-02 모차르트 쎄라퓨틱스 인코포레이티드 결합제 및 이를 사용하는 방법
AU2022253902A1 (en) 2021-04-10 2023-11-02 Genmab A/S Folr1 binding agents, conjugates thereof and methods of using the same
JP7742892B2 (ja) 2021-04-23 2025-09-22 ジェンマブ エー/エス 抗cd70抗体、そのコンジュゲートおよびこれを使用する方法
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TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
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Also Published As

Publication number Publication date
NL300807I2 (enExample) 2016-10-13
LU93067I2 (fr) 2016-07-11
ES2341252T3 (es) 2010-06-17
AU2004293182A1 (en) 2005-06-09
CA2544532A1 (en) 2005-06-09
PL1691833T3 (pl) 2010-08-31
WO2005052004A3 (en) 2006-03-09
DK1691833T3 (da) 2010-05-03
CY1110689T1 (el) 2015-06-10
FR16C1000I1 (enExample) 2016-06-24
AU2004293182B2 (en) 2010-02-18
US20070249529A1 (en) 2007-10-25
SI1691833T1 (sl) 2010-06-30
ATE459374T1 (de) 2010-03-15
DE602004025840D1 (de) 2010-04-15
EP1691833A2 (en) 2006-08-23
CA2544532C (en) 2015-06-16
EP2186527A1 (en) 2010-05-19
FR16C1000I2 (fr) 2017-02-03
EP1691833B1 (en) 2010-03-03
CY2016010I1 (el) 2016-08-31
US10000574B2 (en) 2018-06-19
CY2016010I2 (el) 2016-08-31
BE2016C023I2 (enExample) 2023-12-18
HUS1600019I1 (hu) 2016-06-28
WO2005052004A2 (en) 2005-06-09

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